导师风采
吴松
个人信息
Personal Information
- 性别：男
- 导师类型：博士生导师
- 职称：研究员
- 该职称任职时间：19970701
联系方式
Contact Information
- 所属院系：药物研究所
- 所属专业：药学
- 邮箱 : ws@imm.ac.cn
- 工作电话 : 83163542
个人简介
Personal Profile
1989年分配至中国医学科学院药物研究所工作至今。1994年破格晋升副研究员，1997年破格晋升研究员。现任药物研究所新药开发研究室主任，兼任国家药典委员会委员、国家药品监督管理局外聘专家、农业部兽药审评委员、《中国新药杂志》、《中国药物化学杂志》、《中国抗生素杂志》编委。作为药学负责人研发的治疗脑卒中创新药物匹诺赛林及其冻干粉针剂已经国家药品监督管理局批准进入II期临床研究；作为项目负责人研发的降血脂创新药物IMM-H007已经完成I期临床研究，治疗非酒精性肝炎创新药物IMM-H014已进入I期临床研究。先后负责完成国家二类新药依西美坦等二十余个重要非专利药物项目的研发并投产上市，累计实现销售收入300多亿元。在国内外核心期刊发表论文140余篇，申请发明专利近40项。先后承担了国家自然科学基金、国家高技术研究发展计划（863计划）、国家“十一五”、“十二五”、“十三五”重大新药创制科技重大专项、美国克林顿基金会艾滋病防治药物研究项目等三十多项基础性和应用性的研究项目。获得第五届中国青年科技奖等多项国家及省部级奖励。
团队简介
Team Profile
待补充更新
- 研究方向Research Directions
药物化学,新药研究与开发
- 在校研究生Current Graduate Students
硕士研究生 0 名，博士研究生 7 名
- 科研项目Research Projects
| # | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
|---|---|---|---|---|---|
| 1 | 基于晶体结构和人工智能小分子药效构象识别的新骨架FXR激动剂的发现及抗NAFLD活性初步评价 | 2020-01-01 —— 2023-12-31 | 66.0 | 参与在研的国家或省部级科研项目 | 参与者 |
| 2 | 新型吡咯酰胺类GyrB/ParE双靶点抑制剂抗耐药菌小分子化合物（化学药）的成药性研究 | 2022-08-01 —— 2025-12-31 | 100.0 | 主持在研的国家或省部级科研项目 | 主持者 |
| 3 | 基于核酸适配体（ APT）靶向 EpCAM 新型盐霉素衍生物脂质体构建及抗结直肠癌研究 | 2023-01-01 —— 2024-12-31 | 20.0 | 参与在研的国家或省部级科研项目 | 参与者 |
| 4 | 化药1类创新药物IMM-H007原料药及片剂技术转让 | 2016-10-01 —— | 5000.0 | 参与者 | |
| 5 | 化药1类创新药物IMM-H014原料药及胶囊 | 2020-07-01 —— | 3000.0 | 主持者 | |
| 6 | 儿童用国家新药盐酸溴己新分散片及颗粒关键技术研究 | 2021-06-01 —— | 20.0 | 参与在研的国家或省部级科研项目 | 参与者 |
| 7 | 治疗脑卒中一类新药匹诺塞林及其冻干粉针剂 | 2010-10-08 —— | 8000.0 | 参与者 | |
| 8 | 基于人工智能的靶向药物发现技术研究 | 2021-10-01 —— 2025-12-31 | 1600.0 | 主持者 | |
| 9 | 靶向革兰氏阴性菌小分子抑制剂作用机制研究 | 2020-01-01 —— 2022-12-31 | 8.0 | 主持在研的国家或省部级科研项目 | 主持者 |
- 发表论文Papers
| # | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
|---|---|---|---|---|
| 1 | Synthesis and anti-tumor activity evaluation of salinomycin C20-O-alkyl/benzyl oxime derivatives | Organic & Biomolecular Chemistry | 2023-07-05 | 吴松 |
| 2 | Design, Synthesis, and Biological Evaluation of a New Series of Biphenyl/Bibenzyl Derivatives Functioning as Dual Inhibitors of Acetylcholinesterase and Butyrylcholinesterase | Molecules | 2022-06-10 | 吴松 |
| 3 | Design, synthesis and antibacterial evaluation of pleuromutilin derivatives | Bioorganic & Medicinal Chemistry | 2023-07-05 | 吴松 |
| 4 | Discovery of N-quinazolinone -4-hydroxy-2-quinolone-3-carboxamides as DNA gyrase B-targeted antibacterial agents | Journal of Enzyme Inhibition and Medicinal Chemistry | 2023-07-05 | 吴松 |
| 5 | Machine learning-and structure-based discovery of a novel chemotype as FXR agonists for potential treatment of nonalcoholic fatty liver disease | European Journal of Medicinal Chemistry | 2023-07-05 | 吴松 |
