导师风采
徐运
个人信息
Personal Information
- 性别：女
- 导师类型：博士生导师
- 职称：主任医师
- 该职称任职时间：200408
联系方式
Contact Information
- 所属院系：南京鼓楼医院（南京）
- 所属专业：神经病学
- 邮箱 : xuyun20042001@aliyun.com
- 工作电话 : 025-83106666
个人简介
Personal Profile
徐运，女，南京大学鼓楼医院神经科主任，主任医师，教授、博导。国务院政府特殊津贴专家。中国杰出神经内科医师，江苏省优秀医学领军人才，中国卒中奖等。国家和省临床重点专科、省神经病学重点学科主任、省脑血管病诊疗中心主任，省神经内科质控中心和脑卒中质控中心主任等。曾在德国海德堡大学、美国霍普金斯大学留学。现任中华医学会神经病学分会副主任委员，中华预防学会预防与控制专业委员会副主任委员，中国医师协会神经内科医师分会副会长，江苏省卒中学会理事长等，Neuroscience Bulletin、Aging and Disease、Journal of Alzheimer's Disease副主编、《国际脑血管病杂志》、《临床神经病学病杂志》、《中风与神经疾病杂志》、《中华脑血管病杂志》副总编辑，Advanced Neurology主编等。 主持国家、省部级重点科研项目30多项。其中2022首席科学家主持科技部脑科学重大项目1项，国自然重点项目和重大国合4项等。发表论文300余篇，第一和通讯SCI文章202篇，IF 930.318，H因子48。（PNAS，Stroke，Brain Behav Immun，Mol Endocrinol，JCBFM， Aging Cell，J Neuroinflammation等），发明专利10项。主编和参编论著12部，副主编和参编“五年制”、“八年制”教材4部。获省部级科技1、2等奖5项。
团队简介
Team Profile
待补充更新
- 研究方向Research Directions
脑血管病的基础和临床研究,痴呆早期诊断和治疗的研究
- 在校研究生Current Graduate Students
硕士研究生 3 名，博士研究生 2 名
- 科研项目Research Projects
| # | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
|---|---|---|---|---|---|
| 1 | 靶向Ifitm2逆转CSVD脑白质损伤的机制及其临床价值 | 2022-01-01 —— 2026-12 | 293.0 | 主持在研的国家或省部级科研项目 | 主持者 |
| 2 | SCD转化为阿尔茨海默病新机制及其预警和干预体系的研究 | 2022-12-01 —— 2027-01-01 | 5955.1 | 主持在研的国家或省部级科研项目 | 主持者 |
| 3 | 缺血性脑血管病相关的精准化诊疗研究 | 2016-01-01 —— 2019-01 | 400.0 | 主持在研的国家或省部级科研项目 | 主持者 |
| 4 | 小胶质细胞环境感应元件p2ry13在缺血性脑损伤中的作用及机制研究 | 2020-01-01 —— 2024-12 | 249.0 | 主持在研的国家或省部级科研项目 | 主持者 |
| 5 | 缺血性脑血管病早期诊疗评估体系和预警模型的研究 | 2020-12 —— 2023-06 | 200 | 主持在研的国家或省部级科研项目 | 主持人 |
- 发表论文Papers
| # | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
|---|---|---|---|---|
| 1 | FasL-PDPK1 pathway promotes the cytotoxicity of CD8 T cells during ischemic stroke | Translational Stroke Research | 2020-01 | 通讯作者 |
| 2 | HDAC3 inhibitor RGFP966 ameliorated ischemic brain damage by down-regulating the AIM2 inflammasome. | FASEB Journal | 2020-01 | 通讯作者 |
| 3 | HDAC3 inhibition ameliorates ischemia/reperfusion-induced brain injury by regulating the microglial cGAS-STING pathway. | Theranostics | 2020-01 | 通讯作者 |
| 4 | Targeting connexin 43 provides anti-inflammatory effects after intracerebral hemorrhage injury by regulating YAP signaling. | J Neuroinflammation | 2020-01 | 通讯作者 |
| 5 | Microglial lnc-U90926 facilitates neutrophil infiltration in ischemic stroke via MDH2/CXCL2 axis. | Molecular Therapy | 2021-01 | 通讯作者 |
| 6 | Relationship between estimated glomerular filtration rate and outcome of ischemic stroke patients after mechanical thrombectomy. | CNS Neuroscience & Therapeutics | 2021-01 | 通讯作者 |
| 7 | miR-204-3p/Nox4 mediates memory deficits in a mouse model of Alzheimer's Disease,. | Molecular Therapy | 2021-01 | 通讯作者 |
| 8 | Imperatorin inhibits mitogen-activated protein kinase and nuclear factor kappa-B signaling pathways and alleviates neuroinflammation in ischemic stroke. | CNS Neuroscience & Therapeutics | 2022-01 | 通讯作者 |
| 9 | Effects of cognitive reserve proxies on cognitive function and frontoparietal control network in subjects with white matter hyperintensities: A cross-sectional functional magnetic resonance imaging study. | CNS Neurosci Ther | 2022-01 | 通讯作者 |
