导师风采
詹庆元
个人信息
Personal Information
- 性别：男
- 导师类型：博士生导师
- 职称：主任医师
- 该职称任职时间：2008
联系方式
Contact Information
- 所属院系：中日友好医院
- 所属专业：内科学
- 邮箱 : zhanqy0915@163.com
- 工作电话 : 84205039
个人简介
Personal Profile
詹庆元，主任医师、教授，北京协和医学院、首都医科大学及北京大学医学部博士生导师，中日友好医院呼吸与危重症医学科副主任。全国杰出专业技术人才、教育部人才项目特岗教授、国家百千万人才工程国家级人选。中国医师协会内科医师分会副会长，中国医师协会呼吸医师分会危重症医学工作委员会主任委员，中国医师协会外生命支持专业委员会常委。以呼吸支持技术和重症肺部感染为主要研究方向，在无创支持方式的应用指征、呼吸机相关肺损伤发生机制及防治策略、体外膜肺氧合技术的临床应用及ICU侵袭性肺曲霉菌病的诊断策略等方面进行了深入研究。以项目负责人承担国家十三五重大研发项目1项，国家自然科学基金4项，973子课题1项，省部级课题6项，并作为骨干参与多项国家及省部级课题的研究工作。以第一或通迅作者发表文章200余篇（其中SCI 70余篇），主持制定ARDS、ECMO等10部指南/共识，主编专著5部，副主编教材及专著8部。获省部级科技进步二等奖、一等奖和国家科技进步二等奖各1项。
团队简介
Team Profile
待补充更新
- 研究方向Research Directions
呼吸与危重症医学
- 在校研究生Current Graduate Students
硕士研究生 0 名，博士研究生 0 名
- 科研项目Research Projects
| # | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
|---|---|---|---|---|---|
| 1 | 分子伴侣HSPB8调控肺泡巨噬细胞内质网应激缓解呼吸机诱导性肺损伤机制研究 | 2023-01-01 —— 2026-12-31 | 52万元 | 参与在研的国家或省部级科研项目 | 主持者 |
| 2 | 呼吸机相关性肺炎患者上下呼吸道菌群微生态特征鉴定 | 2022-06-01 —— 2024-09-30 | 60万元 | 参与在研的国家或省部级科研项目 | 主持者 |
| 3 | 中国大陆地区ARDS真实世界研究 | 2021-04-01 —— 2024-03-31 | 20万元 | 参与在研的国家或省部级科研项目 | 主持者 |
| 4 | 一体化自动人工气道管理设备的研发 | 2023-08 —— 2025-08 | 50万元 | 参与在研的国家或省部级科研项目 | 主持者 |
| 5 | “Quic系列”曲霉抗原抗体联合检测对重症监护病房（ICU）侵袭性肺曲霉病（IPA）患者诊断价值的多中心研究 | 2022-08 —— 2024-08 | 15万元 | 参与在研的国家或省部级科研项目 | 主持者 |
| 6 | 整合呼吸介入、新一代测序等诊疗手段的呼吸衰竭病因诊断能力提升研究 | 2022-05 —— 2025-04 | 62.5万元 | 参与在研的国家或省部级科研项目 | 主持者 |
| 7 | 不同疾病所致重度呼吸衰竭诊疗新技术的指征、时机和疗效评价研究 | 2022-05 —— 2025-04 | 62.5万元 | 参与在研的国家或省部级科研项目 | 主持者 |
| 8 | 肺部微生物群在肺移植术后早期肺部感染的诊断及预后价值 | 2022-05 —— 2024-04 | 5万元 | 参与在研的国家或省部级科研项目 | 主持者 |
- 发表论文Papers
| # | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
|---|---|---|---|---|
| 1 | Circulating and Pulmonary T-cell Populations Driving the Immune Response in Non-HIV Immunocompromised Patients with Pneumocystis jirovecii Pneumonia. | Int J Med Sci. | 2019-08 | 通讯作者 |
| 2 | Low-molecular-weight fucoidan attenuates bleomycin-induced pulmonary fibrosis: possible role in inhibiting TGF-β1-induced epithelial-mesenchymal transition through ERK pathway. | Am J Transl Res. | 2019-04 | 共同通讯作者 |
| 3 | Expression profiling analysis of long noncoding RNAs in a mouse model of ventilator-induced lung injury indicating potential roles in inflammation. | J Cell Biochem. | 2019-02 | 通讯作者 |
| 4 | Invasive pulmonary aspergillosis in patients with influenza infection: A retrospective study and review of the literature. | Clin Respir J. | 2019-04 | 通讯作者 |
| 5 | Programmed death ligand 1 is overexpressed by neutrophils in the blood of immunocompromised human immunodeficiency virus-negative patients with Pneumocystis jirovecii pneumonia. | Chin Med J (Engl). | 2019-05 | 通讯作者 |
