导师风采
李梦涛
个人信息
Personal Information
- 性别：男
- 导师类型：博导
- 职称：主任医师
- 该职称任职时间：1999-08-24
联系方式
Contact Information
- 所属院系：北京协和医院
- 所属专业：
- 邮箱 : mengtao.li@cstar.org.cn
- 工作电话 : 13911788572
个人简介
Personal Profile
李梦涛，北京协和医院风湿免疫科主任，主任医师，博士生/博士后导师，协和学者特聘教授，国家卫生健康突出贡献中青年专家。北京医学会风湿病学分会主任委员，中华医学会风湿病学分会副主任委员，中国医师协会风湿免疫科医师分会副会长兼肺血管/间质病学组组长，亚太抗风湿病联盟（APLAR）系统性红斑狼疮研究组委员。同时担任《中华临床免疫和变态反应杂志》主编，Rheumatology and Immunology Research (RIR)副主编，Autoimmunity Reviews, Journal of Scleroderma and related diseases编委，亚太抗风湿病联盟（APLAR）系统性红斑狼疮研究组委员。一直于北京协和医院接受了全面严格的临床、教学和科研培训，1998年赴美国加利福尼亚大学旧金山医学院交换学习，2012年首批“百人计划”赴美国6家风湿病中心访问交流，2019年中层干部赴美国梅奥诊所“医疗保健领导力”培训。连续被评为优秀住院医师、优秀总住院医师、优秀主治医师、优秀诊断学教师、优秀见习生导师、优秀临床带教教授，校级优秀教师，北京市教育工会教育创新标兵。 主要从事疑难风湿免疫病、尤其是结缔组织病相关肺动脉高压的注册队列和应用基础研究。兼任中国系统性红斑狼疮协作组（CSTAR）、国家风湿病数据中心（CRDC）、中国风湿免疫病医联体联盟（CRCA）秘书长，国家皮肤与免疫疾病临床医学研究中心（NCRC-DID）办公室主任，风湿免疫病学教育部重点实验室主任。作为项目首席承担国家十四五重点研发计划常见多发病防治研究专项项目“系统性红斑狼疮重要脏器损害诊治体系研究”（2021YFC2501300），同时承担十三五重点研发计划课题“系统性红斑狼疮的临床队列及预后研究”（2017YFC0907602），首都协同创新重点项目课题“系统性红斑狼疮创新药物的随机对照研究”，包括国自然面上课题在内的7项结缔组织病相关肺动脉高压的科研基金，并参与国家数据平台建设，国际SICCA、EUSTAR、DETECT等多项研究。代表团队在国际会议发言33次，以第一/通讯作者发表于NEJM，European Respiratory Journal，Arthritis Rheumatology，Autoimmunity Reviews，Pharmacology Therapeutics等杂志发表SCI文章119篇，其中>10分20篇。荣获中华医学会风湿病学会优秀研究奖，东亚风湿病学会议（EAGOR）青年研究者奖，亚太抗风湿病联盟（APLAR）青年临床研究者奖，欧洲抗风湿病联盟（EULAR）旅行奖。
团队简介
Team Profile
李梦涛，北京协和医院风湿免疫科主任，主任医师，博士生/博士后导师，协和学者特聘教授，国家卫生健康突出贡献中青年专家。北京医学会风湿病学分会主任委员，中华医学会风湿病学分会副主任委员，中国医师协会风湿免疫科医师分会副会长兼肺血管/间质病学组组长，亚太抗风湿病联盟（APLAR）系统性红斑狼疮研究组委员。同时担任《中华临床免疫和变态反应杂志》主编，Rheumatology and Immunology Research (RIR)副主编，Autoimmunity Reviews, Journal of Scleroderma and related diseases编委，亚太抗风湿病联盟（APLAR）系统性红斑狼疮研究组委员。一直于北京协和医院接受了全面严格的临床、教学和科研培训，1998年赴美国加利福尼亚大学旧金山医学院交换学习，2012年首批“百人计划”赴美国6家风湿病中心访问交流，2019年中层干部赴美国梅奥诊所“医疗保健领导力”培训。连续被评为优秀住院医师、优秀总住院医师、优秀主治医师、优秀诊断学教师、优秀见习生导师、优秀临床带教教授，校级优秀教师，北京市教育工会教育创新标兵。 主要从事疑难风湿免疫病、尤其是结缔组织病相关肺动脉高压的注册队列和应用基础研究。兼任中国系统性红斑狼疮协作组（CSTAR）、国家风湿病数据中心（CRDC）、中国风湿免疫病医联体联盟（CRCA）秘书长，国家皮肤与免疫疾病临床医学研究中心（NCRC-DID）办公室主任，风湿免疫病学教育部重点实验室主任。作为项目首席承担国家十四五重点研发计划常见多发病防治研究专项项目“系统性红斑狼疮重要脏器损害诊治体系研究”（2021YFC2501300），同时承担十三五重点研发计划课题“系统性红斑狼疮的临床队列及预后研究”（2017YFC0907602），首都协同创新重点项目课题“系统性红斑狼疮创新药物的随机对照研究”，包括国自然面上课题在内的7项结缔组织病相关肺动脉高压的科研基金，并参与国家数据平台建设，国际SICCA、EUSTAR、DETECT等多项研究。代表团队在国际会议发言33次，以第一/通讯作者发表于NEJM，European Respiratory Journal，Arthritis Rheumatology，Autoimmunity Reviews，Pharmacology Therapeutics等杂志发表SCI文章119篇，其中>10分20篇。荣获中华医学会风湿病学会优秀研究奖，东亚风湿病学会议（EAGOR）青年研究者奖，亚太抗风湿病联盟（APLAR）青年临床研究者奖，欧洲抗风湿病联盟（EULAR）旅行奖。
- 研究方向Research Directions
风湿免疫病临床转化及应用基础研究
- 在校研究生Current Graduate Students
硕士研究生 0 名，博士研究生 3 名
- 科研项目Research Projects
| # | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
|---|---|---|---|---|---|
| 1 | 基于多组学研究探索利妥昔单抗治疗系统性红斑狼疮相关肺动脉高压的疗效与机制研究 | 2022-10-01 —— 2025-09-01 | 主持的企业/行业委托重大项目 | 主持人 | |