| 10 | Pentoxifylline alleviates ischemic white matter injury through up-regulating Mertk-mediated myelin clearance. | J Neuroinflammation | 2022-01 | 通讯作者 |
| 11 | Prefrontal parvalbumin interneurons deficits mediate early emotional dysfunction in Alzheimer's disease. | Neuropsychopharmacology | 2023-01 | 通讯作者 |
| 12 | Optogenetic Stimulation of mPFC Alleviates White Matter Injury-Related Cognitive Decline after Chronic Ischemia through Adaptive Myelination. | Adv Sci (Weinh) | 2022-01 | 通讯作者 |
| 13 | Absent in melanoma 2 mediates aging-related cognitive dysfunction by acting on complement-dependent microglial phagocytosis. | Aging Cell | 2023-01 | 通讯作者 |
| 14 | Noncanonical contribution of microglial transcription factor NR4A1 to post-stroke recovery through TNF mRNA destabilization. | PLoS Biol | 2023-01 | 通讯作者 |
| 15 | Growth arrest specific protein 6 alleviated white matter injury after experimental ischemic stroke. | J Cereb Blood Flow Metab | 2023-01 | 通讯作者 |
| 16 | Acute ischemia induces spatially and transcriptionally distinct microglial subclusters. | Genome Med | 2023-01 | 通讯作者 |
| 17 | PSD-93 Interacts with SynGAP and Promotes SynGAP Ubiquitination and Ischemic Brain Injury in Mice. | Translational Stroke Research | 2020-01 | 通讯作者 |
| 18 | The efficacy of gray matter atrophy and cognitive assessment in differentiation of aMCI and naMCI. | Appl Neuropsychol Adult | 2020-01 | 通讯作者 |
| 19 | Microstructural disruption of the right inferior fronto-occipital and inferior longitudinal fasciculus contributes to WMH-related cognitive impairment. | CNS Neuroscience & Therapeutics | 2020-01 | 通讯作者 |
| 20 | Guidelines for Acute Ischemic Stroke Treatment. | Neurosci Bull | 2020-01 | 通讯作者 |
| 21 | Muscone Ameliorates Synaptic Dysfunction and Cognitive Deficits in APP/PS1 Mice. | J Alzheimers Dis | 2020-01 | 通讯作者 |
| 22 | Xingnaojing ameliorates synaptic plasticity and memory deficits in an Aβ induced mouse model of Alzheimer's disease. | J. Pharmacol. Sci | 2020-01 | 通讯作者 |
| 23 | Delayed PARP-1 Inhibition Alleviates Post-stroke Inflammation in Male Versus Female Mice: Differences and Similarities. | Front Cell Neurosci | 2020-01 | 通讯作者 |
| 24 | Hederagenin Attenuates Cerebral Ischaemia/Reperfusion Injury by Regulating MLK3 Signalling. | Front Pharmacol | 2020-01 | 通讯作者 |
| 25 | Overexpression of miR-217-5p protects against oxygen-glucose deprivation/reperfusion-induced neuronal injury via inhibition of PTEN. | Hum. Cell | 2020-01 | 通讯作者 |
| 26 | 6-Gingerol attenuates microglia-mediated neuroinflammation and ischemic brain injuries through Akt-mTOR-STAT3 signaling pathway. | Eur J Pharmacol | 2020-01 | 通讯作者 |
| 27 | A comparison of three platelet function tests in ischemic stroke patients with antiplatelet therapy. | J Clin Neurosci | 2020-01 | 通讯作者 |
| 28 | The Asymmetry of White Matter Hyperintensity Burden Between Hemispheres Is Associated With Intracranial Atherosclerotic Plaque Enhancement Grade. | Front Aging Neurosci | 2020-01 | 通讯作者 |