| 6 | Wavelet-based real-time calculation of multiple physiological parameters on an embedded platform. | Physiological Measurement. | 2019-03 | 共同通讯作者 |
| 7 | Acute exacerbation of chronic obstructive pulmonary disease treated by extracorporeal carbon dioxide removal. | Chin Med J (Engl). | 2019-10 | 通讯作者 |
| 8 | An Algorithmic Approach for and Special Characteristics of Veno-Venous Extracorporeal Life Support in Patients With Severe Asthma Attack: A Case Report and Review of the Literature. | Archives of Clinical and Biomedical Research. | 2019-06 | 通讯作者 |
| 9 | Potential role of M2 macrophage polarization in ventilator-induced lung fibrosis. | Int Immunopharmacol. | 2019-10 | 共同通讯作者 |
| 10 | Spontaneous breathing in patients with severe acute respiratory distress syndrome receiving prolonged extracorporeal membrane oxygenation. | BMC Pulm Med. | 2019-12 | 通讯作者 |
| 11 | Transbronchial lung cryobiopsy may be of value for nonresolving acute respiratory distress syndrome: case series and systematic literature review. | BMC Pulm Med. | 2020-06 | 通讯作者 |
| 12 | Influence of venovenous extracorporeal membrane oxygenation on pharmacokinetics of vancomycin in lung transplant recipients. | J Clin Pharm Ther. | 2020-10 | 共同通讯作者 |
| 13 | Non-invasive respiratory support for patients with novel coronavirus pneumonia: clinical efficacy and reduction in risk of infection transmission. | Chin Med J (Engl). | 2020-05 | 通讯作者 |
| 14 | Extracorporeal membrane oxygenation support in 2019 novel coronavirus disease: indications, timing, and implementation. | Chin Med J (Engl). | 2020-05 | 通讯作者 |
| 15 | Co-infection with SARS-CoV-2 and Influenza A Virus in Patient with Pneumonia, China. | Emerg Infect Dis. | 2020-06 | 共同通讯作者 |
| 16 | Acute Kidney Injury in Patients with the Coronavirus Disease 2019: A Multicenter Study. | Kidney Blood Press Res. | 2020-07 | 通讯作者 |
| 17 | Inflammatory risk factors for hypertriglyceridemia in patients with severe influenza. | J Int Med Res. | 2020-08 | 通讯作者 |
| 18 | Incidence and outcomes of acute respiratory distress syndrome in intensive care units of mainland China: a multicentre prospective longitudinal study. | Crit Care. | 2020-08 | 共同通讯作者 |
| 19 | Population Pharmacokinetics of Caspofungin among Extracorporeal Membrane Oxygenation Patients during the Postoperative Period of Lung Transplantation. | Antimicrob Agents Chemother. | 2020-10 | 共同通讯作者 |
| 20 | High-Flow Nasal Oxygen in Coronavirus Disease 2019 Patients With Acute Hypoxemic Respiratory Failure: A Multicenter, Retrospective Cohort Study. | Crit Care Med. | 2020-11 | 共同通讯作者 |
| 21 | Increased physiological dead space in mechanically ventilated COVID-19 patients recovering from severe acute respiratory distress syndrome: a case report. | BMC Infect Dis. | 2020-08 | 通讯作者 |
