导师风采
齐云

个人信息

Personal Information

  • 性别：男
  • 导师类型：博士生导师
  • 职称：研究员
  • 该职称任职时间：14

联系方式

Contact Information

  • 所属院系：药用植物研究所
  • 所属专业：
  • 邮箱 : yqi@implad.ac.cn
  • 工作电话 : 010-57833225

个人简介

Personal Profile

齐云，男，1964年出生，博士生导师，研究员。1999年从成都中医药大学博士毕业后进入中国中医科学院中西医结合专业博士后流动站，参加国家九五攀登计划预选项目“中药现代化关键问题的基础研究—桂枝汤双向调节作用物质基础和机理研究”。该课题于2007年获中国中西医结合学会科学技术一等奖。2001年出站进入中国医学科学院药用植物研究所，2003年晋升为研究员后已主持或作为主研参与国家及部省级课题20余项，其中主持8项。2010年“濒危药材肉苁蓉种植资源评价、保护和利用”获宁夏回族自治区科学技术进步二等奖；2013年“中药中真菌及真菌毒素污染分析及应用研究”获北京市科学进步三等奖；2015年“符合中药特点的增溶性药用辅料的筛选与评价”获中华中医药学会科学技术二等奖。迄今在国内外以第一作者或通讯作者发表学术论文近100余篇，参编著作9部。现为国家食品药品监督管理局新药评审委员、国家科学技术奖评审专家、中国药理学会中药药理专业委员会委员、《中国药理学通报》、《中国实验方剂学杂志》、《中药药理与临床》等杂志编委。

团队简介

Team Profile

本团队主要从事中药与天然药物的抗炎免疫研究。抗炎涉及感染性炎症及代谢性炎症；免疫涉及I型过敏反应及自身免疫性疾病。团队在编工作人员三人，由我及一位科研系列副研究员(硕士生导师)及技术系列的副主任技师组成，加上每年入室研究生，是一个规模在10-15人的中型团队。本室以所训“求真务实”为准则，以“严谨、高效”为追求目标，努力营造人际和谐的舒心科研环境。全组从我做起，共同拒绝与排斥恃强凌弱与弄虚作假(不诚实)这两种恶质，欢迎理念相近者加入。

