导师风采
刘骞
个人信息
Personal Information
- 性别：男
- 导师类型：博士生导师
- 职称：教授
- 该职称任职时间：19980801
联系方式
Contact Information
- 所属院系：肿瘤医院
- 所属专业：
- 邮箱 : fcwpumch@163.com
- 工作电话 : 010-87787110
个人简介
Personal Profile
刘骞，男，医学博士，主任医师，中国医学科学院肿瘤医院结直肠外科副主任，博士研究生导师，主要研究方向为结直肠肿瘤的基础研究与外科治疗。1998年毕业于哈尔滨医科大学临床医学七年制，同年就职于中国医学科学院肿瘤医院，2005年获北京协和医学院博士学位。澳大利亚弗林德斯医学中心访问学者。擅长结直肠肿瘤的外科微创治疗，包括腹腔镜直肠癌TME手术、腹腔镜结肠癌CME手术、超低位直肠癌保留肛门手术、保留盆腔自主神经的直肠癌手术、直肠癌侧方淋巴结清扫术、直肠癌肝转移同期切除术等。主持国家重点研发计划等国家级、省部级课题4项，发表SCI论文60余篇，参编著作11部。兼任中华医学会外科学分会胃肠外科学组委员、中国医师协会结直肠肿瘤专委会腹腔镜专委会副主任委员、中国医师协会结直肠肿瘤医师委员会微创委员会副主任委员/医师委员会常委/青委会副主任委员、中国医师协会肛肠医师分会常委、中国医师协会肛肠医师分会结直肠肿瘤专家委员会副主任委员、中国医师协会整合医师分会肿瘤专委会副主任委员、中国医促会结直肠病分会副主任委员、中国研究型医院学会肿瘤外科分会副主任委员、中国研究型医院学会结直肠 肿瘤分会副主任委员、中国抗癌协会大肠癌专委会委员、中国成人教育协会胃肠委员会副主任委员。兼任《中华胃肠外科杂志》、《中华结直肠疾病电子杂志》、《中国医刊》、《临床肿瘤学》等核心期刊编委。
团队简介
Team Profile
待补充更新
- 研究方向Research Directions
结直肠肿瘤的基础与临床
- 在校研究生Current Graduate Students
硕士研究生 0 名，博士研究生 3 名
- 科研项目Research Projects
| # | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
|---|---|---|---|---|---|
| 1 | 基于影像组学和人工智能的直肠癌侧方淋巴结转移预测系统的构建 | 2022-11 —— 2024-09 | 50万元 | 参与在研的国家或省部级科研项目 | 课题负责人 |
| 2 | 免疫治疗多维预测体系建立及新技术研发 | 2022-11 —— 2025-12 | 250万元 | 参与在研的国家或省部级科研项目 | 课题负责人 |
- 发表论文Papers
| # | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
|---|---|---|---|---|
| 1 | Serial Circulating Tumor DNA in Predicting and Monitoring the Effect of Neoadjuvant Chemoradiotherapy in Patients with Rectal Cancer: A Prospective Multicenter Study | Clinical Cancer Research | 2022-05-31 | 刘骞 |
| 2 | Impact of interval between neoadjuvant chemoradiotherapy and surgery in rectal cancer patients. | World Journal of Gastroenterology | 2022-05-31 | 刘骞 |
| 3 | A Retrospective Study of Risk Factors for Symptomatic Anastomotic Leakage after Laparoscopic Anterior Resection of the Rectal Cancer without a Diverting Stoma. | Gastroenterology Research and Practice | 2022-05-31 | 刘骞 |
| 4 | Low ligation has a lower anastomotic leakage rate after rectal cancer surgery. | World Journal of Gastrointestinal Oncology | 2022-05-31 | 刘骞 |
| 5 | Differential analysis revealing APOC1 to be a diagnostic and prognostic marker for liver metastases of colorectal cancer. | World Journal of Clinical Cases | 2022-05-31 | 刘骞 |
| 6 | Development and Validation of a Nomogram and a Comprehensive Prognostic Analysis of an LncRNA-Associated Competitive Endogenous RNA Network Based on Immune-Related Genes for Locally Advanced Rectal Cancer With Neoadjuvant Therapy | Frontiers in Oncology | 2022-05-31 | 刘骞 |
| 7 | Gastric cancer with repeated metastasis in the colonic lumen: a case report and multi-surgical experience. | Journal of International Medical Research | 2022-05-31 | 刘骞 |
| 8 | Impact factors of lymph node retrieval on survival in locally advanced rectal cancer with neoadjuvant therapy. | World Journal of Clinical Cases | 2022-05-31 | 刘骞 |
| 9 | Evaluation of radical surgical treatment in the management of 58 locally advanced rectal neuroendocrine neoplasms, one multicenter retrospective study | European Journal of Surgical Oncology | 2022-05-31 | 刘骞 |
