导师风采
崔娜
个人信息
Personal Information
- 性别：女
- 导师类型：博导
- 职称：主任医师
- 该职称任职时间：4
联系方式
Contact Information
- 所属院系：北京协和医院
- 所属专业：
- 邮箱 : cuina@pumch.cn
- 工作电话 : 15601212623
个人简介
Personal Profile
崔娜，女，医学博士，中国医学科学院北京协和医院，重症医学科主任医师、教授，博士研究生导师，博士后导师。中国女医师协会重症医学专业委员会全国常委，北京整合医学会血栓与止血分会常委，北京市围手术期医学研究会心脏外科专委会委员，国家卫健委高级人才评审专家，教育部学位评审专家，国自然基金评审专家，北京协和医院医疗委员会委员，临床医学博士后项目管理委员会委员，北京协和医院重症医学科临床主管教授、核心组成员。主要研究方向为脓毒症、重症感染与免疫、多器官功能损伤。
团队简介
Team Profile
本人从事重症医学专业二十年以来，致力于脓毒症感染诊断、脓毒症相关器官功能损伤及免疫分子机制的临床和基础研究，牵头建立了国内最大的“脓毒症”单中心临床病例库，入库患者数量逾2000例。 主持2项国自然科学基金、2项省部委自然科学基金、“十三五”国家科技部重点研发专项子课题、北京市科委重大专项、医科院转化医学等多项国家、省部委和专项基金。作为第一作者和通信作者，近5年发表SCI论著50余篇，总影响因子＞250，主/参编10余部学术专著及教材。 本课题组开展各项临床及基础实验，每位3年制学生毕业前均以第一作者发表2-3篇sci。只要你能秉持着严谨求真的治学态度，学生生涯将用八字概括--”快乐科研，毕业无忧”！
- 研究方向Research Directions
脓毒症、感染与免疫、多器官功能损伤
- 在校研究生Current Graduate Students
硕士研究生 2 名，博士研究生 1 名
- 科研项目Research Projects
| # | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
|---|---|---|---|---|---|
| 1 | 脓毒症免疫功能评估体系建立与治疗决策系统研发 | 2022-10-01 —— 2025-09-01 | 230万 | 主持的企业/行业委托重大项目 | 主持人 |
| 2 | 重症脓毒症患者免疫功能评估与侵袭性念珠菌感染风险预警模型的建立 | 2019-11-01 —— 2021-10-01 | 40万 | 主持的企业/行业委托重大项目 | 主持人 |
| 3 | mTOR调控CD8 T细胞效应分化表型提高机体抗真菌感染免疫力的机制研究 | 2015-01-03 —— 2017-06-03 | 18万 | 主持的企业/行业委托重大项目 | 主持人 |
| 4 | mTOR介导自噬失衡在高原脓毒症心肌病中的作用机制和干预研究 | 2020-06-01 —— 2022-06-01 | 17.7万 | 主持在研的国家或省部级科研项目 | 主持人 |
| 5 | SEPSIS免疫功能临床评估与重症感染早期诊断 | 2020-03-01 —— 2024-03-01 | 60万 | 主持在研的国家或省部级科研项目 | 主持人 |
| 6 | 老年感染严重并发症的免疫反应过程及早期预警模型研究 | 2022-07-01 —— 2025-06-01 | 178万 | 主持在研的国家或省部级科研项目 | 主持人 |
| 7 | mTOR信号通路介导CD8 Tem细胞增殖分化提高脓毒症免疫应答的临床与基础研究 | 2017-01-15 —— 2019-12-15 | 17万 | 主持在研的国家或省部级科研项目 | 主持人 |
| 8 | mTOR介导自噬调节在侵袭性真菌感染T淋巴细胞增殖分化中的作用机制和干预研究 | 2021-01-01 —— 2024-12-31 | 55万 | 主持在研的国家或省部级科研项目 | 主持人 |
- 发表论文Papers
| # | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
|---|---|---|---|---|
| 1 | Prospective evaluation of lymphocyte subtyping for the diagnosis o f invasive candidiasis in non-neutropenic critically ill patients. | International Journal of Infectious Diseases | 2019-01-01 | 通讯作者 |
| 2 | Translation and validation of the Tibetan confusion assessment method for the intensive care unit (CAM-ICU) | Chinese Medical Journal | 2019-05-20 | 通讯作者 |
| 3 | Role of the mTOR Signaling Pathway in human Sepsis induced myocardial dysfunction | Canadian Journal of Cardiology | 2019-06-01 | 通讯作者 |
| 4 | Lymphocyte and NK cell counts can predict sepsis-associated delirium in elderly patients | Frontiers in Aging Neuroscience | 2021-01-12 | 通讯作者 |
| 5 | CD8 T cell survival in lethal fungal sepsis was ameliorated by T-cell-specific mTOR deletion | International Journal of Medical Sciences | 2021-05-12 | 通讯作者 |
| 6 | T-bet expression mediated by the mTOR pathway influences CD4 T cell count in mice with lethal Candida sepsis | Frontiers in Microbiology | 2020-05-03 | 通讯作者 |
| 7 | Lymphocyte subset counts as a diagnostic and prognostic marker for the Carbapenem-resistant Enterobacteriaceae (CRE) infection of critically ill patients | INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2020-05-03 | 通讯作者 |
