导师风采
赵久良
个人信息
Personal Information
- 性别：男
- 导师类型：博导
- 职称：主任医师
- 该职称任职时间：2009
联系方式
Contact Information
- 所属院系：北京协和医院
- 所属专业：
- 邮箱 : zjlpumc@163.com
- 工作电话 : 18612672699
个人简介
Personal Profile
博士，北京协和医院风湿免疫科教授、博士生导师、科副主任。主要从事系统性红斑狼疮、抗磷脂综合征、结缔组织病相关肺动脉高压等风湿免疫病的基础与临床研究。先后参与国家“十一·五”、“十二·五”、“十三·五”科技支撑计划风湿免疫病相关课题，目前承担“十四·五”国家重点研发计划常见多发病防治研究专项课题（2021YFC2501305，系统性红斑狼疮相关肺动脉高压诊治策略研究）、国家自然科学基金面上项目（82271855，肿瘤坏死因子受体相关因子5(TRAF5)对系统性红斑狼疮相关肺动脉高压肺血管重塑的作用及分子机制研）。参与发表SCI文章185余篇，其中第一作者及通讯作者SCI 61篇，先后获得日本风湿病学会国际青年奖、东亚风湿病学会青年奖、国际狼疮大会旅行奖、中华医学会风湿病学会优秀论文奖、《中华医学杂志》“金笔奖”、中国医师报2020年“十大青年研究者奖”、2021年“十大医学菁英奖”、第二届协和杰出青年奖，连续四年获得北京协和医院“优秀助理”称号。目前任中华医学会风湿病学分会青委副主委、亚太风湿病学会联盟（APLAR）青委副主席、中国医师协会风湿免疫科医师分会青委副会长、中国研究型医院学会风湿免疫专业委员会常委兼秘书长，北京医学会风湿病学分会委员兼秘书，海峡两岸医药卫生交流协会风湿免疫病学专业委员会常委兼抗磷脂综合征学组执行副主任委员，北京医学会专家鉴定库成员，《Frontiers in Medicine》Associate Editor for Rheumatology、《Rheumatology and Therapy》、《Frontiers in Immunology》、《Rheumatology and Immunology Research》、《Placenta and Reproductive Medicine》、《数字医学与健康》编委、《中华医学会杂志》通讯编委、《协和医学杂志》、《中华临床免疫和变态反应杂志》青年编委。教学方面：主编《协和内科住院医师手册（第2版）》、《风湿图鉴》，参与国家卫生健康委员会“十三五”住院医师规范化培训规划教材《内科学·风湿免疫科分册(第2版)》、研究生教材《风湿免疫内科学》第3版、全国高级卫生专业技术资格考试习题集《风湿免疫学习题集》等多本教材编委，担任人卫出版社《内科学（第9版）》、9年制《内科学（第4版）》风湿免疫篇编写秘书；参与北京协和医学院研究生课程《血栓与出血性疾病》、《舒缓医学》教学工作。
团队简介
Team Profile
博士，北京协和医院风湿免疫科教授、博士生导师、科副主任。主要从事系统性红斑狼疮、抗磷脂综合征、结缔组织病相关肺动脉高压等风湿免疫病的基础与临床研究。先后参与国家“十一·五”、“十二·五”、“十三·五”科技支撑计划风湿免疫病相关课题，目前承担“十四·五”国家重点研发计划常见多发病防治研究专项课题（2021YFC2501305，系统性红斑狼疮相关肺动脉高压诊治策略研究）、国家自然科学基金面上项目（82271855，肿瘤坏死因子受体相关因子5(TRAF5)对系统性红斑狼疮相关肺动脉高压肺血管重塑的作用及分子机制研）。参与发表SCI文章185余篇，其中第一作者及通讯作者SCI 61篇，先后获得日本风湿病学会国际青年奖、东亚风湿病学会青年奖、国际狼疮大会旅行奖、中华医学会风湿病学会优秀论文奖、《中华医学杂志》“金笔奖”、中国医师报2020年“十大青年研究者奖”、2021年“十大医学菁英奖”、第二届协和杰出青年奖，连续四年获得北京协和医院“优秀助理”称号。目前任中华医学会风湿病学分会青委副主委、亚太风湿病学会联盟（APLAR）青委副主席、中国医师协会风湿免疫科医师分会青委副会长、中国研究型医院学会风湿免疫专业委员会常委兼秘书长，北京医学会风湿病学分会委员兼秘书，海峡两岸医药卫生交流协会风湿免疫病学专业委员会常委兼抗磷脂综合征学组执行副主任委员，北京医学会专家鉴定库成员，《Frontiers in Medicine》Associate Editor for Rheumatology、《Rheumatology and Therapy》、《Frontiers in Immunology》、《Rheumatology and Immunology Research》、《Placenta and Reproductive Medicine》、《数字医学与健康》编委、《中华医学会杂志》通讯编委、《协和医学杂志》、《中华临床免疫和变态反应杂志》青年编委。教学方面：主编《协和内科住院医师手册（第2版）》、《风湿图鉴》，参与国家卫生健康委员会“十三五”住院医师规范化培训规划教材《内科学·风湿免疫科分册(第2版)》、研究生教材《风湿免疫内科学》第3版、全国高级卫生专业技术资格考试习题集《风湿免疫学习题集》等多本教材编委，担任人卫出版社《内科学（第9版）》、9年制《内科学（第4版）》风湿免疫篇编写秘书；参与北京协和医学院研究生课程《血栓与出血性疾病》、《舒缓医学》教学工作。
- 研究方向Research Directions
系统性红斑狼疮/APS的基础转化研究
- 在校研究生Current Graduate Students
硕士研究生 2 名，博士研究生 0 名
- 科研项目Research Projects
| # | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
|---|---|---|---|---|---|
| 1 | 系统性红斑狼疮相关肺动脉高压诊治策略研究 | 2021-12-01 —— 2025-11-30 | 400.0 | 主持在研的国家或省部级科研项目 | 主持者 |
| 2 | 基于基因组学优化系统性红斑狼疮患者3年狼疮肾炎发病风险预测模型 | 2023-12-01 —— 2025-11-30 | 主持的企业/行业委托重大项目 | 主持人 | |
| 3 | 中国产科抗磷脂综合征患者单核苷酸多肽性（SNP）研究 | 2017-06-01 —— 2020-06-01 | 主持的企业/行业委托重大项目 | 主持人 | |
| 4 | 中国抗磷脂综合征临床队列及预后研究 | 2022-07-01 —— 2024-12-01 | 主持的企业/行业委托重大项目 | 主持人 | |