| 10 | Mesorectal excision with lateral lymph node dissection for mid-low rectal cancer with lateral lymph node metastasis: efficacy and prognostic analysis. | World Journal of Surgical Oncology | 2022-05-31 | 刘骞 |
| 11 | Tumor Macroscopic Morphology Is an Important Prognostic Factor in Predicting Chemotherapeutic Efficacy and Clinical Outcomes of Patients With Colorectal Neuroendocrine Neoplasms, One Multicenter Retrospective Cohort Study. | Frontiers in Endocrinology | 2022-05-31 | 刘骞 |
| 12 | DNAJB8 in small extracellular vesicles promotes Oxaliplatin resistance through TP53/MDR1 pathway in colon cancer | Cell Death & Disease | 2022-05-31 | 刘骞 |
| 13 | Mapping of Lymph Node Metastasis From Esophagogastric Junction Tumors | Annals of Surgery | 2022-05-31 | 刘骞 |
| 14 | Perineural invasion is a prognostic factor in stage II colorectal cancer but not a treatment indicator for traditional chemotherapy: a retrospective cohort study. | Journal of Gastrointestinal Oncology | 2022-05-31 | 刘骞 |
| 15 | Laparoscopic Versus Open Surgery for Rectal Gastrointestinal Stromal Tumor: A Multicenter Propensity Score-Matched Analysis. | Diseases of the Colon & Rectum | 2022-05-31 | 刘骞 |
| 16 | Intraoperative intraperitoneal chemotherapy increases the incidence of anastomotic leakage after anterior resection of rectal tumors. | World Journal of Gastrointestinal Oncology | 2022-05-31 | 刘骞 |
| 17 | Analysis of 72 patients with colorectal high-grade neuroendocrine neoplasms from three Chinese hospitals. | World Journal of Gastroenterology | 2022-05-31 | 刘骞 |
| 18 | Protease activated receptor 2 mediates tryptase-induced cell migration through MYO10 in colorectal cancer | American Journal of Cancer Research | 2022-05-31 | 刘骞 |
| 19 | The effect of neoadjuvant imatinib therapy on outcome and survival in rectal gastrointestinal stromal tumors: A multiinstitutional study. | JOURNAL OF SURGICAL ONCOLOGY | 2022-05-31 | 刘骞 |
| 20 | Nomograms and risk score models for predicting survival in rectal cancer patients with neoadjuvant therapy. | World Journal of Gastroenterology | 2022-05-31 | 刘骞 |
| 21 | Differential Expression Analysis Revealing CLCA1 to Be a Prognostic and Diagnostic Biomarker for Colorectal Cancer. | Frontiers in Oncology | 2022-05-31 | 刘骞 |
| 22 | Integrated analysis of competing endogenous RNA networks revealing five prognostic biomarkers associated with colorectal cancer. | Journal of Cellular Biochemistry | 2022-05-31 | 刘骞 |
| 23 | Phosphorylation of CREB-Specific Coactivator CRTC2 at Ser238 Promotes Proliferation, Migration, and Invasion of Colorectal Cancer Cells. | Technology in cancer research & treatment | 2022-05-31 | 刘骞 |
| 24 | Letter to the editor regarding "Intra-versus extracorporeal anastomosis in laparoscopic right colectomy: a meta-analysis of 3699 patients". | International Journal of Colorectal Disease | 2022-05-31 | 刘骞 |
| 25 | Selective lateral lymph node dissection after neoadjuvant chemoradiotherapy in rectal cancer. | World Journal of Gastroenterology | 2022-05-31 | 刘骞 |