| 8 | T-cell-specific mTOR deletion in mice ameliorated CD4( ) T-cell survival in lethal sepsis induced by severe invasive candidiasis. | Virulence | 2019-10-31 | 通讯作者 |
| 9 | Evaluation of the updated "Candida score" with Sepsis 3.0 criteria in critically ill patients | ANNALS OF TRANSLATIONAL MEDICINE | 2020-08-01 | 通讯作者 |
| 10 | Effect of nurse-led, goal-directed lung physical therapy on prognosis of patients with sepsis caused by Acinetobacter baumannii pulmonary infection | INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2021-01-12 | 通讯作者 |
| 11 | Effect of nurse-led goal-directed lung physical therapy on the prognosis of pneumonia in sepsis patients in the ICU: a prospective cohort study | JOURNAL OF INTENSIVE CARE MEDICINE | 2021-01-12 | 通讯作者 |
| 12 | Impact of mTOR signaling pathway on CD8 T cell immunity through Eomesodermin in response to invasive candidiasis | JOURNAL OF MICROBIOLOGY, IMMUNOLOGY AND INFECTION | 2021-03-12 | 通讯作者 |
| 13 | Metagenomic next-generation sequencing for the microbiological diagnosis of abdominal sepsis patients | Frontiers in Microbiology | 2022-02-02 | 通讯作者 |
| 14 | mTOR deletion ameliorates CD4 T cell apoptosis during sepsis by improving autophagosome-lysosome fusion | APOPTOSIS | 2022-04-18 | 通讯作者 |
| 15 | Role of Intensified Lung Physiotherapy Bundle on the Occurrence of Pneumonia After Cardiac Surgery | FRONTIERS IN MEDICINE | 2022-02-23 | 通讯作者 |
| 16 | Early Alterations of Lymphocyte Subsets in Acute Respiratory Distress Syndrome Caused by Acinetobacter baumannii Pneumonia: A Prospective Observational Study | Frontiers in medicine | 2021-10-11 | 通讯作者 |
| 17 | Implementation of Nurse-Led, Goal-Directed Lung Physiotherapy for Older Patients With Sepsis and Pneumonia in the ICU | Frontiers in medicine | 2021-11-01 | 通讯作者 |
| 18 | The Role of Electrical Impedance Tomography for Management of High-Risk Pulmonary Embolism in a Postoperative Patient | Frontiers in medicine | 2021-11-19 | 通讯作者 |
| 19 | Effects of Neutrophil Extracellular Traps in Patients With Septic Coagulopathy and Their Interaction With Autophagy | Frontiers in Immunology | 2021-10-11 | 通讯作者 |
| 20 | Exploring dynamic change in arterial base excess with patient outcome and lactate clearance in the intensive care unit by hierarchical time-series clustering | Frontiers in Medicine | 2022-11-08 | 通讯作者 |
| 21 | T-lymphocyte subtyping: an early warning and a potential prognostic indicator of active cytomegalovirus infection in sepsis patients | IMMUNOLOGY AND CELL BIOLOGY | 2022-09-15 | 通讯作者 |
| 22 | Early Alteration of Peripheral Blood Lymphocyte Subsets as a Risk Factor for Delirium in Critically Ill Patients after Cardiac Surgery: A Prospective Observational Study | Frontiers in Aging Neuroscience | 2022-09-01 | 通讯作者 |
| 23 | Early expression of functional markers on CD4 T cells predicts outcomes in ICU patients with sepsis | Frontiers in Immunology | 2022-07-11 | 通讯作者 |
| 24 | mTOR pathway mediates endoplasmic reticulum stress-induced CD4( ) T cell apoptosis in septic mice | APOPTOSIS | 2022-10-01 | 通讯作者 |
