导师风采
霍力
个人信息
Personal Information
- 性别：女
- 导师类型：博导
- 职称：主任医师
- 该职称任职时间：10
联系方式
Contact Information
- 所属院系：北京协和医院
- 所属专业：
- 邮箱 : huoli@pumch.cn
- 工作电话 : 010-69154712
个人简介
Personal Profile
博士，主任医师，教授，博士研究生导师，北京协和医院核医学科主任 国家核医学质控中心主任，北京医师协会核医学分会主委，中国医学影像技术学会核医学分会副主委，北京医学会核医学分会副主任委员委员 《中华核医学与分子影像学杂志》、《中国医学影像杂志》和《国际国际放射医学与核医学杂志》编委，参与10余本专业书籍编写工作 从事临床核医学工作30年，长期在临床一线工作，经验丰富，北京协和医院多个MDT协作组成员，北京协和医学院临床核医学本科教学及临床核医学住院医师规范化培训基地教师 曾赴美国（2012年6-12月）和欧洲（2017年7-11月）访学
团队简介
Team Profile
团队主要研究方向为新型分子探针临床转化与核医学图像处理，与JOHNS HOPKINS医院核医学科、美国NIH研究院、芬兰国家PET中心、维也纳总医院建立合作，并与清华大学医学院和北京大学化学院建立临床核医学与基础研究合作平台
- 研究方向Research Directions
新型分子探针临床转化与核医学图像处理
- 在校研究生Current Graduate Students
硕士研究生 0 名，博士研究生 5 名
- 科研项目Research Projects
| # | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
|---|---|---|---|---|---|
| 1 | 核医学医工结合精准诊疗新技术研发应用 | 2018-12-01 —— 2020-12-01 | 主持的企业/行业委托重大项目 | 主持人 | |
| 2 | 核医学医工结合精准诊疗平台建设 | 2018-01-01 —— 2020-12-31 | 主持的企业/行业委托重大项目 | 主持人 | |
| 3 | 利用11C-Acetate和18F-FDG PET/CT 联合显像评估多发性骨髓瘤治疗疗效及预后 | 2015-06-01 —— 2018-08-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 4 | 连续移动扫描PET成像技术的临床转化研究 | 2016-01-01 —— 2018-12-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 5 | 肝细胞癌乙酸盐PET动态显像的动力学分析及临床应用研究 | 2016-01-01 —— 2019-12-15 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 6 | 靶向胰腺导管腺癌ECM新型放射性免疫诊疗一体化抗体药制备及应用研究 | 2021-01-01 —— 2024-12-31 | 主持在研的国家或省部级科研项目 | 主持人 |
- 发表论文Papers
| # | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
|---|---|---|---|---|
| 1 | Myocardial tissue and metabolism characterization in men with alcohol consumption by cardiovascular magnetic resonance and 11C-acetate PET/CT. | JOURNAL OF CARDIOVASCULAR MAGNETIC RESONANCE | 2020-04-16 | 通讯作者 |
| 2 | Head-to-head comparison of (68)Ga-DOTA-JR11 and (68)Ga-DOTATATE PET/CT in patients with metastatic, well-differentiated neuroendocrine tumors: a prospective study. | JOURNAL OF NUCLEAR MEDICINE | 2020-06-03 | 通讯作者 |
| 3 | Preoperative localisation of adenomas in primary hyperparathyroidism: the value of (11)C-choline PET/CT in patients with negative or discordant ultrasonography and (99m)Tc-Sesta-MIBI-SPECT/CT. | JOURNAL OF NUCLEAR MEDICINE | 2020-04-03 | 通讯作者 |
| 4 | Evidence of Accumulated Endothelial Progenitor Cells in the Lungs of Rats with Pulmonary Arterial Hypertension by 89Zr-oxine PET Imaging | MOLECULAR THERAPY-METHODS & CLINICAL DEVELOPMENT | 2020-06-01 | 通讯作者 |
| 5 | PET imaging facilitates antibody screening for synergistic radioimmunotherapy with a177Lu-labeled αPD-L1 antibody | Theranostics | 2021-01-01 | 通讯作者 |
| 6 | Comparison of different kinetic models for dynamic F-18-FDG PET/CT imaging of hepatocellular carcinoma with various, also dual-blood input function | PHYSICS IN MEDICINE AND BIOLOGY | 2020-02-01 | 通讯作者 |
| 7 | Imaging CXCR4 Expression in Patients With Suspected Primary Hyperaldosteronism. | EUR J NUCL MED MOL IMAGING | 2020-10-01 | 通讯作者 |
| 8 | A prospective randomized, double-blind study to evaluate the diagnostic efficacy of (68)Ga-NODAGA-LM3 and (68)Ga-DOTA-LM3 in patients with well-differentiated neuroendocrine tumors: compared with (68)Ga-DOTATATE. | EUR J NUCL MED MOL IMAGING | 2022-05-12 | 通讯作者 |