| 26 | Interaction analysis of high-risk pathological features on adjuvant chemotherapy survival benefit in stage II colon cancer patients: a multi-center, retrospective study | BMC Cancer | 2023-09 | 刘骞 |
| 27 | A retrospective analysis of 32 small and well-differentiated rectal neuroendocrine tumors with regional or distant metastasis | Rev Esp Enferm Dig | 2023-06 | 刘骞 |
| 28 | Analysis of the Genetic Characteristics and Metastatic Pathways of G1 and G2 Colorectal Neuroendocrine Neoplasms | J Endocr Soc | 2023-12 | 刘骞 |
| 29 | Carbon Nanotubes Enhance the Chemotherapy Sensitivity of Tumors with Multidrug Resistance | Letters in Drug Design & Discovery | 2019-03 | 刘骞 |
| 30 | Can Elderly Patients with Peritoneal Metastasis Induced by Appendiceal or Colorectal Tumours Benefit from Cytoreductive Surgery (CRS) and Hyperthermic Intraperitoneal Chemotherapy (HIPEC)? | Clin Interv Aging | 2021-03 | 刘骞 |
| 31 | Establishing and validating predictive nomograms for lateral pelvic lymph node metastasis in patients with rectal cancer based on radiologic factors and clinicopathologic characteristics | Eur J Surg Oncol | 2023-04 | |
| 32 | Colorectal Cancer Patient-Derived 2D and 3D Models Efficiently Recapitulate Inter- and Intratumoral Heterogeneity | Adv Sci | 2022-08 | |
| 33 | Comparative short-term and survival outcomes of three specimen extraction techniques in laparoscopic low rectal cancer surgery: does it affect ileostomy closure? | BMC Surg | 2023-05 | 刘骞 |
| 34 | Comment on ‘‘Mapping of Lymph Node Metastasis From Esophagogastric Junction Tumors’’ | Ann Surg | 2021-12 | |
| 35 | Development of novel prediction models for nodal and distant metastasis in G1 and G2 colorectal neuroendocrine tumors | Int J Colorectal Dis | 2023-02 | 刘骞 |
| 36 | Effective dissecting range and prognostic significance of lateral pelvic lymph node dissection for middle-low rectal cancer patients with lateral pelvic lymph node metastasis: Results of a large multicenter lateral node collaborative group in China | Front Oncol | 2022-08 | 刘骞 |
| 37 | Distant Metastasis is the Dominant Cause of Treatment Failure after Lateral Lymph Node Dissection in Patients with Lateral Lymph Node Metastasis: Results of the Large Multicenter Lateral Node Study in China | J Cancer | 2023-10 | 刘骞 |
| 38 | Distinct molecular profiles drive multifaceted characteristics of colorectal cancer metastatic seeds | J Exp Med | 2024-05 | 刘骞 |
| 39 | Efficacy of cell-free DNA methylation-based blood test for colorectal cancer screening in high-risk population:a prospective cohort study | Mol Cancer | 2023-09 | 刘骞 |
| 40 | Effectiveness of a Transanal Drainage Tube for the Prevention of Anastomotic Leakage after Laparoscopic Low Anterior Resection for Rectal Cancer | Asian Pac J Cancer Prev | 2020-05 | 刘骞 |
| 41 | Fascia- vs vessel-oriented lateral lymph node dissection for rectal cancer: Short-term outcomes and prognosis in a single-center experience | World J Gastrointest Surg | 2023-01 | 刘骞 |
