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个人简介
Personal Profile
曹永彤,医学博士,教授、主任医师,博士研究生导师,中日友好医院检验科、输血科主任。相继从事心血管临床医疗、检验、输血治疗工作。现兼任中国中西医结合学会检验医学专业委员会候任主任委员、中华医学会检验分会委员、北京医学会检验医学分会候任主任委员、中华检验医学杂志副总编等。承担多项国家科技部支撑课题、国家自然科学基金课题、国家“863”专项及北京市首都特色专项课题。目前在研国家自然科学基金面上项目2项,发表学术论文累计163篇,其中SCI论文56篇,获发明专利11项,副主编/参编专著4部,牵头撰写《中国早期胃癌筛查检验技术专家共识》、《临床检验样本转运及保存规范化专家共识》、《县级医院医学检验科建设和管理指南》等3部指南和专家共识。
团队简介
Team Profile
曹永彤团队依托于北京市临床检验重点专科和国家呼吸医学中心、国家中西医结合医学中心,研究围绕临床诊疗中常见慢病和疑难病的生物标志物挖掘与验证,发挥临床检验诊断学在疾病诊断中的作用。主要研究方向:慢性肾病及心血管疾病诊断标志物的临床应用及基础研究,具体包括:Lp-PLA2/LPC作为糖尿病肾脏疾病内皮功能紊乱标志物的临床价值及其机制研究;FTO通过m6A修饰LINC00921调控细胞铁死亡在糖尿病心肌梗死中的临床价值及机制研究。研究团队有博导和硕导各1名,在读博士生和硕士生共5名。
硕士研究生 1 名,博士研究生 3 名
# | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
---|---|---|---|---|---|
1 | FTO通过m6A修饰LINC00921调控细胞铁死亡在糖尿病心肌梗死中的临床价值及机制研究 | 2023-01-01 —— 2026-12 | 52万元 | 主持在研的国家或省部级科研项目 | 主持人 |
# | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
---|---|---|---|---|
1 | EDTA plasma in glass and polyethylene terephthalate tubes is suitable for measurement of B-type natriuretic peptide on the Mindray CL-6000i | ANNALS OF CLINICAL BIOCHEMISTRY | 2023-09 | 通讯作者 |
2 | Fast and Sensitive Detection of SARS-CoV-2 Nucleic Acid Using a Rapid Detection System Free of RNA Extraction | INTERNATIONAL JOURNAL OF ANALYTICAL CHEMISTRY | 2023-01 | 通讯作者 |
3 | Persistent increase of carbohydrate antigen 19-9 with an unknown reason: A seven-year follow-up case | JOURNAL OF CLINICAL LABORATORY ANALYSIS | 2022-12 | 通讯作者 |
4 | Association of ABCC2 polymorphism with clopidogrel response in Chinese patients undergoing percutaneous coronary intervention | FRONTIERS IN PHARMACOLOGY | 2022-10 | 通讯作者 |
5 | Case report: First case of pemetrexed plus cisplatin-induced immune hemolytic anemia in a patient with lung adenocarcinoma | FRONTIERS IN MEDICINE | 2022-08 | 通讯作者 |
6 | Rapid detection of the irinotecan-related UGT1A128 polymorphism by asymmetric PCR melting curve analysis using one fluorescent probe | JOURNAL OF CLINICAL LABORATORY ANALYSIS | 2022-08 | 通讯作者 |
7 | The ceRNA Crosstalk between mRNAs and lncRNAs in Diabetes Myocardial Infarction | DISEASE MARKERS | 2022-05 | 通讯作者 |
8 | A novel method for early detection of colorectal cancer based on detection of methylation of two fragments of syndecan-2 (SDC2) in stool DNA | BMC GASTROENTEROLOGY | 2022-04 | 通讯作者 |
9 | A Novel Stool Methylation Test for the Non-Invasive Screening of Gastric and Colorectal Cancer | FRONTIERS IN ONCOLOGY | 2022-03 | 通讯作者 |
10 | Analysis of the relationship between phenotypes and genotypes in 60 Chinese patients with propionic acidemia: a fourteen-year experience at a tertiary hospital | ORPHANET JOURNAL OF RARE DISEASES | 2022-03 | 通讯作者 |
11 | Association of AGTR1 A1166C and CYP2C9*3 Gene Polymorphisms with the Antihypertensive Effect of Valsartan | INTERNATIONAL JOURNAL OF HYPERTENSION | 2022-03 | 通讯作者 |
12 | Relationship between Body Roundness Index and Risk of Type 2 Diabetes in Japanese Men and Women: A Reanalysis of a Cohort Study | INTERNATIONAL JOURNAL OF ENDOCRINOLOGY | 2021-12 | 通讯作者 |
13 | Globular adiponectin inhibits osteoblastic differentiation of vascular smooth muscle cells through the PI3K/AKT and Wnt/beta-catenin pathway | JOURNAL OF MOLECULAR HISTOLOGY | 2021-10 | 通讯作者 |
14 | Susceptibility of ApoB and PCSK9 Genetic Polymorphisms to Diabetic Kidney Disease Among Chinese Diabetic Patients | FRONTIERS IN MEDICINE | 2021-04 | 通讯作者 |
