导师风采
张现忠
个人信息
Personal Information
- 性别：男
- 导师类型：博导
- 职称：教授
- 该职称任职时间：2023-01-03
联系方式
Contact Information
- 所属院系：北京协和医院
- 所属专业：药物化学
- 邮箱 :
- 工作电话 : 18950190564
个人简介
Personal Profile
教授，博士，博士生导师。现为转化医学国家重大科技基础设施（北京协和）诊疗新技术研发平台主任、中国医学科学院临床医学研究所课题组长、北京协和医院核医学科药物组负责人。 张现忠博士于长期致力于放射性药物及核素标记的多功能分子探针基础与转化研究。在分子影像探针设计、合成、标记、体内外评价以及成像方法和临床转化等方面开展一系列研究。在JNM, EJNMMI, J Med Chem等本领域专业期刊发表SCI论文154篇；获授权发明专利 67项，其中3项第一发明人专利技术成功转化并获临床试验批件，分别用于肝功能、肿瘤和冠心病早期诊断。主持科技部973/重点研发计划课题2项，国家自然科学基金核技术联合创新重点项目、肿瘤演进可视化重大研究计划培育项目以及面上项目等30余项。曾获厦门市重点人才（2013）、第十二届福建青年科技奖（2014）、华夏医学科技奖三等奖（2021）和中华医学科学技术奖三等奖（2022）等奖励。入选科技部人才推进计划中青年科技创新领军人才和中组部国家高层次人才特殊支持计划（万人计划）科技创新领军人才（2020）、福建省级高层次人才A类（2021）。 张现忠博士担任国内外多种学术期刊编委会顾问、副编辑和编委等职。任中国化学会高级会员、中国核学会放射性药物分会常务理事、同位素分会理事等职。
团队简介
Team Profile
教授，博士，博士生导师。现为转化医学国家重大科技基础设施（北京协和）诊疗新技术研发平台主任、中国医学科学院临床医学研究所课题组长、北京协和医院核医学科药物组负责人。 张现忠博士于长期致力于放射性药物及核素标记的多功能分子探针基础与转化研究。在分子影像探针设计、合成、标记、体内外评价以及成像方法和临床转化等方面开展一系列研究。在JNM, EJNMMI, J Med Chem等本领域专业期刊发表SCI论文154篇；获授权发明专利 67项，其中3项第一发明人专利技术成功转化并获临床试验批件，分别用于肝功能、肿瘤和冠心病早期诊断。主持科技部973/重点研发计划课题2项，国家自然科学基金核技术联合创新重点项目、肿瘤演进可视化重大研究计划培育项目以及面上项目等30余项。曾获厦门市重点人才（2013）、第十二届福建青年科技奖（2014）、华夏医学科技奖三等奖（2021）和中华医学科学技术奖三等奖（2022）等奖励。入选科技部人才推进计划中青年科技创新领军人才和中组部国家高层次人才特殊支持计划（万人计划）科技创新领军人才（2020）、福建省级高层次人才A类（2021）。 张现忠博士担任国内外多种学术期刊编委会顾问、副编辑和编委等职。任中国化学会高级会员、中国核学会放射性药物分会常务理事、同位素分会理事等职。
- 研究方向Research Directions
药物化学, 放射性药物化学, 分子影像探针
- 在校研究生Current Graduate Students
硕士研究生 0 名，博士研究生 2 名
- 科研项目Research Projects
| # | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
|---|---|---|---|---|---|
| 1 | 稀土放射性核素的配位标记研究 | 2023-12-02 —— 2026-11-02 | 主持在研的国家或省部级科研项目 | 主持人 |
- 发表论文Papers
| # | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
|---|---|---|---|---|
| 1 | Optimum combination of radiopharmaceuticals-based targeting-triggering-therapy effect and PD-L1 blockade immunotherapy | Advanced Therapeutics | 2022-11-11 | 通讯作者 |
| 2 | Synergism of 64Cu-labeled RGD with anti-PD-L1 immunotherapy for the long-acting antitumor effect | BIOCONJUGATE CHEMISTRY | 2022-10-18 | 通讯作者 |
| 3 | Radioiodinated progesterone derivative for progesterone receptor targeting with enhanced nucleus uptake via phenylboronic acid conjugation | JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2019-06-15 | 通讯作者 |
| 4 | Development of [177Lu]Lu‑LNC1003 for radioligand therapy of prostate cancer with a moderate level of PSMA expression | EUR J NUCL MED MOL IMAGING | 2023-04-25 | 通讯作者 |
| 5 | Preclinical and first-in-human evaluation of18F-labeled D-peptide antagonist for PD-L1 status imaging with PET | EUR J NUCL MED MOL IMAGING | 2022-07-14 | 通讯作者 |
