导师风采
赵方辉

个人信息

Personal Information

  • 性别:女
  • 导师类型:博士生导师
  • 职称:研究员
  • 该职称任职时间:2014

联系方式

Contact Information

  • 所属院系:肿瘤医院
  • 所属专业:公共卫生
  • 邮箱 : zhaofangh@cicams.ac.cn
  • 工作电话 : 010-87788977

个人简介

Personal Profile

赵方辉,研究员、博士生导师、协和特聘教授,国家癌症中心/中国医学科学院肿瘤医院流行病学研究室主任,肿瘤流行病学教研室主任。毕业于北京协和医学院,获博士学位。先后在美国国立卫生院/国家癌症研究所(NIH/NCI)和世界卫生组织/国际癌症研究署(WHO/IARC)任高级访问科学家。2015 年荣获 WHO/IARC高级科学家奖,2019年被授予南非斯坦陵布什大学(Stellenbosch)杰出教授。现任WHO全球消除宫颈癌行动计划工作组专家; Lancet SIGHT Commission委员;亚洲大洋洲生殖道感染及肿瘤研究大会(AOGIN)副主席;亚太癌症预防组织(APOCP)教育委员会主席;APEC宫颈癌防治组专家;中国抗癌协会(CACA)肿瘤流行病学专业委员会副主任委员;中国癌症基金会全国宫颈癌协作组副组长;国家免疫规划HPV疫苗技术工作组副组长;国家健康科普首批专家成员等国内外学术兼职。 长期致力于肿瘤流行病学和人群防治研究,研究成果在肿瘤防治基础研究、技术研发及人群应用领域处于国内/国际领先地位。先后主持科研项目20余项,包括国家自然基金会项目、国家重点研发计划专项、国家863计划课题、国家公益性行业科研专项、美国中华医学基金会(CMB)公开竞标项目、比尔及梅琳达盖茨基金会国际合作项目、世界卫生组织/国际癌症研究署(WHO/IARC)合作项目、医科院创新工程重点专项等科研项目。发表科学论文180余篇,包括The Lancet, Lancet Oncol, The Lancet Public Health, JNCI 等国际知名杂志,影响因子累计391.295,SCI他引达 894次。参与编写《宫颈癌筛查及临床处理》、《子宫颈癌综合防控指南》、《子宫颈病变的诊治要点》及多部世界卫生组织(WHO)宫颈癌防治指南的编写和制定。学术成绩对宫颈癌病因学、筛查及人群防治具有重要的科学与实用价值,并多次获得国家省部级的科学技术和科学研究成果奖。指导博士生研究生20余名,硕士研究生10名。培养博士研究生有2名连续蝉联2020年度首届和2021年第二届北京协和医学院优秀毕业生最高校长奖;1名学生获中英联合研究创新基金博士生交流项目(牛顿基金)并获北京市级优秀毕业生;4名博士研究生获得国家留学基金委的资助,在英国、法国、比利时等国家开展交流学习;3名博士生获得国家奖学金;3名博士研究生获得中国医学科学院北京协和医学院博士创新基金。此外,作为美国Fogarty和Fulbright项目和芝加哥大学暑期交流项目的导师,近10年来指导了14名博士研究生和17名芝加哥大学本科生在中国的学习。

团队简介

Team Profile

待补充更新

  • 研究方向Research Directions
肿瘤流行病学,人群防治与健康促进,统计分析与模型预测
  • 在校研究生Current Graduate Students

