导师风采
王露楠
个人信息
Personal Information
- 性别：女
- 导师类型：博士生导师
- 职称：研究员
- 该职称任职时间：20090801
联系方式
Contact Information
- 所属院系：国家卫生健康委临床检验中心
- 所属专业：
- 邮箱 : lnwang@nccl.org.cn
- 工作电话 : 01085133609
个人简介
Personal Profile
王露楠 研究员，博士，博士生导师。1990年毕业于北京医科大学药学院，1990 年以来在国家卫生健康委临床检验中心一直从事免疫学、分子生物学的质量控制和标准化研究工作，多次获得北京市科技进步奖、中华医学会医学科学技术奖。社会任职包括国家卫生标准委员会血液标准专业委员会委员、中华预防医学会血液安全专业委员会常务委员。
团队简介
Team Profile
待补充更新
- 研究方向Research Directions
临床检验诊断学,传染性疾病分子和血清学检测标准化,隐匿性乙肝分子机制的研究
- 在校研究生Current Graduate Students
硕士研究生 4 名，博士研究生 2 名
- 科研项目Research Projects
| # | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
|---|---|---|---|---|---|
| 1 | 新型冠状病毒疫苗大规模使用的免疫策略研究 | 2021-11-30 —— 2023-12-31 | 98.0 | 主持在研的国家或省部级科研项目 | 主持者 |
| 2 | 乙型肝炎病毒S蛋白跨膜结构域突变促进隐匿性乙型肝炎病毒感染的机制研究 | 2022-01-01 —— 2024-12-31 | 20.0 | 主持在研的国家或省部级科研项目 | 主持者 |
| 3 | 血液安全保障及新产品新技术研究 | 2021-10-20 —— 2025-12-31 | 400.0 | 主持在研的国家或省部级科研项目 | 主持者 |
- 发表论文Papers
| # | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
|---|---|---|---|---|
| 1 | Occult HBV infection inChinese blood donors: role of N-glycosylation mutations and amino acidsubstitutions in S protein transmembrane domains | Emerging Microbes & Infections | 2019-08 | 通讯作者 |
| 2 | Naturally occurring pre-S mutations promote occult HBV infection by affecting pre-S2/S promoter activity | Antiviral Res | 2022-12 | 通讯作者 |
| 3 | Nucleic acid testing andmolecular characterization of HIV infections. | European Journal of Clinical Microbiology & Infectious Diseases | 2019-05 | 通讯作者 |
| 4 | Demographic characteristics oftransfusion-transmitted infections among blood donorsin China | BMC Infectious Diseases | 2019-01 | 通讯作者 |
| 5 | Low seroprevalence of hepatitis delta virus co-infection in hepatitis B virus-infected blood donors in China: A multicenter study | Front Microbiol | 2022-07 | 通讯作者 |
| 6 | Evaluation of the Aptima HBV Quant Assay Compared to Abbott RealTime M2000 HBV Quant Assay and Procleix Ultrio Plus dHBV Assay in Plasma Samples | Microbiol Spectr | 2022-04 | 通讯作者 |
| 7 | Evaluation of ELISA and CLIA for Treponema pallidum specific antibody detection in China: A multicenter study | J Microbiol Methods | 2019-02 | 通讯作者 |
| 8 | Coronavirus Disease 2019: Coronaviruses and Blood Safety | Transfus Med Rev | 2020-04 | 通讯作者 |
| 9 | Severe Acute Respiratory Syndrome Coronavirus 2 RNA Detected in Blood Donations | Emerg Infect Dis | 2020-07 | 通讯作者 |
| 10 | Laboratory testing of SARS-CoV, MERS-CoV, and SARS-CoV-2 (2019-nCoV): Current status, challenges, and countermeasures | Rev Med Virol | 2020-03 | 通讯作者 |
| 11 | A Strategy for Screening and Confirmation of HTLV-1/2 Infections in Low-Endemic Areas | Front Microbiol | 2020-11 | 通讯作者 |
| 12 | Paradoxical HBsAg and anti-HBs coexistence among Chronic HBV Infections: Causes and Consequences | International Journal of Biological Sciences | 2021-04 | 通讯作者 |
| 13 | Comparison of seven commercial SARS-CoV-2 nucleic acid detection reagents with pseudovirus as quality control material. | J Mol Diagn | 2021-03 | 通讯作者 |
| 14 | HIV-1 molecular epidemiology and drug resistance-associated mutations among treatment-na？ve blood donors in China | Sci Rep | 2020-01 | 通讯作者 |
| 15 | No evidence of SARS-CoV-2 RNA among blood donors: A multicenter study in Hubei, China | Transfusion | 2020-09 | 通讯作者 |
| 16 | Molecular characterization of hepatitis C virus for subtype determination and resistance-associated substitutions detection among Chinese voluntary blood donors | Antiviral Res | 2020-11 | 通讯作者 |
