导师风采
李剑
个人信息
Personal Information
- 性别：男
- 导师类型：博导
- 职称：主任医师
- 该职称任职时间：2001-08-23
联系方式
Contact Information
- 所属院系：北京协和医院
- 所属专业：内科学
- 邮箱 : lijian@pumch.cn
- 工作电话 : 18610852525
个人简介
Personal Profile
2001年毕业于北京协和医学院八年制临床专业，获得医学博士学位。 现为北京协和医院血液内科科主任，中华医学会血液学分会委员，北京医学会血液学分会副主任委员，北京医师协会血液科医师分会副会长、中国医师协会血液科医师分会多发性骨髓瘤委员会委员，中华血液学杂志编委。 主要研究方向是血液肿瘤的临床及基础。近5年来，已经在Circulation、Blood、Leukemia等杂志上发表多篇临床及基础研究文章。承担国家自然基金面上基金3项，北京自然基金2项，首都特色医疗基金1项，首发基金2项、医科院青年基金1项。
团队简介
Team Profile
2001年毕业于北京协和医学院八年制临床专业，获得医学博士学位。 现为北京协和医院血液内科科主任，中华医学会血液学分会委员，北京医学会血液学分会副主任委员，北京医师协会血液科医师分会副会长、中国医师协会血液科医师分会多发性骨髓瘤委员会委员，中华血液学杂志编委。 主要研究方向是血液肿瘤的临床及基础。近5年来，已经在Circulation、Blood、Leukemia等杂志上发表多篇临床及基础研究文章。承担国家自然基金面上基金3项，北京自然基金2项，首都特色医疗基金1项，首发基金2项、医科院青年基金1项。
- 研究方向Research Directions
血液病学
- 在校研究生Current Graduate Students
硕士研究生 0 名，博士研究生 7 名
- 科研项目Research Projects
| # | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
|---|---|---|---|---|---|
| 1 | POEMS综合征中高水平血管内皮生长因子A的异构体组成及其调控机制 | 2016-01-01 —— 2019-12-03 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 2 | AL-LC通过促进心肌细胞自噬导致轻链型心肌淀粉样变发病的机制研究 | 2020-01-01 —— 2023-12-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 3 | ASB15基因在轻链型淀粉样变发病中的意义 | 2018-01-01 —— 2020-12-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 4 | 比较化疗联合或不联合多西环素治疗晚期原发性轻链型淀粉样变患者的前瞻性、多中心、随机对照研究 | 2018-01-01 —— 2020-12-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 5 | 建立孤立性浆细胞瘤最佳治疗策略的临床研究 | 2022-10-01 —— 2024-09-01 | 主持的企业/行业委托重大项目 | 主持人 | |
| 6 | 轻链型心脏淀粉样变的精准诊断和治疗 | 2022-12-01 —— 2025-11-01 | 主持的企业/行业委托重大项目 | 主持人 |
- 发表论文Papers
| # | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
|---|---|---|---|---|
| 1 | Clinical and positron emission tomography responses to long-term high-dose interferon- treatment among patients with Erdheim-Chester disease | ORPHANET J RARE DIS | 2019-01-01 | 通讯作者 |
| 2 | The role of high serum CXCL13 level in Waldenström macroglobulinemia | LEUKEMIA RESEARCH | 2019-06-01 | 通讯作者 |
| 3 | Improvement of thyroid function in POEMS syndrome after combination therapy of lenalidomide and dexamethasone | Leukemia & Lymphoma | 2019-02-01 | 通讯作者 |
| 4 | Bortezomib-based chemotherapy can improve renal and tubular functions in patients with light chain-associated Fanconi syndrome | Annals of Hematology | 2019-05-01 | 通讯作者 |
| 5 | Clinical characteristics and the long-term outcome of patients with atypical POEMS syndrome variant with undetectable monoclonal gammopathy | Annals of Hematology | 2019-03-01 | 通讯作者 |
| 6 | What is the best first-line treatment for POEMS syndrome: autologous transplantation, melphalan and dexamethasone, or lenalidomide and dexamethasone? | Leukemia | 2019-04-01 | 通讯作者 |
| 7 | Phase 2 study using oral thalidomide-cyclophosphamide-prednisone for idiopathic Multicentric Castleman disease | BLOOD | 2019-04-01 | 通讯作者 |
| 8 | Outcome of Cardiac Light-Chain Amyloidosis in the Era of Novel Therapy: A Single-Center Cohort Study of 227 Patients | CIRCULATION JOURNAL | 2019-03-01 | 通讯作者 |
| 9 | Bortezomib-based chemotherapy reduces early mortality and improves outcomes in patients with ultra-high-risk light-chain amyloidosis: a retrospective case control study | AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS | 2019-06-01 | 通讯作者 |
| 10 | Clinical presentation and prognosis of immunoglobulin light-chain amyloidosis with high percentage of bone marrow plasma cells | LEUKEMIA RESEARCH | 2019-06-01 | 通讯作者 |
| 11 | Genomic profiling in amyloid light-chain amyloidosis reveals mutation profiles associated with overall survival | AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS | 2020-01-01 | 通讯作者 |