硕士研究生 2 名,博士研究生 11 名

  • 科研项目Research Projects
# 项目名称 起止日期 金额 项目类型 本人角色
1careLYFE 宫颈病变基因甲基化PCR检测试剂盒用于宫颈癌筛查的临床阈值探索研究-L2570-12020-08-27 —— 2022-0628.44万元主持的企业/行业委托重大项目主持者
2中国宁波高级别宫颈上皮内病变和宫颈癌HPV型别分布研究:观察性研究-L2630-12020-11-03 —— 2023-12498.89万元主持的企业/行业委托重大项目主持者
3"适合我国国情的消除宫颈癌综合防控技术与策 略研究子课题——宫颈癌精准筛查技术的研发评价和综合防控策略的探讨-揭榜挂帅"2021-10-07 —— 1200万元主持在研的国家或省部级科研项目主持者
4重组九价人乳头瘤病毒(6/11/16/18/31/33/45/52/58型)疫苗(大肠埃希菌)在中国18-45岁健康男性中的安全性、有效性和免疫原性的多中心、随机双盲、安慰剂对照临床试验-L9008-12021-05-01 —— 1384.03万元主持的企业/行业委托重大项目主持者
5"中国一般人群口腔HPV感染和男性肛门生殖器 HPV感染的流行病学研究(中国 PROGRESS Plus研究)-L9014-1"2021-12-10 —— 2031-121008.34万元主持的企业/行业委托重大项目主持者
6一项3期随机、双盲,以安慰剂作为对照的临床研究,旨在评价九价人乳头瘤病毒(HPV)疫苗(V503)在20至45岁中国男性中的保护效力、免疫原性和安全性-L9013-12021-09-01 —— 1384.26万元主持的企业/行业委托重大项目主持者
7以超声为基础的全国多中心乳腺癌筛查队列研究-I2212019-03-01 —— 2024-020.0主持的企业/行业委托重大项目主持者
8一项III期随机、双盲研究,以4价HPV疫苗(佳达修)作为对照,旨在评价9价HPV疫苗(V503)在20~45岁中国女性中的保护效力、免疫原性和安全性(V503-023)-L9001-12019-05-01 —— 2776.58万元主持的企业/行业委托重大项目主持者
9中国女性人群接种 HPV 四价疫苗的长期效果评估:一项3期、双盲、随机对照V501-041研究的10年和15年随访研究-L2675-12020-11-19 —— 2026-01178.44万元主持的企业/行业委托重大项目主持者
10中国 HPV 疫苗与宫颈癌筛查技术在低资源国家的应用示范2022-12 —— 2025-11190万元主持在研的国家或省部级科研项目主持人
11中国年轻女性接种不同剂次国产双价 HPV6/18 疫苗的特异性抗体亲和力及细胞免疫反应研究2023-01 —— 2026-1252万元主持在研的国家或省部级科研项目主持人
12落实宫颈癌消除的试点研究2021-11 —— 2025-121467.07万元主持的企业/行业委托重大项目主持人
13减少剂次国产二价HPV疫苗在中国女孩和年轻女性中的免疫原性研究2022-01 —— 2025-1260万美元主持的企业/行业委托重大项目主持人
14重大慢病防控关键技术在“一带一路”国家推广及评价研究-宫颈癌危险人群筛查防控成熟适宜技术的推广和评价2018-09 —— 2021-12126万元主持在研的国家或省部级科研项目主持人
15中国 HIV 流行区宫颈癌筛查的HIV/HPV 即时共诊断技术研究2017-01 —— 2021-12166.41万元主持在研的国家或省部级科研项目主持人
16基于人工智能辅助诊断技术用于乳腺癌筛查的效果评估:一项多中心、随机对照研究2023-01 —— 2024-1251.8万元主持的企业/行业委托重大项目主持人
17重组人乳头瘤病毒6/11/16/18/31/33/45/52/58型九价疫苗(大肠埃希菌)Ⅲ期临床试验实验室检测 —— 1504.24万元主持的企业/行业委托重大项目主持人
18中国消除宫颈癌战略规划与防控路径研究2021-12 —— 2022-1225主持在研的国家或省部级科研项目主持人
19宫颈癌综合防控关键信息采集和质量控制标准2022-09 —— 2023-067万元主持在研的国家或省部级科研项目主持人
  • 发表论文Papers
# 论文题目 期刊名称 发表年份 论文署名
1Prevalence and risk factors for anogenital HPV infection and neoplasia among women living with HIV in ChinaSexually Transmitted Infections2021-06赵方辉
2Impact of HPV-16/18 AS04-adjuvanted vaccine on preventing subsequent infection and disease after excision treatment: Post-hoc analysis from a randomized controlled trialBMC Infectious Diseases2022-07-08赵方辉
3不同介质标本中人乳头瘤病毒E6癌蛋白检测效果对比研究病毒学报2022-07-08赵方辉
4hrHPV DNA载量分型和E6蛋白对宫颈癌前病变进展的预测作用中国肿瘤临床2022-07-08赵方辉
5宫颈不同疾病状态年转归概率的荟萃分析中华医学杂志2022-07-08赵方辉
6Prospective comparison of hybrid capture 2 and SPF10-LiPA for carcinogenic human papillomavirus detection and risk prediction of cervical cancer: a population-based cohort study in ChinaJournal of Gynecologic Oncology2022-07-08赵方辉
7Efficacy of the AS04-adjuvanted HPV-16/18 vaccine in young Chinese women with oncogenic HPV infection at baseline: post-hoc analysis of a randomized controlled trialHuman Vaccines & Immunotherapeutics2021-04赵方辉
8HPV治疗性疫苗研究进展中华预防医学杂志2022-07-08赵方辉