| 42 | Evaluating short-term and survival outcomes of natural orifice specimen extraction surgery for colorectal cancer: A single-centre retrospective study | Front Surg | 2023-02 | 刘骞 |
| 43 | Epidemiological trends and novel prognostic evaluation approaches of patients with stage II-IV colorectal neuroendocrine neoplasms: A population-based study with external validation | Front Endocrinol (Lausanne) | 2023-02 | 刘骞 |
| 44 | Evaluating the predictive factors for anastomotic leakage after total laparoscopic resection with transrectal natural orifice specimen extraction for colorectal cancer | Asia Pac J Clin Oncol | 2020-12 | 刘骞 |
| 45 | High-grade postoperative complications affect survival outcomes of patients with colorectal Cancer peritoneal metastases treated with Cytoreductive surgery and Hyperthermic Intraperitoneal chemotherapy | BMC Cancer | 2021-01 | 刘骞 |
| 46 | Feasibility, Indications, and Prognostic Significance of Selective Lateral Pelvic Lymph Node Dissection After Preoperative Chemoradiotherapy in Middle/ Low Rectal Cancer: Results of a Multicenter Lateral Node Study in China | Dis Colon Rectum | 2024-02 | 刘骞 |
| 47 | Feasibility and safety of lateral pelvic lymph node dissection for elderly patients with middle‑low rectal cancer: results of a large multicenter lateral node collaborative group study in China | Tech Coloproctol | 2023-08 | 刘骞 |
| 48 | HAMP as a Prognostic Biomarker for Colorectal Cancer Based on Tumor Microenvironment Analysis | Front Oncol | 2022-08 | 刘骞 |
| 49 | Mesorectal excision with lateral lymph node dissection for mid-low rectal cancer with lateral lymph node metastasis: efcacy and prognostic analysis | World J Surg Oncol | 2023-03 | 刘骞 |
| 50 | Melanosis coli combinded with colon cancer causality or coincidence? | Frontiers in Surgery | 2022-08 | 刘骞 |
| 51 | Interaction analysis of high-risk pathological features on adjuvant chemotherapy survival benefit in stage II colon cancer patients: a multi-center, retrospective study | BMC Cancer | 2023-09 | 刘骞 |
| 52 | Management of internal iliac and obturator lymph nodes in mid-low rectal cancer | World J Surg Oncol | 2024-01 | 刘骞 |
| 53 | Mesorectal Excision with or without Lateral Lymph Node Dissection for Elderly Patients with Mid-Low Rectal Cancer: Safety and Feasibility Analysis | Jpn J Clin Oncol | 2023-01 | 刘骞 |
| 54 | Optimization of therapeutic strategies for selective lateral lymph node dissection after neoadjuvant chemoradiotherapy in patients with rectal cancer with clinical suspected lateral lymph node metastasis | Front Oncol | 2023-10 | 刘骞 |
| 55 | MRI-based Radiomics Model for Preoperative Prediction of Lateral Pelvic Lymph Node Metastasis in Locally Advanced Rectal Cancer | Acad Radiol | 2023-08 | 刘骞 |
| 56 | Neoadjuvant Chemoradiotherapy Prior to Lateral Lymph Node Dissection in Rectal Cancer with Suspected Lateral Lymph Node Metastasis: a Multicenter Lateral Node Study in China | J Gastrointest Surg | 2023-01 | 刘骞 |
| 57 | Primary Tumor Resection for Rectal Cancer With Unresectable Liver Metastases: A Chance to Cut Is a Chance for Improved Survival | Front Oncol . | 2021-03 | 刘骞 |