| 22 | Non-HIV-infected patients with Pneumocystis pneumonia in the intensive care unit: A bicentric, retrospective study focused on predictive factors of in-hospital mortality. | Clin Respir J. | 2022-02 | 共同通讯作者 |
| 23 | TMT-Based proteomics analysis of LPS-induced acute lung injury. | Exp Lung Res. | 2021-10 | 通讯作者 |
| 24 | Impact of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers on the Inflammatory Response and Viral Clearance in COVID-19 Patients. | Front Cardiovasc Med. | 2021-08 | 通讯作者 |
| 25 | Clinical factors associated with composition of lung microbiota and important taxa predicting clinical prognosis in patients with severe community-acquired pneumonia. | Front Med. | 2021-07 | 共同通讯作者 |
| 26 | Risk Factors of Mortality From Pneumocystis Pneumonia in Non-HIV Patients: A Meta-Analysis. | Front Public Health. | 2021-06 | 通讯作者 |
| 27 | The association between outcomes and body mass index in patients with acute respiratory distress syndrome. | Clin Respir J. | 2021-06 | 共同通讯作者 |
| 28 | Early identification of patients with severe influenza-associated aspergillosis (IAA) in the intensive care unit--an IAA prediction score system (Asper-PreSS). | J Infect. | 2020-10 | 通讯作者 |
| 29 | Phase 2a, open-label, dose-escalating, multi-center pharmacokinetic study of favipiravir (T-705) in combination with oseltamivir in patients with severe influenza. | EBioMedicine. | 2020-12 | 共同第一作者 |
| 30 | Metagenomic Next-Generation Sequencing for Pathogenic Diagnosis and Antibiotic Management of Severe Community-Acquired Pneumonia in Immunocompromised Adults. | Front Cell Infect Microbiol. | 2021-06 | 通讯作者 |
| 31 | 3-month, 6-month, 9-month, and 12-month respiratory outcomes in patients following COVID-19-related hospitalisation: a prospective study. | Lancet Respir Med. | 2021-07 | 共同第一作者 |
| 32 | Awake Extracorporeal Membrane Oxygenation for Acute Respiratory Distress Syndrome: Which Clinical Issues Should Be Taken Into Consideration. | Front Med (Lausanne). | 2021-07 | 通讯作者 |
| 33 | Diagnostic value of galactomannan test in non-immunocompromised critically ill patients with influenza-associated aspergillosis: data from three consecutive influenza seasons. | Eur J Clin Microbiol Infect Dis. | 2021-09 | 通讯作者 |
| 34 | Acute fibrinous and organizing pneumonia complicated with hemophagocytic lymphohistiocytosis caused by chronic active Epstein-Barr virus infection: a case report. | BMC Infect Dis. | 2021-12 | 共同通讯作者 |
| 35 | Effectiveness, nephrotoxicity, and therapeutic drug monitoring of polymyxin B in nosocomial pneumonia among critically ill patients. | Clin Respir J. | 2022-05 | 通讯作者 |