| 6 | MicroSPECT Imaging of Acute Ischemic Stroke with Radioiodinated Riboflavin in Rat MCAO Models via Riboflavin Transporter Targeting | ACS Chemical Neuroscience | 2022-07-06 | 通讯作者 |
| 7 | Rational Design and Pharmacomodulation of Protein-Binding Theranostic Radioligands for Targeting Fibroblast Activation Protein | JOURNAL OF MEDICINAL CHEMISTRY | 2022-06-06 | 通讯作者 |
| 8 | PD-L1-targeted radionuclide therapy combined with αPD-L1 antibody immunotherapy synergistically improves anti-tumor effect | MOLECULAR PHARMACEUTICS | 2022-06-02 | 通讯作者 |
| 9 | MicroPET Imaging of Bacterial Infection with Nitroreductase-specific Responsive 18F-labelled Nitrogen Mustard Analogues | EUR J NUCL MED MOL IMAGING | 2022-02-05 | 通讯作者 |
| 10 | Preclinical and Exploratory Human Studies of Novel 68Ga-labeled ᴅ-Peptide Antagonist for PET Imaging of TIGIT Expression in Cancers | EUR J NUCL MED MOL IMAGING | 2022-01-17 | 通讯作者 |
| 11 | Development and Preclinical Evaluation of Radiolabeled Covalent G12C-Specific Inhibitors for Directly Imaging of Oncogenic KRAS Mutant | MOLECULAR PHARMACEUTICS | 2021-08-19 | 通讯作者 |
| 12 | Controllable stripping of radiolabeled group in vivo to optimize nuclear imaging via NO-responsive bioorthogonal cleavage reaction | RSC Advances | 2020-11-03 | 通讯作者 |
| 13 | Synthesis of 18F-radiolabeled organophosphine fluorides for thiol-chemoselective peptide conjugation | JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2020-10-12 | 通讯作者 |
| 14 | Tumor Microenvironment-Activated Ultrasensitive Nanoprobes for Specific Detection of Intratumoral Glutathione by Ratiometric Photoacoustic Imaging | ACS Applied Materials & Interfaces | 2019-07-29 | 通讯作者 |
| 15 | In Situ Live Imaging of Gut Microbiota | mSphere | 2021-09-29 | 通讯作者 |
| 16 | Radioiodinated Estradiol Dimer for Estrogen Receptor Targeted Breast Cancer Imaging | Chemical Biology & Drug Design | 2020-06-30 | 通讯作者 |
| 17 | Radioiodinated 4-(p-iodophenyl) butanoic acid modified estradiol derivative for ER targeting SPECT imaging | ANALYTICAL CHEMISTRY | 2021-10-06 | 通讯作者 |
| 18 | A logic-gated modular nanovesicle enables programmable drug release for on-demand chemotherapy | Theranostics | 2019-02-14 | 通讯作者 |
| 19 | Radioiodinated ethinylestradiol derivatives for estrogen receptor targeting breast cancer imaging | ACS Medicinal Chemistry Letters | 2022-01-27 | 通讯作者 |
| 20 | Evans blue-modified radiolabeled fibroblast activation protein inhibitor as long-acting cancer therapeutics | Theranostics | 2022-01-01 | 通讯作者 |
