导师风采
张丹
个人信息
Personal Information
- 性别：女
- 导师类型：博士生导师
- 职称：研究员
- 该职称任职时间：8
联系方式
Contact Information
- 所属院系：药物研究所
- 所属专业：药理学
- 邮箱 : danzhang@imm.ac.cn
- 工作电话 : 01063165178
个人简介
Personal Profile
1996.8－2001.7北京大学医学部，就读于药理系，获得理学学士学位 2001.8－2006.7中国协和医科大学，就读于药理系，获得博士学位 2006.8－2010.8美国NIH从事博士后研究工作 2010.8-至今中国医学科学院药物研究所药理系工作
团队简介
Team Profile
待补充更新
- 研究方向Research Directions
神经退行性疾病发病机制研究,神经系统药物研发,神经免疫及神经炎症机制研究
- 在校研究生Current Graduate Students
硕士研究生 0 名，博士研究生 9 名
- 科研项目Research Projects
| # | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
|---|---|---|---|---|---|
| 1 | 天然药物药效物质发现与药效评价新技术研究 | 2022-01-01 —— | 100.0 | 参与者 | |
| 2 | 微生物天然产物的智能创制与改良 | 2019-01-01 —— | 80.0 | 参与在研的国家或省部级科研项目 | 参与者 |
- 发表论文Papers
| # | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
|---|---|---|---|---|
| 1 | Gardenia jasminoides J.Ellis extract GJ-4 alleviated cognitive deficits of APP/PS1 transgenic mice. | Phytomedicine | 2022-07-08 | 张丹 |
| 2 | Phloroglucinol derivative compound 21 attenuates cuprizone-induced multiple sclerosis mice through promoting remyelination and inhibiting neuroinflammation. | Science China-Life Sciences | 2022-07-08 | 张丹 |
| 3 | Inhibition of CXCR2 enhances CNS remyelination via modulating PDE10A/cAMP signaling pathway. | Neurobiol Dis. | 2023-07-05 | 张丹 |
| 4 | Yinma Jiedu Granule attenuates LPS-induced acute lung injury in rats via suppressing inflammation level. | J Ethnopharmacol. | 2023-07-05 | 张丹 |
| 5 | The toxic natural product tutin causes epileptic seizures in mice by activating calcineurin. | Signal Transduct Target Ther | 2023-07-05 | 张丹 |
| 6 | The Protective Effects of Gardenia jasminoides (Fructus Gardenia) on Amyloid-β-Induced Mouse Cognitive Impairment and Neurotoxicity. | Am J Chin Med | 2022-07-08 | 张丹 |
| 7 | Autoimmune polyendocrine syndrome induced by immune checkpoint inhibitors: a systematic review. | Cancer Immunol Immunother | 2022-07-08 | 张丹 |
| 8 | Discovery of coumarinMannich base derivatives as multifunctional agents against monoamine oxidase B and neuroinflammation for the treatment of Parkinson's disease. | European journal of medicinal chemistry | 2022-07-08 | 张丹 |
| 9 | Src Inhibition Attenuates Neuroinflammation and Protects Dopaminergic Neurons in Parkinson's Disease Models. | FRONTIERS IN NEUROSCIENCE | 2022-07-08 | 张丹 |
| 10 | Design, Synthesis, and Biological Evaluation of Phenol Bioisosteric Analogues of 3-Hydroxymorphinan. | Sci Rep | 2022-07-08 | 张丹 |
| 11 | TLR2 Potentiates SR-Marco-Mediated Neuroinflammation by Interacting with the SRCR Domain. | Mol Neurobiol | 2022-07-08 | 张丹 |
| 12 | Nicotinamide Adenine Dinucleotide Phosphate Oxidase and Neurodegenerative Diseases: Mechanisms and Therapy. | ANTIOXIDANTS & REDOX SIGNALING | 2022-07-08 | 张丹 |
| 13 | F ecal microbiota transplantation protects rotenone-induced Parkinson's disease mice via suppressin g inflammation mediated by the lipopolysaccharide-TLR4 signaling pathway through the microbiota-g ut-brain axis | Microbiome | 2022-07-08 | 张丹 |
| 14 | Novel phloroglucinol derivative Compound 21 protects experimental autoimmune encephalomyelitis rats via inhibiting Th1/Th17 cell infiltration. | Brain Behav Immun. | 2022-07-08 | 张丹 |
| 15 | Novel compound FLZ alleviates rotenone-induced PD mouse model by suppre ssing TLR4/MyD88/NF-κB pathway through microbiota-gut-brain axis. | Acta Pharm Sin B | 2022-07-08 | 张丹 |
| 16 | The role of FUNDC1 in mitophagy, mitochondrial dynamics and human diseases | Biochemical Pharmacology | 2022-07-08 | 张丹 |
| 17 | Induction of glial cell line-derived neurotrophic factor by the squamosamide derivative FLZ in astroglia has neuroprotective effects on dopaminergic neurons. | Brain Res Bull | 2022-07-08 | 张丹 |
