导师风采
孙伟
个人信息
Personal Information
- 性别：男
- 导师类型：硕士生导师
- 职称：副研究员
- 该职称任职时间：2009
联系方式
Contact Information
- 所属院系：基础学院
- 所属专业：药理学
- 邮箱 : sunwei@ibms.pumc.edu.cn
- 工作电话 : 01065196943
个人简介
Personal Profile
2005年博士毕业于中国协和医科大学病理学与病理生理学专业，同年留校工作。2007年获全国优秀博士学位论文奖，同年到美国国家卫生研究院质谱实验室访问学习。2008年被聘为中国医学科学院基础医学研究所副研究员，2010年至中心实验室工作，负责质谱中心工作，现为质谱中心负责人。主要研究方向：质谱检测技术及其临床应用。在国内首先采用液质联用方法分析尿液蛋白质组学，并开发了微波辅助方法快速酶切样品，可以大规模进行临床样品的快速处理。近年主要利用质谱技术进行精准医学研究，通过蛋白质组学和代谢组学分析，与临床医院合作，研究了各种疾病的蛋白质标志物，并建立了国际上最大的体液蛋白质组学数据库。
团队简介
Team Profile
本平台现有工作人员4人，均为多年从事质谱检测分析人员，可以进行蛋白质组、代谢组、脂质组及多组学分析，发表SCI文章20余篇，主持和参与和多项国家级省部级课题。
- 研究方向Research Directions
质谱检测技术及其临床应用
- 在校研究生Current Graduate Students
硕士研究生 5 名，博士研究生 0 名
- 科研项目Research Projects
| # | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
|---|---|---|---|---|---|
| 1 | 应用术前尿液预测心脏手术后急性肾损伤机器学习模型的建立及相关分子在肾损伤过程中的机制研究 | 2022-01-01 —— 2025-12 | 55.0 | 主持在研的国家或省部级科研项目 | 主持者 |
| 2 | 北京市自然科学基金（重点项目） | 2024-10 —— 2027-10 | 100 | 主持在研的国家或省部级科研项目 | 主持 |
- 发表论文Papers
| # | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
|---|---|---|---|---|
| 1 | Alteration of lung tissues proteins in birch pollen induced asthma mice before and after SCIT | PLoS One | 2021-10 | 孙伟 |
| 2 | LC-MS-Based Plasma Metabolomics and Lipidomics Analyses for Differential Diagnosis of Bladder Cancer and Renal Cell Carcinoma | Front Oncol | 2020-08 | 孙伟 |
| 3 | 96DRA-Urine: A high throughput sample preparation method for urinary proteome analysis | J Proteomics | 2022-04 | 孙伟 |
| 4 | Comprehensive proteomics and functional annotation of mouse brown adipose tissue | PLoS One | 2020-05 | 孙伟 |
| 5 | Qualitative and quantitative proteomic and metaproteomic analyses of healthy human urine sediment | Proteomics Clin Appl | 2022-05 | 孙伟 |
| 6 | Analysis of the saliva metabolic signature in patients with primary Sjögren's syndrome | PLoS One | 2022-06-16 | 孙伟 |
| 7 | Diagnostic Potential of Plasma IgA1 O-Glycans in Discriminating IgA Nephropathy From Other Glomerular Diseases and Healthy Participants | Front Mol Biosci | 2022-04 | 孙伟 |
| 8 | Proteomic analysis of pulmonary arterial hypertension | Ther Adv Chronic Dis | 2021-09 | 孙伟 |
| 9 | Urine metabolites for preoperative prediction of acute kidney injury after coronary artery bypass graft surgery | J Thorac Cardiovasc Surg | 2021-04 | 孙伟 |
| 10 | Aqueous humor proteomic analysis of acute angle-closure glaucoma with visual field loss | Ann Transl Med | 2021-11 | 孙伟 |
| 11 | Investigation of Plasma Metabolic and Lipidomic Characteristics of a Chinese Cohort and a Pilot Study of Renal Cell Carcinoma Biomarker | Front Oncol | 2020-08 | 孙伟 |
| 12 | Cytoplasmic RAD23B interacts with CORO1C to synergistically promote colorectal cancer progression and metastasis | Cancer Lett | 2021-05 | 孙伟 |
| 13 | Proteome Characterization of Glaucoma Aqueous Humor | Mol Cell Proteomics | 2021-06 | 孙伟 |