| 5 | 系统性红斑狼疮相关肺动脉高压患者达标治疗后靶向药物减停策略研究——一项单中心开放标签探索性研究 | 2019-11-01 —— 2021-10-01 | 主持的企业/行业委托重大项目 | 主持人 | |
| 6 | 系统性红斑狼疮相关肺动脉高压诊治策略研究 | 2021-12-01 —— 2024-11-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 7 | 肿瘤坏死因子受体相关因子5（TRAF5）对系统性红斑狼疮相关肺动脉高压肺血管重塑的作用及分子机制研究 | 2023-01-01 —— 2026-12-31 | 主持在研的国家或省部级科研项目 | 主持人 |
- 发表论文Papers
| # | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
|---|---|---|---|---|
| 1 | Implementation of the treat-to-target approach and treatment satisfaction in patients with rheumatoid arthritis: perspectives of Chinese rheumatologists | Clin Rheumatol | 2022-06-20 | 赵久良 |
| 2 | The treatment strategy of connective tissue disease associated pulmonary arterial hypertension: Evolving into the future | Pharmacol Ther | 2022-06-20 | 赵久良 |
| 3 | Thrombocytopenia in primary antiphospholipid syndrome: Association with prognosis and clinical implications | Rheumatology (Oxford) | 2022-06-20 | 赵久良 |
| 4 | The role of anti-ribosomal P autoantibodies in the prediction of neuropsychiatric damage in systemic lupus erythematosus based on CSTAR cohort (XIV) | Clin Rheumatol | 2022-06-20 | 赵久良 |
| 5 | Impact of pregnancy in patients with systemic lupus erythematosus-associated pulmonary arterial hypertension: case series and literature review | Lupus Sci Med | 2022-06-20 | 赵久良 |
| 6 | Characteristics and risk factors of pulmonary embolism in patients with systemic lupus erythematosus: a case control study | Clinical and experimental rheumatology | 2020-09-01 | 通讯作者 |
| 7 | Immunoglobulin A isotype of antiphospholipid antibodies does not provide added value for the diagnosis of antiphospholipid syndrome in a Chinese population | Front. Immunol. | 2020-10-01 | 通讯作者 |
| 8 | Platelet distribution width is highly associated with thrombotic events in primary antiphospholipid syndrome | CLINICAL RHEUMATOLOGY | 2021-07-02 | 通讯作者 |
| 9 | Clinical characteristics and prognosis of patients with isolated thrombotic vs. obstetric antiphospholipid syndrome: a prospective cohort study | ARTHRITIS RESEARCH & THERAPY | 2021-03-01 | 通讯作者 |
| 10 | Early Initiation of Anticoagulation Improves the Long-Term Prognosis in Patients With Antiphospholipid Syndrome Associated Portal Vein Thrombosis | frontiers in medicine | 2021-02-04 | 通讯作者 |
| 11 | Risk Osteonecrosis of systemic lupus erythematosus: an 11-year chinese single center cohort study | LUPUS | 2021-05-05 | 通讯作者 |
| 12 | the role of anti-ribosomal P autoantibodies in the prediction of neuropsychiatric damage in systemic lupus erythematosus based on CSTAR cohort (XIV) | CLINICAL RHEUMATOLOGY | 2022-02-10 | 通讯作者 |
| 13 | Comparison of Different Test Systems for the Detection of Antiphospholipid Antibodies in a Chinese Cohort | Frontiers in Immunology | 2021-07-02 | 通讯作者 |
