导师风采
毕艳
个人信息
Personal Information
- 性别：女
- 导师类型：博士生导师
- 职称：主任医师
- 该职称任职时间：20161211
联系方式
Contact Information
- 所属院系：南京鼓楼医院（南京）
- 所属专业：内科学
- 邮箱 : biyan@nju.edu.cn
- 工作电话 : 025-68182474
个人简介
Personal Profile
毕艳 南京大学医学院附属鼓楼医院副院长兼临床医学研究院院长、内分泌科学科带头人，主任医师，教授，博士生导师。中华医学会糖尿病学分会委员，中华医学会糖尿病学分会肥胖与糖尿病学组副组长，中国康复医学会糖尿病预防与康复专业委会副主任委员，江苏省医学会糖尿病学分会副主任委员，江苏省老年医学学会老年内分泌分会主任委员，南京医学会内分泌学分会主任委员，南京市糖尿病并发症研究会脑病分会主任委员，中华糖尿病杂志编委。研究集中于2型糖尿病和肥胖的治疗靶点及临床转化研究，以第一及通讯作者在Cell Metabolism, Diabetes Care, Nature Communications, Journal of Hepatology, Diabetes等杂志发表SCI论著96篇。成果写入国际糖尿病联盟全球糖尿病指南和亚太工作组非酒精性脂肪性肝病指南。在美国糖尿病年会、欧洲糖尿病年会、国际糖尿病联盟西太平洋会议、中华医学会糖尿病学分会全国年会等大会报告40次。主持国家自然科学基金重点项目、科技部国家重点研发计划子课题等科研项目29项。相关研究获中国糖尿病十大研究最具影响力研究奖，江苏医学科技奖一等奖，江苏省医学新技术引进一等奖。担任代谢领域国际一流期刊Diabetes Care等杂志审稿人和Diabetes Obesity &Metabolism编委。入选中华医学会糖尿病学分会杰出青年科学研究者，江苏省医学重点人才，江苏省333高层次人才培养工程第二层次培养对象，江苏省六大人才高峰，南京市有突出贡献中青年专家。
团队简介
Team Profile
待补充更新
- 研究方向Research Directions
内分泌与代谢病
- 在校研究生Current Graduate Students
硕士研究生 5 名，博士研究生 2 名
- 科研项目Research Projects
| # | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
|---|---|---|---|---|---|
| 1 | 基于人工智能的多模态一体化NASH无创诊断和决策系统的建设 | 2022-06-23 —— | 50.0 | 主持在研的国家或省部级科研项目 | 主持者 |
| 2 | “十四五”省医学重点学科建设单位，内分泌病学与代谢病学 | 2022-12-09 —— | 40.0 | 主持在研的国家或省部级科研项目 | 主持者 |
| 3 | CD9 CD55low脂肪前体细胞介导高脂诱导脂肪组织炎症和2型糖尿病的作用和机制研究 | 2022-09-07 —— | 52.0 | 主持在研的国家或省部级科研项目 | 主持者 |
| 4 | 泌乳素介导营养感应通过神经-内分泌机制调控肝脏脂质代谢稳态的研究 | 2020-09-18 —— | 297.0 | 主持在研的国家或省部级科研项目 | 主持者 |
- 发表论文Papers
| # | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
|---|---|---|---|---|
| 1 | Enhancement of Impaired Olfactory Neural Activation and Cognitive Capacity by Liraglutide, but not Dapagliflozin or Acarbose, in Patients with Type 2 Diabetes: A 16 Week Randomized Parallel Comparative Study | Diabetes Care | 2022-05 | 通讯作者 |
| 2 | Altered Brain Spontaneous and Synchronization Activity in latent autoimmune diabetes in adults: A Resting-State Functional MRI Study | Diabetes-Metabolism Research and Reviews | 2023-01 | 通讯作者 |
| 3 | The association between visceral adipocyte hypertrophy and NAFLD in subjects with different degrees of adiposity | Hepatology International | 2023-02 | 通讯作者 |
| 4 | Gender differences in the association of body composition and biopsy-proved nonalcoholic steatohepatitis | Hepatology International | 2022-04 | 通讯作者 |
| 5 | Altered odor-induced brain activity as an early manifestation of cognitive decline in patients with type 2 diabetes | Diabetes | 2018-05 | 通讯作者 |
| 6 | Prolactin improves hepatic steatosis via CD36 pathway | J Hepatol | 2018-06 | 通讯作者 |
| 7 | Adipose group 1 innate lymphoid cells promote adipose tissue fibrosis and diabetes in obesity | Nat Commun | 2019-07 | 通讯作者 |
| 8 | Extracellular vesicles mediate the communication of adipose tissue with brain and promote cognitive impairment associated with insulin resistance | Cell Metabolism | 2022-09 | 通讯作者 |
| 9 | Comparison of therapeutic effects of mesenchymal stem cells from umbilical cord and bone marrow in the treatment of type 1 diabetes | Stem Cell Research & Therapy | 2022-08 | 通讯作者 |