| 29 | Lower Cerebrovascular Reactivity Contributed to White Matter Hyperintensity-Related Cognitive Impairment: A Resting-State Functional MRI Study. | J Magn Reson Imaging | 2020-01 | 通讯作者 |
| 30 | Poncirin suppresses lipopolysaccharide (LPS)-induced microglial inflammation and ameliorates brain ischemic injury in experimental stroke in mice. | Ann Transl Med | 2020-01 | 通讯作者 |
| 31 | A study on the inhibition of Aβ1-42-induced inflammatory response by Huatuo Zaizao pill based on the NF-κB signaling pathway. | Archives of Medical Science | 2020-01 | 通讯作者 |
| 32 | Early Segmental White Matter Fascicle Microstructural Damage Predicts the Corresponding Cognitive Domain Impairment in Cerebral Small Vessel Disease Patients by Automated Fiber Quantification. | Front Aging Neurosci | 2020-01 | 通讯作者 |
| 33 | Exosomal microRNAs contribute to cognitive impairment in hypertensive patients by decreasing frontal cerebrovascular reactivity. | Frontiers in Neuroscience | 2021-01 | 通讯作者 |
| 34 | CART mitigates oxidative stress and DNA damage in memory deficits of APP/PS1 mice via upregulating β‑amyloid metabolism‑associated enzymes. | Molecular Medicine Reports | 2021-01 | 通讯作者 |
| 35 | MicroRNA-532-5p protects against cerebral ischemia-reperfusion injury by directly targeting CXCL1. | Aging (Albany NY) | 2021-01 | 通讯作者 |
| 36 | The role of lncRNAs in ischemic stroke. | Neurochemistry International | 2021-01 | 通讯作者 |
| 37 | Knockdown of lncRNA SNHG14 alleviates LPS-induced inflammation and apoptosis of PC12 cells by regulating miR-181b-5p. | Experimental and Therapeutic Medicine | 2021-01 | 通讯作者 |
| 38 | Akt3-mTOR regulates hippocampal neurogenesis in adult mouse. | Journal of Neurochemistry | 2021-01 | 通讯作者 |
| 39 | Silencing of miR-497-5p inhibits cell apoptosis and promotes autophagy in Parkinson's disease by upregulation of FGF2. | Environmental Toxicology | 2021-01 | 通讯作者 |
| 40 | Influence of white matter lesions on the prognosis of acute cardioembolic stroke without reperfusion therapy. | BMC Neurology | 2021-01 | 通讯作者 |
| 41 | Synthetic VSMCs induce BBB disruption mediated by MYPT1 in ischemic stroke. | iScience | 2021-01 | 通讯作者 |
| 42 | JLX001 ameliorates cerebral ischemia injury by modulating microglial polarization and compromising NLRP3 inflammasome activation via the NF-κB signaling pathway. | International Immunopharmacology | 2021-01 | 通讯作者 |
| 43 | γ-Glutamylcysteine Alleviates Ischemic Stroke-Induced Neuronal Apoptosis by Inhibiting ROS-Mediated Endoplasmic Reticulum Stress. | Oxidative Medicine and Cellular Longevity | 2021-01 | 通讯作者 |
| 44 | Magnetic Resonance Imaging Features of Tropical Candidal Meningoencephalitis. | JAMA Neurol | 2022-01 | 通讯作者 |
| 45 | The Role of Microglial Phagocytosis in Ischemic Stroke. | Front Immunol | 2021-01 | 通讯作者 |
| 46 | The Cerebrovascular Reactivity-Adjusted Spontaneous Brain Activity Abnormalities in White Matter Hyperintensities Related Cognitive Impairment: A Resting-State Functional MRI Study. | J Alzheimers Dis | 2022-01 | 通讯作者 |
| 47 | γδ T cells aggravate blood-brain-barrier injury via IL-17A in experimental ischemic stroke. | Neurosci Lett | 2022-01 | 通讯作者 |