| 9 | Characterization of myocardial oxidative metabolism and myocardial external efficiency in high-risk alcohol cardiotoxicity and alcoholic cardiomyopathy via dynamic 11C-Acetate positron emission tomography | JOURNAL OF NUCLEAR CARDIOLOGY | 2022-01-12 | 通讯作者 |
| 10 | Biodistribution and radiation dosimetry of D-isomer of 4-borono-2-[18F]fluoro-phenylalanine: A comparative PET/CT study with L-isomer in healthy human volunteers | NUCLEAR MEDICINE AND BIOLOGY | 2021-01-05 | 通讯作者 |
| 11 | Comparison of PET imaging of activated fibroblasts and 18F-FDG for diagnosis of primary hepatic tumours: a prospective pilot study | EUR J NUCL MED MOL IMAGING | 2021-05-06 | 通讯作者 |
| 12 | Fibroblast imaging of hepatic carcinoma with 68Ga-FAPI-04 PET/CT: a pilot study in patients with suspected hepatic nodules | EUR J NUCL MED MOL IMAGING | 2021-01-06 | 通讯作者 |
| 13 | Functional characterization of adrenocortical masses in nononcological patients using [ 68 Ga]-pentixafor | JOURNAL OF NUCLEAR MEDICINE | 2021-07-22 | 通讯作者 |
| 14 | The Performance Comparison of F-18-FDG PET/MRI and F-18-FDG PET/CT for the Identification of Pancreatic Neoplasms | MOLECULAR IMAGING AND BIOLOGY | 2022-06-01 | 通讯作者 |
| 15 | Fatty acid-conjugated radiopharmaceuticals for fibroblast activation protein-targeted radiotherapy | EUR J NUCL MED MOL IMAGING | 2022-06-06 | 通讯作者 |
| 16 | Feasibility of In Vivo Imaging of Fibroblast Activation Protein in Human Arterial Walls | JOURNAL OF NUCLEAR MEDICINE | 2022-06-06 | 通讯作者 |
| 17 | Development and comparison of three (89)Zr-labeled anti-CLDN18.2 antibodies to noninvasively evaluate CLDN18.2 expression in gastric cancer: a preclinical study. | EUR J NUCL MED MOL IMAGING | 2022-07-06 | 通讯作者 |
| 18 | Functional nodules in primary aldosteronism: identification of CXCR4 expression with 68Ga-pentixafor PET/CT | EUROPEAN RADIOLOGY | 2022-09-07 | 通讯作者 |
| 19 | Dynamic PET/CT scan of 68Ga?FAPI?04 for the optimal acquisition time in suspected malignant hepatic cancer patients | Abdominal Radiology | 2023-03-01 | 通讯作者 |
| 20 | Feasibility of 68Ga-Labeled Fibroblast Activation Protein Inhibitor PET/CT in Light-Chain Cardiac Amyloidosis | JACC-Cardiovascular Imaging | 2022-11-01 | 通讯作者 |
| 21 | Usefulness of 68Ga-Pentixafor PET/CT on Diagnosis and Management of Cushing Syndrome. | CLINICAL NUCLEAR MEDICINE | 2022-08-01 | 通讯作者 |
| 22 | Prognostic value of preoperative [68 Ga]Ga-FAPI-04 PET/CT in patients with resectable pancreatic ductal adenocarcinoma in correlation with immunohistological characteristics | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2023-01-25 | 通讯作者 |
| 23 | Preclinical and pilot clinical evaluation of a small molecule carbonic anhydrase IX targeting PET tracer in clear cell renal cell carcinoma | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2023-05-12 | 通讯作者 |
| 24 | Performance of PET imaging for the localization of epileptogenic zone in patients with epilepsy: a meta-analysis | European Radiology | 2021-08-01 | 通讯作者 |
| 25 | Diagnostic efficacy of [ 68Ga]Ga‑NY104 PET/CT to identify clear cell renal cell carcinoma | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2024-06-25 | 通讯作者 |