| 14 | Evaluation of the Diagnostic Value of Non-criteria Antibodies for Antiphospholipid Syndrome Patients in a Chinese Cohort | Frontiers in Immunology | 2021-09-01 | 通讯作者 |
| 15 | Characteristics and risk factors of retinal vasculopathy in antiphospholipid syndrome | LUPUS | 2022-04-11 | 通讯作者 |
| 16 | Implementation of the treat-to-target approach and treatment satisfaction in patients with rheumatoid arthritis: perspectives of Chinese rheumatologists | CLINICAL RHEUMATOLOGY | 2022-03-30 | 通讯作者 |
| 17 | Clinical characteristics and prognoses of patients with systemic lups erythematosus hospitalized for pulmonary infections | frontiers in Medicine | 2021-09-29 | 通讯作者 |
| 18 | Sex Differences in Clinical Characteristics and Prognosis in Primary Thrombotic Antiphospholipid Syndrome | Frontiers in Cardiovascular Medicine | 2022-07-04 | 通讯作者 |
| 19 | Immune Thrombocytopenia Could be an Independent Clinical Phenotype of Antiphospholipid Syndrome: A Prospective Cohort Study | Rheumatology and Therapy | 2023-01-30 | 通讯作者 |
| 20 | Prevalence and diagnostic value of non-criteria antiphospholipid antibodies for antiphospholipid syndrome in Chinese patients | Frontiers in Immunology | 2023-04-12 | 通讯作者 |
| 21 | Mortality and prognostic factors in connective tissue disease-associated pulmonary arterial hypertension patients complicated with right heart failure | International Journal of Rheumatic Diseases | 2023-05-15 | 通讯作者 |
| 22 | Dorsolateral Medullary infartion during skin infection by Stenotrophomonas maltophilia in a patient with triple antiphospholipid antibody positivity:a case-based review | Clinical Rheumatology | 2021-07-01 | 通讯作者 |
| 23 | Effectiveness of iguratimod as monotherapy or combined therapy in patients with rheumatoid arthritis: a systematic review and meta-analysis of RCTs | Journal of Orthopaedic Surgery and Research | 2021-07-16 | 通讯作者 |
| 24 | Impact of pregnancy in patients with systemic lupus erythematosus-associated pulmonary arterial hypertension: case series and literature review | Lupus Science & Medicine | 2022-03-07 | 通讯作者 |
| 25 | Anti-β2GPI-domain I antibody is associated with extra-criteria manifestations in a large prospective antiphospholipid syndrome cohort in China | Lupus Science & Medicine | 2023-08-01 | 通讯作者 |
| 26 | Effect of smoking on thrombotic antiphospholipid syndrome: a 10-year prospective cohort study | RHEUMATOLOGY | 2023-09-20 | 通讯作者 |
| 27 | Serum Calprotectin as a Potential Predictor of Microvascular Manifestations in Patients with Antiphospholipid Syndrome | Rheumatology and Therapy | 2023-10-11 | 通讯作者 |
| 28 | Chronic abdominal aortic occlusive disease related to antiphospholipid syndrome: a rare presentation | RMD open | 2024-01-04 | 通讯作者 |