| 36 | Prognostic Value of Syndecan-1 in the Prediction of Sepsis-Related Complications and Mortality: A Meta-Analysis. | Front Public Health. | 2022-04 | 通讯作者 |
| 37 | Microarray Analysis Reveals the Changes in Circular RNA Expression and Molecular Mechanisms in Mice With Ventilator-Induced Lung Injury. | Front Physiol. | 2022-03 | 共同通讯作者 |
| 38 | Prediction of Pulmonary Function Parameters Based on a Combination Algorithm. | Bioengineering (Basel). | 2022-03 | 共同通讯作者 |
| 39 | High-flow nasal cannula versus conventional oxygen therapy in acute COPD exacerbation with mild hypercapnia: a multicenter randomized controlled trial. | Crit Care. | 2022-04 | 共同通讯作者 |
| 40 | Transbronchial lung biopsy versus transbronchial lung cryobiopsy in critically ill patients with undiagnosed acute hypoxemic respiratory failure: a comparative study. | BMC Pulm Med. | 2022-05 | 共同通讯作者 |
| 41 | Mucus-permeable polymyxin B-hyaluronic acid/ poly (lactic-co-glycolic acid) nanoparticle platform for the nebulized treatment of lung infections. | J Colloid Interface Sci. | 2022-10 | 共同通讯作者 |
| 42 | Risk factors for bloodstream infection (BSI) in patients with severe acute respiratory distress syndrome (ARDS) supported by veno-venous extracorporeal membrane oxygenation (VV-ECMO). | BMC Pulm Med. | 2022-09 | 共同通讯作者 |
| 43 | Impact of extracorporeal membrane oxygenation on voriconazole plasma concentrations: A retrospective study. | Front Pharmacol. | 2022-08 | 通讯作者 |
| 44 | Efficacy of low-dose corticosteroids in patients with acute respiratory distress syndrome: a prospective observational study. | J Thorac Dis. | 2022-07 | 共同通讯作者 |
| 45 | The population pharmacokinetics and dose optimization of polymyxin B in critically ill patients with or without extracorporeal membrane oxygenation. | J Clin Pharm Ther. | 2022-10 | 通讯作者 |
| 46 | Effect of prone position in patients with acute respiratory distress syndrome supported by venovenous extracorporeal membrane oxygenation: a retrospective cohort study. | BMC Pulm Med. | 2022-06 | 通讯作者 |
| 47 | IL35 attenuated LPS-induced acute lung injury by regulating macrophage polarization. | Mol Biol Rep. | 2022-07 | 共同通讯作者 |
| 48 | A Paired Comparison of Plasma and Bronchoalveolar Lavage Fluid for Metagenomic Next-Generation Sequencing in Critically Ill Patients with Suspected Severe Pneumonia. | Infect Drug Resist. | 2022-08 | 共同通讯作者 |
| 49 | An inflammation-targeted nanoparticle with bacteria forced release of polymyxin B for pneumonia therapy. | Nanoscale. | 2022-10 | 共同通讯作者 |
| 50 | Clinical characteristics of new-onset acute kidney injury in patients with established acute respiratory distress syndrome: A prospective single-center post hoc observational study. | Front Med (Lausanne). | 2022-09 | 共同通讯作者 |