| 2 | 评价西罗莫司对标准治疗应答不足的活动期系统性红斑狼疮的治疗安全性及有效性研究 | 2020-03-01 —— 2024-03-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 3 | 系统性红斑狼疮重要脏器损害诊治体系研究 | 2021-12-01 —— 2024-11-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 4 | 系统性红斑狼疮的临床队列及预后研究 | 2017-07-01 —— 2020-12-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 5 | 系统性红斑狼疮队列完善及预测模型构建研究 | 2021-12-01 —— 2024-11-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 6 | 协和特聘学者奖励计划 | 2015-11-01 —— 2018-10-31 | 主持的企业/行业委托重大项目 | 主持人 | |
| 7 | 评价西罗莫司对标准治疗应答不足的活动期系统性红斑狼疮的治疗安全性及有效性研究——随机、双盲、安慰剂对照的2期单中心临床研究 | 2020-03-01 —— 2024-03-31 | 105万 | 主持在研的国家或省部级科研项目 | 主持人 |
| 8 | 系统性红斑狼疮相关肺动脉高压易感基因STK11对肺动脉内皮的作用及分子机制研究 | 2023-01-01 —— 2025-12-31 | 主持在研的国家或省部级科研项目 | 主持人 |
- 发表论文Papers
| # | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
|---|---|---|---|---|
| 1 | Chinese Systemic Lupus Erythematosus Treatment and Research Group (CSTAR) Registry XI: gender impact on long-term outcomes | Lupus | 2019-05-01 | 通讯作者 |
| 2 | Clinical characteristics and risk factors of microvascular involvement in primary antiphospholipid syndrome: a longitudinal single-center study in China | LUPUS | 2019-11-01 | 通讯作者 |
| 3 | Chinese SLE Treatment and Research group (CSTAR) registry: Clinical significance of thrombocytopenia in Chinese patients with systemic lupus erythematosus | Plos One | 2019-11-01 | 通讯作者 |
| 4 | Clinical features of transverse myelitis associated with systemic lupus erythematosus | LUPUS | 2020-04-01 | 通讯作者 |
| 5 | Systemic lupus erythematosus associated diffuse alveolar hemorrhage: a single-center, matched case-control study in China | Lupus | 2020-07-01 | 通讯作者 |
| 6 | Characteristics and risk factors of pulmonary embolism in patients with systemic lupus erythematosus: a case control study | Clinical and experimental rheumatology | 2020-09-01 | 通讯作者 |
| 7 | Satisfaction of Patients and Physicians with Treatments for Rheumatoid Arthritis: A Nationwide Survey in China | Patient Prefer Adher. | 2020-06-01 | 通讯作者 |
| 8 | Musculoskeletal ultrasound imaging training, use, and knowledge among rheumatologists in China | Clin Rheumatol | 2020-06-01 | 通讯作者 |
| 9 | Clinical Features and outcomes of neuropsychiatric systemic lupus erythematosus in China | Journal of Immunology Research | 2021-01-15 | 通讯作者 |
| 10 | Clinical characteristics and prognosis of concomitant systemic lupus erythematosus and primary biliary cholangitis | Clin Rheumatol | 2020-10-01 | 通讯作者 |
| 11 | Tofacitinib as a possible treatment for skin thickening in diffuse cutaneous systemic sclerosis | RHEUMATOLOGY | 2021-05-14 | 通讯作者 |
| 12 | Clinical efficacy and safety of sirolimus in systemic lupus erythematosus: a real-world study and meta-analysis | THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE | 2020-09-01 | 通讯作者 |
| 13 | Early Initiation of Anticoagulation Improves the Long-Term Prognosis in Patients With Antiphospholipid Syndrome Associated Portal Vein Thrombosis | frontiers in medicine | 2021-02-04 | 通讯作者 |
