导师风采
邢念增

个人信息

Personal Information

  • 性别:男
  • 导师类型:博士生导师
  • 职称:主任医师
  • 该职称任职时间:20071001

联系方式

Contact Information

  • 所属院系:肿瘤医院
  • 所属专业:
  • 邮箱 : nianzeng2006@vip.sina.com
  • 工作电话 : 87787170

个人简介

Personal Profile

邢念增,医学博士,教授,主任医师,博士/博士后研究生导师。中国医学科学院肿瘤医院副院长,中国医师协会泌尿外科医师分会会长,全国人大代表。荣获第22届吴杨医学药学奖、世界华人泌尿外科学会首届创新贡献奖、国家百千万人才工程人选、国家级有突出贡献中青年专家、首都科技领军人才、第四届国之名医-卓越建树等荣誉,享受国务院特殊津贴,中央保健会诊专家。在国内外发表论文380余篇,其中SCI收录的论文130余篇,论文已被引用3000余次。出版专著15部,包括我国第一部3D腹腔镜手术教程。获中国发明及实用新型专利九项,美国专利两项,数项已转化应用。获中国中西医结合学会科技进步一等奖、华夏科技进步一等奖、教育部科技进步二等奖、北京市科技进步二等奖等10余项科技奖励。

团队简介

Team Profile

待补充更新

  • 研究方向Research Directions
泌尿系肿瘤分子机制,泌尿系肿瘤微创治疗
  • 在校研究生Current Graduate Students

硕士研究生 0 名,博士研究生 4 名

  • 科研项目Research Projects
# 项目名称 起止日期 金额 项目类型 本人角色
1国家重点研发计划战略性科技创新合作重点专项2022-06-01 —— 2025-05200.0主持在研的国家或省部级科研项目主持者
2首都卫生发展科研专项重点攻关项目2022-06-01 —— 2024-12120.0主持在研的国家或省部级科研项目主持者
3中国医学科学院医学与健康科技创新工程重大协同创新项目2022-06 —— 2025-121280万主持在研的国家或省部级科研项目主持人
4"十四五"国家重点研发计划常见多发病防治研究重点专项2023-11 —— 2026-10945.95万元主持在研的国家或省部级科研项目主持人
  • 发表论文Papers
# 论文题目 期刊名称 发表年份 论文署名
1Deubiquitination of CDC6 by OTUD6A promotes tumour progression and chemoresistance.Mol Cancer.2024-04共同通讯
2High and selective cytotoxicity of ex vivo expanded allogeneic human natural killer cells from peripheral blood against bladder cancer: implications for natural killer cell instillation after transurethral resection of bladder tumorJ Exp Clin Cancer Res.2024-01最后通讯
3Targeting DNA Damage and Repair Machinery via Delivering WEE1 Inhibitor and Platinum (IV) Prodrugs to Stimulate Sting Pathway for Maximizing Chemo-immunotherapy in Bladder CancerAdv Mater.2023-10最后通讯
4Polyphotosensitizer-Based Nanoparticles with Michael Addition Acceptors Inhibiting GST Activity and Cisplatin Deactivation for Enhanced Chemotherapy and Photodynamic Immunotherapy.Adv Sci (Weinh).2023-03最后通讯
5Cuproptosis Induced by ROS Responsive Nanoparticles with Elesclomol and Copper Combined with αPD-L1 for Enhanced Cancer Immunotherapy.Adv Mater.2023-03最后通讯
6Membrane dual-targeting probes: A promising strategy for fluorescence-guided prostate cancer surgery and lymph node metastases detection.Acta Pharm Sin B. 2022-08最后通讯
7Clinical practice guideline for transurethral plasmakinetic resection of prostate for benign prostatic hyperplasia (2021 Edition)Mil Med Res. 2022-04共同通讯
8The establishment of polypeptide PSMA-targeted chimeric antigen receptor-engineered natural killer cells for castration-resistant prostate cancer and the induction of ferroptosis-related cell death.Cancer Commun (Lond).2022-06最后通讯
9Combined treatment with anti-PSMA CAR NK-92 cell and anti-PD-L1 monoclonal antibody enhances the antitumour efficacy against castration-resistant prostate cancer. Clin Transl Med.2022-07最后通讯
10Targeting the radiation-induced TR4 nuclear receptor-mediated QKI/circZEB1/miR-141-3p/ZEB1 signaling increases prostate cancer radiosensitivity.Cancer Lett.2020-08共同通讯