9Impact of International Collaborative Training Programs on Medical Students' Research AbilityJOURNAL OF CANCER EDUCATION2022-07-08赵方辉
10HPV载量在阴道镜下随机活检中的作用分析中华预防医学杂志2022-07-08赵方辉
11High-risk human papillomavirus genotype distribution and attribution to cervical cancer and precancerous lesions in a rural Chinese populationJournal of Gynecologic Oncology2022-07-08赵方辉
12预防性人类乳头瘤病毒疫苗开启了宫颈癌的全面防控时代中华预防医学杂志2022-07-08赵方辉
13山西省襄垣县农村妇女和基层医务人员对宫颈癌及其筛查的认知和评价中国妇幼卫生杂志2022-07-08赵方辉
14汉族和蒙古族女性HPV感染率及型别分布的差异分析中华流行病学杂志2022-07-08赵方辉
15全球子宫颈癌前病变及宫颈癌治疗指南制定现状的系统综述中华医学杂志2022-07-08赵方辉
16Training Future Leaders: Experience from China-ASEAN Cancer Control Training ProgramJOURNAL OF CANCER EDUCATION2022-07-08赵方辉
17阴道镜结果正常或低度病变妇女发生宫颈癌前病变的前瞻性风险分层研究中国肿瘤临床2022-07-08赵方辉
18HPV16/18 DNA分型对宫颈细胞学ASC-US女性的风险分层管理作用研究肿瘤学杂志2022-07-08赵方辉
19Temporal trends and projection of cancer attributable to human papillomavirus infection in China,2007-2030Cancer Epidemiology, Biomarkers & Prevention2022-07-08赵方辉
20A nationwide post-marketing survey of knowledge, attitude and practice toward human papillomavirus vaccine in general population: Implications for vaccine roll-out in mainland ChinaVaccine2021-01赵方辉
21Performance of cervical cancer screening and triage strategies among women living with HIV in ChinaCancer Medicine2021-09赵方辉
22高危型HPV DNA单独检测及与薄层液基细胞学联合筛查对宫颈癌及宫颈高度病变的筛查效果比较中华预防医学杂志2022-07-08赵方辉
23全球人乳头瘤病毒疫苗接种指南制定现状的系统综述中华医学杂志2022-07-08赵方辉
24Risk of High-Risk Human Papillomavirus Infection and Cervical Precancerous Lesions With Past or Current Trichomonas Infection: A Pooled Analysis of 25,054 Women in Rural ChinaJournal of Clinical Virology2022-07-08赵方辉
25Risk Prediction of Cervical Cancer and Precancers by Type-specific Human Papillomavirus: Evidence from a Population-based Cohort Study in ChinaCancer Prevention Research2022-07-08赵方辉
26加快中国消除宫颈癌步伐 树立“健康中国”癌症防治典范中华医学杂志2022-07-08赵方辉
27Effect of Sequential Rounds of Cervical Cancer Screening on Management of HPV-positive Women: A 15-year Population-based Cohort Study from ChinaCancer Prevention Research2022-07-08赵方辉
28山西省宫颈癌筛查队列中人乳头瘤病毒基因型别分布10年动态变化规律研究中华流行病学杂志2022-07-08赵方辉
29热凝治疗女性人乳头瘤病毒感染及宫颈上皮内瘤样病变的效果分析中华医学杂志2021-06赵方辉
30Has the human papillomavirus (HPV) immunization programme improved obstetric outcomes in spontaneous delivery? An ecological studyEuropean Journal of Obstetrics & Gynecology and Reproductive Biology2021-07赵方辉
31A nationwide post-marketing survey of knowledge, attitudes and recommendations towards human papillomavirus vaccines among healthcare providers in ChinaPreventive Medicine2021-02赵方辉
32预防性HPV疫苗的应用研究进展中华肿瘤杂志2022-07-08赵方辉
33新时代下的肿瘤预防研究中华预防医学杂志2022-07-08赵方辉
34Efficacy, immunogenicity, and safety of the HPV-16/18 AS04-adjuvanted vaccine in Chinese women aged 18-25 years: event-triggered analysis of a randomized controlled trial.Cancer Medicine2022-07-08赵方辉
35WHO全球消除宫颈癌战略及我国面临的挑战和应对策略中华医学杂志2022-07-08赵方辉
