个人简介

Personal Profile

李大培 副研究员 硕士研究生导师 （北京协和医学院） 邮箱：dapei_1173@163.com 座机电话：0512-62873379教育科研经历 2002年-2006年，安徽大学，本科。 2006年- 2009年，安徽大学&军事医学科学院，硕士。 2009年-2012年，军事医学科学院，科研助理。 2012年-2016年，军事医学科学院，博士。 2016年-2020年，苏州系统医学研究所，助理研究员。 2020年-至今，苏州系统医学研究所，副研究员。研究方向 主要研究方向为：1、抗感染免疫分子调控；2、泛素-蛋白酶体降解系统的调控；3、小分子药物与炎症性疾病等。 发表论文（* 共同第一作者，#共同通讯作者）[1] Zigang Qiao*, Dapei Li*, Fan Zhang*, Jingfei Zhu, Siying Liu, Xue Bai, Haiping Yao, Zhengrong Chen, Yongdong Yan, Xiulong Xu, Feng Ma. USP5 inhibits anti-RNA viral innate immunity by deconjugating K48-linked unanchored and K63-linked anchored ubiquitin on IRF3. PLoS Pathog. 2025, 21(1):e1012843. [2] Zhu J, Wu R, Yang T, Yuan Y, Liu G, Chen S, Chen Z, Liu S, Wang S, Li D, Yao H, He Y, He S, Qin CF, Dai J, Ma F. Harnessing ZIKV NS2A RNA for alleviating acute hepatitis and cytokine release storm by targeting translation machinery. Hepatology. 2025 Jul 1;82(1):110-126. [3] Qincai Dong*, Dapei Li*, Huailong Zhao*, Xun Zhang*, Yue Liu, Yong Hu, Yi Yao, Lin Zhu, Guang-Fei Wang, Hainan Liu, Ting Gao, Xiayang Niu, Tong Zheng, Caiwei Song, Di Wang, Yu Bai, Jing Jin, Zijing Liu, Yanwen Jin, Ping Li,Cheng Cao# and Xuan Liu#. Anti-apoptotic HAX-1 suppresses cell apoptosis by promoting c-Abl kinase-involved ROS clearance. Cell Death and Disease (2022) 13:298. [4] Dapei Li*#, Lifen Xie*, Zigang Qiao*, Jingfei Zhu, Haiping Yao, Yanghua Qin, Yongdong Yan, Zhengrong Chen, Feng Ma#. IFI16 Isoforms with Cytoplasmic and Nuclear Locations Play Differential Roles in Recognizing Invaded DNA Viruses. The Journal of Immunology (2021). [5] Dapei Li*#, Lifen Xie*, Zigang Qiao, Sanyue Mai, Jingfei Zhu, Fan Zhang, Shengchuan Chen, Liang Li, Fangrong Shen, Yanghua Qin, Haiping Yao, Sudan He, Feng Ma#. STING-mediated degradation of IFI16 negatively regulates apoptosis by inhibiting p53 phosphorylation at serine 392. J. Biol. Chem. (2021). [6] Dapei Li, Rongsheng Wu, Wen Guo, Lifen Xie, Zigang Qiao, Shengchuan Chen, Jingfei Zhu,Chaohao Huang,Jian Huang, Bicheng Chen,Yanghua Qin, Feng Xu, and Feng Ma#. STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production. Cell Reports (2019). [7] Li C, Zu S, Deng YQ, Li D, Parvatiyar K, Quanquin N, Shang J, Sun N, Su J, Liu Z, Wang M, Aliyari SR, Li XF, Wu A, Ma F, Shi Y, Nielsevn-Saines K, Jung JU, Qin FX, Qin CF#, Cheng G#. Azithromycin Protects against Zika virus Infection by Upregulating virus-induced Type I and III Interferon Responses. Antimicrob Agents Chemother (2019). [8] Huang C, Chen S, Zhang T, Li D, Huang Z, Huang J, Qin Y, Chen B, Cheng G, Ma F#, Zhou M#. TLR3 Ligand PolyI:C Prevents Acute Pancreatitis Through the Interferon-β/Interferon-α/β Receptor Signaling Pathway in a Caerulein-Induced Pancreatitis Mouse Model. Front Immunol (2019). [9] Chen Q*, Wu J*, Ye Q*, Ma F*, Zhu Q, Wu Y, Shan C, Xie X, Li D, Zhan X, Li C, Li XF, Qin X, Zhao T, Wu H, Shi PY#, Man J#, Qin CF#. Treatment of Human Glioblastoma with a Live Attenuated Zika Virus Vaccine Candidate. mBio (2018). [10] Huang C, Xiang Y, Chen S, Yu H, Wen Z, Ye T, Sun H, Kong H, Li D, Yu D, Chen B, Zhou M#. Dermokine contributes to epithelial-mesenchymal transition through increased activation of signal transducer and activator of transcription 3 in pancreatic cancer. Cancer Sci (2017). [11] Dapei Li, Qincai Dong, Qingping Tao, Jing Gu, Yan Cui, Xuefeng Jiang, Jing Yuan, Weihua Li, Rao Xu,Yanwen Jin, Ping Li, David T. Weaver, Qingjun Ma, Xuan Liu#, and Cheng Cao#. c-Abl Regulates Proteasome Abundance by Controlling the Ubiquitin-Proteasomal Degradation of PSMA7 Subunit. Cell Reports (2015). 申请专利：（1）马烽，李大培，谢李芬. 一种核内病毒模拟物的递送系统、制备方法及应用。专利号：202010142917.0（中国），授权。 (2) 马烽; 李大培; 何欢; 一种USP5 抑制剂在制备抗病毒药物中的用途，2024-4-12，中国，202410013163.7，实审。

团队简介

Team Profile

团队属于系统所马烽课题组，课题组一直从事病毒学、分子免疫学研究以及炎症性疾病研究，已在Immunity、Nature Immunology、Hepatology等免疫学和分子生物学核心期刊发表学术论文50 余篇，具备成熟的技术体系和突出的创新能力。