| 51 | High-flow nasal cannula may prolong the length of hospital stay in patients with hypercapnic acute COPD exacerbation. | Respir Med. | 2023-12 | 通讯作者 |
| 52 | Clinical and Temporal Radiological Findings from Critical Patients with COVID-19 Pneumonia: A Descriptive Study. | Curr Med Imaging. | 2023-11 | 通讯作者 |
| 53 | Extracorporeal membrane oxygenation in immunocompromised patients with acute respiratory failure: A retrospective cohort study. | Clin Respir J. | 2023-09 | 共同通讯作者 |
| 54 | Coinfection and superinfection in ICU critically ill patients with severe COVID-19 pneumonia and influenza pneumonia: are the pictures different?. | Front Public Health. | 2023-08 | 共同通讯作者 |
| 55 | Incidence, outcomes and risk factors of barotrauma in veno-venous extracorporeal membrane oxygenation for acute respiratory distress syndrome. | Respir Med. | 2023-07 | 共同通讯作者 |
| 56 | A narrative review of progress in the application of artificial intelligence in acute respiratory distress syndrome: subtypes and predictive models. | Ann Transl Med. | 2023-01 | 共同通讯作者 |
| 57 | Using machine learning for the early prediction of sepsis-associated ARDS in the ICU and identification of clinical phenotypes with differential responses to treatment. | Front Physiol. | 2022-12 | 通讯作者 |
| 58 | Feasibility of transbronchial lung cryobiopsy in patients with veno-venous extracorporeal membrane oxygenation support. | ERJ Open Res. | 2022-12 | 通讯作者 |
| 59 | Clinical characteristics and outcomes of immunocompromised patients with severe community-acquired pneumonia: A single-center retrospective cohort study. | Front Public Health. | 2023-02 | 通讯作者 |
| 60 | The association between early fluid strategy and prognosis of acute respiratory distress syndrome: A post hoc study of CHARDS. | Pulm Circ. | 2023-07 | 共同通讯作者 |
| 61 | Clinical characteristics and prognosis of pneumonia-related bloodstream infections in the intensive care unit: a single-center retrospective study. | Front Public Health. | 2023-09 | 共同通讯作者 |
| 62 | Rutin alleviates ventilator-induced lung injury by inhibiting NLRP3 inflammasome activation. | iScience. | 2023-09 | 共同通讯作者 |
| 63 | Risk factors and the value of microbiological examinations of COVID-19 associated pulmonary aspergillosis in critically ill patients in intensive care unit: the appropriate microbiological examinations are crucial for the timely diagnosis of CAPA. | Front Cell Infect Microbiol. | 2023-11 | 共同通讯作者 |
| 64 | Association between the lung microbiome and perioperative prognosis in lung transplant recipients. J Appl Microbiol. | J Appl Microbiol. | 2024-04 | 共同通讯作者 |