15 | Association of Apolipoprotein E Polymorphisms and Risks of Ischemic Stroke in Chinese Patients with Type 2 Diabetes Mellitus | JOURNAL OF DIABETES RESEARCH | 2021-01 | 通讯作者 |
16 | Short-term biological variation and Reference change values of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine and 8-oxo-7,8-dihydroguanosine | JOURNAL OF CLINICAL LABORATORY ANALYSIS | 2020-12 | 通讯作者 |
17 | A Linear Relationship Between a Body Shape Index and Risk of Incident Type 2 Diabetes: A Secondary Analysis Based on a Retrospective Cohort Study in Japan | DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY | 2020-06 | 通讯作者 |
18 | Association of Epoxide Hydrolase 2 Gene Arg287Gln with the Risk for Primary Hypertension in Chinese | INTERNATIONAL JOURNAL OF HYPERTENSION | 2020-02 | 通讯作者 |
19 | The Dose-Response Relationship between Gamma-Glutamyl Transferase and Risk of Diabetes Mellitus Using Publicly Available Data: A Longitudinal Study in Japan | INTERNATIONAL JOURNAL OF ENDOCRINOLOGY | 2020-02 | 通讯作者 |
20 | Characteristics of women infected with human papillomavirus in a tertiary hospital in Beijing China, 2014-2018 | BMC INFECTIOUS DISEASES | 2019-07 | 通讯作者 |
21 | Genetically elevated circulating homocysteine concentrations increase the risk of diabetic kidney disease in Chinese diabetic patients | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2019-04 | 通讯作者 |
22 | Interaction of MTHFR C677T polymorphism with smoking in susceptibility to diabetic nephropathy in Chinese men with type 2 diabetes | JOURNAL OF HUMAN GENETICS | 2019-01 | 通讯作者 |
23 | Regulation of soluble epoxide hydrolase in renal-associated diseases: insights from potential mechanisms to clinical researches. | FRONTIERS IN ENDOCRINOLOGY | 2024-02 | 通讯作者 |
24 | Normal triglyceride concentration and the risk of diabetes mellitus type 2 in the general population of China | FRONTIERS IN ENDOCRINOLOGY | 2024-02 | 通讯作者 |
25 | Development of a Novel Multiplex PCR Method for the Rapid Detection of SARS-CoV-2, Influenza A Virus, and Influenza B Virus | INTERNATIONAL JOURNAL OF ANALYTICAL CHEMISTRY | 2024-02 | 通讯作者 |
26 | Serum circPRDM5 as a novel diagnostic biomarker for acute myocardial infarction | GENE | 2024-03 | 通讯作者 |
27 | Tangshen formula improves diabetic nephropathy in STZ-induced diabetes rats fed with hyper-methionine by regulating the methylation status of kidney | CLINICAL EPIGENETICS | 2024-01 | 通讯作者 |
28 | Experimental Characteristics of Patients with Newly Diagnosed Multiple Myeloma | ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE | 2023-11 | 通讯作者 |
29 | A novel assay based on DNA melting temperature for multiplexed identification of SARS-CoV-2 and influenza A/B viruses | FRONTIERS IN MICROBIOLOGY | 2023-12 | 通讯作者 |
30 | CircRNA and ferroptosis in human disease: Insights for new treatments | ANIMAL MODELS AND EXPERIMENTAL MEDICINE | 2023-12 | 通讯作者 |
31 | Role of HLA class I and II alleles in susceptibility to ankylosing spondylitis in Chinese Han | JOURNAL OF CLINICAL LABORATORY ANALYSIS | 2023-12 | 通讯作者 |
32 | Discrimination of SARS-CoV-2 omicron variant and its lineages by rapid detection of immune-escape mutations in spike protein RBD using asymmetric PCR-based melting curve analysis | VIROLOGY JOURNAL | 2023-08 | 通讯作者 |
