导师风采
刘昱东
个人信息
Personal Information
- 性别：男
- 导师类型：硕士生导师
- 职称：副研究员
- 该职称任职时间：2020
联系方式
Contact Information
- 所属院系：北京医院
- 所属专业：临床检验诊断学
- 邮箱 : yudongliu1983@126.com
- 工作电话 : 010-58115091
个人简介
Personal Profile
刘昱东、现任北京医院 国家卫健委临床检验中心副主任。美国阿拉巴马大学伯明翰分校（UAB）免疫学博士，美国国立卫生研究院（NIH）风湿免疫学博士后。曾任国家卫健委老年医学研究所副所长、国家卫健委老年医学重点实验室副主任。近五年获批国家自然科学基金面上项目三项、中国医学科学院医学与健康科技创新工程项目、中央高水平医院等项目。以第一/通讯作者在Ann Rheum Dis、J Autoimmun、EBioMedicine、JCI Insight等国际主流期刊上发表相关研究成果35篇。担任北京市医药卫生科技创新成果转化专家、中国老年保健医学研究会检验分会常委、中国老年保健医学研究会风湿免疫分会委员、中国免疫学会自身免疫分会委员、北京免疫学会理事、北京医师协会检验分会理事、Frontiers in Immunology副主编、《中国科学-生命科学》及《SCIENCE CHINA life sciences》青年编委。
团队简介
Team Profile
待补充更新
- 研究方向Research Directions
自身免疫病发病机制和诊疗标志物的研发
- 在校研究生Current Graduate Students
硕士研究生 4 名，博士研究生 0 名
- 科研项目Research Projects
| # | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
|---|---|---|---|---|---|
| 1 | 肽基精氨酸脱亚氨酶II（PAD2）和PAD4分别在调控类风湿关节炎免疫失衡中的作用解析及机制研究 | 2022-01 —— 2025-12 | 58万元 | 主持在研的国家或省部级科研项目 | 主持 |
| 2 | 蛋白激酶CK2调控系统性红斑狼疮免疫失衡和器官损伤的机制研究 | 2024-01 —— 2027-12 | 49万元 | 主持在研的国家或省部级科研项目 | 主持 |
| 3 | cGAS-STING-IFN I通路在系统性红斑狼疮发病机制中的作用 | 2020-01 —— 2023-12 | 55万元 | 主持在研的国家或省部级科研项目 | 主持 |
- 发表论文Papers
| # | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
|---|---|---|---|---|
| 1 | High levels of antibodies to citrullinated α-enolase peptide-1 (CEP-1) identify erosions and interstitial lung disease (ILD) in a Chinese rheumatoid arthritis cohort | Clinical Immunology | 2019-03 | 第一/通讯作者 |
| 2 | The transferability and evolution of NDM-1 and KPC-2 co-producing Klebsiella pneumoniae from clinical settings | EBioMedicine | 2020-01 | 共同第一作者 |
| 3 | Neutrophils in the Pathogenesis of Rheumatic Diseases: Fueling the Fire | Clinical Reviews in Allergy & Immunology | 2021-02 | 第一/通讯作者 |
| 4 | Elevated Granulocyte Colony-stimulating Factor Levels in Patients With Active Phase of Adult-onset Still Disease | The Journal of Rheumatology | 2021-05 | 通讯作者 |
| 5 | Serum Human Epididymis Protein 4 as a Novel Biomarker in Identifying Patients With Interstitial Lung Disease in Rheumatoid Arthritis | Frontiers in Medicine | 2021-10 | 通讯作者 |
| 6 | Lipid Metabolism: Immune Regulation and Therapeutic Prospectives in Systemic Lupus Erythematosus | Frontiers in Immunology | 2022-03 | 通讯作者 |
| 7 | Mechanistic insight into premature atherosclerosis and cardiovascular complications in systemic lupus erythematosus | Journal of Autoimmunity | 2022-10 | 第一作者 |
| 8 | ACPA-negative rheumatoid arthritis: From immune mechanisms to clinical translation | EBioMedicine | 2022-09 | 通讯作者 |
| 9 | Correspondence on 'Anticardiolipin and other antiphospholipid antibodies in critically ill COVID-19 positive and negative patients' | Annals of the Rheumatic Diseases | 2023-08 | 通讯作者 |