| 14 | Activation of Toll-Like Receptor 7 Signaling Pathway in Primary Sjögren’s Syndrome-Associated Thrombocytopenia. | Frontiers in Immunology | 2021-05-05 | 通讯作者 |
| 15 | Predicting risk of pulmonary arterial hypertension in systemic lupus erythematosus: CSTAR cohort study | Arthritis & Rheumatology | 2021-06-09 | 通讯作者 |
| 16 | Validation of the REVEAL Prognostic Models in Systemic Lupus Erythematosus-associated Pulmonary Arterial Hypertension | frontiers in medicine | 2021-03-15 | 通讯作者 |
| 17 | Bone mineral density and microarchitecture among Chinese patients with rheumatoid arthritis: a cross-sectional study with HR-pQCT | ARTHRITIS RESEARCH & THERAPY | 2021-01-15 | 通讯作者 |
| 18 | Chinese SLE Treatment and Research Group (CSTAR) Registry XIII: prevalence and risk factors for chronic scarring alopecia in patients with systemic lupus erythematosus. | ARTHRITIS RESEARCH & THERAPY | 2021-01-15 | 通讯作者 |
| 19 | the role of anti-ribosomal P autoantibodies in the prediction of neuropsychiatric damage in systemic lupus erythematosus based on CSTAR cohort (XIV) | CLINICAL RHEUMATOLOGY | 2022-02-10 | 通讯作者 |
| 20 | Exploring the risk factors and prognosis of transverse myelitis in systemic lupus erythematosus | Therapeutic Advances in Chronic Disease | 2022-05-12 | 通讯作者 |
| 21 | Sirolimus versus tacrolimus for systemic lupus erythematosus treatment: results from a real-world CSTAR cohort study | LUPUS SCIENCE & MEDICINE | 2022-01-01 | 通讯作者 |
| 22 | Prognostic factors of systemic lupus erythematosus patients with pulmonary embolism: An 11-year cohort study | LUPUS | 2022-04-12 | 通讯作者 |
| 23 | Characteristics and risk factors of severe coronary artery disease in systemic lupus erythematosus: A multicenter, Chinese Rheumatism Date Center database study | International Journal of Rheumatic Diseases | 2022-10-01 | 通讯作者 |
| 24 | Renal tubular acidosis and associated factors in patients with primary Sjogren’s syndrome: a registry‐based study | CLINICAL RHEUMATOLOGY | 2022-11-16 | 通讯作者 |
| 25 | Sex differences in systemic lupus erythematosus (SLE): an inception cohort of the Chinese SLE Treatment and Research Group (CSTAR) registry XVII | CHINESE MEDICAL JOURNAL | 2022-09-20 | 通讯作者 |
| 26 | Hyperglobulinemia predicts increased risk of mortality in primary Sjögren's syndrome: based on a Chinese multicentre registry | MOD RHEUMATOL. | 2023-01-23 | 通讯作者 |
| 27 | Risk factors for avascular necrosis in patients with systemic lupus erythematosus: a multi-center cohort study of Chinese SLE Treatment and Research Group (CSTAR) Registry XXII | ARTHRITIS RESEARCH & THERAPY | 2023-05-12 | 通讯作者 |
| 28 | The diagnostic and prognostic value of growth differentiation factor‐15 in systemic lupus erythematosus‐associated pulmonary arterial hypertension | Pulmonary Circulation | 2023-01-23 | 通讯作者 |
