导师风采
鲁炳怀
个人信息
Personal Information
- 性别：男
- 导师类型：博士生导师
- 职称：主任医师
- 该职称任职时间：20180701
联系方式
Contact Information
- 所属院系：中日友好医院
- 所属专业：临床检验诊断学
- 邮箱 : zs25041@126.com
- 工作电话 : 01084206256
个人简介
Personal Profile
中日友好医院（国家呼吸医学中心）呼吸与危重症医学科临床微生物与感染实验室。主任医师，医学博士，北京协和医学院博士研究生导师。兼任中华医学会检验分会微生物学组委员。中国医促会临床微生物与感染分会常委，北京新冠肺炎医疗救治市级专家组专家，北京市医药卫生科技创新成果转化专家库2023 年度第一批入库专家。擅长临床感染性疾病诊断。
团队简介
Team Profile
课题组近年主持课题10项，主要从事病原微生物与感染研究。
- 研究方向Research Directions
微生物学，耐药机制研究，病原学诊断技术研发
- 在校研究生Current Graduate Students
硕士研究生 1 名，博士研究生 0 名
- 科研项目Research Projects
| # | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
|---|---|---|---|---|---|
| 1 | 基于tNGS技术的肺炎链球菌血清型识别、鉴定与临床应用研究 | 2023-01-01 —— 2025-12-31 | 29.3 | 参与在研的国家或省部级科研项目 | 主持者 |
| 2 | 中国医学科学院医学与健康科技创新工程，微生物药物发现技术研究及应用-针对多重耐药革兰阴性杆菌耐药机制的研究及抗生素联合治疗的探索 | 2021-10-01 —— 2025-12 | 400.0 | 参与在研的国家或省部级科研项目 | 主持人 |
| 3 | 靶向基因组测序（tNGS）在下呼吸道感染诊治中的临床应用研究 | 2024-01 —— 2026-12 | 100 | 主持在研的国家或省部级科研项目 | 主持人 |
| 4 | 插入序列介导mgrB基因失活致碳青霉烯耐药肺炎克雷伯菌对多黏菌素的耐药机制研究 | 2024-01 —— 2026-12 | 20 | 主持在研的国家或省部级科研项目 | 主持人 |
- 发表论文Papers
| # | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
|---|---|---|---|---|
| 1 | Genetic Diversity of Polymyxin-Resistance Mechanisms in Clinical Isolates of Carbapenem-Resistant Klebsiella pneumoniae: a Multicenter Study in China | Microbiol Spectr | 2023-02 | 通迅作者 |
| 2 | Molecular Characteristics of an NDM-4 and OXA-181 Co-Producing K51-ST16 Carbapenem-Resistant Klebsiella pneumoniae: Study of Its Potential Dissemination Mediated by Conjugative Plasmids and Insertion Sequences | Antimicrob Agents Chemother | 2023-01 | 通迅作者 |
| 3 | Convergence of MCR-8.2 and Chromosome-Mediated Resistance to Colistin and Tigecycline in an NDM-5-Producing ST656 Klebsiella pneumoniae Isolate From a Lung Transplant Patient in China | Front Cell Infect Microbiol | 2022-07 | 并列通迅作者 |
| 4 | Comparison of Performances of GeneXpert MTB/RIF, Bactec MGIT 960, and Bactec Myco/F Systems in Detecting Mycobacterium tuberculosis in Biopsy Tissues: a Retrospective Study | Microbiol Spectr | 2023-06 | 并列通迅作者 |
| 5 | Evaluation of BACTEC MGIT 960 system for recovery of Nocardia from clinical specimen | Diagn Microbiol Infect Dis | 2023-08 | 通迅作者 |
| 6 | Osteomyelitis and Septic Arthritis Due to Burkholderia pseudomallei: A 10-Year Retrospective Melioidosis Study From South China | Front Cell Infect Microbiol | 2021-05 | 通迅作者 |
| 7 | Microbiological, Epidemiological, and Clinical Characteristics of Patients With Cryptococcal Meningitis at a Tertiary Hospital in China: A 6-Year Retrospective Analysis | Front Microbiol | 2020-07 | 通迅作者 |
| 8 | Severity of influenza virus and respiratory syncytial virus coinfections in hospitalized adult patients | J Clin Virol | 2020-12 | 并列通迅作者 |
| 9 | Synergistic Activity of Imipenem in Combination with Ceftazidime/Avibactam or Avibactam against Non-MBL-Producing Extensively Drug-Resistant Pseudomonas aeruginosa | Microbiol Spectr | 2022-04 | 并列通迅作者 |
| 10 | Epidemiology and Antimicrobial Resistance Profiles of the Nocardia Species in China, 2009 to 2021 | Microbiol Spectr | 2022-04 | 并列通迅作者 |
| 11 | Co-infection with SARS-CoV-2 and Influenza A Virus in Patient with Pneumonia, China | Emerg Infect Dis | 2020-06 | 并列通迅作者 |
| 12 | High concentration of Cas12a effector tolerates more mismatches on ssDNA | FASEB J | 2021-01 | 并列通迅作者 |
| 13 | Microbiological and clinical characteristics of Streptococcus gallolyticus subsp. pasteurianus infection in China | BMC Infect Dis | 2019-09 | 通迅作者 |
| 14 | Mycotic aneurysm secondary to melioidosis in China: A series of eight cases and a review of literature | PLoS Negl Trop Dis | 2020-08 | 通迅作者 |
| 15 | Fatal deep venous thrombosis and pulmonary embolism secondary to melioidosis in China: case report and literature review | BMC Infect Dis | 2019-11 | 通迅作者 |
| 16 | Risk Factors for Mortality of Inpatients with Pseudomonas aeruginosa Bacteremia in China: Impact of Resistance Profile in the Mortality | Infect Drug Resist | 2020-11 | 并列通迅作者 |
| 17 | Biofilm formation and invasive ability contribute to CC17 serotype III group B Streptococcus virulence | Chinese Medical Journal | 2022-04 | 通迅作者 |
| 18 | Listeriosis Cases and Genetic Diversity of Their L. monocytogenes Isolates in China, 2008-2019 | Front Cell Infect Microbiol | 2021-02 | 通迅作者 |
| 19 | Characterization of an NDM-5-producing hypervirulent Klebsiella pneumoniae sequence type 65 clone from a lung transplant recipient | Emerg Microbes Infect | 2021-12 | 并列通迅作者 |
| 20 | Comparison of influenza- and COVID-19-associated pulmonary aspergillosis in China. | Eur J Clin Microbiol Infect Dis. | 2024-04 | 并列通迅作者 |
| 21 | Loss and gain of ceftazidime-avibactam susceptibility in a non-carbapenemase-producing K1-ST23 hypervirulent Klebsiella pneumoniae. | Virulence | 2024-12 | 并列通迅作者 |
| 22 | Coexistence of virulent and multidrug-resistant plasmids in an uropathogenic Escherichia coli. | J Glob Antimicrob Resist. | 2024-06 | 通迅作者 |
| 23 | Carbapenem-resistant Citrobacter freundii harboring blaKPC-2 and blaNDM-1: a study on their transferability and potential dissemination via generating a transferrable hybrid plasmid mediated by IS6100. | Front Microbiol. | 2023-08 | 通迅作者 |
- 科研获奖Research Awards
无
- 研究成果Research Findings
| # | 成果类型 | 项目/专利/新品种名称 |
|---|---|---|
| 1 | 作为主创人员获得授权的发明专利和新品种 | 用于下呼吸道感染细菌的核酸试剂、试剂盒及系统 |