| 12 | Reliability of optic disc edema area in estimating the severity of papilledema in patients with POEMS syndrome | Orphanet Journal of Rare Diseases | 2020-05-19 | 通讯作者 |
| 13 | Clinical characeteristics and treatment outcome of type 1 cryoglobulinemia in Chinese pateints: a single-center study of 45 patients | ANNALS OF HEMATOLOGY | 2020-06-13 | 通讯作者 |
| 14 | Evaluating heart function in patients with POEMS syndrome | ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES | 2019-11-01 | 通讯作者 |
| 15 | Clinical presentation and prognostic analysis of Chinese patients with systemic light chain amyloidosis with liver involvement | LEUKEMIA RESEARCH | 2019-11-01 | 通讯作者 |
| 16 | UCD with MCD-like inflammatory state: surgical excision is highly effective | Blood Advances | 2021-01-12 | 通讯作者 |
| 17 | Whole-genome sequencing suggests a role of MIF in the pathophysiology of TEMPI syndrome | Blood Advances | 2021-01-22 | 通讯作者 |
| 18 | Clinical presentation and prognostic analysis of adult patients with Langerhans cell histiocytosis with pulmonary involvement | BMC CANCER | 2020-09-23 | 通讯作者 |
| 19 | Endocrine evaluation in POEMS syndrome ：a cohort study | Frontiers in Endocrinology | 2020-10-01 | 通讯作者 |
| 20 | Ischemic stroke in patients with POEMS syndrome | BLOOD ADVANCES | 2020-07-01 | 通讯作者 |
| 21 | Rituximab-containing therapy for cold agglutinin disease: a retrospective study of 16 patients | SCIENTIFIC REPORTS | 2020-07-01 | 通讯作者 |
| 22 | A highly heterogeneous mutational pattern in POEMS syndrome | LEUKEMIA | 2020-12-01 | 通讯作者 |
| 23 | Clinical characteristics and treatment outcome of type I cryoglobulinemia in Chinese patients: a single-center study of 45 patients | ANNALS OF HEMATOLOGY | 2020-08-01 | 通讯作者 |
| 24 | Impact of Physicians' Personalities and Behavioral Traits on Treatment-Related Decision-making for Elderly Acute Myeloid Leukemia | JOURNAL OF GENERAL INTERNAL MEDICINE | 2021-01-28 | 通讯作者 |
| 25 | Treatment and outcome patterns of patients with Waldenström’s macroglobulinemia: a large, multicenter retrospective review in China | LEUKEMIA & LYMPHOMA | 2021-06-09 | 通讯作者 |
| 26 | Posttreatment dFLC less than 10 mg/L predicts superior organ response and longer time to next treatment in newly diagnosed light-chain amyloidosis patients treated with bortezomib | LEUKEMIA & LYMPHOMA | 2020-11-20 | 通讯作者 |
| 27 | Baseline bone marrow ADC value of diffusion-Weighted MRI: a potential independent predictor for progression and death in pateints with newly diagnosed multiple myeloma | EUROPEAN RADIOLOGY | 2020-07-23 | 通讯作者 |
| 28 | A phase I study of anti-BCMA CAR T cell therapy in relapsed/refractory multiple myeloma and plasma cell leukemia | Clinical and Translational Medicine | 2021-03-08 | 通讯作者 |
| 29 | "Revealing serum lipidomic characteristics and potential lipid biomarkers in patients with POEMS syndrome Journal: Journal of Cellular and Molecular Medicine" | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2021-03-28 | 通讯作者 |
| 30 | cereblon expression is a prognostic marker in newly diagnosed POEMS syndrome patients treated with lenalidomide plus dexamethasone | ANNALS OF HEMATOLOGY | 2021-04-10 | 通讯作者 |
| 31 | Treatment outcomes and prognostic factors of patients with adult Langerhans cell histiocytosis | AMERICAN JOURNAL OF HEMATOLOGY | 2022-02-01 | 通讯作者 |
| 32 | Benefit of high-dose idarubicin as induction therapy in acute myeloid leukemia: a prospective phase 2 study | ANNALS OF HEMATOLOGY | 2022-04-15 | 通讯作者 |
| 33 | Comprehensive geriatric assessment in newly diagnosed older myeloma patients: a multicentre, prospective, non-interventional study | AGE AND AGEING | 2022-01-06 | 通讯作者 |