  • 研究方向Research Directions
抗炎免疫药理学
  • 在校研究生Current Graduate Students

硕士研究生 2 名，博士研究生 1 名

  • 科研项目Research Projects
# 项目名称 起止日期 金额 项目类型 本人角色
1基于先天与获得性免疫研究化湿败毒方对COVID-19细胞因子风暴的作 用与机制2021-01-01 —— 2024-12-3155.0主持在研的国家或省部级科研项目主持者
  • 发表论文Papers
# 论文题目 期刊名称 发表年份 论文署名
1Sophoraflavanone M, a prenylated flavonoid from Sophora flavescens Ait., suppresses pro-inflammatory mediators through both NF-κB and JNK/AP-1 signaling pathways in LPS-primed macrophagesEur J Pharmacol2021-06Han YX, Zhang XY, Kang Y, Gao Y, Li XM, Qi RJ, Cai RL, Qi Y*
2Penicillin causes non-allergic anaphylaxis by activating the contact systemScientific Reports2020-08Gao Y, Han YX, Zhang XY, Fei QL, Qi RJ, Hou R, Cai RL, Peng C*, Qi Y*
3Qing-Kai-Ling Injection Induces Immediate Hypersensitivity Reaction via the Activation of Anaphylatoxin C3Frontiers in Pharmacology2020-01Gao Y, Qi RJ, Zhang XY, Xu XD, Han YX, Fei QL, Wang XJ, Cai RL, Sun GB*, Qi Y*
4Potentilla discolor ameliorates LPS-induced inflammatory responses through suppressing NF-κB and AP-1 pathwaysBiochemical Pharmacology2021-08Zhang XY, Kang Y, Li XM, Huang YF, Qi RJ, Hana YX, Cai RL, Gao Y*, Qi Y*
5Forsythiasides-rich extract from Forsythiae Fructus inhibits mast cell degranulation by enhancing mitochondrial Ca2 uptakeFrontiers in Pharmacology2021-06Qi RJ, Kang Y, Li XM, Zhang XY, Han YX, Cai RL, Gao Y*, Qi Y*
6Isodeoxyelephantopin, a sesquiterpene lactone from Elephantopus scaber Linn., inhibits pro-inflammatory mediators’ production through both NF-κB and AP-1 pathways in LPS-activated macrophagesInt Immunopharmacol2020-04Han YX, Li XM, Zhang XY, Gao Y, Qi RJ, Cai RL, Qi Y*
7Ethanol extract of Elephantopus scaber Linn. Attenuates inflammatory response via the inhibition of NF-κB signaling by dampening p65-DNA binding activity in lipopolysaccharide-activated macrophagesJournal of Ethnopharmacology2020-01Qi RJ, Li XM, Zhang XY, Huang YF, Fei QL, Han YX, Cai RL, Gao Y*, Qi Y*
8Aloe-emodin, a naturally occurring anthraquinone, is a highly potent mast cell stabilizer through activating mitochondrial calcium uniporterBiochemical Pharmacology2021-02Gao Y, Zhang XY, Li XM, Qi RJ, Han YX, Kang Y, Cai RL, Peng C*, Qi Y*
9Lucyoside B, a triterpenoid saponin from Luffa cylindrica, inhibits the production of inflammatory mediators via both nuclear factor-κB and activator protein-1 pathways in activated macrophagesJ Funct Foods2020-01Han YX, Zhang XY, Qi RJ, Li XM, Gao Y, Zou ZM, Cai RL, Qi Y*
10Compound Kushen Injection Induces Immediate Hypersensitivity Reaction Through Promoting the Production of Platelet-Activating Factor via de Novo PathwayFrontiers in Pharmacology2021-10Gao Y, Lina Hai LN, Kang Y, QinWJ, Liu F, Cai RL, Yang XW*, Qi Y*
11Scutellarein suppresses the production of ROS and inflammatory mediators of LPS-activated bronchial epithelial cells and attenuates acute lung injury in miceAntioxidants2024-06Li XM, Zhang XY, Kang Y, Cai M, Yan JJ, Zang CC, Gao Y*, Qi Y*
12“新冠三方”的体外抗氧化作用比较中国现代应用药学2024-04李西蒙， 康媛，高 源，刘壮壮，李文静，徐瑱璐，张小雨，蔡润兰，齐 云*
13清肺排毒汤、化湿败毒方和宣肺败毒方体外抗补体活化作用的比较研究中药药理与临床2024-03李西蒙，藏晨晨，郭怡琳，蔡敏，闫晶晶，李文静，刘壮壮，高 源*，齐 云*
14柴胡解表退热功效相关生物活性指标与柴胡皂苷a、柴胡皂苷d 含量相关性分析中国现代中药2024-01刘壮壮，康媛，郭怡琳，郭欣慰，李西蒙，蔡润兰，高源*，齐云*
15Bupleurum chinense exerts a mild antipyretic effect on LPS-induced pyrexia rats involving inhibition of peripheral TNF-α productionJ Ethnopharmacol2023-03Kang Y, Gao Y, Li XM, Guo XW, Liu ZZ, Li WJ, Wei JH*, Qi Y*
16Edible O. fragrans flower ameliorates LPS-induced inflammatory responses through suppressing NF-κB and AP-1 pathwaysJ Funct Foods2023-03Liu ZZ, Li XM, Li WJ, Cai M, Yan JJ, Zang CC, Cai RL, Gao L*, Qi Y*
17Salicylate sodium suppresses monocyte chemoattractant protein-1 production by directly inhibiting phosphodiesterase 3B in TNF-α-stimulated adipocytesInt. J. Mol. Sci.2023-01Zhang XY, Gao Y, Liu ZZ, Li WJ, Kang Y, Li XM, Xu ZL, Peng C*, Qi Y*
18Comparing the effects of three decoctions for COVID-19 on SARS-CoV-2 related TLRs-mediated inflammationsJ Tradit Chin Med2023-01Li XM, Yuan Kang, Li WJ, Liu ZZ, Xu ZL, Zhang XY, Cai RL, Gao Y*, Qi Y*
19Resibufogenin, one of bufadienolides in toad venom, suppresses LPS-induced inflammation via inhibiting NF-κB and AP-1 pathwaysInt Immunopharmacol2022-10Gao Y, Xu ZL, Li XM, Liu ZZ, Li WJ, Kang Y, Zhang XY, Qi Y *
20Oral administration of Forsythiasides-rich extract from Forsythiae fructus decreases the IgE production through suppressing Th2 response in shrimp protein-sensitized BALB/c micePhytomedicine Plus2022-10Qi RJ, Li WJ, Liu ZZ, Xu ZL, Kang Y, Li XM, Zhang XY, Gao Y*, Qi Y*
21A comparative study of spike protein of SARS-CoV-2 and its variant Omicron (B.1.1.529) on some immune characteristics.Sci Rep2022-10Li XM, Li WJ, Liu ZZ, Kang Y, Zhang XY, Xu ZL, Gao Y*, Qi Y*
22Anti-oxidative and anti-inflammatory activities of the ethanol extract of edible flower from Chimonanthus praecoxFront Pharmacol2022-09Kang Y, Liu ZZ, Li WJ, Li XM, Zhang XY, Xu ZL, Gao Y*, Qi Y*
23Hua-Shi-Bai-Du decoction inactivates NLRP3 inflammasome through inhibiting PDE4B in macrophages and ameliorates mouse acute lung injuryPhytomedicine2024-08Li XM1, Li WJ1, Zang CC, Yan JJ, Cai M, Zhu, Liu ZZ, Cai RL, Gao Y*, Qi Y*
24The natural sesquiterpene lactone inulicin suppresses the production of pro-inffammatory mediators via inhibiting NF-κB and AP-1 pathways in LPS-activated macrophagesImmunopharmacology and Immunotoxicology2024-07Yan JJ, Cai M, Zang CC, Li WJ, Liu ZZ, Li XM, Gao Y*, Qi Y*
  • 科研获奖Research Awards

无

  • 研究成果Research Findings
# 成果类型 项目/专利/新品种名称
1作为主创人员获得授权的发明专利和新品种(2R)-3a,7,4'-三羟基-5-甲氧基-8-(r,r-二甲基丙烯基)二氢黄酮作为抗炎剂的新用途
2作为主创人员获得授权的发明专利和新品种一种基于黄柏酮的化合物
3作为主创人员获得授权的发明专利和新品种蜡梅花提取物作为环氧酶-2抑制剂的新用途
4作为主创人员获得授权的发明专利和新品种芦荟大黄素作为抗肥大细胞活化剂的新用途