| 10 | Olfactory dysfunction mediates adiposity in cognitive impairment of type 2 diabetes: insights from clinical and functional neuroimaging studies | Diabetes Care | 2019-07 | 通讯作者 |
| 11 | Single-cell analysis reveals a subpopulation of adipose progenitor cells that impairs glucose homeostasis | Nat Commun | 2024-06 | 通讯作者 |
| 12 | Harvesting stem cell exosomes from herringbone microfluidic bioreactor for wound healing | Nano Today | 2023-10 | 通讯作者 |
| 13 | Bio-inspired self-adhesive microparticles with melanin nanoparticles integration for wound closure and healing | Nano Today | 2024-02 | 通讯作者 |
| 14 | Low levels of osteocalcin, but not CTX or P1NP, are associated with nonalcoholic hepatic steatosis and steatohepatitis | Diabetes Metab | 2023-03 | 通讯作者 |
| 15 | Associations between complexity of glucose time series and cognitive function in adults with type 2 diabetes | Diabetes Obes Metab | 2024-03 | 通讯作者 |
| 16 | The presence and severity of NAFLD are associated with cognitive impairment and hippocampal damage | J Clin Endocrinol Metab | 2023-11 | 通讯作者 |
| 17 | Comparison on cognitive outcomes of antidiabetic agents for type 2 diabetes: A systematic review and network meta-analysis | Diabetes Metab Res Rev | 2023-06 | 通讯作者 |
| 18 | Th1 bias of liver mucosal-associated invariant T cells promotes hepatic gluconeogenesis in type 2 diabetes mellitus | Diabetes Metab Res Rev | 2023-05 | 通讯作者 |
| 19 | Multiple Bio-Actives Loaded Gellan Gum Microfibers from Microfluidics for Wound Healing | Small | 2023-07 | 通讯作者 |
| 20 | Placenta-derived exosomes exacerbate beta cell dysfunction in gestational diabetes mellitus through delivery of miR-320b | Front Endocrinol | 2024-01 | 通讯作者 |
| 21 | Role of clinical pharmacists in multidisciplinary collaborative management of blood glucose in COVID-19 patients with hyperglycemia | Res Social Adm Pharm | 2024-02 | 通讯作者 |
| 22 | Development and Validation of a Risk Score for Mild Cognitive Impairment in Individuals with Type 2 Diabetes in China: A Practical Cognitive Prescreening Tool | Diabetes Metab Syndr Obes | 2024-03 | 通讯作者 |
| 23 | Detection of Glutamate Decarboxylase Antibodies and Simultaneous Multi-Molecular Translocation Exploration by Glass Nanopores | Biosensors | 2024-05 | 通讯作者 |
| 24 | The role of miRNAs carried by extracellular vesicles in type 2 diabetes and its complications | J Diabetes | 2023-10 | 通讯作者 |
| 25 | Comparison of Beinaglutide Versus Metformin for Weight Loss in Overweight and Obese Non-diabetic Patients | Exp Clin Endocrinol Diabetes | 2022-06 | 通讯作者 |
| 26 | Associations Between Obesity and Kidney Disease in Chinese Men and Women With Type 2 Diabetes: A Retrospective Cohort Study | Can J Diabetes | 2022-02 | 通讯作者 |
| 27 | Effects of Early Intensive Insulin Therapy on Endothelial Progenitor Cells in Patients with Newly Diagnosed Type 2 Diabetes | Diabetes Ther | 2022-04 | 通讯作者 |
| 28 | Increased plasmablasts enhance T cell-mediated beta cell destruction and promote the development of type 1 diabetes | Mol Med | 2022-02 | 通讯作者 |
| 29 | Expression and clinical significance of VISTA and PD-L1 in adrenocortical carcinoma | Endocr Relat Cancer | 2022-05 | 通讯作者 |
