导师风采
李玉秀
个人信息
Personal Information
- 性别：女
- 导师类型：博导
- 职称：主任医师
- 该职称任职时间：1999-08-25
联系方式
Contact Information
- 所属院系：北京协和医院
- 所属专业：
- 邮箱 : liyuxiu@medmail.com.cn
- 工作电话 : 13581705295
个人简介
Personal Profile
李玉秀，主任医师、教授，博士研究生导师。1987年毕业于哈尔滨医科大学。1996年至1999年在中国协和医科大学北京协和医院内分泌科获得博士学位。主要社会兼职：中华医学会内分泌学会委员，中华医学会内分泌学会肥胖血组副组长。中华内分泌代谢杂志编委。 一直从从事内分泌、糖尿病基础与临床研究工作，了解糖尿病的研究发展的动向。完成了北京协和医院院内青年科研基金“FoxO转录因子在胰岛素抵抗机制中作用”和“自身免疫性糖尿病早期筛查与合理治疗”"协和医院青年科研基金“UCP2基因敲除对游离脂肪酸介导的胰岛素分泌障碍的影响”和中华医学会糖尿病专项基金“腹膜透析患者血糖波动特点与西格列汀治疗安全性与有效性”、国家自然科学基金课题“端粒长度对2型糖尿病的预测和发病机制中的作用”、北京科委项目“基于金纳米结构自身免疫性糖尿病超灵敏蛋白芯片的研制”、北京自然基金面上项目1项，中国医学科学院临床与转化医学基金1项等项目。目前参与的研究项目：医科院内分泌疾病精准诊疗，中央高水平医院项目：基于大数据的糖尿病诊疗研究等。已经毕业博士研究生7名、硕士生5名、联合培养硕士研究生2名.。目前在研3名临床型博士研究生、1名临床博士后。
团队简介
Team Profile
李玉秀，主任医师、教授，博士研究生导师。1987年毕业于哈尔滨医科大学。1996年至1999年在中国协和医科大学北京协和医院内分泌科获得博士学位。主要社会兼职：中华医学会内分泌学会委员，中华医学会内分泌学会肥胖血组副组长。中华内分泌代谢杂志编委。 一直从从事内分泌、糖尿病基础与临床研究工作，了解糖尿病的研究发展的动向。完成了北京协和医院院内青年科研基金“FoxO转录因子在胰岛素抵抗机制中作用”和“自身免疫性糖尿病早期筛查与合理治疗”"协和医院青年科研基金“UCP2基因敲除对游离脂肪酸介导的胰岛素分泌障碍的影响”和中华医学会糖尿病专项基金“腹膜透析患者血糖波动特点与西格列汀治疗安全性与有效性”、国家自然科学基金课题“端粒长度对2型糖尿病的预测和发病机制中的作用”、北京科委项目“基于金纳米结构自身免疫性糖尿病超灵敏蛋白芯片的研制”、北京自然基金面上项目1项，中国医学科学院临床与转化医学基金1项等项目。目前参与的研究项目：医科院内分泌疾病精准诊疗，中央高水平医院项目：基于大数据的糖尿病诊疗研究等。已经毕业博士研究生7名、硕士生5名、联合培养硕士研究生2名.。目前在研3名临床型博士研究生、1名临床博士后。
- 研究方向Research Directions
糖脂代谢异常与衰老
- 在校研究生Current Graduate Students
硕士研究生 1 名，博士研究生 2 名
- 科研项目Research Projects
| # | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
|---|---|---|---|---|---|
| 1 | 成人1型糖尿病患者饮食与血糖波动相关性及个体化营养治疗的初步探索 | 2019-11-01 —— 2021-10-31 | 40万 | 主持的企业/行业委托重大项目 | 主持人 |
| 2 | 基于组学和大数据技术的糖尿病精准诊疗体系的建立 | 2022-10-01 —— 2025-09-01 | 主持的企业/行业委托重大项目 | 主持人 | |
| 3 | 成年1型糖尿病患者的饮食与血糖波动相关性及个体化医学营养治疗的初步探索 | 2019-11-01 —— 2021-10-01 | 主持的企业/行业委托重大项目 | 主持人 | |
| 4 | lncRNA在1型糖尿病患者循环Treg细胞中的表达特征谱及调控作用 | 2019-01-04 —— 2021-12-04 | 主持在研的国家或省部级科研项目 | 主持人 |
- 发表论文Papers
| # | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
|---|---|---|---|---|
| 1 | Insulin treatment affects leukocyte telomere length in patients with type 2 diabetes: 6-year longitudinal study | J DIABETES COMPLICAT | 2019-05-01 | 通讯作者 |
| 2 | Negative association of serum uric acid with peripheral blood cellular aging markers | Journal of Nutrition Health & Aging | 2019-04-17 | 通讯作者 |
| 3 | Decreased serum microRNA-21, microRNA-25, microRNA-146a and microRNA-181a in autoimmune diabetes: potential biomarkers for diagnosis and possible involvement in pathogenesis. | International Journal of Endocrinology | 2019-09-09 | 通讯作者 |
| 4 | Sex-specific negative association between iron intake and cellular aging markers: mediation models involving TNFα. | Oxidative Medicine and Cellular Longevity | 2019-11-11 | 通讯作者 |
| 5 | Leukocyte Telomere Length Independently Predicts 3-Year Diabetes Risk in a Longitudinal Study of Chinese Population. | Oxidative Medicine and Cellular Longevity | 2020-03-09 | 通讯作者 |