| 34 | Distinct Mutation Landscapes Between Acute Myeloid Leukemia With Myelodysplasia- Related Changes and De Novo Acute Myeloid Leukemia | AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2022-05-04 | 通讯作者 |
| 35 | A prospective, multicenter study of bortezomib, cyclophosphamide, and dexamethasone in relapsed/refractory iMCD | LEUKEMIA & LYMPHOMA | 2022-03-15 | 通讯作者 |
| 36 | Validation of the composite organ and hematologic response model for prognostic prediction in a Chinese light chain amyloidosis cohort | Leuk Lymphoma | 2021-08-01 | 通讯作者 |
| 37 | Bortezomib plus dexamethasone as first-line therapy for patients with POEMS syndrome | Annals of Hematology | 2021-07-31 | 通讯作者 |
| 38 | Light-chain amyloidosis with peripheral neuropathy as an initial presentation | Frontiers in Neurology | 2021-09-08 | 通讯作者 |
| 39 | A national, multicenter, retrospective study of Castleman disease in China implementing CDCN criteria | Lancet Regional Health-Western Pacific | 2023-03-24 | 通讯作者 |
| 40 | Feasibility of 68Ga-Labeled Fibroblast Activation Protein Inhibitor PET/CT in Light-Chain Cardiac Amyloidosis | JACC-Cardiovascular Imaging | 2022-11-01 | 通讯作者 |
| 41 | Doxycycline combined with bortezomib-cyclophosphamide-dexamethasone chemotherapy for newly diagnosed cardiac light-chain amyloidosis: a multicenter randomized controlled trial | CIRCULATION | 2022-01-04 | 通讯作者 |
| 42 | Prognostic Value of Circulating sST2 for the Prediction of Mortality in Patients With Cardiac Light-Chain Amyloidosis | Frontiers in Cardiovascular Medicine | 2021-01-20 | 通讯作者 |
| 43 | Prevalence, clinical characteristics and treatment outcome of factor X deficiency in a consecutive cohort of primary light-chain amyloidosis | LEUKEMIA RESEARCH | 2022-09-15 | 通讯作者 |
| 44 | Efficacy and safety of intravenous daratumumab-based treatments for AL amyloidosis: a systematic review and meta-analysis | Cancer Cell International | 2022-07-04 | 通讯作者 |
| 45 | Evolution of Pulmonary Involvement in Idiopathic Multicentric Castleman Disease-Not Otherwise Specified: From Nodules to Cysts or Consolidation | CHEST | 2023-08-01 | 通讯作者 |
| 46 | Insulin-like growth factor 1 receptor inhibits the proliferation of acute myeloid leukaemia cells via NK cell activation | Annals of Hepatology | 2023-07-31 | 通讯作者 |
| 47 | Idiopathic multicentric Castleman disease (iMCD)-idiopathic plasmacytic lymphadenopathy: A distinct subtype of iMCD-not otherwise specified with different clinical features and better survival | BRITISH JOURNAL OF HAEMATOLOGY | 2024-02-15 | 通讯作者 |
| 48 | A prospective study of zanubrutinib, a Bruton tyrosine kinase inhibitor, in relapsed/refractory idiopathic multicentric Castleman disease | INTERNATIONAL JOURNAL OF HEMATOLOGY | 2024-03-28 | 通讯作者 |
| 49 | Long-Term Outcomes of Autologous Stem Cell Transplantation in Patients with Newly Diagnosed POEMS Syndrome | Transplantation and Cellular Therapy | 2024-02-15 | 通讯作者 |
| 50 | Light-Chain Cardiac Amyloidosis: Cardiac Magnetic Resonance for Assessing Response to Chemotherapy | KOREAN JOURNAL OF RADIOLOGY | 2024-05-15 | 通讯作者 |
| 51 | Treatment Response Assessment in Multiple Myeloma: Histogram Analysis of Total Tumor Apparent Diffusion Coefficient based on Whole-body Diffusion-weighted MR Imaging | JOURNAL OF MAGNETIC RESONANCE IMAGING | 2023-12-13 | 通讯作者 |
| 52 | Can We Differentiate Between Primary Sjögren Syndrome and Idiopathic Multicentric Castleman Disease Based on the Characteristics of Pulmonary Cysts? | jornal of Thorac Imaging | 2024-04-06 | 通讯作者 |
| 53 | Chinese consensus on the diagnosis and treatment of immunoglobulin light-chain cardiac amyloidosis | CHINESE MEDICAL JOURNAL | 2023-12-22 | 通讯作者 |
- 科研获奖Research Awards
无
- 研究成果Research Findings
无