36Cancer burden attributable to human papillomavirus infection by sex, cancer site, age, and geographical area in ChinaCancer Medicine2022-07-08赵方辉
37Global guidelines for breast cancer screening: A systematic reviewThe Breast2022-07-08赵方辉
38A nationwide post-marketing survey of knowledge, attitude and practice toward human papillomavirus vaccine in general population: Implications for vaccine roll-out in mainland ChinaVaccine2022-07-08赵方辉
39Accuracy of triage strategies for human papillomavirus DNA- positive women in low-resource settings: A cross-sectional study in ChinaChinese Journal of Cancer Research 2022-06-08赵方辉
40Risk stratification of HPV 16 DNA methylation combined with E6 oncoprotein in cervical cancer screening: a 10-year prospective cohort studyClinical Epigenetics2022-06-08赵方辉
41Association between Common Vaginal Infections and Cervical Non-HPV16/18 Infection in HPV-Vaccinated WomenJOURNAL OF INFECTIOUS DISEASES2021-02赵方辉
42Role of Epstein-Barr virus and human papillomavirus co-infection in the development of cervical intraepithelial neoplasia in women living with HIVFrontiers in Cellular and Infection Microbiology2021-09赵方辉
43Eight-type human papillomavirus E6/E7 oncoprotein detection as a novel and promising triage strategy for managing HPV-positive womenINTERNATIONAL JOURNAL OF CANCER2022-06-08赵方辉
44Projections up to 2100 and a budget optimisation strategy towards cervical cancer elimination in China: a modelling studyLancet Public Health2022-06-08赵方辉
45Durability of Clinical Performance afforded By Self-Collected HPV Testing: A 15-Year Cohort Study in ChinaGYNECOLOGIC ONCOLOGY2022-06-08赵方辉
46Cervical cancer prevention in China: a key to cancer controlLANCET2022-06-08赵方辉
47Triage Options to Manage High-Risk Human Papillomavirus-Positive Women: A Population-Based Cross-Sectional Study From Rural ChinaINTERNATIONAL JOURNAL OF CANCER 2022-06-08赵方辉
48Comparative Performance Evaluation of Different HPV Tests and Triaging Strategies Using Self-Samples and Feasibility Assessment of Thermal Ablation in 'Colposcopy and Treat' Approach: A Population-Based Study in Rural ChinaINTERNATIONAL JOURNAL OF CANCER 2022-06-08赵方辉
49Human papillomavirus viral load as a useful triage tool for non-16/18 high-risk human papillomavirus positive women: A prospective screening cohort study.GYNECOLOGIC ONCOLOGY2022-06-08赵方辉
50Clinical evaluation of p16 INK4a immunocytology in cervical cancer screening: A population-based cross-sectional study from rural ChinaCancer Cytopathology2021-09赵方辉
51Distribution of high-risk human papillomavirus genotype prevalence and attribution to cervical precancerous lesions in rural North ChinaChinese Journal of Cancer Research2022-06-08赵方辉
52Evaluation of multiple primary and combination screening strategies in postmenopausal women for detection of cervical cancer in ChinaINTERNATIONAL JOURNAL OF CANCER2022-06-08赵方辉