| 48 | The flexibility of cognitive reserve in regulating the frontoparietal control network and cognitive function in subjects with white matter hyperintensities. x | Behav Brain Res | 2022-01 | 通讯作者 |
| 49 | Abnormal Cerebrovascular Reactivity and Functional Connectivity Caused by White Matter Hyperintensity Contribute to Cognitive Decline. | Front Neurosci | 2022-01 | 通讯作者 |
| 50 | TMAO as a Novel Predictor of Major Adverse Vascular Events and Recurrence in Patients with Large Artery Atherosclerotic Ischemic Stroke. | Clin Appl Thromb Hemost | 2022-01 | 通讯作者 |
| 51 | Lobar Cerebral Microbleeds Are Associated With Cognitive Decline in Patients With Type 2 Diabetes Mellitus. | Front Neurol | 2022-01 | 通讯作者 |
| 52 | Serpine1 Regulates Peripheral Neutrophil Recruitment and Acts as Potential Target in Ischemic Stroke. | J Inflamm Res | 2022-01 | 通讯作者 |
| 53 | Neuronal Death Mechanisms and Therapeutic Strategy in Ischemic Stroke. | Neurosci Bull | 2022-01 | 通讯作者 |
| 54 | Fraxetin alleviates microglia-mediated neuroinflammation after ischemic stroke. | Ann Transl Med | 2022-01 | 通讯作者 |
| 55 | Medial Temporal Atrophy Contributes to Cognitive Impairment in Cerebral Small Vessel Disease. | Front Neurol | 2022-01 | 通讯作者 |
| 56 | The Regulation and Modification of GSDMD Signaling in Diseases. | Front Immunol | 2022-01 | 通讯作者 |
| 57 | The Enhanced Interhemispheric Functional Connectivity in the Striatum Is Related to the Cognitive Impairment in Individuals With White Matter Hyperintensities. | Front Neurosci | 2022-01 | 通讯作者 |
| 58 | Identification of a Small Molecule with Strong Anti-Inflammatory Activity in Experimental Autoimmune Encephalomyelitis and Sepsis through Blocking Gasdermin D Activation. | J Immunol | 2022-01 | 通讯作者 |
| 59 | ERK inhibition reduces neuronal death and ameliorates inflammatory responses in forebrain-specific Ppp2cα knockout mice. | FASEB J | 2022-01 | 通讯作者 |
| 60 | Bergapten attenuates microglia-mediated neuroinflammation and ischemic brain injury by targeting Kv1.3 and Carbonyl reductase 1. | Eur J Pharmacol | 2022-01 | 通讯作者 |
| 61 | Regulation of Microglia-Activation-Mediated Neuroinflammation to Ameliorate Ischemia-Reperfusion Injury via the STAT5-NF-κB Pathway in Ischemic Stroke. | Brain Sci | 2022-01 | 通讯作者 |
| 62 | Altered local gyrification and functional connectivity in type 2 diabetes mellitus patients with mild cognitive impairment: A pilot cross-sectional small-scale single center study. | Front Aging Neurosci | 2022-01 | 通讯作者 |
| 63 | A monoamine oxidase B inhibitor ethyl ferulate suppresses microglia-mediated neuroinflammation and alleviates ischemic brain injury. | Front Pharmacol | 2022-01 | 通讯作者 |
| 64 | An explainable machine learning model for predicting the outcome of ischemic stroke after mechanical thrombectomy. | J Neurointerv Surg | 2022-01 | 通讯作者 |
| 65 | A splicing-dependent ER retention signal regulates surface expression of the mechanosensitive TMEM63B cation channel. | J Biol Chem | 2022-01 | 通讯作者 |
| 66 | Glymphatic Dysfunction Mediates the Influence of White Matter Hyperintensities on Episodic Memory in Cerebral Small Vessel Disease. | Brain Sci | 2022-01 | 通讯作者 |