| 6 | TNFa mediates the interaction of telomeres and mitochondria induced by hyperglycemia: a rural community-based cross-sectional study. | Oxidative Medicine and Cellular Longevity | 2020-05-05 | 通讯作者 |
| 7 | Potential protective effect of dietary intake of non-α-tocopherols on cellular aging markers mediated by TNF-α in pre-diabetes: a cross-sectional study of Chinese adults. | Oxidative Medicine and Cellular Longevity | 2020-05-15 | 通讯作者 |
| 8 | Dietary magnesium intake and leukocyte telomere attrition in adults: the regulatory role of serum tumour necrosis factor α magnesium intake and telomere attrition. | Mediators of Inflammation | 2020-05-22 | 通讯作者 |
| 9 | Triglyceride is independently correlated with insulin resistance and islet beta cell function, and superoxide dismutase might play an important role: a study in populations with different glucose and lipid metabolism states. | Lipids in Health and Disease | 2020-06-02 | 通讯作者 |
| 10 | Relationship between Decreased Serum Superoxide Dismutase Activity and Metabolic Syndrome: Synergistic Mediating Role of Insulin Resistance and β-Cell Dysfunction | Oxidative Medicine and Cellular Longevity | 2020-06-13 | 通讯作者 |
| 11 | Negative Association between Caloric Intake and Estimated Glomerular Filtration Rate in a Chinese Population: Mediation Models Involving Mitochondrial Function | GERONTOLOGY | 2020-09-01 | 通讯作者 |
| 12 | Association Between Leukocyte Mitochondrial DNA Copy Number and Non-alcoholic Fatty Liver Disease in a Chinese Population Is Mediated by 8-Oxo-2′-Deoxyguanosine | frontiers in medicine | 2020-07-29 | 通讯作者 |
| 13 | Association between metformin and neurodegenerative diseases of observational studies: systematic review and meta-analysis | BMJ OPEN DIABETES RESEARCH & CARE | 2020-01-01 | 通讯作者 |
| 14 | C-peptide:A Mediator of the Associantion Between Serum Uric Acid to Creatinine Ratio and Non-Alcoholic Fatty Liver Disease in a chinese population with Normal Serum Uric Acid Levels | Frontiers in endocrinology | 2020-11-01 | 通讯作者 |
| 15 | The Effect of LM25 and LM50 on Hypoglycemia in Chinese T2DM Patients: Post Hoc Analysis of a Randomized Crossover Trial | DIABETES THERAPY | 2020-03-01 | 通讯作者 |
| 16 | TNF alpha Mediates the Interaction of Telomeres and Mitochondria Induced by Hyperglycemia: A Rural Community-Based Cross-Sectional Study | OXIDATIVE MEDICINE AND CELLULAR LONGEVITY | 2020-05-01 | 通讯作者 |
| 17 | Low glucose enhanced metformin's inhibitory effect on pancreatic cancer cells by suppressing glycolysis and inducing energy stress via up-regulation of miR-210-5p | CELL CYCLE | 2020-07-01 | 通讯作者 |
| 18 | Negative association between antioxidant vitamin intake and non-alcoholic fatty liver disease in chinese non-diabetic adults:mediation models involving superoxide dismutase | Free radical research | 2020-09-01 | 通讯作者 |