| 14 | A comparative proteomic analysis to define the influencing factors on gingival crevicular fluid using LC-MS/MS | J Proteomics | 2022-02 | 孙伟 |
| 15 | A Global Multiregional Proteomic Map of the Human Cerebral Cortex | Genomics Proteomics Bioinformatics | 2022-08 | 孙伟 |
| 16 | A comparative proteomic analysis to define the influencing factors on gingival crevicular fluid using LC-MS/MS | J Proteomics | 2022-02 | 孙伟 |
| 17 | A qualitative and quantitative analysis of the human gingival crevicular fluid proteome and metaproteome | Proteomics | 2021-08 | 孙伟 |
| 18 | Alleviation of Lipopolysaccharide-Induced Acute Respiratory Distress Syndrome in Rats by Yiqi Huayu Jiedu Decoction: A Tandem Mass Tag-Based Proteomics Study | Front Pharmacol | 2020-08 | 孙伟 |
| 19 | Proteomic Study of Aqueous Humor and Its Application in the Treatment of Neovascular Glaucoma | Front Mol Biosci | 2020-10 | 孙伟 |
| 20 | HOMA-IR as a risk factor of gestational diabetes mellitus and a novel simple surrogate index in early pregnancy | Int J Gynaecol Obstet | 2021-08 | 孙伟 |
| 21 | Proteomic analysis of human frontal and temporal cortex using iTRAQ-based 2D LC-MS/MS | Chin Neurosurg J | 2021-05 | 孙伟 |
| 22 | Noninvasive urinary protein signatures associated with colorectal cancer diagnosis and metastasis | Nat Commun | 2022-05 | 孙伟 |
| 23 | A pilot investigation of a urinary metabolic biomarker discovery in renal cell carcinoma | Int Urol Nephrol | 2022-05 | 孙伟 |
| 24 | Special electromagnetic field-treated water and far-infrared radiation alleviates lipopolysaccharide-induced acute respiratory distress syndrome in rats by regulating haptoglobin | Bioengineered | 2021-12 | 孙伟 |
| 25 | Urinary protein biomarkers for pediatric medulloblastoma | J Proteomics | 2020-05 | 孙伟 |
| 26 | Predictive Ability of Hepatic Steatosis Index for Gestational Diabetes Mellitus and Large for Gestational Age Infant Compared with Other Noninvasive Indices Among Chinese Pregnancies | Diabetes Metab Syndr Obes | 2021-12 | 孙伟 |
| 27 | Differential proteomics analysis of bile between gangrenous cholecystitis and chronic cholecystitis | Med Hypotheses | 2022-05 | 孙伟 |
| 28 | Urinary Proteomics Analysis of Active Vitiligo Patients: Biomarkers for Steroid Treatment Efficacy Prediction and Monitoring | Front Mol Biosci | 2022-02 | 孙伟 |
| 29 | Urinary Metabolomic Study in a Healthy Children Population and Metabolic Biomarker Discovery of Attention-Deficit/Hyperactivity Disorder (ADHD) | Front Psychiatry | 2022-05 | 孙伟 |
| 30 | UPLC-MS based integrated plasma proteomic and metabolomic profiling of TSC-RAML and its relationship with everolimus treatment | Front Mol Biosci | 2023-02 | 孙伟 |
| 31 | Serum metabolites as early detection markers of non-muscle invasive bladder cancer in Chinese patients | Front Oncol | 2023-05 | 孙伟 |