| 26 | Comparing the clinical value of baseline [68 Ga]Ga-FAPI-04 PET/CT and [18F]F-FDG PET/CT in pancreatic ductal adenocarcinoma: additional prognostic value of the distal pancreatitis. | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2023-07-26 | 通讯作者 |
| 27 | Gallium-68 labeled somatostatin receptor antagonist PET/CT in over 500 patients with neuroendocrine neoplasms: experience from a single center in China | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2024-06-01 | 通讯作者 |
| 28 | The status of nuclear medicine in China: the first official national survey | EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING | 2024-04-02 | 通讯作者 |
| 29 | Hepatic Angiomyolipoma Having FDG Uptake at the Similar Level of the Normal Liver Parenchyma | CLINICAL NUCLEAR MEDICINE | 2019-06-10 | 通讯作者 |
| 30 | Inconsistency Between Contrast-Enhanced CT and Bone Scintigraphy in Revealing Radiation Nephritis | Clinical Nuclear Medicine | 2019-06-03 | 通讯作者 |
| 31 | FDG PET Findings of Hyperprogression During Immunotherapy in a Patient With Hepatocellular Carcinoma | Clinical Nuclear Medicine | 2020-01-03 | 通讯作者 |
| 32 | Incidental Detection of Adenocarcinoma in the Neck of the Pancreas by FDG PET Imaging When a Cystic Lesion in the Body of Pancreas Was Evaluated. | CLINICAL NUCLEAR MEDICINE | 2020-07-03 | 通讯作者 |
| 33 | Abdominal Metastases of Intracranial Germ Cell Tumor Via Ventriculoperitoneal Shunt Detected by 18F-FDG PET/CT | CLINICAL NUCLEAR MEDICINE | 2020-10-01 | 通讯作者 |
| 34 | Extensive Tumor Thrombosis of Portal Venous System Demonstrated on Ga-68-DOTATATE and Ga-68-NODAGA-LM3 PET/CT in a Patient With Well-Differentiated Neuroendocrine Tumor | CLINICAL NUCLEAR MEDICINE | 2020-11-01 | 通讯作者 |
| 35 | Intense Ga-68-Pentixafor Activity in Aldosterone-Producing Adrenal Adenomas | CLINICAL NUCLEAR MEDICINE | 2020-04-01 | 通讯作者 |
| 36 | Ga-68-FAPI-04 accumulation in myocardial infarction in a patient with neuroendocrine carcinom | Clinical nuclear medicine | 2020-12-01 | 通讯作者 |
| 37 | pembrolizumab Exacerbates Thyroid Disease shown on FDG PET/CT | Clinical nuclear medicine | 2020-12-01 | 通讯作者 |
| 38 | Adrenal Castleman Disease on 99mTc-HYNIC-TOC Scan and FDG PET/CT | CLINICAL NUCLEAR MEDICINE | 2021-01-01 | 通讯作者 |
| 39 | Cortisol-Producing Adrenal Adenomas With Intense Activity on 68Ga-Pentixafor PET/CT | CLINICAL NUCLEAR MEDICINE | 2021-04-01 | 通讯作者 |
| 40 | Increased 68Ga-FAPI Uptake of Symptomatic Intracranial Atherosclerotic Plaque Revealed by PET/MR. | CLINICAL NUCLEAR MEDICINE | 2022-05-12 | 通讯作者 |
| 41 | Clinical Value of 68Ga-Pentixafor PET/CT in Subtype Diagnosis of Primary Aldosteronism Patients with Adrenal Micronodules. | JOURNAL OF NUCLEAR MEDICINE | 2024-01-02 | 通讯作者 |
- 科研获奖Research Awards
无
- 研究成果Research Findings
| # | 成果类型 | 项目/专利/新品种名称 |
|---|---|---|
| 1 | 出版高水平专著 | 核医学学习指导与习题集 |
| 2 | 出版高水平专著 | PET/MRI |
| 3 | 获得省部级及以上科研奖励 | 正电子发射断层（PET)显像的技术创新与转化应用 |
| 4 | 获得省部级及以上科研奖励 | 正电子发射断层（PET）显像的技术创新及转化应用 |
| 5 | 作为主创人员获得授权的发明专利和新品种 | 协和PET心脏图像处理软件 |
| 6 | 作为主创人员获得授权的发明专利和新品种 | 一种CAR-T活体示踪方法 |
| 7 | 作为主创人员获得授权的发明专利和新品种 | 一种18F核素标记的生长抑素受体抑制剂探针及其制备方法和试剂盒 |