| 10 | Antibodies against neutrophil extracellular traps (NETs) potentiate clinical performance of anti-double-stranded DNA antibodies in systemic lupus erythematosus | Clinical Immunology | 2023-04 | 通讯作者 |
| 11 | Recent advances on neutrophil dysregulation in the pathogenesis of rheumatic diseases | Current Opinion In Rheumatology | 2024-03 | 通讯作者 |
| 12 | Loss of mucosal tolerance to glycoprotein 2 isoform 1 is a potential novel diagnostic biomarker for cholangiocarcinoma | Digestive and Liver Disease | 2024-06 | 通讯作者 |
| 13 | Molecular characterization of PANoptosis-related genes with features of immune dysregulation in systemic lupus erythematosus | Clinical Immunology | 2023-08 | 通讯作者 |
| 14 | Dynamics of T follicular helper cells in patients with rheumatic diseases and subsequent antibody responses in a three-dose immunization regimen of CoronaVac | Immunology | 2023-01 | 通讯作者 |
| 15 | Correspondence on 'Critical role of neutrophil extracellular traps (NETs) in patients with Behcet's disease' | Annals of the Rheumatic Diseases | 2023-02 | 通讯作者 |
| 16 | Pathological mechanisms and crosstalk among different forms of cell death in systemic lupus erythematosus | Journal of Autoimmunity | 2022-10 | 通讯作者 |
| 17 | Alterations of Plasma Microbiome: A Potentially New Perspective to the Dysbiosis in Systemic Lupus Erythematosus? | The Journal of Rheumatology | 2022-06 | 第一作者 |
| 18 | Elevated Serum Human Epididymis Protein 4 Is Associated With Disease Activity and Systemic Involvements in Primary Sjogren's Syndrome | Frontiers in Immunology | 2021-06 | 通讯作者 |
| 19 | Neutrophil Dysregulation in the Pathogenesis of Systemic Lupus Erythematosus | Rheumatic Disease Clinics of North America | 2021-08 | 第一作者 |
| 20 | Elevated circulating pro-inflammatory low-density granulocytes in adult-onset Still's disease | Rheumatology (Oxford) | 2021-01 | 第一/通讯作者 |
| 21 | Co-existence of a novel plasmid-mediated efflux pump with colistin resistance gene mcr in one plasmid confers transferable multidrug resistance in Klebsiella pneumoniae | Emerging Microbes & Infections | 2020-12 | 共同第一作者 |
| 22 | Prospective multi-center evaluation on risk factors, clinical characteristics and outcomes due to carbapenem resistance in Acinetobacter baumannii complex bacteraemia: experience from the Chinese Antimicrobial Resistance Surveillance of Nosocomial Infections (CARES) Network | Journal of Medical Microbiology | 2020-06 | 第一作者 |
| 23 | Clinical performance of non-criteria antibodies to phospholipids in Chinese patients with antiphospholipid syndrome | Clinica Chimica Acta | 2019-08 | 通讯作者 |
| 24 | 神经系统副肿瘤综合征相关自身抗体的临床应用现状与前景展望 | 中华检验医学杂志 | 2023-11 | 通讯作者 |
| 25 | 抗PAD2和抗PAD4自身抗体在类风湿关节炎中的临床应用价值探讨 | 中华检验医学杂志 | 2021-11 | 通讯作者 |
- 科研获奖Research Awards
无
- 研究成果Research Findings
| # | 成果类型 | 项目/专利/新品种名称 |
|---|---|---|
| 1 | 作为主创人员获得授权的发明专利和新品种 | 一种干燥综合征专用保湿防风眼镜装置 |