| 17 | A study based on four immunoassays: Hepatitis C virus antibody against different antigens may have unequal contributions to detection | Virol J | 2021-01 | 通讯作者 |
| 18 | 新型冠状病毒核酸混采对检测结果的影响 | 中华检验医学杂 | 2021-05 | 通讯作者 |
| 19 | HIV-1 gp41 genetic diversity and enfuvirtide resistance-associated mutations among enfuvirtide-na？ve patients in southern China | Virus Res | 2021-11 | 通讯作者 |
| 20 | Hepatitis B virus (HBV) preS region: Clinical implications and applications. | Rev Med Virol | 2020-12 | 通讯作者 |
| 21 | Seroprevalence of human T-lymphotropic virus infection among blood donors in China: a first nationwide survey | Retrovirology | 2021-02 | 通讯作者 |
| 22 | The prevalence of antibodies to SARS-CoV-2 among blood donors in China. | Nat Commun . | 2021-03 | 通讯作者 |
| 23 | 新型冠状病毒核酸血液筛查系统的检测性能评价 | 国际病毒学杂志 | 2020-06 | 通讯作者 |
| 24 | Quantitative Evaluation of theTranscriptional Activity of Steroid Hormone Receptor Mutants and Variants Usinga Single Vector With Two Reporters and a Receptor Expression Cassette. | Front Endocrinol | 2020-07 | 通讯作者 |
| 25 | CDK4/6 inhibitor palbociclib promotes SARS-CoV-2 cell entry by down-regulating SKP2 dependent ACE2 degradation | Antiviral Res | 2023-06 | 通讯作者 |
| 26 | Role of S protein transmembrane domain mutations in the development of occult hepatitis B virus infection | Emerg Microbes Infect | 2022-12 | 通讯作者 |
| 27 | Comparing Immune Responses to Inactivated Vaccines against SARS-CoV-2 between People Living with HIV and HIV-Negative Individuals: A Cross-Sectional Study in China | Viruses | 2022-01 | 通讯作者 |
| 28 | Evaluation of the Aptima HBV Quant Assay Compared to Abbott RealTime M2000 HBV Quant Assay and Procleix Ultrio Plus dHBV Assay in Plasma Samples | Microbiol Spectr | 2022-08 | 王露楠 |
| 29 | Circulating immune complexes and mutations of HBsAg are associated with the undetectable HBsAg in anti-HBs and HBeAg positive occult hepatitis B virus infection | Front Microbiol | 2022-11 | 通讯作者 |
| 30 | Development and validation of a duplex real-time PCR for the rapid detection and quantitation of HTLV-1 | Virol J | 2023-01 | 通讯作者 |
| 31 | Serosurvey for SARS-CoV-2 among blood donors in Wuhan, China from September to December 2019 | Protein & Cell | 2023-01 | 通讯作者 |
| 32 | A study based on four immunoassays: Hepatitis C virus antibody against different antigens may have unequal contributions to detection | Virol J | 2021-01 | 通讯作者 |
| 33 | osttranslational modifications of ACE2 protein: Implications for SARS-CoV-2 infection and beyond | J Med Virol | 2023-12 | 通讯作者 |
| 34 | Posttranslational modifications of ACE2 protein: Implications for SARS-CoV-2 infection and beyond | J Med Virol | 2023-12 | 通讯作者 |
| 35 | Nuermaimait,et al. Acceptance of COVID-19 boosters among hypertensive patients in China: A multicenter cross-sectional study | Hum Vaccin Immun other | 2023-12 | 通讯作者 |
| 36 | Genetic typing and intrafamilial transmission of human T-lymphotropic virus type 1 in non-endemic areas of China | Front Microbiol | 2023-12 | 通讯作者 |
| 37 | he role of sex hormones and receptors in HBV infection and development of HBV-related HCC | J Med Virol | 2023-12 | 通讯作者 |
| 38 | 我国血站血液检测实验室检测能力基本情况分析 | 中国输血杂志 | 2022-07 | 通讯作者 |
| 39 | 无偿献血者中HIV阳性者的病毒载量分析 | 2019-03 | 通讯作者 | |
| 40 | 我国OBI献血者中乙型肝炎病毒BCP/前C区及C区的分子特征 | 国际病毒学杂志 | 2022-05 | 通讯作者 |
| 41 | 血液筛查实验室HBsAg检测的室间质量评价 | 国际病毒学杂志 | 2023-02 | 通讯作者 |
- 科研获奖Research Awards
无
- 研究成果Research Findings
| # | 成果类型 | 项目/专利/新品种名称 |
|---|---|---|
| 1 | 作为主创人员获得授权的发明专利和新品种 | 用于检测HLA-A29等位基因的UAP寡核苷酸、试剂盒和方法 |