| 30 | The correlation of the neutrophil-lymphocyte ratio to clinical and imaging parameters in patients with thyroid eye disease | Endocr Connect | 2022-10 | 通讯作者 |
| 31 | Lower serum PRL is associated with the development of non-alcoholic fatty liver disease: a retrospective cohort study | BMC Gastroenterol | 2022-12 | 通讯作者 |
| 32 | Effect of probiotics combined with metformin on improvement of menstrual and metabolic patterns in women with polycystic ovary syndrome: a randomized clinical trial | Gynecol Endocrinol | 2022-10 | 通讯作者 |
| 33 | Association of Omental Adipocyte Hypertrophy and Fibrosis with Human Obesity and Type 2 Diabetes | Obesity | 2021-06 | 通讯作者 |
| 34 | Risk Prediction Model of Gestational Diabetes Mellitus in a Chinese Population Based on a Risk Scoring System | Diabetes Ther | 2021-06 | 通讯作者 |
| 35 | Are Chinese Patients with Type 2 Diabetes and a Body Mass Index of 27.5-32.5 kg/m2 Suitable for Metabolic Surgery? A One-Year Post-Surgery Study | Diabetes Ther | 2021-05 | 通讯作者 |
| 36 | One repeated transplantation of allogeneic umbilical cord mesenchymal stromal cells in type 1 diabetes: an open parallel controlled clinical study | Stem Cell Res Ther | 2021-06 | 通讯作者 |
| 37 | Corneal confocal microscopy: A useful tool for diagnosis of small fiber neuropathy in type 2 diabetes | J Diabetes Investig | 2021-12 | 通讯作者 |
| 38 | Body Adiposity Index Is Predictive of Weight Loss after Roux-en-Y Gastric Bypass | Ann Nutr Metab | 2021-05 | 通讯作者 |
| 39 | Peripheral Administration of NMU Promotes White Adipose Tissue Beiging and Improves Glucose Tolerance | Int J Endocrinol | 2021-08 | 通讯作者 |
| 40 | Better Islet Function and Cardiovascular Autonomic Function in Chinese Type 2 Diabetic Patients with Pure Small Fiber Neuropathy than with Mixed Neuropathy | Diabetes Ther | 2021-09 | 通讯作者 |
- 科研获奖Research Awards
| # | 获奖证书编号 | 奖项名称 | 获奖级别 | 获奖类别 | 获奖等级 | 获奖日期 | 颁奖单位 | 本单位是否为第一完成单位 | 完成单位排名 | 本人排序 | 备注 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2018-A-193600P9-1 | 中国2型糖尿病高血糖病理生理特点及干预新靶点 | 省部级 | 江苏医学科技奖 | 一等奖 | 2018-12-28 | 江苏省医学会 | 是 | 1 | 1 | |
| 2 | 2018-3-1 | 糖尿病心血管自主神经病变早期筛查技术及其临床应用 | 省部级 | 江苏省医学新技术引进奖 | 一等奖 | 2018-10-26 | 江苏省卫健委 | 是 | 1 | 1 | |
| 3 | 2018-2-66-R2 | 糖尿病发病新机制和诊疗新技术 | 省部级 | 江苏省科学技术奖 | 二等奖 | 2019-03-29 | 江苏省人民政府 | 是 | 1 | 2 | |
| 4 | 2023-1-2-1 | 嗅觉定量诊断在2型糖尿病认知障碍风险预警中的作用及临床应用 | 省部级 | 江苏省医学新技术引进奖 | 一等奖 | 2023-11-17 | 江苏省卫健委 | 是 | 1 | 1 | |
| 5 | 2022-A-000830107 | 糖尿病神经并发症的早期诊断技术研究与临床应用 | 省部级以下 | 江苏省瑞华慈善基金会临床研究创新奖三等奖 | 特等奖 | 2022-11-01 | 江苏省瑞华慈善基金会 | 是 | 1 | 1 | |
| 6 | 2022-0-2-1 | 非酒精性脂肪性肝病新风险指标的建立及临床应用 | 省部级以下 | 南京市医学新技术奖特等奖 | 特等奖 | 2023-02-02 | 南京市卫健委 | 是 | 1 | 1 |
- 研究成果Research Findings
| # | 成果类型 | 项目/专利/新品种名称 |
|---|---|---|
| 1 | 作为主创人员获得授权的发明专利和新品种 | 一种基于脂肪外泌体的神经元转染方法及其应用 |
| 2 | 作为主创人员获得授权的发明专利和新品种 | 可自动计数心率并报出听诊声音的加热式听诊器 |
| 3 | 出版高水平专著 | 《内分泌内科学》第3版 |
| 4 | 出版高水平专著 | 二甲双胍与糖尿病治疗——百问百答 |
| 5 | 作为主创人员获得授权的发明专利和新品种 | NEURON TRANSFECTION METHOD BASED ON FAT EXOSOME AND APPLICATION THEREOF |
| 6 | 作为主创人员获得授权的发明专利和新品种 | 一种具有嗅觉检测功能的穿戴式设备 |
| 7 | 出版高水平专著 | 内分泌代谢病临床思维训练 |