| 6 | Structural optimization and biological evaluation of 1-adamantylcarbonyl-4-phenylpiperazine derivatives as FXR agonists for NAFLD | European Journal of Medicinal Chemistry | 2023-07-05 | 吴松 |
| 7 | Metallaphotoredox -catalyzed C–H activation: regio-selective annulation of allenes with benzamide | Organic Chemistry Frontiers | 2022-06-10 | 吴松 |
| 8 | synthesis and biological activity of salinomycin-hydroxamic acid conjugates | Bioorganic & Medicinal Chemistry Letters？ | 2022-06-10 | 吴松 |
| 9 | Design, synthesis, and biological evaluation of novel iso-flavones derivatives as H3R antagonists | JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY | 2022-06-10 | 吴松 |
| 10 | Design, synthesis, biological evaluation, and molecular docking of novel flavones as H3R inhibitors | Chemical Biology & Drug Design | 2022-06-10 | 吴松 |
| 11 | Systems metabolic engineering of Escherichia coli to enhance the production of flavonoid glucuronides | RSC advance | 2022-06-10 | 吴松 |
| 12 | Liver-target nanotechnology facilitates berberine to ameliorate cardio-metabolic diseases | Nature Communications | 2022-06-10 | 吴松 |
| 13 | Design, synthesis, and evaluation of novel isoflavone derivatives as multifunctional agents for the treatment of Alzheimer‘s disease | European Journal of Medicinal Chemistry | 2022-06-10 | 吴松 |
| 14 | The discovery of novel HDAC3 inhibitors via virtual screening and in vitro bioassay | Journal of Enzyme Inhibition and Medicinal Chemistry | 2022-06-10 | 吴松 |
| 15 | Design and synthesis of conformationally constrained salinomycin derivatives | European Journal of Medicinal Chemistry | 2022-06-10 | 吴松 |
| 16 | Synthesis and biological activity evaluation of 20- epi-salinomycin and its 20-O-acyl derivatives | RSC advance | 2022-06-10 | 吴松 |
| 17 | Bacterial lipoprotein biosynthetic pathway as a potential target for structure-based design of antibacterial agents | Current Medicinal Chemistry | 2022-06-10 | 吴松 |
| 18 | Evaluation of Novel Dual Acetyl- and Butyrylcholinesterase Inhibitors as Potential Anti-Alzheimer' s Disease Agents Using Pharmacophore, 3D-QSAR and Molecular Docking Approaches | Molecules | 2022-06-10 | 吴松 |
| 19 | A useful synthesis of 2-acylamino- 1,3,4-oxadiazoles from acylthiosemicarbazides using potassium iodate and the discovery of new antibacterial compounds | Molecules | 2022-06-10 | 吴松 |
| 20 | Cobalt (II)-catalyzed benzylic oxidations with potassium persulfate in TFA/TFAA | RSC advance | 2022-06-10 | 吴松 |
| 21 | A novel synthesis of 4-acetoxyl 5(4H)-oxazolones by direct α-oxidation of N-benzoyl amino-acid using hypervalent iodine | Molecules | 2022-06-10 | 吴松 |
| 22 | A novel and efficient strategy involving a CuI catalyzed cascade reaction to synthesize acenaphtho[1,2-b]quinoline derivatives | Chinese Chemical Letters | 2022-06-10 | 吴松 |