| 29 | Treatment of refractory lupus nephritis using leflunomide: A prospective study | Frontiers in Immunology | 2023-05-12 | 通讯作者 |
| 30 | Establishing a Risk Prediction Model for Atherosclerosis in Systemic Lupus Erythematosus | Frontiers in Immunology | 2021-04-16 | 通讯作者 |
| 31 | Wangbi granule as a combination therapy to achieve clinical deep remission in rheumatoid arthritis: protocol for a multicenter, triple-blind, randomised, placebo-controlled trial | CHIN MED J | 2023-02-28 | 通讯作者 |
| 32 | Lupus gut microbiota transplants cause autoimmunity and inflammation. | CLINICAL IMMUNOLOGY | 2021-11-20 | 通讯作者 |
| 33 | Role of JAK-STAT Signaling Pathway in Pathogenesis and Treatment of Primary Sjögren’s Syndrome | CHINESE MEDICAL JOURNAL | 2023-04-26 | 通讯作者 |
| 34 | Progress in the Pathogenesis and Treatment of Neuropsychiatric Systemic Lupus Erythematosus | Journal of Clinical Medicine | 2022-08-24 | 通讯作者 |
| 35 | Immunosuppressive therapy in patients with connective tissue disease-associated pulmonary arterial hypertension: A systematic review. | International Journal of Rheumatic Diseases | 2022-06-14 | 通讯作者 |
| 36 | The treatment strategy of connective tissue disease associated pulmonary arterial hypertension: Evolving into the future. | Pharmacology & therapeutics | 2022-11-01 | 通讯作者 |
| 37 | Relapse rates and risk factors for unfavorable neurological prognosis of transverse myelitis in systemic lupus erythematosus: A systematic review and meta-analysis | AUTOIMMUNITY REVIEWS | 2021-11-16 | 通讯作者 |
| 38 | Primary Sjogren's syndrome is associated with increased risk of malignancies besides lymphoma: A systematic review and meta-analysis. | Autoimmunity reviews | 2022-05-01 | 通讯作者 |
| 39 | Factors Associated With Renal Involvement in Primary Sjogren's Syndrome: A Meta-Analysis | Frontiers in medicine | 2020-11-01 | 通讯作者 |
| 40 | Prevalence, predictors and prognostic benefits of remission achievement in patients with systemic lupus erythematosus: a systematic review | Arthritis Care Res (Hoboken) | 2020-09-01 | 通讯作者 |
| 41 | Relationship between disease activity, organ damage and health-related quality of life in patients with systemic lupus erythematosus: a systemic review and meta-analysis | Autoimmun Rev | 2020-06-01 | 通讯作者 |
| 42 | JAK inhibitors: prospects in connective tissue diseases | Clin Rev Allergy Immunol | 2020-03-01 | 通讯作者 |
| 43 | Remission rate and predictors of remission in patients with rheumatoid arthritis under treat-to-target strategy in real-world studies: a systematic review and meta-analysis | Clin Rheumatol | 2019-03-01 | 通讯作者 |
| 44 | Predictive value of bone marrow megakaryocyte count for immunotherapeutic response in primary Sjögren's syndrome patients with severe immune thrombocytopenia: A single-center case-control study in China | INT J RHEUM DIS | 2023-07-01 | 通讯作者 |
