导师风采
王锐
个人信息
Personal Information
- 性别：男
- 导师类型：博士生导师
- 职称：教授
- 该职称任职时间：1995
联系方式
Contact Information
- 所属院系：药物研究所
- 所属专业：药物化学
- 邮箱 : wangrui@imm.ac.cn
- 工作电话 :
个人简介
Personal Profile
王锐，药物化学家、多肽药物专家。1988获博士学位（兰州大学与日本京都大学联合培养)，美国堪萨斯大学博士后。第十三、十四届全国政协常委、中国工程院院士 (医药卫生学部)、中国医学科学院学部委员、中国医学科学院药物研究所执行所长、北京协和医学院特聘教授、兰州大学萃英学者一级教授、中国药学会副理事长、中华医学会常务理事、中 国药典委员会执行委员。
团队简介
Team Profile
待补充更新
- 研究方向Research Directions
药物化学/多肽药物
- 在校研究生Current Graduate Students
硕士研究生 6 名，博士研究生 8 名
- 科研项目Research Projects
| # | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
|---|---|---|---|---|---|
| 1 | 基于非天然氨基酸的多肽药物修饰及临床导向的多肽药物研发 | 2021-10-01 —— | 5000.0 | 主持者 | |
| 2 | 生物大分子药物设计、制备与智能递送关键技 术研究 | 2021-10-01 —— | 5600.0 | 主持者 |
- 发表论文Papers
| # | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
|---|---|---|---|---|
| 1 | Design of a highly potent GLP-1R and GCGR dual-agonist for recovering hepatic fibrosis | Acta Pharmaceutica Sinica B | 2022-05 | 通讯 |
| 2 | Activation of allylic esters in an intramolecular vinylogous kinetic resolution reaction with synergistic magnesium catalysts | Nat. Commun | 2020-05 | 通讯 |
| 3 | Visible-Light-Promoted Stereoselective C(sp3)？H Glycosylation for the Synthesis of C -Glycoamino Acids and C -Glycopeptides | Angew. Chem. Int. Ed. | 2022-03 | 通讯 |
| 4 | Therapeutic peptides: current applications and future directions | Signal Transduction and Targeted Therapy | 2022-02 | 通讯 |
| 5 | MEL endomorphins act as potent inflammatory analgesics with the T inhibition of activated non-neuronal cells and modulation of pro- inflammatory cytokines. | Neuropharmacology | 2020-05 | 通讯 |
| 6 | 1,3-dipolar cycloaddition between dehydroalanines and C,N‐cyclic azomethine imines: application to late‐stage peptide modification. | Angew. Chem. Int. Ed. | 2020-11 | 通讯 |
| 7 | NDTP Mediated Direct Rapid Amide and Peptide Synthesis without Epimerization | Org. Lett. | 2022-01 | 通讯 |
| 8 | Copper(I)-Catalyzed Late-Stage Introduction of Oxime Ethers into Peptides at the Carboxylic Acid Site | Org. Lett. | 2022-12 | 通讯 |
| 9 | Covalent organic framework membrane for efficient removal of emerging trace organic contaminants from water | Nature Water | 2023-12 | 通讯 |
| 10 | Microcolin H, a novel autophagy inducer, exerts potent antitumour activity by targeting PITPα/β | Signal Transduction and Targeted Therapy | 2023-11 | 通讯 |
| 11 | Metal-porphyrin-based three-dimensional covalent organic frameworks for electrocatalytic nitrogen reduction | Applied Catalysis B: Environmental | 2024-03 | 通讯 |
| 12 | Concerted Enantioselective [2 2] Cycloaddition Reaction of Imines Mediated by a Magnesium Catalyst | J. Am. Chem. Soc. | 2022-12 | 通讯 |
| 13 | A novel and low-toxic peptide DR3penA alleviates pulmonary fibrosis by regulating the MAPK/miR-23b-5p/AQP5 signaling axis | Acta Pharmaceutica Sinica B | 2023-09 | 通讯 |
