导师风采
张凤奎
个人信息
Personal Information
- 性别：男
- 导师类型：博士生导师
- 职称：主任医师
- 该职称任职时间：20000601
联系方式
Contact Information
- 所属院系：血液病医院（天津）
- 所属专业：
- 邮箱 : fkzhang@ihcams.ac.cn
- 工作电话 : 022-23909409
个人简介
Personal Profile
张凤奎，男，医学博士，血液内科学教授 主任医师。现任中国医学科学院、北京协和医科大学 血液学研究所血液病医院 贫血诊疗中心主任 国家新药临床试验机构主任。毕业后一直从事内科临床工作，经验丰富。目前主要进行造血系统红细胞疾病临床及实验研究，对各种血液病，尤其各种疑难贫血性疾病诊断与治疗经验非常丰富，重型再生障碍性贫血治疗效果达国际先进水平，率先系统报告我国大颗粒淋巴细胞白血病、先天性红细胞生成异常性贫血、再障造血细胞遗传不稳定性、一线应用兔ATG联合CsA及大剂量环磷酰胺治疗再障等。积极开展临床科研，将单个核细胞DNA电泳技术用于先天性骨髓造血衰竭疾病的筛查，获得良好效果，并对骨髓增生异常综合征造血细胞克隆性染色体异常、再障骨髓微血管密度以及晚期克隆性血液学异常发生机制进行了深入研究。主持和参与多项课题研究，发表论文九十余篇。曾多次被评为先进工作者、优秀共产党员、医科院优秀教师和天津市“五一劳动奖章”。
团队简介
Team Profile
待补充更新
- 研究方向Research Directions
骨髓衰竭性疾病的临床和基础研究,红细胞疾病的临床和基础研究,疑难性贫血的临床和基础研究
- 在校研究生Current Graduate Students
硕士研究生 1 名，博士研究生 3 名
- 科研项目Research Projects
| # | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
|---|---|---|---|---|---|
| 1 | 重大血液疾病及其治疗相关造血干细胞损伤修复调控机制研究 | 2022-12 —— 2027-11 | 84万元 | 参与在研的国家或省部级科研项目 | 参与者 |
- 发表论文Papers
| # | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
|---|---|---|---|---|
| 1 | Efficacy and safety of porcine ALG compared to rabbit ATG as first-line treatment for children with acquired aplastic anemia | European Journal of Hematology | 2020-06 | 通讯 |
| 2 | Current Treatment Patterns of Aplastic Anemia in China: A Prospective Cohort Registry Study | Acta Haematologica | 2019-09 | 通讯 |
| 3 | A multicenter phase II study on the efficacy and safety of hetrombopag in patients with severe aplastic anemia refractory to immunosuppressive therapy | Therapeutic Advances in Hematology | 2022-03 | 通讯 |
| 4 | Clinical features and treatment outcomes in patients with T-cell large granular lymphocytic leukemia: A single-institution experience | Leukemia Research | 2020-03 | 通讯 |
| 5 | Allo-HSCT compared with immunosuppressive therapy for acquired aplastic anemia: a system review and meta-analysis | BMC Immunology | 2020-03 | 通讯 |
| 6 | Comparison of Levitt's CO breath test and the 15 N-glycine labeling technique for measuring the lifespan of human red blood cells | Amercian Journal of Hematology | 2021-10 | 通讯 |
| 7 | Time and residual hematopoiesis are crucial for PNH clones escape in hepatitis-associated aplastic anemia | Annals of Hematology | 2021-10 | 通讯 |
| 8 | First-line immunosuppressive therapy with rATG and CsA for severe aplastic anemia: 15 years' experience | Annals of Hematology | 2022-11 | 通讯 |
| 9 | Long-term outcomes of aplastic anemia with cytogenetic abnormalities at diagnosis | European Journal of Hematology | 2023-04 | 通讯 |
| 10 | Efficacy of eltrombopag with immunosuppressive therapy for children with acquired aplastic anemia | Frontiers in Pediatrics | 2023-01 | 通讯 |
| 11 | Pharmacokinetics of single- and multiple-dose flumatinib in patients with chronic phase chronic myeloid leukemia | Frontiers in Oncology | 2023-02 | 通讯 |
| 12 | Genotype-degree of hemolysis correlation in hereditary spherocytosis | BMC Genomics | 2023-06 | 通讯 |
| 13 | A preliminary study of roxadustat in the treatment of aplastic anemia patients with inadequate erythroid responses | Annals of Hematology | 2024-05 | 通讯 |
| 14 | A case report of dyskeratosis congenita caused by a novel TERC mutation | Annals of Hematology | 2023-12 | 通讯 |
| 15 | Efficacy and safety of eltrombopag in Chinese patients with refractory or relapsed severe aplastic anemia | Scientific Reports | 2023-11 | 通讯 |
| 16 | Development and validation of early death risk score model for emergency status prediction in very severe aplastic anemia | Frontiers in Immunology | 2023-04 | 通讯 |
| 17 | Hetrombopag plus porcine ATG and cyclosporine for the treatment of aplastic anaemia: early outcomes of a prospective pilot study | Experimental Hematology & Oncology | 2023-02 | 通讯 |
| 18 | Antihuman T lymphocyte porcine immunoglobulin combined with cyclosporine as first-line immunosuppressive therapy for severe aplastic anemia in China: a large single-center, 10-year retrospective study | Therapeutic advances in hematology | 2023-01 | 通讯 |
| 19 | Iron chelation of hetrombopag in aplastic anemia: a post hoc analysis of a phase II study | Annals of Hematology | 2022-10 | 通讯 |
| 20 | Unrelated donor hematopoietic stem cell transplantation compared to immunosuppressive therapy plus eltrombopag as first-line treatment for adults with severe aplastic anemia | Blood Cancer Journal | 2024-03 | 共同通讯 |
- 科研获奖Research Awards
无
- 研究成果Research Findings
无