| 67 | Low-dose intravenous tirofiban infusion after endovascular recanalization for non-acute middle cerebral artery occlusion. | Heliyon | 2022-01 | 通讯作者 |
| 68 | Subsystem mechanisms of default mode network underlying white matter hyperintensity-related cognitive impairment. | Hum Brain Mapp | 2023-01 | 通讯作者 |
| 69 | CD11c microglia promote white matter repair after ischemic stroke. | Cell Death Dis | 2023-01 | 通讯作者 |
| 70 | MYPT1 Mice Function as a Novel Spontaneous Age- and Hypertension-Dependent Animal Model of CSVD. | Transl Stroke Res | 2023-01 | 通讯作者 |
| 71 | Altered neuroimaging patterns of cerebellum and cognition underlying the gait and balance dysfunction in cerebral small vessel disease. | Front Aging Neurosci | 2023-01 | 通讯作者 |
| 72 | Determination of the role of hippocampal astrocytes in the bilateral common carotid artery stenosis mouse model by RNA sequencing. | Neurosci Lett | 2023-01 | 通讯作者 |
| 73 | Fasting blood glucose-to-glycated hemoglobin ratio for evaluating clinical outcomes in patients with ischemic stroke. | Front Neurol | 2023-01 | 通讯作者 |
| 74 | Astrocytic CXCL5 hinders microglial phagocytosis of myelin debris and aggravates white matter injury in chronic cerebral ischemia. | J Neuroinflammation, | 2023-01 | 通讯作者 |
| 75 | Altered static and dynamic functional network connectivity related to cognitive decline in individuals with white matter hyperintensities. | Behav Brain Res | 2023-01 | 通讯作者 |
| 76 | Compound from Magnolia officinalis Ameliorates White Matter Injury by Promoting Oligodendrocyte Maturation in Chronic Cerebral Ischemia Models. | Neurosci Bull | 2023-01 | 通讯作者 |
| 77 | A newly-synthesized compound CP-07 alleviates microglia-mediated neuroinflammation and ischemic brain injury via inhibiting STAT3 phosphorylation. | J Transl Int Med | 2023-01 | 通讯作者 |
| 78 | Altered morphological connectivity mediated white matter hyperintensity-related cognitive impairment. | Brain Res Bull | 2023-01 | 通讯作者 |
| 79 | QHRD106 ameliorates ischemic stroke injury as a long-acting tissue kallikrein preparation. | iScience | 2023-01 | 通讯作者 |
| 80 | A splicing-dependent ER retention signal regulates surface expression of the mechanosensitive TMEM63B cation channel. | J Biol Chem | 2023-01 | 通讯作者 |
| 81 | Infiltrating myeloid cell-derived properdin markedly promotes microglia-mediated neuroinflammation after ischemic stroke. | J Neuroinflammation | 2023-01 | 通讯作者 |
| 82 | MFG-E8 Alleviates Cognitive Impairments Induced by Chronic Cerebral Hypoperfusion by Phagocytosing Myelin Debris and Promoting Remyelination. | Neurosci Bull | 2023-01 | 通讯作者 |
| 83 | LLDT-8 ameliorates experimental autoimmune encephalomyelitis by mediating macrophage functions in the priming stage. | Eur J Pharmacol | 2024-01 | 通讯作者 |
| 84 | Characteristic patterns of functional connectivity-mediated cerebral small vessel disease-related cognitive impairment and depression. | Cereb Cortex | 2023-01 | 通讯作者 |
| 85 | MicroRNA-195 liposomes for therapy of Alzheimer's disease. | J Control Release | 2023-01 | 通讯作者 |
