导师风采
张玉石
个人信息
Personal Information
- 性别：男
- 导师类型：博导
- 职称：主任医师
- 该职称任职时间：9
联系方式
Contact Information
- 所属院系：北京协和医院
- 所属专业：
- 邮箱 : zhangyushi@126.com
- 工作电话 : 010-69152518
个人简介
Personal Profile
张玉石，北京协和医院泌尿外科主任医师，教授，博士研究生导师，泌尿外科主任。中华医学会泌尿外科学分会机器人学组委员，中国抗癫痫协会结节性硬化专业委员会委员，中国医师协会泌尿外科分会微创与机器人学组委员，中国医师协会泌尿外科分会肾上腺高血压协作组副组长，中国抗癌协会泌尿生殖肿瘤整合康复专业委员会常委，中国老年医学学会泌尿外科分会常委，中国医学救援协会急性疼痛医学分会副会长，北京慢性病防治与健康教育研究会老年泌尿系统疾病筛查与防治专业委员会副主任委员，北京医学会泌尿外科专业委员会委员，北京医师协会男科医师分会副会长，北京整合医学会泌尿外科学分会副会长。《中国临床案例成果数据库》学委会委员,《中华泌尿外科杂志》《现代泌尿外科杂志》《中华内分泌外科杂志》《中华诊断学电子杂志》《泌尿外科杂志（电子版）》《协和医学杂志》《临床军医杂志》《中国继续医学教育杂志》编委。
团队简介
Team Profile
目前研究团队10人，博士后6人，博士生4人。主要研究领域为肾上腺肿瘤的基础与临床，结节性硬化症相关肾血管平滑肌脂肪瘤的发病机理，肾癌的靶向与免疫治疗。
- 研究方向Research Directions
肾上腺肿瘤的基础与临床研究
- 在校研究生Current Graduate Students
硕士研究生 0 名，博士研究生 4 名
- 科研项目Research Projects
| # | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
|---|---|---|---|---|---|
| 1 | miRNA-9对结节性硬化症生物行为的调控作用及机制研究 | 2016-11-01 —— 2018-11-30 | 主持的企业/行业委托重大项目 | 主持人 | |
| 2 | 基于临床大数据的肾上腺外科疾病诊治标准化体系的建立 | 2022-10-01 —— 2025-09-01 | 主持的企业/行业委托重大项目 | 主持人 | |
| 3 | ATF2-miRNA9在结节性硬化症发生发展中的作用及机制研究 | 2017-01-30 —— 2020-12-30 | 主持在研的国家或省部级科研项目 | 主持人 |
- 发表论文Papers
| # | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
|---|---|---|---|---|
| 1 | CT characteristics predict the response to everolimus or sirolimus of renal angiomyolipomas in patients with tuberous sclerosis complex. | International Urology and Nephrology | 2019-04-01 | 通讯作者 |
| 2 | A pilot investigation of a urinary metabolic biomarker discovery in renal cell carcinoma | INTERNATIONAL UROLOGY AND NEPHROLOGY | 2020-03-01 | 通讯作者 |
| 3 | Investigation of Plasma Metabolic and Lipidomic Characteristics of a Chinese Cohort and a Pilot Study of Renal Cell Carcinoma Biomarker | FRONTIERS IN ONCOLOGY | 2020-08-01 | 通讯作者 |
| 4 | LC-MS-Based Plasma Metabolomics and Lipidomics Analyses for Differential Diagnosis of Bladder Cancer and Renal Cell Carcinoma | FRONTIERS IN ONCOLOGY | 2020-05-01 | 通讯作者 |
| 5 | High Preoperative Plasma Fibrinogen Independently Predicts a Poor Prognosis in Patients with Nonmetastatic RCC | JOURNAL OF CANCER | 2020-02-01 | 通讯作者 |
| 6 | PTEN inhibitor VO-OHpic suppresses TSC2(-)(/)(-) MEFs proliferation by excessively inhibiting autophagy via the PTEN/PRAS40 pathway | EXPERIMENTAL AND THERAPEUTIC MEDICINE | 2020-06-01 | 通讯作者 |
| 7 | UPLC-MS based urine untargeted metabolomic analyses to differentiate bladder cancer from renal cell carcinoma | BMC CANCER | 2019-12-01 | 通讯作者 |
| 8 | Urine Metabolomics for Renal Cell Carcinoma (RCC) Prediction: Tryptophan Metabolism as an Important Pathway in RCC | FRONTIERS IN ONCOLOGY | 2019-07-01 | 通讯作者 |
