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李大培 副研究员 硕士研究生导师 （北京协和医学院） 邮箱：dapei_1173@163.com 座机电话：0512-62873379教育科研经历 2002年-2006年，安徽大学，本科。 2006年- 2009年，安徽大学&军事医学科学院，硕士。 2009年-2012年，军事医学科学院，科研助理。 2012年-2016年，军事医学科学院，博士。 2016年-2020年，苏州系统医学研究所，助理研究员。 2020年-至今，苏州系统医学研究所，副研究员。研究方向 主要研究方向为：1、抗感染免疫分子调控；2、泛素-蛋白酶体降解系统的调控；3、泛素化和去泛素化修饰与抗感染免疫调控等。 发表论文（* 共同第一作者，#共同通讯作者）[1] Qincai Dong*, Dapei Li*, Huailong Zhao*, Xun Zhang*, Yue Liu, Yong Hu, Yi Yao, Lin Zhu, Guang-Fei Wang, Hainan Liu, Ting Gao, Xiayang Niu, Tong Zheng, Caiwei Song, Di Wang, Yu Bai, Jing Jin, Zijing Liu, Yanwen Jin, Ping Li,Cheng Cao# and Xuan Liu#. Anti-apoptotic HAX-1 suppresses cell apoptosis by promoting c-Abl kinase-involved ROS clearance. Cell Death and Disease (2022) 13:298. [2] Dapei Li*#, Lifen Xie*, Zigang Qiao*, Jingfei Zhu, Haiping Yao, Yanghua Qin, Yongdong Yan, Zhengrong Chen, Feng Ma#. IFI16 Isoforms with Cytoplasmic and Nuclear Locations Play Differential Roles in Recognizing Invaded DNA Viruses. The Journal of Immunology (2021). [3] Dapei Li*#, Lifen Xie*, Zigang Qiao, Sanyue Mai, Jingfei Zhu, Fan Zhang, Shengchuan Chen, Liang Li, Fangrong Shen, Yanghua Qin, Haiping Yao, Sudan He, Feng Ma#. STING-mediated degradation of IFI16 negatively regulates apoptosis by inhibiting p53 phosphorylation at serine 392. J. Biol. Chem. (2021). [4] Dapei Li, Rongsheng Wu, Wen Guo, Lifen Xie, Zigang Qiao, Shengchuan Chen, Jingfei Zhu,Chaohao Huang,Jian Huang, Bicheng Chen,Yanghua Qin, Feng Xu, and Feng Ma#. STING-Mediated IFI16 Degradation Negatively Controls Type I Interferon Production. Cell Reports (2019). [5] Li C, Zu S, Deng YQ, Li D, Parvatiyar K, Quanquin N, Shang J, Sun N, Su J, Liu Z, Wang M, Aliyari SR, Li XF, Wu A, Ma F, Shi Y, Nielsevn-Saines K, Jung JU, Qin FX, Qin CF#, Cheng G#. Azithromycin Protects against Zika virus Infection by Upregulating virus-induced Type I and III Interferon Responses. Antimicrob Agents Chemother (2019). [6] Huang C, Chen S, Zhang T, Li D, Huang Z, Huang J, Qin Y, Chen B, Cheng G, Ma F#, Zhou M#. TLR3 Ligand PolyI:C Prevents Acute Pancreatitis Through the Interferon-β/Interferon-α/β Receptor Signaling Pathway in a Caerulein-Induced Pancreatitis Mouse Model. Front Immunol (2019). [7] Chen Q*, Wu J*, Ye Q*, Ma F*, Zhu Q, Wu Y, Shan C, Xie X, Li D, Zhan X, Li C, Li XF, Qin X, Zhao T, Wu H, Shi PY#, Man J#, Qin CF#. Treatment of Human Glioblastoma with a Live Attenuated Zika Virus Vaccine Candidate. mBio (2018). [8] Huang C, Xiang Y, Chen S, Yu H, Wen Z, Ye T, Sun H, Kong H, Li D, Yu D, Chen B, Zhou M#. Dermokine contributes to epithelial-mesenchymal transition through increased activation of signal transducer and activator of transcription 3 in pancreatic cancer. Cancer Sci (2017). [9] Dapei Li, Qincai Dong, Qingping Tao, Jing Gu, Yan Cui, Xuefeng Jiang, Jing Yuan, Weihua Li, Rao Xu,Yanwen Jin, Ping Li, David T. Weaver, Qingjun Ma, Xuan Liu#, and Cheng Cao#. c-Abl Regulates Proteasome Abundance by Controlling the Ubiquitin-Proteasomal Degradation of PSMA7 Subunit. Cell Reports (2015). 申请专利：（1）马烽，李大培，谢李芬. 一种核内病毒模拟物的递送系统、制备方法及应用。专利号：202010142917.0（中国），授权。 (2) 马烽; 李大培; 何欢; 一种USP5 抑制剂在制备抗病毒药物中的用途，2024-4-12，中国，202410013163.7，实审。

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