53Development and validation of an artificial intelligence system for grading colposcopic impressions and guiding biopsiesBMC Medicine2022-06-08赵方辉
54Comment on "Will HPV vaccination prevent cervical cancer"BMC MEDICINE2022-06-08赵方辉
55Efficacy of point-of-care thermal ablation among high-risk human papillomavirus positive women in ChinaINTERNATIONAL JOURNAL OF CANCER2022-06-08赵方辉
56Risk Stratification and Long-term Risk Prediction of E6 Oncoprotein in a Prospective Screening Cohort in China.INTERNATIONAL JOURNAL OF CANCER2021-03赵方辉
57Outcomes in Women With Biopsy-Confirmed Cervical Intraepithelial Neoplasia Grade 1 or Normal Cervix and Related Cofactors: A 15-year Population-Based Cohort Study From ChinaGYNECOLOGIC ONCOLOGY2022-06-08赵方辉
58The role of HPV DNA viral load in predicting the long-term risk of cervical cancer: a 15-year prospective cohort study in ChinaJOURNAL OF INFECTIOUS DISEASES2022-06-08赵方辉
59Effectiveness and cost-effectiveness of eliminating cervical cancer through a tailored optimal pathway: a modeling studyBMC Medicine2021-03赵方辉
60Cervical Cancer Screening via Visual Inspection With Acetic Acid and Lugol Iodine for Triage of HPV-Positive Women.JAMA Network Open2024-03通讯作者
61KnowledgeAttitude,and ntakof Human Papillomavirus (HPV) Vaccination among Chinese Female Adults: A NationaCross-Sectional Web-Based Survey Based on a Large E-Commerce PlatformMatern Child Health J2024-04通讯组着
62Characteristics of human papillomavirus prevalence and infection patterns among women aged 25–64 according to age groups and cytology results in Ordos City, ChinaVirol J2024-01通讯作者
63Optimal allocation strategies for HPV vaccination introduction and expansion in China accommodated to different supply and dose schedule scenarios: a modelling studyEClinicalMedicine2023-02通讯作者
64Cost‑effectiveness of the screen‑and‑treat strategies using HPV test linked to thermal ablation for cervical cancer prevention in China: a modeling studyBMC Medicine2023-04通讯作者
65Health and economic impact of delaying large-scale HPV vaccination and screening implementation on cervical cancer in China: a modelling studyLancet Regional Health-Western Pacific2023-04通讯作者
66Estimation of economic burden throughout course of cervical squamous intraepithelial lesion and cervical cancer in China: A nationwide multicenter cross-sectional studyChinese Journal of Cancer Research2023-12通讯作者
67Integration of Handheld Ultrasound or Automated Breast Ultrasound among Women with Negative Mammographic Screening Findings: A Multi-center Population-based Study in ChinaACADEMIC RADIOLOGY2023-09通讯作者
68The impact of low-dose CT on smoking behavior among non-smokers, former-smokers, and smokers: A population-based screening cohort in rural ChinaCancer Medicine2023-02通讯作者