| 21 | Versatile fluorinated Pd@Au nanoplates doped with yttrium for tumor theranostics | Biomaterials Science | 2021-03-23 | 通讯作者 |
| 22 | Development of a novel radiofluorinated riboflavin probe for riboflavin receptor-targeting PET imaging | PHARMACOLOGICAL RESEARCH | 2022-08-13 | 通讯作者 |
| 23 | 18F-labeled ethisterone derivative for progesterone receptor targeted PET imaging of breast cancer | NUCLEAR MEDICINE AND BIOLOGY | 2019-07-12 | 通讯作者 |
| 24 | 68Ga-labeled maleimide for blood pool and lymph PET imaging through covalent bonding to serum albumin in vivo | ACS Omega | 2022-08-05 | 通讯作者 |
| 25 | Development of 18F-Labeled Acridone Analogue for Tumor Imaging via Stimulator of Interferon Genes Targeting | MOLECULAR PHARMACEUTICS | 2023-05-27 | 通讯作者 |
| 26 | Synthesis and Preclinical Evaluation of a 68Ga-Labeled Pyridine-Based Benzamide Dimer for Malignant Melanoma Imaging | MOLECULAR PHARMACEUTICS | 2023-02-01 | 通讯作者 |
| 27 | Longitudinal MicroSPECT Imaging of Systemic Sclerosis Model Mice with [99mTc]Tc-HYNFA via Folate Receptor Targeting | MOLECULAR PHARMACEUTICS | 2022-10-28 | 通讯作者 |
| 28 | A Novel 18F-Labeled Agonist for PET Imaging of Stimulator of Interferon Genes Expression in Tumor-bearing Mice | EUR J NUCL MED MOL IMAGING | 2022-09-06 | 通讯作者 |
| 29 | A paradigm of cancer immunotherapy based on 2-[18F]FDG and anti-PD-L1 mAb combination to enhance the anti-tumor effect | CLINICAL CANCER RESEARCH | 2022-07-01 | 通讯作者 |
| 30 | Ligand-Engineering of Titanium-Oxo Nanoclusters for Cerenkov Radiation-Reinforced Photo/Chemodynamic Tumor Therapy | ACS Applied Materials & Interfaces | 2021-11-12 | 通讯作者 |
| 31 | MicroSPECT imaging-guided treatment of idiopathic pulmonary fibrosis in mice with a vimentin-targeting 99mTc-labeled N-acetylglucosamine-polyethyleneimine | MOLECULAR PHARMACEUTICS | 2021-11-01 | 通讯作者 |
| 32 | A radioiodinated FR-β-targeted tracer with improved pharmacokinetics through modification with an albumin binder for imaging of macrophages in AS and NAFL | EUR J NUCL MED MOL IMAGING | 2021-06-21 | 通讯作者 |
| 33 | Immuno-SPECT/PET imaging with radioiodinated anti-PD-L1 antibody to evaluate PD-L1 expression in immune-competent murine models and PDX model of lung adenocarcinoma | NUCLEAR MEDICINE AND BIOLOGY | 2020-05-23 | 通讯作者 |
| 34 | Molecular imaging of advanced atherosclerotic plaques with folate receptor-targeted 2D nanoprobes | Nano Research | 2019-12-19 | 通讯作者 |
| 35 | Integrin αvβ3-targeted radionuclide therapy combined with immune checkpoint blockade immunotherapy synergistically enhances anti-tumor efficacy | Theranostics | 2019-10-16 | 通讯作者 |