| 29 | The additional role of anti-nucleosome antibodies in the prediction of renal damage in systemic lupus erythematosus based on CSTAR (XXV) | LUPUS | 2024-06-09 | 通讯作者 |
| 30 | Validation of three prediction models for thrombosis recurrence in antiphospholipid syndrome patients based on a prospective cohort. | RMD open | 2023-07-01 | 通讯作者 |
| 31 | Exploring the impact of acute viral exposure on clinical characteristics and antibody profiles in antiphospholipid syndrome: a study in CAPSTONE | CLINICAL AND EXPERIMENTAL MEDICINE | 2024-06-18 | 通讯作者 |
| 32 | Higher Dietary Inflammatory Index and Increased Mortality Rate of Adults With Hyperuricemia: Findings From the National Health and Nutritional Examination Survey (2001–2018) | ARTHRITIS CARE & RESEARCH | 2024-03-26 | 通讯作者 |
| 33 | Antiphospholipid antibodies as potential predictors of disease severity and poor prognosis in systemic lupus erythematosus-associated thrombocytopenia: results from a real-world CSTAR cohort study | ARTHRITIS RESEARCH & THERAPY | 2024-03-12 | 通讯作者 |
| 34 | Changes in serum immunoglobulin G glycosylation patterns for antiphospholipid syndrome patients with lectin microarray | SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 2024-06-01 | 通讯作者 |
| 35 | Performance validation of the 2023 American College of Rheumatology/European League Against Rheumatism antiphospholipid syndrome classification criteria in an antiphospholipid syndrome cohort | JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2024-05-09 | 通讯作者 |
| 36 | Tacrolimus shows adequate efficacy in patients with antiphospholipid antibodies associated thrombocytopenia: a retrospective cohort study | CLINICAL AND EXPERIMENTAL MEDICINE | 2023-12-01 | 通讯作者 |
| 37 | Efficacy and safety of Janus kinase inhibitors in systemic and cutaneous lupus erythematosus: A systematic review and meta-analysis | AUTOIMMUNITY REVIEWS | 2023-10-31 | 通讯作者 |
| 38 | Hepatic Infarction Caused by Antiphospholipid Syndrome Secondary to Systemic Lupus Erythematosus | JOURNAL OF RHEUMATOLOGY | 2019-07-01 | 通讯作者 |
| 39 | Successful treatment of refractory thrombotic thrombocytopenic purpura associated with systemic lupus erythematosus with combination of plasma exchange and low-dose rituximab | lupus | 2020-12-01 | 通讯作者 |
| 40 | Janus kinase inhibitor tofacitinib is a potential therapeutic option for refractory eosinophilic fasciitis | CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | 2020-05-01 | 通讯作者 |
| 41 | Clinical characteristics and risk factors of microvascular involvement in primary antiphospholipid syndrome: a longitudinal single-center study in China | LUPUS | 2019-11-01 | 第一作者 |
| 42 | Predictive value of non-invasive right ventricle to pulmonary circulation coupling in systemic lupus erythematosus patients with pulmonary arterial hypertension | European Heart Journal-Cardiovascular Imaging | 2019-12-23 | 第一作者 |