| 32 | Quantitative proteomics identifies and validates urinary biomarkers of rhabdomyosarcoma in children | Clin Proteomics | 2023-05 | 孙伟 |
| 33 | Urinary complement proteins in IgA nephropathy progression from a relative quantitative proteomic analysis | Peer J | 2023-04 | 孙伟 |
| 34 | LC-MS based urine untargeted metabolomic analyses to identify and subdivide urothelial cancer | Front Oncol | 2023-05 | 孙伟 |
| 35 | Metaproteomics Characterizes the Human Gingival Crevicular Fluid Microbiome Function in Periodontitis | J Proteome Res | 2023-06 | 孙伟 |
| 36 | Blood and Urine-Based Liquid Biopsy for early stage cancer investigation: Taken Clear Renal Cell Carcinoma as A Model | Mol Cell Proteomics | 2023-06 | 孙伟 |
| 37 | LC-MS-based serum metabolomics analysis for the screening and monitoring of colorectal cancer | Front Oncol | 2023-06 | 孙伟 |
| 38 | Cerebrospinal fluid metabolite alterations in patients with different etiologies, diagnoses, and prognoses of disorders of consciousness | Brain Behav | 2023-08 | 孙伟 |
| 39 | Proteomic Study of Middle Ear Effusion and Its Clinical Application for Otitis Media with Effusion | Infect Drug Resist | 2023-09 | 孙伟 |
| 40 | Untargeted Metabolomic Analyses of Body Fluids to Differentiate TBI DOC and NTBI DOC | Curr Mol Med. | 2023-10 | 孙伟 |
| 41 | Multi-omics analyses reveal bacteria and catalase associated with keloid disease. | EBioMedicine | 2023-12 | 孙伟 |
| 42 | Urine and serum metabolomic analysis of endometrial cancer diagnosis and classification based on ultra-performance liquid chromatography mass spectrometry | Metabolomics | 2024-01 | 孙伟 |
| 43 | Cerebrospinal Fluid Metabolomic Pattern of Different Pituitary Stalk Lesions | J Clin Endocrinol Metab | 2024-02 | 孙伟 |
| 44 | Characterization of the proteome of stable and unstable carotid atherosclerotic plaques using data-independent acquisition mass spectrometry | J Transl Med | 2024-03 | 孙伟 |
| 45 | Data-Independent Acquisition-Based Quantitative Proteomic Analysis Reveals Potential Salivary Biomarkers of Primary Sjögren's Syndrome | Chin Med Sci J. | 2024-03 | 孙伟 |
| 46 | Serum metabolism alteration behind different etiology, diagnosis, and prognosis of disorders of consciousness | Chin Neurosurg J | 2024-04 | 孙伟 |
- 科研获奖Research Awards
无
- 研究成果Research Findings
| # | 成果类型 | 项目/专利/新品种名称 |
|---|---|---|
| 1 | 作为主创人员获得授权的发明专利和新品种 | 尿液中冠心病的蛋白标志物及其用途 |
| 2 | 作为主创人员获得授权的发明专利和新品种 | 尿液中心肌梗死的蛋白标志物及其在诊断和预后中的用途 |
| 3 | 作为主创人员获得授权的发明专利和新品种 | 胶质母细胞瘤相关的尿液蛋白标志物及其应用 |
| 4 | 作为主创人员获得授权的发明专利和新品种 | 唾液中干燥综合征的蛋白标志物及其 用途 |
| 5 | 作为主创人员获得授权的发明专利和新品种 | 尿液中低级别胶质瘤相关的代谢标志物及其应用 |
| 6 | 作为主创人员获得授权的发明专利和新品种 | 透明肾细胞癌代谢标志物在肾细胞癌早期筛查和诊断产品中的应用 |
| 7 | 作为主创人员获得授权的发明专利和新品种 | 尿液蛋白质在进展期白癜风激素疗效评估中的应用 |
| 8 | 作为主创人员获得授权的发明专利和新品种 | 用于预测进展期白癜风对激素治疗敏感性的生物标志物及其应用 |
| 9 | 作为主创人员获得授权的发明专利和新品种 | 一种用于蛋白质组学分析的样品制备方法 |