| 45 | The prognosis and management of reclassified systemic lupus erythematosus associated pulmonary arterial hypertension according to 2022 ESC/ERS guidelines. | ARTHRITIS RESEARCH & THERAPY | 2024-05-27 | 通讯作者 |
| 46 | Pathformer: a biological pathway informed transformer for disease diagnosis and prognosis using multi-omics data. | BIOINFORMATICS | 2024-05-02 | 通讯作者 |
| 47 | Protein proöling in systemic sclerosis patients with diòerent pulmonary complications using proteomic antibody microarray | ARTHRITIS RESEARCH & THERAPY | 2024-01-17 | 通讯作者 |
| 48 | Association study identified HLA-DQA1 as a novel genetic risk of systemic lupus erythematosus-associated pulmonary arterial hypertension. | Arthritis & Rheumatology | 2023-10-24 | 通讯作者 |
| 49 | The additional role of anti-nucleosome antibodies in the prediction of renal damage in systemic lupus erythematosus based on CSTAR (XXV) | LUPUS | 2024-06-09 | 通讯作者 |
| 50 | A prognostic model for systemic lupus erythematosus-associated pulmonary arterial hypertension: CSTAR-PAH cohort study | RESPIRATORY RESEARCH | 2023-10-16 | 通讯作者 |
| 51 | Identification of potential susceptibility genes in patients with primary Sj?gren’s syndrome-associated pulmonary arterial hypertension through whole exome sequencing | ARTHRITIS RESEARCH & THERAPY | 2023-09-20 | 通讯作者 |
| 52 | Validation of three prediction models for thrombosis recurrence in antiphospholipid syndrome patients based on a prospective cohort. | RMD open | 2023-07-01 | 通讯作者 |
| 53 | Performance validation of the 2023 American College of Rheumatology/European League Against Rheumatism antiphospholipid syndrome classification criteria in an antiphospholipid syndrome cohort | JOURNAL OF THROMBOSIS AND HAEMOSTASIS | 2024-05-09 | 通讯作者 |
| 54 | Development and external validation of a prediction model for venous thromboembolism in systemic lupus erythematosus | RMD open | 2023-12-01 | 通讯作者 |
| 55 | Anemia and Low Body Mass Index in Axial Spondyloarthritis: Results from ChinaSpA, the Chinese Spondyloarthritis Registry | Rheumatology and Therapy | 2024-04-15 | 通讯作者 |
| 56 | Efficacy and safety of Janus kinase inhibitors in systemic and cutaneous lupus erythematosus: A systematic review and meta-analysis | AUTOIMMUNITY REVIEWS | 2023-10-31 | 通讯作者 |
| 57 | Management of rheumatoid arthritis in China: a study of the implementation of 2019 EULAR recommendations | ANNALS OF THE RHEUMATIC DISEASES | 2022-02-15 | 通讯作者 |
| 58 | Successful treatment of arthritis and rash with tofacitinib in systemic lupus erythematosus: the experience from a single center | ANNALS OF THE RHEUMATIC DISEASES | 2019-04-11 | 通讯作者 |
| 59 | Pulmonary arterial hypertension in systemic lupus erythematosus based on a CSTAR-PAH study: Baseline characteristics and risk factors | Int J Rheum Dis | 2019-05-01 | 第一作者 |
