导师风采
高晶
个人信息
Personal Information
- 性别：女
- 导师类型：博导
- 职称：主任医师
- 该职称任职时间：2000-02-29
联系方式
Contact Information
- 所属院系：北京协和医院
- 所属专业：
- 邮箱 : gj107@163.com
- 工作电话 : 13011809777
个人简介
Personal Profile
高晶 北京协和医院神经科主任医师教授 中华医学会神经科分会痴呆与认知障碍学组副组长 神经病理学组委员， 北京医学会神经病学分会 常委 北京医学会神经病理学组组长 中华神经科杂志编委 BMJ中文版编委 中华老年多器官衰竭杂志编委 主要临床研究专注于痴呆与脑白质病，从认知、脑结构、生物标记物、基因特征直至病理动态分析痴呆以及脑白质病的疾病本质，关注疾病的诊治、关注临床与病理；建立了协和认知评价系统，修订了MOCA协和版。认知评价以及非肿瘤脑病理是技术专长。对于痴呆的鉴别诊断和治疗照料有丰富的临床经验以及研究积累。
团队简介
Team Profile
高晶 北京协和医院神经科主任医师教授 中华医学会神经科分会痴呆与认知障碍学组副组长 神经病理学组委员， 北京医学会神经病学分会 常委 北京医学会神经病理学组组长 中华神经科杂志编委 BMJ中文版编委 中华老年多器官衰竭杂志编委 主要临床研究专注于痴呆与脑白质病，从认知、脑结构、生物标记物、基因特征直至病理动态分析痴呆以及脑白质病的疾病本质，关注疾病的诊治、关注临床与病理；建立了协和认知评价系统，修订了MOCA协和版。认知评价以及非肿瘤脑病理是技术专长。对于痴呆的鉴别诊断和治疗照料有丰富的临床经验以及研究积累。
- 研究方向Research Directions
痴呆与认知障碍的生物标志物和病理研究
- 在校研究生Current Graduate Students
硕士研究生 2 名，博士研究生 1 名
- 科研项目Research Projects
| # | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
|---|---|---|---|---|---|
| 1 | 不同年龄组痴呆临床队列、多组学生物标记及病理研究 | 2020-12-01 —— 2025-11-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 2 | 不同年龄和类型分层的痴呆研究队列、脑病组织库及多组学生物标记物研究 | 2020-12-01 —— 2025-11-01 | 主持在研的国家或省部级科研项目 | 主持人 |
- 发表论文Papers
| # | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
|---|---|---|---|---|
| 1 | Differences in multimodal electroencephalogram and clinical correlations between early onset Alzheimer’s disease and frontotemporal dementia | frontiers in neuroscience | 2021-07-13 | 第一作者 |
| 2 | Biopsy histopathology in the diagnosis of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) | NEUROLOGICAL SCIENCES | 2020-02-01 | 通讯作者 |
| 3 | Type IIB focal cortical dysplasia with balloon cells in medial temporal lobe epilepsy: Clinical, neuroimaging, and histopathological findings | EPILEPSY RESEARCH | 2019-11-03 | 通讯作者 |
| 4 | A longitudinal observation of brain structure between AD and FTLD | CLINICAL NEUROLOGY AND NEUROSURGERY | 2021-03-24 | 通讯作者 |
| 5 | Accuracy of the Short-Form Montreal Cognitive Assessment Chinese Versions | Frontiers in Aging Neuroscience | 2021-06-22 | 通讯作者 |
| 6 | Phenotype Heterogeneity and Genotype Correlation of MAPT Mutations in a Chinese PUMCH Cohort | JOURNAL OF MOLECULAR NEUROSCIENCE | 2021-05-01 | 通讯作者 |
| 7 | White matter hyperintensities and patterns of atrophy in early onset Alzheimer's disease with causative gene mutations | CLINICAL NEUROLOGY AND NEUROSURGERY | 2021-04-24 | 通讯作者 |
| 8 | Cerebrospinal Fluid Alzheimer's Biomarkers and Neurofilament Light Profile of Idiopathic Normal Pressure Hydrocephalus in China: A PUMCH Cohort Study | Neurodegenerative Diseases | 2021-06-02 | 通讯作者 |
| 9 | Clinical phenotype and mutation spectrum of Alzheimer's disease with causative genetic mutation in a Chinese cohort | Current Alzheimer Research | 2021-04-18 | 通讯作者 |