| 19 | Comparison of differences in bone microarchitecture in adult- versus juvenile-onset type 1 diabetes Asian males versus non-diabetes males: an observational cross-sectional pilot study. | ENDOCRINE | 2020-12-11 | 通讯作者 |
| 20 | The Role of Lactate Exercise Test and Fasting Plasma C-Peptide Levels in the Diagnosis of Mitochondrial Diabetes: Analysis of Clinical Characteristics of 12 Patients With Mitochondrial Diabetes in a Single Center With Long-Term Follow-Up | FRONTIERS IN ENDOCRINOLOGY | 2022-02-21 | 通讯作者 |
| 21 | High Hemoglobin Glycation Index Is Associated With Telomere Attrition Independent of HbA1c, Mediated by TNF alpha | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2022-01-18 | 通讯作者 |
| 22 | Liraglutide Inhibits Osteoclastogenesis and Improves Bone Loss by Downregulating Trem2 in Female Type 1 Diabetic Mice: Findings From Transcriptomics | FRONTIERS IN ENDOCRINOLOGY | 2021-12-15 | 通讯作者 |
| 23 | Analysis of 55 patients with multiple endocrine neoplasia type 1-associated insulinoma from a single center in China | Orphanet Journal of Rare Diseases | 2022-05-26 | 通讯作者 |
| 24 | Dipeptidyl peptidase-4 inhibitors and gallbladder or biliary disease in type 2 diabetes: Systematic review and pairwise and network meta-analysis of randomized controlled trials | BMJ-British Medical Journal | 2022-06-27 | 通讯作者 |
| 25 | Insulin and liraglutide attenuate brain pathology in diabetic mice by enhancing Wnt/β-Catenin signaling pathway | Experimental and Therapeutic Medicine | 2022-05-04 | 通讯作者 |
| 26 | Association between glucose fluctuation during 2-hour oral glucose tolerance test, inflammation and oxidative stress markers, and β-cell function in a Chinese population with normal glucose tolerance | Annals of Translational Medicine | 2021-02-08 | 通讯作者 |
| 27 | Impact of diabetes duration and weight loss on tumor biological behavior in patients with pancreatic cancer and diabetes mellitus | Journal of Diabetes | 2022-04-04 | 通讯作者 |
| 28 | Hemoglobin A1c modifies the association between triglyceride and time in hypoglycemia determined by flash glucose monitoring in adults with type 1 diabetes: implications for individualized therapy and decision-making. | Annals of Translational Medicine | 2021-04-04 | 通讯作者 |
| 29 | New insights on hyperglycemia in 17-hydroxylase/17,20-lyase deficiency | Frontiers in Endocrinology | 2022-07-22 | 通讯作者 |
| 30 | The optimal diagnostic criteria of endogenous hyperinsulinemic hypoglycemia based on a large cohort of Chinese patients | Frontiers in Endocrinology | 2022-10-19 | 通讯作者 |
| 31 | Large mid-upper arm circumference is associated with reduced insulin resistance independent of BMI and waist circumference: A cross-sectional study in the Chinese population | Frontiers in Endocrinology | 2022-12-23 | 通讯作者 |