33 | Severe autoimmune hemolytic anemia complicating hereditary spherocytosis treated successfully with glucocorticoids and cyclosporine: a case report | HEMATOLOGY | 2023-12 | 通讯作者 |
34 | 高密度脂蛋白量和质在动脉粥样硬化中的临床应用 | 中华检验医学杂志 | 2023-07 | 通讯作者 |
35 | 中国早期胃癌筛查检验技术专家共识 | 中华检验医学杂志 | 2023-04 | 第一作者 |
36 | 临床检验样本转运及保存规范化专家共识 | 中华检验医学杂志 | 2023-03 | 通讯作者 |
37 | 县级医院医学检验科建设和管理指南 | 中华检验医学杂志 | 2022-07 | 第一作者 |
38 | 冠心病患者血清CTRP3与Lp-PLA2水平监测的临床价值分析 | 中华检验医学杂志 | 2021-07 | 通讯作者 |
39 | 动脉粥样硬化性心血管疾病风险评估中进一步脂质检测与应用 | 中华检验医学杂志 | 2021-07 | 通讯作者 |
40 | 2型糖尿病患者载脂蛋白E基因多态性与心肌梗死的相关性 | 中华检验医学杂志 | 2021-10 | 通讯作者 |
41 | EPHX2 rs751141变异位点对肾脏微炎症的影响及其分子机制研究 | 首都医科大学学报 | 2021-10 | 通讯作者 |
42 | 核酸快速检测系统在新型冠状病毒检测中的应用评价 | 中华预防医学杂志 | 2021-02 | 通讯作者 |
43 | 肺移植患者术中输血的关联因素分析及输血对患者预后的影响分析 | 解放军医学院学报 | 2021-10 | 通讯作者 |
44 | 载脂蛋白E基因多态性与2型糖尿病患者发生脑梗死的相关性研究 | 中华检验医学杂志 | 2020-02 | 通讯作者 |
45 | 血管紧张素转换酶基因多态性与2型糖尿病肾病的相关性研究 | 中华检验医学杂志 | 2019-02 | 通讯作者 |
46 | A sensitive LC-MS/MS method for the quantification of serum epoxyeicosatrienoic and dihydroxyeicosatrienoic acids in the identification of diabetic kidney disease | ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2025-05 | 通讯作者 |
47 | Comparative urine proteomic study involving papillary thyroid carcinoma and benign thyroid nodules | FRONTIERS IN ONCOLOGY | 2025-04 | 通讯作者 |
48 | New insights in the treatment of DKD: recent advances and future prospects | BMC NEPHROLOGY | 2025-02 | 通讯作者 |
49 | A mammary gland secretion function exploratory study based on a quantitative comparison between milk and serum | MOLECULAR AND CELLULAR BIOCHEMISTRY | 2025-05 | 通讯作者 |
50 | Early blood pressure drop predicts renal function deterioration and mortality in ICU patients with liver failure: a retrospective cohort study | MEDICINA INTENSIVA | 2025-03 | 通讯作者 |
51 | The Analysis of Plasma Proteomics for Luminal A Breast Cancer | CANCER MEDICINE | 2024-12 | 通讯作者 |
52 | Association between estimated glucose disposal rate and cardiovascular mortality across the spectrum of glucose tolerance in the US population | DIABETES OBESITY & METABOLISM | 2024-12 | 通讯作者 |
53 | The utility of methylmalonic acid, methylcitrate acid, and homocysteine in dried blood spots for therapeutic monitoring of three inherited metabolic diseases | FRONTIERS IN NUTRITION | 2024-06 | 通讯作者 |
54 | 血清钙结合蛋白S100A9与特发性肺纤维化患者肺功能的相关性研究 | 中华检验医学杂志 | 2025-03 | 通讯作者 |
55 | 凝血项目参考区间建立中直接法与间接法的比较及应用 | 中华预防医学杂志 | 2025-03 | 通讯作者 |
56 | 衰老相关分泌表型在特发性肺纤维化中的研究进展 | 中华检验医学杂志 | 2024-10 | 通讯作者 |
57 | 尿液蛋白质组学对间质性肺病诊断价值 | 中华检验医学杂志 | 2024-10 | 通讯作者 |
58 | 基于检验指标构建多参数模型在特发性肺纤维化临床评估中的应用 | 中华检验医学杂志 | 2024-10 | 通讯作者 |
59 | 特发性肺纤维化诊断与预后生物标志物研究进展 | 中华检验医学杂志 | 2024-10 | 通讯作者 |
无
# | 成果类型 | 项目/专利/新品种名称 |
---|---|---|
1 | 作为主创人员获得授权的发明专利和新品种 | 一种一次性真空采血管保存盒 |
2 | 作为主创人员获得授权的发明专利和新品种 | 一种人ABCC2基因多态性检测的引物设计方法及试剂盒 |
3 | 作为主创人员获得授权的发明专利和新品种 | 一种流式细胞检测前的样本避光实验盒 |
4 | 作为主创人员获得授权的发明专利和新品种 | 一种基于胶乳增强免疫比浊法的检测试剂及其制备方法和试剂盒 |
5 | 作为主创人员获得授权的发明专利和新品种 | 一种荧光微球和抗体的偶联方法以及免疫层析试纸条 |
6 | 作为主创人员获得授权的发明专利和新品种 | 免疫反应干扰物及应用 |
7 | 作为主创人员获得授权的发明专利和新品种 | 同时检测n种目标基因的荧光实时检测系统、方法、多重引物、试剂盒 |
8 | 作为主创人员获得授权的发明专利和新品种 | 一种改良型微量试剂瓶 |
9 | 作为主创人员获得授权的发明专利和新品种 | 用于检测线粒体m.3243A>G突变率的引物对双探针组合物及其试剂盒与方法 |
10 | 作为主创人员获得授权的发明专利和新品种 | 一种检测UGT1A1基因多态性的试剂及检测方法 |
11 | 出版高水平专著 | 国家卫生健康委员会住院医师规范化培训规划教材配套精选习题集:检验医学科分册 |
12 | 出版高水平专著 | 检验医学病例与临床思维分析(检验医学科住院医技师规范化培训用书) |
13 | 出版高水平专著 | 分子诊断标准化操作程序(第2版) |