| 65 | Association between red blood cell distribution width-to-platelet ratio and post-discharge readmission rate in patients with heart failure: A retrospective cohort study. | Heliyon. | 2024-02 | 共同通讯作者 |
| 66 | The role of lung microbiota in primary graft dysfunction in lung transplant recipients. | Clin Transplant. | 2023-12 | 共同通讯作者 |
| 67 | Rutin targets AKT to inhibit ferroptosis in ventilator-induced lung injury. Phytother Res. | Phytother Res. | 2024-04 | 通讯作者 |
| 68 | 成人经鼻高流量湿化氧疗临床规范应用专家共识 | 中华结核和呼吸杂志 | 2019-01 | 共同通讯作者 |
| 69 | 成人重症新型冠状病毒肺炎患者气道管理推荐意见（试行） | 中华医学杂志 | 2020-01 | 共同通讯作者 |
| 70 | 中国呼吸危重症患者营养支持治疗专家共识 | 共同通讯作者 | 2020-01 | 中华医学杂志 |
| 71 | 呼吸危重症患者行肺组织活检操作专家意见 | 中华医学杂志 | 2022-01 | 共同通讯作者 |
| 72 | 奥密克戎变异株所致重症新型冠状病毒感染临床救治专家推荐意见 | 中华结核和呼吸杂志 | 2023-01 | 共同通讯作者 |
| 73 | ICU患者支气管肺泡灌洗液采集、送检、检测及结果解读规范 | 中华结核和呼吸杂志 | 2020-01 | 共同通讯作者 |
| 74 | 严重急性呼吸道感染常规呼吸支持治疗的临床指征与院感防控 | 中华结核和呼吸杂志 | 2020-01 | 共同通讯作者 |
| 75 | 体外膜式氧合治疗成人重症呼吸衰竭推荐意见 | 中华结核和呼吸杂志 | 2019-01 | 共同通讯作者 |
| 76 | 危重症获得性衰弱的研究进展 | 国际呼吸杂志 | 2020-01 | 通讯作者 |
| 77 | 肺移植供受者术中及术后48小时内肺部病原菌分布特点及预防性抗菌药物应用策略 | 中华移植杂志(电子版) | 2021-01 | 通讯作者 |
| 78 | 基于GEO数据库呼吸机相关性肺损伤小鼠基因芯片数据的生物信息学分析及关键基因验证 | 中华危重病急救医学 | 2022-01 | 通讯作者 |
| 79 | 呼吸机相关性肺损伤发生发展机制研究进展 | 国际呼吸杂志 | 2023-01 | 通讯作者 |
| 80 | 急性呼吸窘迫综合征早期进展与预后的关系 | 中国呼吸与危重监护杂志 | 2024-01 | 通讯作者 |
| 81 | 体外生命支持下超保护性肺通气的实施 | 中国实用内科杂志 | 2024-01 | 通讯作者 |
| 82 | 实质性推进呼吸与危重症医学专科中危重症医疗体系与能力建设 | 中华医学杂志 | 2023-01 | 第一作者并通讯作者 |
| 83 | 免疫抑制患者重症社区获得性肺炎的病原学分布特点 | 中华结核和呼吸杂志 | 2021-01 | 通讯作者 |
| 84 | 老年急性呼吸窘迫综合征患者的预后及影响因素分析 | 中华结核和呼吸杂志 | 2021-01 | 共同通讯作者 |
| 85 | 应用食道压力指导急性呼吸窘迫综合征患者呼气末正压的设置 | 中国呼吸与危重监护杂志 | 2019-01 | 通讯作者 |
| 86 | 经鼻高流量氧疗 | 中国临床新医学 | 2019-01 | 通讯作者 |
| 87 | 重症超声——危重症患者动态监测的新手段 | 中华结核和呼吸杂志 | 2019-01 | 通讯作者 |
| 88 | 重症流感病毒性肺炎合并侵袭性肺曲霉病15例临床特征分析 | 中华结核和呼吸杂志 | 2020-01 | 通讯作者 |
| 89 | 有创机械通气及体外膜氧合治疗重症新型冠状病毒肺炎的介入时机 | 中华结核和呼吸杂志 | 2020-01 | 通讯作者 |
| 90 | 脓毒症并发急性呼吸窘迫综合征的危险因素及预测评分研究进展 | 解放军医学杂志 | 2020-01 | 通讯作者 |
| 91 | 体外膜肺氧合对成人患者抗菌药物药代动力学影响的研究进展 | 中华危重病急救医学 | 2020-01 | 通讯作者 |
| 92 | 危重型流感合并金黄色葡萄球菌感染四例临床特点分析 | 国际呼吸杂志 | 2019-01 | 通讯作者 |
| 93 | 长程静脉-静脉体外膜式氧合救治重度急性呼吸窘迫综合征患者四例 | 中华结核和呼吸杂志 | 2019-01 | 通讯作者 |
| 94 | 经鼻高流量氧疗在急性呼吸衰竭治疗中的应用 | 中华结核和呼吸杂志 | 2019-01 | 通讯作者 |
- 科研获奖Research Awards
无
- 研究成果Research Findings
| # | 成果类型 | 项目/专利/新品种名称 |
|---|---|---|
| 1 | 作为主创人员获得授权的发明专利和新品种 | 用力肺活量计算方法、装置、电子设备及存储介质 |
| 2 | 作为主创人员获得授权的发明专利和新品种 | 一种模拟正常人声带功能的咳嗽辅助装置 |
| 3 | 作为主创人员获得授权的发明专利和新品种 | 一种痰液分级、计量吸引装置 |
| 4 | 作为主创人员获得授权的发明专利和新品种 | 一种预测ARDS患者预后的人工智能模型的建立方法 |
| 5 | 出版高水平专著 | 呼吸医师专培教材 |
| 6 | 出版高水平专著 | 危重症医学（第3版） |
| 7 | 出版高水平专著 | 呼吸支持技术 |
| 8 | 出版高水平专著 | 西氏内科学精要（第9版） |
| 9 | 出版高水平专著 | 呼吸危重症实践与临床思维2018 |
| 10 | 出版高水平专著 | 内科重症监护病房工作手册 |
| 11 | 出版高水平专著 | West呼吸生理学精要（第11版） |
| 12 | 出版高水平专著 | ECMO实操手册 |
| 13 | 出版高水平专著 | 呼吸治疗教程（第2版） |
| 14 | 出版高水平专著 | 呼吸支持与重症肺炎 |