| 9 | The small size and superficial location suggest that laparoscopic partial nephrectomy is the first choice for the treatment of juxtaglomerular cell tumors | FRONT ENDOCRINOL (LAUSANNE) | 2021-04-30 | 通讯作者 |
| 10 | High-throughput screening of circRNAs reveals novel mechanisms of tuberous sclerosis complex-related renal angiomyolipoma. | Human Genomics | 2021-07-09 | 通讯作者 |
| 11 | Integrative Analysis Identified MCT4 as an Independent Prognostic Factor for Bladder Cancer. | Frontiers in Oncology | 2021-08-26 | 通讯作者 |
| 12 | Analysis of serum lipid parameters predicting lipid metabolic disorders in TSC-AML patients with treatment of mTOR inhibitors | JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS | 2022-03-01 | 通讯作者 |
| 13 | Analysis of clinical features and next-generation sequencing of 12 tuberous sclerosis in China. | FRONT MED | 2022-05-27 | 通讯作者 |
| 14 | Analysis of renal lesions in Chinese tuberous sclerosis complex patients with different types of TSC gene mutations | GENETICS AND MOLECULAR BIOLOGY | 2022-05-27 | 通讯作者 |
| 15 | A Multi-Centric Study Assessing Safety and Efficacy of Everolimus in Adult Chinese Patients With Tuberous Sclerosis Complex Associated Renal Angiomyolipomas | Frontiers in Oncology | 2022-07-04 | 通讯作者 |
| 16 | Construction and validation of an m6A RNA methylation regulator prognostic model for early-stage clear cell renal cell carcinoma | Oncology Letters | 2022-08-01 | 通讯作者 |
| 17 | A multi?omics study of diagnostic markers and the unique inflammatory tumor micro?environment involved in tuberous sclerosis complex?related renal angiomyolipoma | INTERNATIONAL JOURNAL OF ONCOLOGY | 2022-11-01 | 通讯作者 |
| 18 | Functional nodules in primary aldosteronism: identification of CXCR4 expression with 68Ga-pentixafor PET/CT | EUROPEAN RADIOLOGY | 2022-09-07 | 通讯作者 |
| 19 | UPLC-MS based integrated plasma proteomic and metabolomic profiling of TSC-RAML and its relationship with everolimus treatment | Frontiers in Molecular Biosciences | 2023-02-20 | 通讯作者 |
| 20 | Construction of TSC2 knockout cell line using CRISPR/Cas9 system and demonstration of its effects on NIH-3T3 cells | CELL BIOCHEMISTRY AND BIOPHYSICS | 2022-10-01 | 通讯作者 |
| 21 | Preclinical and pilot clinical evaluation of a small molecule carbonic anhydrase IX targeting PET tracer in clear cell renal cell carcinoma | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2023-05-12 | 通讯作者 |
| 22 | Blood- and Urine-Based Liquid Biopsy for Early-Stage Cancer Investigation: Taken Clear Renal Cell Carcinoma as a Model | MOLECULAR & CELLULAR PROTEOMICS | 2023-06-20 | 通讯作者 |
| 23 | Surgical strategies of complicated pheochromocytomas/ paragangliomas and literature review | Frontiers in Endocrinology | 2023-04-21 | 通讯作者 |