| 86 | GM-CSF Promotes the Development of Dysfunctional Vascular Networks in Moyamoya Disease. | Neurosci Bull | 2023-01 | 通讯作者 |
| 87 | Linarin ameliorates ischemia-reperfusion injury by the inhibition of endoplasmic reticulum stress targeting AKR1B1. | Brain Res Bull | 2024-01 | 通讯作者 |
| 88 | SRGN amplifies microglia-mediated neuroinflammation and exacerbates ischemic brain injury. | J Neuroinflammation | 2024-01 | 通讯作者 |
| 89 | Echinatin protects from ischemic brain injury by attenuating NLRP3-related neuroinflammation. | Neurochem Int | 2024-01 | 通讯作者 |
| 90 | γ-Glutamylcysteine ameliorates blood-brain barrier permeability and neutrophil extracellular traps formation after ischemic stroke by modulating Wnt/β-catenin signalling in mice. | Eur J Pharmacol | 2024-01 | 通讯作者 |
| 91 | Impairments of GABAergic transmission in hippocampus mediate increased susceptibility of epilepsy in the early stage of Alzheimer's disease. | Cell Commun Signal | 2024-01 | 通讯作者 |
| 92 | Stride length and cerebellar regulation: Key features of early gait disorder in cerebral small vessel disease. | CNS Neurosci Ther | 2024-01 | 通讯作者 |
| 93 | Lower cerebrovascular reactivity in prefrontal cortex and weaker negative functional connectivity between prefrontal cortex and insula contribute to white matter hyperintensity-related anxiety or depression. | J Affect Disord | 2024-01 | 通讯作者 |
| 94 | The characteristic patterns of individual brain susceptibility networks underlie Alzheimer's disease and white matter hyperintensity-related cognitive impairment. | Transl Psychiatry | 2024-01 | 通讯作者 |
| 95 | Progressive reduction of nuclear receptor Nr4a1 mediates age-dependent cognitive decline. | Alzheimers Dement | 2024-01 | 通讯作者 |
| 96 | Environmental risk factors provoke new thinking for prevention and treatment of dementia with Lewy bodies. | Heliyon | 2024-01 | 通讯作者 |
| 97 | Inhibition of ADORA3 promotes microglial phagocytosis and alleviates chronic ischemic white matter injury. | CNS Neurosci Ther | 2024-01 | 通讯作者 |
| 98 | Ficolin-A induces macrophage polarization to a novel pro-inflammatory phenotype distinct from classical M1. | Cell Commun Signal | 2024-01 | 通讯作者 |
- 科研获奖Research Awards
| # | 获奖证书编号 | 奖项名称 | 获奖级别 | 获奖类别 | 获奖等级 | 获奖日期 | 颁奖单位 | 本单位是否为第一完成单位 | 完成单位排名 | 本人排序 | 备注 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2018-02-01-zx | 传统中药及其提取物对脑卒中及阿尔茨海默 | 省部级 | 其他省部级奖励 | 二等奖 | 2018-02-28 | 中医药科学技术奖评审委员会 | 是 | 1 | 1 | |
| 2 | 无 | 缺血性脑卒中和阿尔茨海默病的转化医学研究 | 省部级 | 其他省部级奖励 | 一等奖 | 2018-08-01 | 江苏省教育厅 | 是 | 1 | 1 | |
| 3 | 2020-1-60-1 | 脑小血管病早期诊断多模态MRI新技术 | 省部级 | 科技进步奖、哲学社科奖 | 一等奖 | 2020-11-09 | 江苏省卫生健康委员会 | 是 | 1 | 1 | |
| 4 | 202003014P0801 | 免疫炎症与缺血性卒中转归的机制及临床转化研究 | 国家级 | 其他国家级奖励 | 三等奖 | 2021-03-10 | 中华医学会 | 是 | 1 | 1 | |
| 5 | 2020-A-190100P9-1 | 缺血性脑损伤免疫炎症机制以及临床转化研究 | 省部级 | 其他省部级奖励 | 一等奖 | 2020-12-01 | 江苏省医学会 | 是 | 1 | 1 | |
| 6 | 2020-1-31-R1 | 缺血性脑卒中相关精准诊疗转化研究 | 省部级 | 科技进步奖、哲学社科奖 | 一等奖 | 2021-01-07 | 江苏省人民政府 | 1 | 1 |
- 研究成果Research Findings
| # | 成果类型 | 项目/专利/新品种名称 |
|---|---|---|
| 1 | 出版高水平专著 | 《神经内科学》第三版 |
| 2 | 出版高水平专著 | 神经内科临床病例精解 |