| 18 | FLZ Attenuates α-Synuclein-Induced Neurotoxicity by Activating Heat Shock Protein 70. | Mol Neurobiol. | 2022-07-08 | 张丹 |
| 19 | CXCR2 antagonism promotes oligodendrocyte precursor cell differentiation and enhances remyelination in a mouse model of multiple sclerosis. | Neurobiol. Dis | 2022-07-08 | 张丹 |
| 20 | Squamosamide Derivative FLZ Diminishes Aberrant Mitochondrial Fission by Inhibiting Dynamin-Related Protein 1. | Front Pharmacol | 2022-07-08 | 张丹 |
| 21 | Integrin CD11b mediates α-synuclein-induced activation of NADPH oxidase through a Rho-dependent pathway | Redox Biology | 2022-07-08 | 张丹 |
| 22 | HACE1 negatively regulates neuroinflammation through ubiquitylating and degrading Rac1 in Parkinson's disease models | Acta Pharmacologica Sinica | 2022-07-08 | 张丹 |
| 23 | Gut microbi ota mediates the absorption of FLZ, a new drug for Parkinson's disease treatment | Acta Pharm Sin B | 2022-07-08 | 张丹 |
| 24 | Inhibitory effects of flavonoids on P-glycoprotein in vitro and in vivo: food/ herb-drug interactions and structure–activity relationships. | Toxicology and Applied Pharmacology. | 2022-07-08 | 张丹 |
| 25 | Gardenia jasminoides J. Ellis extract alleviated white matter damage through promoting the differentiation of oligodendrocyte precursor cells via suppressing neuroinflammation | Food & Function | 2022-07-08 | 张丹 |
| 26 | GJ-4 ameliorates memory impairment in focal cerebral ischemia/reperfusion of rats via inhibiting JAK2/STAT1-mediated neuroinflammation. | Journal of Ethnopharmacology. | 2022-07-08 | 张丹 |
| 27 | NADPH oxidase-derived H(2)O(2) medi ates the regulatory effects of microglia on astrogliosis in experimental models of Parkinson's di sease. | Redox Biology | 2022-07-08 | 张丹 |
| 28 | Heat shock protein 70 suppresses neuroinflammation induced by α-synuclein in rat primary astrocytes. | Mol Cell Neurosci | 2022-07-08 | 张丹 |
| 29 | A Novel Synthetic Derivative of Phloroglucinol Inhibits Neuroinflammatory Responses Through Attenuating Kalirin Signaling Pathway in Murine BV2 Microglial Cells. | Mol Neurobiol. | 2022-07-08 | 张丹 |
| 30 | Phloroglucinol derivative compound 21 attenuates cuprizone-induced multiple sclerosis mice through promoting remyelination and inhibiting neuroinflammation. | Sci China Life Sci. | 2022-07-08 | 张丹 |
| 31 | Induction of glial cell line-derived neurotrophic factor by the squamosamide derivative FLZ in astroglia has neuroprotective effects on dopaminergic neurons. | Brain Res Bull | 2022-07-08 | 张丹 |
| 32 | A novel synthetic derivative of squamosamide FLZ inhibits the high mobility group box 1 protein-mediated neuroinflammatory responses in murine BV2 microglial cells. | Naunyn Schmiedebergs Arch Pharmacol | 2022-07-08 | 张丹 |
| 33 | Inhibition of NADPH oxidase by apocynin prevents learning and memory deficits in a mouse Parkinson's disease model. | Redox Biology | 2022-07-08 | 张丹 |
| 34 | Gardenia jasminoides Extract GJ-4 Alleviates Memory Deficiency of Vascular Dementia in Rats through PERK-Mediated Endoplasmic Reticulum Stress Pathway. | Am J Chin Med. | 2023-07-05 | 张丹 |
- 科研获奖Research Awards
| # | 获奖证书编号 | 奖项名称 | 获奖级别 | 获奖类别 | 获奖等级 | 获奖日期 | 颁奖单位 | 本单位是否为第一完成单位 | 完成单位排名 | 本人排序 | 备注 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2020-J08-01-R10 | 北京市科学技术进步奖 | 省部级 | 科技进步奖、哲学社科奖 | 一等奖 | 2021-09-20 | 北京市人民政府 | 是 | 1 | 10 |
- 研究成果Research Findings
| # | 成果类型 | 项目/专利/新品种名称 |
|---|---|---|
| 1 | 作为主创人员获得授权的发明专利和新品种 | 一种具有氧化活性的酚酸类化合物及其应用 |
| 2 | 作为主创人员获得授权的发明专利和新品种 | 咪唑酮-吗啡喃及其制备方法和应用 |
| 3 | 作为主创人员获得授权的发明专利和新品种 | 间苯三酚类衍生物及其在治疗神经退行性疾病中的用途。 |
| 4 | 作为主创人员获得授权的发明专利和新品种 | 藏红花色素类组合物在制备用于治疗帕金森症的药物中的应用 |