| 24 | Diagnostic efficacy of [ 68Ga]Ga‑NY104 PET/CT to identify clear cell renal cell carcinoma | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2024-06-25 | 通讯作者 |
| 25 | Radiofrequency ablation plays double role in immunosuppression and activation of PBMCs in recurrent hepatocellular carcinoma | Frontiers in Immunology | 2024-01-11 | 通讯作者 |
| 26 | The predictive value of PFKFB3 in bladder cancer prognosis | Heliyon | 2024-05-15 | 通讯作者 |
| 27 | Juxtaglomerular cell tumor-case series of fourteen patients | 中国临床案例成果数据库 | 2021-08-01 | 通讯作者 |
| 28 | Solitary vaginal paraganglioma with mature sacrococcygeal teratoma:a rare case report | BMC endocrine disorders | 2021-07-07 | 通讯作者 |
| 29 | Re: Masayuki Hagiwara, Atsushi Fushimi, Kazuhiro Matsumoto, Mototsugu Oya. The Significance of PARP1 as a Biomarker for Predicting the Response to PD-L1 Blockade in Patients with PBRM1-mutated Clear Cell Renal Cell Carcinoma. Eur Urol. 2022;81:145–8. | EUR UROL | 2022-03-01 | 通讯作者 |
| 30 | Re: Oscar Reig Torras, Akhilesh Mishra, Alana Christie, et al. Molecular Genetic Determinants of Shorter Time on Active Surveillance in a Prospective Phase 2 Clinical Trial in Metastatic Renal Cell Carcinoma. Eur Urol. In press. https://doi.org/10.1016/j.eururo.2021.12.003. | EUR UROL | 2022-05-03 | 通讯作者 |
| 31 | The association between computed tomography attenuation value of renal angiomyolipoma associated with tuberous sclerosis complex and response to everolimus | WORLD JOURNAL OF UROLOGY | 2024-01-06 | 通讯作者 |
| 32 | Imaging CXCR4 Expression in Patients With Suspected Primary Hyperaldosteronism. | EUR J NUCL MED MOL IMAGING | 2020-10-01 | 第一作者 |
| 33 | Everolimus versus sirolimus for angiomyolipoma associated with tuberous sclerosis complex: a multi-institutional retrosepctive study in China | Orphanet J Rare Dis | 2021-07-01 | 第一作者 |
- 科研获奖Research Awards
| # | 获奖证书编号 | 奖项名称 | 获奖级别 | 获奖类别 | 获奖等级 | 获奖日期 | 颁奖单位 | 本单位是否为第一完成单位 | 完成单位排名 | 本人排序 | 备注 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 201203007P0802 | 肾上腺外科疾病基础与临床研究 | 省部级 | 华夏医学科技奖 | 三等奖 | 2012-12-30 | 中国医学科学院 北京协和医学院 北京协和医院泌尿外科 | 是 | 1 | 2 | |
| 2 | 201003031P0805 | 肾上腺外科疾病诊治标准体系建立 | 省部级 | 中华医学科技奖 | 三等奖 | 2011-12-16 | 中国医学科学院 北京协和医学院 北京协和医院泌尿外科 | 是 | 1 | 5 |
- 研究成果Research Findings
| # | 成果类型 | 项目/专利/新品种名称 |
|---|---|---|
| 1 | 出版高水平专著 | 原位新膀胱关键技术 |
| 2 | 出版高水平专著 | 内分泌外科学 |
| 3 | 出版高水平专著 | 肾上腺手术图谱 |
| 4 | 出版高水平专著 | 坎贝尔-沃尔什泌尿外科学(第2分册) 泌尿肿瘤与感染外科学 |
| 5 | 出版高水平专著 | 结节性硬化相关肾脏病变 |
| 6 | 出版高水平专著 | 遗传性肾癌-基础与临床 |
| 7 | 出版高水平专著 | 嗜铬细胞瘤/副神经节瘤外科诊疗策略 |
| 8 | 出版高水平专著 | 中华医学百科全书泌尿外科学 |
| 9 | 出版高水平专著 | 协和泌尿外科腹腔镜手术例释 |
| 10 | 出版高水平专著 | 协和肾上腺外科学 |
| 11 | 出版高水平专著 | 副神经节瘤/嗜铬细胞瘤病例3D影像解析 |
| 12 | 出版高水平专著 | Surgical Management of Pheochromocytoma and Retro peritoneal Paraganglioma |
| 13 | 作为主创人员获得授权的发明专利和新品种 | 一种包皮手术用的工具环 |