| 32 | Dietary patterns, oxidative Stress, inflammation and biological variation in hemoglobin A1c: Association and Mediation analysis in a rural community in north China | DIABETES RESEARCH AND CLINICAL PRACTICE | 2022-12-20 | 通讯作者 |
| 33 | Hypoglycemia Caused by Exogenous Insulin Antibody Syndrome: A Large Single-Center Case Series From China | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2023-02-15 | 通讯作者 |
| 34 | Occupational and domestic physical activity and diabetes risk in adults: Results from a long-term follow-up cohort | Frontiers in Endocrinology | 2022-12-09 | 通讯作者 |
| 35 | Development and validation of questionnaire-based machine learning models for predicting all-cause mortality in a representative population of China | Frontiers in Public Health | 2023-01-27 | 通讯作者 |
| 36 | Estimates and trends of the global burden of NASH-related liver cancer attributable to high fasting plasma glucose in 1990-2019: analysis of data from the 2019 Global Burden of Disease Study | Diabetology & Metabolic Syndrome | 2023-01-17 | 通讯作者 |
| 37 | Liraglutide Attenuates Hepatic Oxidative Stress, Inflammation, and Apoptosis in Streptozotocin-Induced Diabetic Mice by Modulating the Wnt/β-Catenin Signaling Pathway | MEDIATORS OF INFLAMMATION | 2023-01-29 | 通讯作者 |
| 38 | Temozolomide Is a Potential Therapeutic Tool for Patients With Metastatic Pheochromocytoma/Paraganglioma-Case Report and Review of the Literature | Front Endocrinol | 2020-04-02 | 通讯作者 |
| 39 | High Dietary Zinc Intake Is Associated with Shorter Leukocyte Telomere Length, Mediated by Tumor Necrosis Factor-α: A Study of China Adults | Journal of Nutrition Health & Aging | 2023-10-23 | 通讯作者 |
| 40 | Tumor necrosis factor-alpha mediates the negative association between telomere length and kidney dysfunction | International Journal of Medical Sciences | 2023-09-25 | 通讯作者 |
| 41 | Leukocyte telomere length independently predicts hyperuricemia risk in a longitudinal study of the Chinese population | NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES | 2023-10-10 | 通讯作者 |
| 42 | Global Burden of Dementia Death from 1990 to 2019, with Projections to 2050: An Analysis of 2019 Global Burden of Disease Study | JPAD-Journal of Prevention of Alzheimers Disease | 2024-05-02 | 通讯作者 |
| 43 | Impact of a dual glucose-dependent insulinotropic peptide/glucagon-like peptide-1 receptor agonist tirzepatide on heart rate among patients with type 2 diabetes: A systematic review and pairwise and network meta-analysis | DIABETES OBESITY & METABOLISM | 2024-02-01 | 通讯作者 |
- 科研获奖Research Awards
无
- 研究成果Research Findings
| # | 成果类型 | 项目/专利/新品种名称 |
|---|---|---|
| 1 | 出版高水平专著 | 内分泌外科学 |
| 2 | 出版高水平专著 | 实用糖尿病治疗学 |
| 3 | 出版高水平专著 | 协和内分泌大查房 |
| 4 | 出版高水平专著 | 协和内分泌疾病诊疗常规 |
| 5 | 出版高水平专著 | 泌语协行内分泌的秘密 |
| 6 | 出版高水平专著 | 遗传性内分泌代谢疾病 |
| 7 | 出版高水平专著 | 《中国老年糖尿病诊疗指南（2021版）》专家解读 |
| 8 | 获得省部级及以上科研奖励 | 遗传性内分泌代谢疾病新型诊疗体系的建立及应用 |