| 23 | MUBD-DecoyMaker 2.0: A Python GUI application to generate maximal unbiased benchmarking data sets for virtual drug screening | Molecular Informatics | 2022-06-10 | 吴松 |
| 24 | Virtual Screening against Phosphoglycerate Kinase 1 in Quest of Novel Apoptosis Inhibitors | Molecules | 2022-06-10 | 吴松 |
| 25 | The Synthesis of the Metabolites of 2′,3′,5′-Tri-O-acetyl-N6-(3-hydroxyphenyl) Adenosine (WS070117) | Molecules | 2022-06-10 | 吴松 |
| 26 | The Development of Target-Specific Pose Filter Ensembles To Boost Ligand Enrichment for Structure-Based Virtual Screening | Journal of Chemical Information and Modeling | 2022-06-10 | 吴松 |
| 27 | Discovery of novel isoflavone derivatives as AChE/BuChE dual-targeted inhibitors: synthesis,biological evaluation and molecular modelling | Journal of Enzyme Inhibition and Medicinal Chemistry | 2022-06-10 | 吴松 |
| 28 | A novel protein tyrosine phosphatase 1B inhibitor with therapeutic potential for insulin resistance | British journal of pharmacology | 2022-06-10 | 吴松 |
| 29 | Pose Filter-based Ensemble Learning Enables Discovery of Orally Active, Nonsteroidal Farnesoid X Receptor Agonists | Journal of Chemical Information and Modeling | 2022-06-10 | 吴松 |
| 30 | A Thoroughly Validated Virtual Screening Strategy for Discovery of Novel HDAC3 Inhibitors | International Journal of Molecular Sciences | 2022-06-10 | 吴松 |
| 31 | Quantitative 1H Nuclear Magnetic Resonance Method for Assessing the Purity of Dipotassium Glycyrrhizinate | Molecules | 2022-06-10 | 吴松 |
| 32 | Discovery and structure-activity relationship study of phthalimidephenylpyridine conjugate as inhibitor of Wnt pathway | Bioorganic & Medicinal Chemistry Letters | 2022-06-10 | 吴松 |
| 33 | Structure–activity & structure–toxicity relationship study of salinomycin diastereoisomers and their benzoylated derivatives | Organic & Biomolecular Chemistry | 2022-06-10 | 吴松 |
| 34 | Tumor-selective lipopolyplex encapsulated small active RNA hampers colorectal cancer growth in vitro and in orthotopic murine | Biomaterials | 2022-06-10 | 吴松 |
| 35 | Computational Representations of Protein-ligand Interfaces for Structure-based Virtual Screening | Expert Opinion on Drug Discovery | 2022-06-10 | 吴松 |
| 36 | N-Thiadiazole-4-Hydroxy-2-Quinolone-3-Carboxamides Bearing Heteroaromatic Rings as Novel Antibacterial Agents: Design, Synthesis, Biological Evaluation and Target Identification | European Journal of Medicinal Chemistry | 2022-06-10 | 吴松 |
| 37 | Anti-MRSA Drug Discovery by Ligand-based Virtual Screening and Biological Evaluation | Bioorganic Chemistry | 2022-06-10 | 吴松 |
| 38 | A concise synthesis of (r)-7-O-galloyltricetiflavan | RSC Advances | 2022-06-10 | 吴松 |