| 43 | Red blood cell distribution width as a potential predictor of survival of pulmonary arterial hypertension associated with primary Sjogren's syndrome: a retrospective cohort study | CLINICAL RHEUMATOLOGY | 2019-02-01 | 第一作者 |
| 44 | Cysteine-rich protein 61 as a novel biomarker in systemic lupus erythematosus-associated pulmonary arterial hypertension | CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | 2019-04-01 | 第一作者 |
| 45 | Interventricular systolic asynchrony predicts prognosis in patients with systemic sclerosis-associated pulmonary arterial hypertension | RHEUMATOLOGY | 2021-05-01 | 第一作者 |
| 46 | Predictive Value of Pulmonary Arterial Compliance in Systemic Lupus Erythematosus Patients With Pulmonary Arterial Hypertension | HYPERTENSION | 2020-10-01 | 第一作者 |
| 47 | Right Ventricle to Pulmonary Artery Coupling Predicts the Risk Stratification in Patients With Systemic Sclerosis-Associated Pulmonary Arterial Hypertension | Frontiers in Cardiovascular Medicine | 2022-05-11 | 第一作者 |
| 48 | Thrombocytopenia in primary antiphospholipid syndrome: Association with prognosis and clinical implications | RHEUMATOLOGY | 2022-05-10 | 第一作者 |
| 49 | The LPS induced pyroptosis exacerbates BMPR2 signaling deficiency to potentiate SLE-PAH | FASEB Journal | 2021-10-01 | 第一作者 |
| 50 | Clinical characteristics and prognosis of patients with antiphospholipid antibodies based on cluster analysis: an 8-year cohort study | ARTHRITIS RESEARCH & THERAPY | 2022-05-04 | 第一作者 |
| 51 | Characteristics and risk factors of severe coronary artery disease in systemic lupus erythematosus: A multicenter, Chinese Rheumatism Date Center database study | International Journal of Rheumatic Diseases | 2022-10-01 | 第一作者 |
| 52 | Rheumatoid meningitis: a rare neurological complication of rheumatoid arthritis. | Frontiers in Immunology | 2023-06-07 | 第一作者 |
| 53 | The treatment strategy of connective tissue disease associated pulmonary arterial hypertension: Evolving into the future. | Pharmacology & therapeutics | 2022-11-01 | 第一作者 |
| 54 | Profile and clinical relevance of non-criteria antiphospholipid antibodies in patients diagnosed with or highly suspected of APS | RHEUMATOLOGY | 2024-03-01 | 第一作者 |
| 55 | Development and external validation of a prediction model for venous thromboembolism in systemic lupus erythematosus | RMD open | 2023-12-01 | 第一作者 |
- 科研获奖Research Awards
无
- 研究成果Research Findings
| # | 成果类型 | 项目/专利/新品种名称 |
|---|---|---|
| 1 | 出版高水平专著 | 临床医学综合能力考试（西医） |
| 2 | 出版高水平专著 | 北京协和医院 风湿免疫科疑难病诊断——协和医生临床思维例释 |
| 3 | 出版高水平专著 | 风湿免疫内科学 |
| 4 | 出版高水平专著 | 中国类风湿关节炎发展报告 2020 |
| 5 | 出版高水平专著 | 中国系统性红斑狼疮发展报告 2020 |
| 6 | 出版高水平专著 | 系统性红斑狼疮 患者教育手册 |
| 7 | 出版高水平专著 | 类风湿关节炎 患者教育手册 |
| 8 | 出版高水平专著 | 内科学风湿免疫科分册 |
| 9 | 出版高水平专著 | 风湿图鉴 |
| 10 | 出版高水平专著 | 《内科学》第二版 |