69Implementation of visual inspection with acetic acid and Lugol's iodine for cervical cancer screening in rural ChinaINTERNATIONAL JOURNAL OF GYNECOLOGY & OBSTETRICS2023-02通讯作者
70Trend in Cervical Cancer Incidence and Mortality Rates in China, 2006-2030: A Bayesian Age-Period-Cohort Modeling Study.CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION2023-06通讯作者
71Efficacy, immunogenicity and safety of the AS04-HPV-16/18 vaccine in Chinese women aged 18-25 years: End-of-study results from a phase II/III, randomised, controlled trialCancer Medicine2019-10通讯作者
72The Potential of Adding Mammography to Handheld Ultrasound or Automated Breast Ultrasound to Reduce Unnecessary Biopsies in BI-RADS Ultrasound Category 4a: A Multicenter Hospital-Based Study in ChinaCurrent Oncology2023-03通讯作者
73Distribution of high-risk human papillomavirus genotype prevalence and attribution to cervical precancerous lesions in rural North ChinaChinese Journal of Cancer Research2019-08通讯作者
74阴道镜结果正常或低度病变妇女发生宫颈癌前病变的前瞻性风险分层研究中国肿瘤临床2019-08通讯作者
75Training Future Leaders: Experience from China-ASEAN Cancer Control Training ProgramJOURNAL OF CANCER EDUCATION2019-12通讯作者
76Combined risk factors and risk of upper gastrointestinal cancer mortality in the Linxian general populationInternational Journal of Cancer2022-11通讯作者
77Risk assessment of self-sampling HPV tests based on PCR, signal amplification to guide the appropriate screening intervals: A prospective study in ChinaJournal of the National Cancer Center2022-08通讯作者
78Quantitative evaluation of radon tobacco use and lung cancer association in an occupational cohort with 27 follow up yearsECOTOXICOLOGY AND ENVIRONMENTAL SAFETY2022-03通讯作者
  • 科研获奖Research Awards
# 获奖证书编号 奖项名称 获奖级别 获奖类别 获奖等级 获奖日期 颁奖单位 本单位是否为第一完成单位 完成单位排名 本人排序 备注
1APEC健康女性·健康经济共同体最高奖国际级国际和国外奖励其他2020-10-02亚太经合组织(APEC)11
2中国子宫颈癌病因流行病学及综合防控研究省部级中华医学科技奖三等奖2023-03-24中华医学会11
3北京市优秀研究生指导教师团队省部级北京市优秀研究生指导教师团队其他2022-12-31北京市教育委员会、北京市学位委员会25
4群公学者省部级以下院校级特等奖2023-03-01北京协和医学院群医学及公共卫生学院11
5中国子宫颈癌病因流行病学及综合防控研究省部级中华预防医学会科学技术奖二等奖2024-03-19中华预防医学会11
6研-2021-0011思政教学名师,课程思政示范课程省部级教学成果奖励其他2021-05-04教育部11
  • 研究成果Research Findings
# 成果类型 项目/专利/新品种名称
1出版高水平专著WHO guideline for screening and treatment of cervical pre-cancer lesions for cervical cancer prevention, second edition
2出版高水平专著WHO guideline for screening and treatment of cervical pre-cancer lesions for cervical cancer prevention, second edition: use of mRNA tests for human papillomavirus (?HPV)?
3出版高水平专著WHO guidelines for the use of thermal ablation for cervical pre-cancer lesions
4出版高水平专著Introducing and scaling up testing for human papillomavirus as part of a comprehensive programme for prevention and control of cervical cancer: a step-by-step guide
5出版高水平专著Cervical Cancer Screening, IARC Handbook of Cancer Prevention,VOLUME 18
6出版高水平专著《老年流行病学》,人民卫生出版社,2023 年 12 月,ISBN:9787117349932