| 39 | Discovery of potent PTP1B inhibitors via structure-based drug design, synthesis and in vitro bioassay of Norathyriol derivatives | Bioorganic Chemistry | 2022-06-10 | 吴松 |
| 40 | Novel PORCN inhibitor WHN-88 targets Wnt/β-catenin pathway and prevents the growth of Wnt-driven cancers | European Journal of Pharmacology | 2023-07-05 | 吴松 |
| 41 | Discovery and druggability evaluation of pyrrolamide-type GyrB/ParE inhibitor against drug-resistant bacterial infection | Acta Pharm. Sin. B | 2023-08 | 通讯作者 |
| 42 | Exploration and Biological Evaluation of 1,3-Diamino 7H pyrrol- [3,2 f]quinazoline Derivatives as DihydrofolateReductase Inhibitors | J. Med. Chem. | 2023-05 | 通讯作者 |
| 43 | Deep reinforcement learning enables better bias control in benchmark for virtual screening | Computers in Biology and Medicine | 2024-04 | 通讯作者 |
- 科研获奖Research Awards
| # | 获奖证书编号 | 奖项名称 | 获奖级别 | 获奖类别 | 获奖等级 | 获奖日期 | 颁奖单位 | 本单位是否为第一完成单位 | 完成单位排名 | 本人排序 | 备注 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 008 | 中国药学会科学技术奖 | 省部级 | 其他省部级奖励 | 三等奖 | 2014-07-01 | 中国药学会 | 是 | 1 | 1 | |
| 2 | 01 | 第五届中国青年科技奖获得者 | 国家级 | 其他国家级奖励 | 其他 | 1997-01-30 | 中国科协、人事部、中组部颁发 | 是 | 1 | 1 | |
| 3 | 2014药-1-001-14 | 北京市科学技术奖 | 省部级 | 省（市、自治区）政府自然科学奖、技术发明奖 | 一等奖 | 2014-10-01 | 北京市人民政府 | 是 | 1 | 14 |
- 研究成果Research Findings
| # | 成果类型 | 项目/专利/新品种名称 |
|---|---|---|
| 1 | 作为主创人员获得授权的发明专利和新品种 | 泮托拉唑钠及其起始原料中基因毒性杂质的分析方法 |
| 2 | 作为主创人员获得授权的发明专利和新品种 | 1,3-二氧代异吲哚啉苯甲酰胺类化合物及其用途 |
| 3 | 作为主创人员获得授权的发明专利和新品种 | 调节WNT信号通路的酰胺类化合物及其用途 |
| 4 | 作为主创人员获得授权的发明专利和新品种 | 4-羟基-2-喹诺酮-氮-(4-喹唑啉酮)-3-甲酰胺类衍生物 |
| 5 | 作为主创人员获得授权的发明专利和新品种 | 一类左旋双环吗啉，其制备方法、药物组合物和应用 |
| 6 | 作为主创人员获得授权的发明专利和新品种 | 吡啶酮酰联芳基胺类化合物及其用途 |
| 7 | 作为主创人员获得授权的发明专利和新品种 | 邻苯二甲酰亚胺类化合物及用途 |
| 8 | 作为主创人员获得授权的发明专利和新品种 | 琥珀酰亚胺或马来酰亚胺类化合物及用途 |
| 9 | 作为主创人员获得授权的发明专利和新品种 | 面向药物发现的最大无偏好性基准数据集计算软件 |
| 10 | 作为主创人员获得授权的发明专利和新品种 | 一种用于给药或载药的功能性吸管 |
| 11 | 作为主创人员获得授权的发明专利和新品种 | 5＇-磷酸-N6-(3-羟基苯基）腺苷的制备及医药用途 |
| 12 | 作为主创人员获得授权的发明专利和新品种 | N-邻甲氧羰基苄基四氢小檗碱及其治疗高血压症的用途 |
| 13 | 作为主创人员获得授权的发明专利和新品种 | 用于生物催化黄酮类化合物葡萄糖苷化的基因工程菌 |
| 14 | 作为主创人员获得授权的发明专利和新品种 | 盐霉素肟及肟醚生物以及制备方法和抗肿瘤用途 |
| 15 | 作为主创人员获得授权的发明专利和新品种 | 一种可以载药或给药、加快药物溶出的功能性吸管装置 |
| 16 | 作为主创人员获得授权的发明专利和新品种 | 一种双环醇类衍生物及其制备和应用 |
| 17 | 作为主创人员获得授权的发明专利和新品种 | 一种用于儿童或老人口服给药的功能性给药装置 |
| 18 | 作为主创人员获得授权的发明专利和新品种 | 虫草素衍生物治疗炎症疾病的用途 |
| 19 | 作为主创人员获得授权的发明专利和新品种 | 一个异黄酮衍生物的多靶点作用及其改善学习记忆用途 |
| 20 | 作为主创人员获得授权的发明专利和新品种 | 一种腺苷化合物在制备防治应激障碍药物中的用途 |
| 21 | 作为主创人员获得授权的发明专利和新品种 | C20位差向异构化盐霉素及其酰化衍生物以及制备方法和抗肿瘤用途 |
| 22 | 作为主创人员获得授权的发明专利和新品种 | 用于生物催化黄酮类化合物葡萄糖苷化的基因工程菌 |
| 23 | 出版高水平专著 | 中国仿制药蓝皮书 |
| 24 | 获得新药研究成果 | IMM-H014片获得药物I期临床试验批准（通知书2023LP01078) |
| 25 | 获得新药研究成果 | IMM-H007片获得药物I期临床试验批准（通知书2021LP01958) |