| 60 | CD74 auto-antibodies display little clinical value in Chinese Han population with axial spondyloarthritis | Medicine (Baltimore) | 2020-11-01 | 第一作者 |
| 61 | Long-Term Prognosis of Patients with Systemic Lupus Erythematosus-Associated Pulmonary Arterial Hypertension: CSTAR-PAH Cohort Study | Eur Respir J | 2019-02-01 | 第一作者 |
| 62 | Association between comorbidities and extraglandular manifestations in primary Sjögren’s syndrome: a multicenter cross-sectional study | Clin Rheumatol | 2020-03-01 | 第一作者 |
| 63 | Efficacy and safety of ambrisentan in Chinese patients with connective tissue disease-pulmonary arterial hypertension: a post-hoc analysis | BMC CARDIOVASCULAR DISORDERS | 2020-07-01 | 第一作者 |
| 64 | Comparison of the Efficacy and Safety of Adalimumab (Humira) and the Adalimumab Biosimilar Candidate (HS016) in Chinese Patients with Active Ankylosing Spondylitis: A Multicenter, Randomized, Double-Blind, Parallel, Phase III Clinical Trial | BIODRUGS | 2020-06-01 | 第一作者 |
| 65 | Predicting risk of pulmonary arterial hypertension in systemic lupus erythematosus: CSTAR cohort study | Arthritis & Rheumatology | 2021-06-09 | 第一作者 |
| 66 | Pulmonary arterial hypertension associated with primary Sjogren's syndrome: a multicentre cohort study from China | EUROPEAN RESPIRATORY JOURNAL | 2020-11-19 | 第一作者 |
| 67 | Changes in efficacy indicators for adalimumab biosimilar candidate (HS016) for the treatment of active ankylosing spondylitis at various time points. | Frontiers in Pharmacology | 2020-11-15 | 第一作者 |
| 68 | Sirolimus versus tacrolimus for systemic lupus erythematosus treatment: results from a real-world CSTAR cohort study | LUPUS SCIENCE & MEDICINE | 2022-01-01 | 第一作者 |
| 69 | Evaluation of adalimumab biosimilar candidate (HS016) in Chinese patients with active ankylosing spondylitis based on a health survey: sub-analysis of a phase 3 study. | CLIN RHEUMATOL | 2022-03-01 | 第一作者 |
| 70 | Risk assessment in systemic lupus erythematosus-associated pulmonary arterial hypertension: CSTAR-PAH cohort study | Therapeutic Advances in Chronic Disease | 2022-07-21 | 第一作者 |
| 71 | Comparative efficacy of traditional non-selective NSAIDs and selective cyclo-oxygenase-2 inhibitors in patients with acute gout: a systematic review and meta-analysis | BMJ open | 2020-01-01 | 第一作者 |
| 72 | Comparative Efficacy of Secukinumab Versus Tumor Necrosis Factor Inhibitors for the Treatment of Takayasu Arteritis | Arthritis & Rheumatology | 2023-08-01 | 第一作者 |
- 科研获奖Research Awards
无
- 研究成果Research Findings
| # | 成果类型 | 项目/专利/新品种名称 |
|---|---|---|
| 1 | 出版高水平专著 | 北京协和医院 风湿免疫科疑难病诊断——协和医生临床思维例释 |
| 2 | 出版高水平专著 | 全国高级卫生专业技术资格考试习题集丛书.风湿免疫学习题集 |
| 3 | 出版高水平专著 | 风湿免疫内科学<第3版> |
| 4 | 出版高水平专著 | 中国系统性红斑狼疮发展报告 2020 |
| 5 | 出版高水平专著 | 中国类风湿关节炎发展报告 2020 |
| 6 | 出版高水平专著 | 北京医学会风湿病学分会病例串串烧优秀集锦 |
| 7 | 出版高水平专著 | 系统性红斑狼疮患者教育手册 |
| 8 | 出版高水平专著 | 类风湿关节炎患者教育手册 |
| 9 | 出版高水平专著 | 风湿病诊疗规范 |