| 10 | effect of ApoE genotype on clinical phenotypes in early-onset and late-onset Alzheimer's disease in china:data from the pumch dementia cohort | Brain and Behavior | 2021-08-06 | 通讯作者 |
| 11 | Association Between Common Variants of APOE, ABCA7, A2M, BACE1, and Cerebrospinal Fluid Biomarkers in Alzheimer’s Disease: Data from the PUMCH Dementia Cohort | JOURNAL OF ALZHEIMERS DISEASE | 2021-12-21 | 通讯作者 |
| 12 | Typical and atypical phenotype and neuroimaging of X-linked adrenoleukodystrophy in a Chinese cohort | NEUROLOGICAL SCIENCES | 2022-01-08 | 通讯作者 |
| 13 | Random Forest Model in the Diagnosis of Dementia Patients with Normal Mini-Mental State Examination Scores | JOURNAL OF PERSONALIZED MEDICINE | 2022-01-04 | 通讯作者 |
| 14 | <p>Generation of a human induced pluripotent stem cell (iPSC) line from skin fibroblasts of a patient carrying an E363Q mutation in PSEN1 gene</p> | STEM CELL RESEARCH | 2022-05-03 | 通讯作者 |
| 15 | A pilot study of multiple time points and multidomain assessment in cerebrospinal fluid tap test for patients with idiopathic normal pressure hydrocephalus | Clin Neurol Neurosurg | 2021-07-13 | 通讯作者 |
| 16 | Effects of ApoE genotype on clinical phenotypes in early-onset and late-onset Alzheimer's disease in China: Data from the PUMCH dementia cohort | Brain Behav | 2021-07-13 | 通讯作者 |
| 17 | Genetic Spectrum and Clinical Heterogeneity of Chinese Frontotemporal Dementia Patients: Data from PUMCH Dementia Cohort | JOURNAL OF ALZHEIMERS DISEASE | 2022-08-08 | 通讯作者 |
| 18 | Clinical-neuroimaging-pathological relationship analysis of adult onset Neuronal Intranuclear Inclusion Disease (NIID) | BMC Neurology | 2022-12-01 | 通讯作者 |
| 19 | Distribution of Cortical Atrophy Associated with Cognitive Decline in Alzheimer's Disease: A Cross-Sectional Quantitative Structural MRI Study from PUMCH Dementia Cohort | Current Alzheimer Research | 2022-09-10 | 通讯作者 |
| 20 | CSF biomarkers for early-onset Alzheimer's disease in Chinese population from PUMCH dementia cohort | Frontiers in Neurology | 2023-01-09 | 通讯作者 |
| 21 | Association of APOE ε4/ε4 with fluid biomarkers in patients from the PUMCH dementia cohort. | Frontiers in Aging Neuroscience | 2023-03-31 | 通讯作者 |
| 22 | Differentiation of Alzheimer's Disease from Frontotemporal Dementia and Mild Cognitive Impairment Based on Arterial Spin Labeling Magnetic Resonance Imaging: A Pilot Cross-Sectional Study from PUMCH Dementia Cohort | JOURNAL OF ALZHEIMERS DISEASE | 2023-05-16 | 通讯作者 |
| 23 | How far is the goal of applying β-amyloid in cerebrospinal fluid for clinical diagnosis of Alzheimer's disease with standardization of measurements? | CLINICAL BIOCHEMISTRY | 2023-02-01 | 通讯作者 |
- 科研获奖Research Awards
无
- 研究成果Research Findings
| # | 成果类型 | 项目/专利/新品种名称 |
|---|---|---|
| 1 | 出版高水平专著 | 中国痴呆诊疗指南 （2017版） |