| 25 | mTOR Modulates the Endoplasmic Reticulum Stress-Induced CD4 T Cell Apoptosis Mediated by ROS in Septic Immunosuppression | MEDIATORS OF INFLAMMATION | 2022-07-23 | 通讯作者 |
| 26 | Intensive care unit readmission and unexpected death after emergency general surgery | HELIYON | 2023-03-09 | 通讯作者 |
| 27 | Multisite Metagenomic Next-Generation Sequencing Improved Diagnostic Performance for Sepsis-Associated Lymphopenia Patients | Microbiology Spectrum | 2022-12-15 | 通讯作者 |
| 28 | Development and validation of a risk score for predicting invasive candidiasis in intensive care unit patients by incorporating clinical risk factors and lymphocyte subtyping | Frontiers in Cellular and Infection Microbiology | 2022-04-27 | 通讯作者 |
| 29 | mTOR in programmed cell death and its therapeutic implications | CYTOKINE & GROWTH FACTOR REVIEWS | 2023-06-24 | 通讯作者 |
| 30 | Ferroptosis in sepsis: the mechanism, the role and the therapeutic potential | Frontiers in Immunology | 2022-08-05 | 通讯作者 |
| 31 | Autophagy regulates pyroptotic cell death: mechanism and medical implication in sepsis | MEDIATORS OF INFLAMMATION | 2021-06-12 | 通讯作者 |
| 32 | Effect of Improved Nursing Strategy on Prognosis of Immunosuppressed Patients With Pneumonia and Sepsis: A Prospective Cohort Study | JOURNAL OF INTENSIVE CARE MEDICINE | 2023-09-18 | 通讯作者 |
| 33 | Depletion of mTOR ameliorates CD4 T cell pyroptosis by promoting autophagy activity in septic mice | INTERNATIONAL IMMUNOPHARMACOLOGY | 2023-11-01 | 通讯作者 |
| 34 | SIMPLIFIED IMMUNE-DYSREGULATION INDEX: A NOVEL MARKER PREDICTS 28-DAY MORTALITY OF INTENSIVE CARE PATIENTS WITH SEPSIS | SHOCK | 2024-04-01 | 通讯作者 |
| 35 | Utility of paired plasma and drainage fluid mNGS in diagnosing acute intra-abdominal infections with sepsis | BMC INFECTIOUS DISEASES | 2024-04-17 | 通讯作者 |
| 36 | Advances in the regulatory mechanisms of mTOR in necroptosis | Frontiers in Immunology | 2023-12-18 | 通讯作者 |
| 37 | mTOR aggravated CD4 T cell pyroptosis by regulating the PPARγ-Nrf2 pathway in sepsis. | INTERNATIONAL IMMUNOPHARMACOLOGY | 2024-08 | 通讯作者 |
| 38 | mTOR aggravated CD4 T cell pyroptosis by regulating the PPARγ-Nrf2 pathway in sepsis. | INTERNATIONAL IMMUNOPHARMACOLOGY | 2024-08 | 通讯作者 |
- 科研获奖Research Awards
无
- 研究成果Research Findings
| # | 成果类型 | 项目/专利/新品种名称 |
|---|---|---|
| 1 | 出版高水平专著 | 实用重症感染学 |
| 2 | 作为主创人员获得授权的发明专利和新品种 | A Risk Scoring System for Predicting Invasive Candidiasis of Critical Patients by Combining Clinical Risk Factors and Lymphocyte Subtypes and Its Establishment Method |
| 3 | 作为主创人员获得授权的发明专利和新品种 | Prediction Model of Delirium in Critical Patients after Cardiac Surgery and Its Construction Method |
| 4 | 作为主创人员获得授权的发明专利和新品种 | Prediction model construction method for predicting secondary delirium in elderly sepsis patients |
| 5 | 作为主创人员获得授权的发明专利和新品种 | Prediction model for readmission to ICU or unexpected death of critically ill patients after emergency general surgery and its construction method |