11Targeting the Radiation-Induced ARv7-Mediated circNHS/miR-512-5p/XRCC5 Signaling With Quercetin Signaling Increases Prostate Cancer Radiosensitivity. Journal of ExperimentalJ Exp Clin Cancer Res. 2022-08最后通讯
12Whole-genome sequencing identifies ADGRG6 enhancer mutations and FRS2 duplications as angiogenesis-related drivers in bladder cancerNat Commun. 2019-02共同第一
13Notch activation defines immune-suppressive subsets of ccRCCs with unfavorable benefits from immunotherapy over VEGFR/mTOR inhibitorsiScience2023-10最后通讯
14Analysis of risk factors for positive surgical margin after laparoscopic radical prostatectomy with and without neoadjuvant hormonal therapyFront Endocrinol (Lausanne).2023-10最后通讯
15siRNA-based approaches for castration-resistant prostate cancer therapy targeting the androgen receptor signaling pathwayFuture Oncol.2023-09最后通讯
16TIGIT immune checkpoint blockade enhances immunity of human peripheral blood NK cells against castration-resistant prostate cancerCancer Lett.2023-08最后通讯
17Single-cell RNA sequencing reveals the cellular and molecular characteristics of high-grade and metastatic bladder cancer.Cell Oncol (Dordr).2023-10最后通讯
18Tumor immune contexture predicts recurrence after prostatectomy and efficacy of androgen deprivation and immunotherapy in prostate cancer.J Transl Med.2023-03最后通讯
19Re: Valentin H. Meissner, Isabel Rauscher, Kristina Schwamborn, et al. Radical Prostatectomy Without Prior Biopsy Following Multiparametric Magnetic Resonance Imaging and Prostate-specific Membrane Antigen Positron Emission Tomography. Eur Urol. In press.Eur Urol. 2022-02最后通讯
20Preoperative red cell distribution width is associated with postoperative lymphovascular invasion in prostate cancer patients treated with radical prostatectomy: A retrospective study.Front Endocrinol (Lausanne).2022-10最后通讯
21Histone methyltransferase Ezh2 negatively regulates NK cell terminal maturation and function.J Leukoc Biol.2021-08共同通讯
22Gene polymorphism-related differences in the outcomes of abiraterone for prostate cancer: a systematic overviewAm J Cancer Res.2021-05共同通讯
23Quercetin reverses docetaxel resistance in prostate cancer via androgen receptor and PI3K/Akt signaling pathways.Int J Biol Sci.2020-02最后通讯
  • 科研获奖Research Awards
# 获奖证书编号 奖项名称 获奖级别 获奖类别 获奖等级 获奖日期 颁奖单位 本单位是否为第一完成单位 完成单位排名 本人排序 备注
120201021B中国中西医结合学会科学技术奖省部级科技进步奖、哲学社科奖一等奖2020-03-01中国中西医结合学会11
2201501067P1202华夏医学科技奖省部级科技进步奖、哲学社科奖一等奖2016-06-01中国医疗保健国际交流促进会22
32019-J06-2-09-R01北京市科技进步奖省部级省(市、自治区)政府自然科学奖、技术发明奖二等奖2019-01-01北京市11
4201602024P1001华夏医学科技奖省部级科技进步奖、哲学社科奖二等奖2016-06-01中国医疗保健国际交流促进会11
52017-261教育部科技进步奖省部级教育部高校科研成果奖(科学技术、人文社科)二等奖2018-01-01教育部11
  • 研究成果Research Findings
# 成果类型 项目/专利/新品种名称
1作为主创人员获得授权的发明专利和新品种一种手术用膀胱冲洗器
2作为主创人员获得授权的发明专利和新品种一种微创腹腔镜手术用翘头剪
3作为主创人员获得授权的发明专利和新品种一种用于膀胱癌尿流改道手术的多腔导尿管
4作为主创人员获得授权的发明专利和新品种复合柱状水囊前列腺扩裂导管
5作为主创人员获得授权的发明专利和新品种一种膀胱尿道吻合引导器
6作为主创人员获得授权的发明专利和新品种内窥镜夹持机械手
7作为主创人员获得授权的发明专利和新品种一种自主导尿装置
8作为主创人员获得授权的发明专利和新品种腹腔镜用腹膜外腔可视球囊扩张器
9出版高水平专著腹腔镜肾上腺、肾脏手术荟萃
10出版高水平专著泌尿外科微创手术图谱
11出版高水平专著泌尿外科内镜诊疗技术
12出版高水平专著泌尿外科3D腹腔镜手术荟萃
13出版高水平专著经自然腔道取标本手术学-腹盆腔肿瘤