导师风采
潘璇
个人信息
Personal Information
- 性别：女
- 导师类型：硕士生导师
- 职称：副研究员
- 该职称任职时间：4
联系方式
Contact Information
- 所属院系：药物研究所
- 所属专业：药物化学、药学
- 邮箱 : panxuan@imm.ac.cn
- 工作电话 : 无
个人简介
Personal Profile
潘璇，1987年1月3日出生。本科毕业于浙江大学药学院，博士毕业于北京协和医学院。2014年进入中国医学科学院药物研究所工作，2019年聘任为副研究员。
团队简介
Team Profile
待补充更新
- 研究方向Research Directions
创新药物的研究与开发,生物活性天然产物全合成及结构改造,有机合成方法学研究
- 在校研究生Current Graduate Students
硕士研究生 3 名，博士研究生 0 名
- 科研项目Research Projects
| # | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
|---|---|---|---|---|---|
| 1 | 天然产物griseofamines及其衍生物的合成以及抗菌活性研究 | 2020-01-01 —— 2022-12-31 | 25.2 | 主持在研的国家或省部级科研项目 | 主持者 |
- 发表论文Papers
| # | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
|---|---|---|---|---|
| 1 | Design, synthesis and cytotoxicity of novel hexacyclic saframycin–ecteinascidin analogs | Organic & Biomolecular Chemistry | 2022-07-18 | 潘璇 |
| 2 | Asymmetric synthesis of highly functionalized tyrosine derivatives for the construction of bistetrahydroisoquinoline alkaloids | Tetrahedron Letters | 2022-07-18 | 潘璇 |
| 3 | Asymmetric total synthesis of three stereoisomers of (-)-renieramycin G and their cytotoxic activities | Tetrahedron | 2022-07-18 | 潘璇 |
| 4 | Effective synthesis and cytotoxicity of novel microtubule-stabilizing agent ceratamine A analogues | Tetrahedron | 2022-07-18 | 潘璇 |
| 5 | Design, synthesis and biological evaluation of a series of novel GPR40 agonists containing nitrogen heterocyclic rings | Bioorganic & Medicinal Chemistry Letters | 2022-07-18 | 潘璇 |
| 6 | An improved total synthesis of griseofamine A | Tetrahedron Letters | 2022-07-18 | 潘璇 |
| 7 | Stereoselective total synthesis of (±)-parthenolide and (±)-7-epiparthenolide | Tetrahedron | 2022-07-18 | 潘璇 |
| 8 | Synthesis and cytotoxicity of a novel series of saframycin-ecteinascidin analogs containing tetrahydro-β-carbboline moieties | European Journal of Medicinal Chemistry | 2022-07-18 | 潘璇 |
| 9 | Synthesis and cytotoxicity of novel imidazo[4,5-d]azepine compounds derived from marine natural product ceratamine A | Bioorganic & Medicinal Chemistry Letters | 2022-07-18 | 潘璇 |
| 10 | Synthesis of 3-aryl-3-benzazepines via aryne [1,2] Stevens rearrangement of 1,2,3,4-tetrahydroisoquinolines | Organic Chemistry Frontiers | 2022-07-18 | 潘璇 |
| 11 | Synthesis and cytotoxicity of (？)-homorenieramycin G and its derivatives | Organic & Biomolecular Chemistry | 2022-07-18 | 潘璇 |
| 12 | A novel specific peroxisome proliferator-activated receptor γ (PPARγ) modulator YR4-42 ameliorates hyperglycaemia and dyslipidaemia and hepatic steatosis in diet-induced obese mice | Diabetes Obesity and Metabolism | 2022-07-18 | 潘璇 |
| 13 | Synthesis and biological evaluation of novel tetrahydroisoquinoline-C-aryl glucosides as SGLT2 inhibitors for the treatment of type 2 diabetes | European Journal of Medicinal Chemistry | 2022-07-18 | 潘璇 |
| 14 | Regioselective bromination of 6-hydroxytetrahydroisoquinolines | Journal of Heterocyclic Chemistry | 2022-07-18 | 潘璇 |
| 15 | The asymmetric total synthesis of (？)-eurothiocin A and its enantiomer | Journal of Natural Products | 2022-07-18 | 潘璇 |
| 16 | A concise synthesis of (E)-3-aryl-2,3,4,5-tetrahydro-1H-3-benzazonines by aryne induced [2,3] Stevens rearrangement of 1,2,3,4-tetrahydroisoquinolines | Organic & Biomolecular Chemistry | 2022-07-18 | 潘璇 |
| 17 | Design, synthesis and biological evaluation of exiguamine A analogues as IDO1 inhibitors | European Journal of Medicinal Chemistry | 2022-07-18 | 潘璇 |
| 18 | Total synthesis and antibacterial activity evaluation of griseofamine A and 16-epi-griseofamine A | Organic Letters | 2022-07-18 | 潘璇 |
| 19 | Asymmetric total synthesis of griseofamine B and its three stereoisomers | Journal of Natural Products | 2022-07-18 | 潘璇 |
| 20 | Synthesis of indolo[2,3-a]pyrrolo[3,4-c]carbazoles via the oxidative cyclization of bisindolylmaleimides with Pd(TFA)2/Cu(OAc)2 | Journal of Heterocyclic Chemistry | 2022-07-18 | 潘璇 |
- 科研获奖Research Awards
无
- 研究成果Research Findings
| # | 成果类型 | 项目/专利/新品种名称 |
|---|---|---|
| 1 | 作为主创人员获得授权的发明专利和新品种 | 一类IDO1抑制剂的制备和用途 |
| 2 | 获得新药研究成果 | 一类含中环四氢咔啉-四氢异喹啉化合物的制备和用途 |