| 14 | Dimethyl Sulfoxide/Visible-Light Comediated Chemoselective C–S Bond Formation Between Tryptophans and Thiophenols Enables Site-Selective Functionalization of Peptides | CCS Chemistry | 2024-06 | 通讯 |
| 15 | Development of Neuropeptide Hemokinin 1 Analogues with Antimicrobial and Wound-Healing Activity | J. Med. Chem. | 2023-03 | 通讯 |
| 16 | Structure−Activity Relationship Study of Antimicrobial Peptide PE2 Delivered Novel Linear Derivatives with Potential of Eradicating Biofilms and Low Incidence of Drug Resistance | J. Med. Chem. | 2023-06 | 通讯 |
| 17 | Direct inhibition of microglial activation by a μ receptor selective agonist alleviates inflammatory-induced pain hypersensitivity | European Journal of Pharmacology | 2023-12 | 通讯 |
| 18 | The novel peptide DR4penA attenuates the bleomycin- and paraquat-induced pulmonary fibrosis by suppressing the TGF-β/Smad signaling pathway | The FASEB Journal | 2023-10 | 通讯 |
| 19 | Linear peptide-based PET tracers for imaging PD-L1 in tumors | Molecular Pharmaceutics | 2023-06 | 通讯 |
| 20 | NaClO-Mediated Cross Installation of Indoles and Azoles Benefits Anticancer Hit Discovery | ChemMedChem | 2023-03 | 通讯 |
| 21 | Topologically Tunable Conjugated Metal–Organic Frameworks for Modulating Conductivity and Chemiresistive Properties for NH3 Sensing | Angew. Chem. Int. Ed. | 2024-02 | 通讯 |
| 22 | Enantioselective synthesis of [4]helicenes by organocatalyzed intermolecular C-H amination | nature communications | 2024-01 | 通讯 |
| 23 | Design and discovery of a highly potent ultralong-acting GLP-1 and glucagon co-agonist for attenuating renal fibrosis | Acta Pharmaceutica Sinica B | 2024-03 | 通讯 |
| 24 | Novel antimicrobial peptides modified with fluorinated sulfono-γ-AA having high stability and targeting multidrug-resistant bacteria infections | European Journal of Medicinal Chemistry | 2024-01 | 通讯 |
| 25 | The Peptide DH α-(4-pentenyl)-ANPQIR-NH2 Exhibits Antifibrotic Activity in Multiple Pulmonary Fibrosis Models Induced by Particulate and Soluble Chemical Fibrogenic Agents | J Pharmacol Exp Ther. | 2023-12 | 通讯 |
| 26 | Cysteine-Specific Multifaceted Bioconjugation of Peptides and Proteins Using 5-Substituted 1,2,3-Triazines | Adv. Sci. | 2024-03 | 通讯 |
- 科研获奖Research Awards
| # | 获奖证书编号 | 奖项名称 | 获奖级别 | 获奖类别 | 获奖等级 | 获奖日期 | 颁奖单位 | 本单位是否为第一完成单位 | 完成单位排名 | 本人排序 | 备注 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2009-Z-103-2-02-R01 | 若干手性催化合成方法学及其在多肽研究中的应用 | 国家级 | 国家自然科学奖 | 二等奖 | 2009-12-23 | 中华人民共和国国务院 | 否 | 1 | ||
| 2 | 2016-F-302-2-02-R01 | 多肽化学修饰德关键技术及其在多肽新药创制中的应用 | 国家级 | 国家技术发明奖 | 二等奖 | 2016-12-21 | 中华人民共和国国务院 | 否 | 1 |
- 研究成果Research Findings
| # | 成果类型 | 项目/专利/新品种名称 |
|---|---|---|
| 1 | 作为主创人员获得授权的发明专利和新品种 | 多肽FK2在制备抗肾脏纤维化药物中的应用 |
| 2 | 获得新药研究成果 | 一种肿瘤靶向的多肽药物偶联物及其应用 |