| 36 | Radioiodinated Portable Albumin Binder as a Versatile Agent for in vivo Imaging with Single-Photon Emission Computed Tomography | MOLECULAR PHARMACEUTICS | 2019-01-03 | 通讯作者 |
| 37 | Radiotracers for Nuclear Imaging of Reactive Oxygen Species: Advances Made so Far | BIOCONJUGATE CHEMISTRY | 2022-04-25 | 通讯作者 |
| 38 | Small molecules as theranostic agents in cancer immunology | Theranostics | 2019-10-15 | 通讯作者 |
| 39 | PET Imaging of Adenosine Receptors in Diseases | CURRENT TOPICS IN MEDICINAL CHEMISTRY | 2019-07-08 | 通讯作者 |
| 40 | Rational Design and Comparison of Novel 99mTc-Labeled FAPI Dimers for Visualization of Multiple Tumor Types | JOURNAL OF MEDICINAL CHEMISTRY | 2024-05-08 | 通讯作者 |
| 41 | Rational Design and Pharmacomodulation of 18F-Labeled Biotin/FAPI-Conjugated Heterodimers | JOURNAL OF MEDICINAL CHEMISTRY | 2024-05-10 | 通讯作者 |
| 42 | Preclinical Evaluation of 131I/18F-Labeled Covalent Small-Molecule Inhibitors for STING Status Imaging | ACS Pharmacol. Transl. Sci. | 2024-05-09 | 通讯作者 |
| 43 | 18F-Labeled Amidobenzimidazole Analogue for Visualizing STING Expression in Tumor | MOLECULAR PHARMACEUTICS | 2024-04-01 | 通讯作者 |
| 44 | A proof-of-concept study on bioorthogonal-based pretargeting and signal amplify radiotheranostic strategy | JOURNAL OF NANOBIOTECHNOLOGY | 2024-03-10 | 通讯作者 |
| 45 | 68Ga-Labeled TMTP1 Modified with d-Amino Acid for Positron Emission Tomography Diagnosis of Highly Metastatic Hepatocellular Carcinoma | JOURNAL OF MEDICINAL CHEMISTRY | 2024-02-08 | 通讯作者 |
| 46 | Development of small-molecular-based radiotracers for PET imaging of PD-L1 expression and guiding the PD-L1 therapeutics | EUR J NUCL MED MOL IMAGING | 2024-01-22 | 通讯作者 |
| 47 | In vivo Comparative Study of Radioiodinated Folate Receptor Targeting Albumin Probes for Atherosclerosis Plaque Imaging | BIOCONJUGATE CHEMISTRY | 2023-12-20 | 通讯作者 |
| 48 | Development of radiotracers for riboflavin transporter 3 imaging in diseases - a brief overview | JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 2023-12-22 | 通讯作者 |
- 科研获奖Research Awards
无
- 研究成果Research Findings
| # | 成果类型 | 项目/专利/新品种名称 |
|---|---|---|
| 1 | 作为主创人员获得授权的发明专利和新品种 | 一种干扰素刺激蛋白靶向化合物、其放射性标记物、及它们的制备方法与应用 |
| 2 | 作为主创人员获得授权的发明专利和新品种 | 一种放射性核素标记的雌激素受体分子靶向化合物及其应用 |
| 3 | 作为主创人员获得授权的发明专利和新品种 | 一种雌激素受体靶向放射性示踪剂、制备方法及应用 |
| 4 | 作为主创人员获得授权的发明专利和新品种 | 一种放射性碘标记的蛋白结合配体及其应用 |
| 5 | 作为主创人员获得授权的发明专利和新品种 | 放射性核素标记的苯并喋啶类衍生物及其制备和应用 |
| 6 | 作为主创人员获得授权的发明专利和新品种 | 一种靶向TIGIT的放射性标记化合物及其制备方法和应用 |
| 7 | 作为主创人员获得授权的发明专利和新品种 | 一种放射性18F标记化合物及其应用 |
| 8 | 作为主创人员获得授权的发明专利和新品种 | 一种用于肿瘤免疫治疗的药物组合 |