| 58 | Optimization of treatment strategies based on preoperative imaging features and local recurrence areas for locally advanced lower rectal cancer after lateral pelvic lymph node dissection | Front Oncol | 2023-02 | 刘骞 |
| 59 | Risk factors and prognostic significance of postoperative complications following lateral pelvic lymph node dissection for rectal cancer: results of the multicenter lateral node study in China | Jpn J Clin Oncol | 2022-10 | 刘骞 |
| 60 | Reduced serum high-density lipoprotein cholesterol levels and aberrantly expressed cholesterol metabolism genes in colorectal cancer | World J Clin Cases | 2022-05 | 刘骞 |
| 61 | Short- and long-term outcomes of laparoscopic versus open selective lateral pelvic lymph node dissection for locally advanced middle-low rectal cancer: Results of a multicentre lateral node study in China | Colorectal Dis | 2022-11 | 刘骞 |
| 62 | Tumor Differentiation is the Dominant Prognostic Factor for Patients with Colorectal Neuroendocrine Neoplasms with Distant Metastasis | Int J Endocrinol | 2022-12 | 刘骞 |
| 63 | The safety and prognosis of radical surgery in colorectal cancer patients over 80 years old | BMC Sur | 2023-02 | 刘骞 |
| 64 | Survival outcomes in unresectable metastatic rectal cancer patients after both primary site resection and chemoradiotherapy a SEER-based observational study | Transl Cancer Res | 2022-01 | 刘骞 |
| 65 | Three-Dimensional (3D) Laparoscopy Versus Two-Dimensional (2D) Laparoscopy: A Single-Surgeon Prospective Randomized Comparative Study | Asian Pac J Cancer Prev | 2020-10 | 刘骞 |
| 66 | 腹腔镜结直肠癌手术中肠系膜下动脉及其主要属支处理 | 中国实用外科杂志 | 2023-10 | 刘骞 |
| 67 | 低位直肠癌经括约肌间切除术中国专家共识（2023） | 中华胃肠外科杂志 | 2023-06 | 刘骞 |
| 68 | 降结肠、乙状结肠癌及直肠癌第253组淋巴结转移影响因素及预后分析的多中心研究 | 中华外科杂志 | 2024-05 | 刘骞 |
| 69 | 回肠造口旁腹壁伤口裂开一例并文献复习 | 中华结直肠疾病电子杂志 | 2024-04 | 刘骞 |
| 70 | 基于SEER数据库的早发性局部进展期直肠腺癌生存分析 | 中华胃肠外科杂志 | 2023-01 | 刘骞 |
| 71 | 美国结直肠外科医师协会《慢性放射性直肠炎临床实践指南》第1版解读 | 中国实用外科杂志 | 2020-07 | 刘骞 |
| 72 | 筋膜导向在低位直肠癌侧方淋巴结清扫中的应用价值 | 中华胃肠外科杂志 | 2020-04 | 刘骞 |
| 73 | 细胞减灭术联合腹腔热灌注化疗治疗结直肠和阑尾癌腹膜转移的疗效分析 | 中华普通外科杂志 | 2023-09 | 刘骞 |
| 74 | 下段直肠淋巴引流途径和低位直肠癌侧方淋巴结清扫的必要性 | 中国实用外科杂志 | 2019-08 | 刘骞 |
| 75 | 新辅助放疗与预防性造口对中低位直肠癌根治术后吻合口漏发生率的影响 | 中华胃肠外科杂志 | 2021-06 | 刘骞 |
| 76 | 吲哚胺-2，3-双加氧酶-1 在肿瘤免疫及治疗中的研究现状 | 肿瘤研究与临床 | 2023-09 | 刘骞 |
| 77 | 早发性结直肠癌的临床病理特征 | 中华消化外科杂志 | 2024-05 | 刘骞 |
| 78 | 直肠癌侧方淋巴结清扫的研究进展与相关争议 | 中国肿瘤临床 | 2023-01 | 刘骞 |
| 79 | 直肠和乙状结肠癌区域淋巴结清扫的规范化开展 | 中华胃肠外科杂志 | 2023-09 | 刘骞 |
| 80 | 腹腔镜直肠癌侧方淋巴结清扫术中意外的预防及处理 | 中国实用外科杂志 | 2023-01 | 刘骞 |
| 81 | 筋膜导向与血管导向解剖入路行直肠癌侧方淋巴结清扫的疗效对比分析 | 中华胃肠外科杂志 | 2023-09 | 刘骞 |
- 科研获奖Research Awards
无
- 研究成果Research Findings
| # | 成果类型 | 项目/专利/新品种名称 |
|---|---|---|
| 1 | 出版高水平专著 | 上消化道肿瘤 |
| 2 | 出版高水平专著 | 结直肠外科名家手术精粹 |
| 3 | 出版高水平专著 | 经自然腔道取标本手术学·结直肠肿瘤 |
| 4 | 出版高水平专著 | 胃肠外科手术系膜解剖原理：基础和临床应用 |
| 5 | 出版高水平专著 | 腹腔镜胃肠手术笔记（第二版） |
| 6 | 出版高水平专著 | 外科学（第2版） |
| 7 | 出版高水平专著 | 结直肠癌 |
| 8 | 出版高水平专著 | 腹部外科肿瘤治疗病例讨论精选 |
| 9 | 出版高水平专著 | ]中华医学百科全书·临床医学肿瘤学 |
| 10 | 出版高水平专著 | 腹腔镜右半结肠切除术：技术与理念 |
| 11 | 出版高水平专著 | 胰腺癌 |
| 12 | 出版高水平专著 | 结直肠肿瘤学 |
| 13 | 出版高水平专著 | 肿瘤学 |