导师风采
陈有信
个人信息
Personal Information
- 性别：男
- 导师类型：博导
- 职称：主任医师
- 该职称任职时间：27
联系方式
Contact Information
- 所属院系：北京协和医院
- 所属专业：
- 邮箱 : chenyouxinpumch@163.com
- 工作电话 : 13801025972
个人简介
Personal Profile
陈有信，男，主任医师，教授，博士生导师，历任北京协和医院眼科副主任、常务副主任、主任，中国医学科学院眼底病重点实验室主任。中华医学会眼科学分会常务委员、现任北京医师协会第五届理事会常务理事、北京医师协会眼科专业委员会会长、中国老年保健协会眼保健分会会长、中国老年医学会眼科学分会常委兼秘书长、海峡两岸医药卫生交流协会眼科分会副主任委员、《中华眼科杂志》编委、《BMC眼科杂志》编委、《APJO》编委。 1986年大学毕业，1989年获眼科硕士学位，1993年师从张承芬教授系统学习眼底病的临床及科研，1996年获眼科博士学位。1999年-2001年在美国南加州大学Doheny眼科研究所做视网膜博士后研究。1995年在国内率先开展脉络膜血管的临床及研究工作，并较早开展光动力学治疗及抗VEGF眼内药物注射。三十年来专注于眼底病临床与基础研究，尤其擅长眼底血管性疾患如息肉状脉络膜血管病变、糖尿病视网膜病变、视网膜脱离、黄斑裂孔、黄斑前膜、视网膜中央静脉阻塞、视网膜血管瘤样增生、年龄相关性黄斑变性、眼内肿瘤等疾病的诊治。编译《眼科学》，主编《眼底疾病病例精解-问题导向学习手册》、《视网膜黄斑病变陈有信2020观点》、《视网膜血管性疾病多模影像图谱》、《扫频源光相干断层扫描及血流成像图谱》、《眼科诊疗常规》等专著。参与《眼底病学》（副主编）、《荧光素眼底血管造影》（共同主编）、《现代黄斑疾病诊断治疗学》、《现代眼科检查学》、《糖尿病眼部并发症及治疗》、《老年黄斑变性基础与临床研究》等10几专著的写作、共同主编了《视网膜色素上皮的基础与临床》的写作。翻译出版了《白内障诊治》、《Retinal Vascular disease》、《Retina》第一卷。 2004年被授予中华眼科学会奖，2008年授予亚太眼科学会“杰出服务奖”，2016、2018年授予亚太眼科学会“成就奖”，2018年获得ARVO海外华人视觉及眼科研究者协会“杰出领导力奖”。“息肉状脉络膜血管病变诊疗体系的建立及理论创新”获得2022年华夏医学科技奖二等奖。
团队简介
Team Profile
研究团队目前致力于息肉状脉络膜血管病变发病机制、动物模型构建等研究，此外，团队在人工智能和眼底疾病诊治结合的领域，进行了大量卓有成效的研究。
- 研究方向Research Directions
眼底病学
- 在校研究生Current Graduate Students
硕士研究生 3 名，博士研究生 3 名
- 科研项目Research Projects
| # | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
|---|---|---|---|---|---|
| 1 | 用于抑制脉络膜新生血管的玻璃体内抗VEGF蛋白药物缓释制剂 | 2019-09-01 —— 2020-08-31 | 主持的企业/行业委托重大项目 | 主持人 | |
| 2 | 中国糖尿病视网膜病变人工智能眼底图像标准数据库的建立 | 2018-12-01 —— 2020-12-01 | 主持的企业/行业委托重大项目 | 主持人 | |
| 3 | 《眼科学（双语教材）》 | 2020-07-01 —— 2022-12-31 | 主持的企业/行业委托重大项目 | 主持人 | |
| 4 | 眼底病精准诊治与防控研究 | 2018-01-01 —— 2020-12-31 | 主持的企业/行业委托重大项目 | 主持人 | |
| 5 | 眼科人工智能精准诊疗研究及创新型医疗器械研发 | 2022-10-01 —— 2025-09-01 | 主持的企业/行业委托重大项目 | 主持人 | |
| 6 | 主要致盲性眼底病的人工智能辅助筛查系统研究 | 2019-08-01 —— 2022-08-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 7 | 息肉状脉络膜血管病变的抗血管内皮生长因子治疗反应性与单核苷酸多态性的相关性研究 | 2020-11-01 —— 2023-10-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 8 | 糖尿病视网膜病变辅助诊断软件上市后的临床应用研究与推广 | 2022-11-01 —— 2025-12-31 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 9 | 智能可视化多点眼底光凝仪 | 2018-01-01 —— 2020-12-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 10 | 涡静脉扩张与息肉状脉络膜血管病变发病机制的相关性研究 | 2017-01-03 —— 2020-12-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 11 | 脉络膜静脉高压力下血管内皮细胞剪切应力改变及其介导的炎症反应在息肉状脉络膜血管病变的发病机制研究 | 2023-01-01 —— 2026-12-31 | 主持在研的国家或省部级科研项目 | 主持人 |
- 发表论文Papers
| # | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
|---|---|---|---|---|
| 1 | RANIBIZUMAB VERSUS VERTEPORFIN PHOTODYNAMIC THERAPY IN ASIAN PATIENTS WITH MYOPIC CHOROIDAL NEOVASCULARIZATION BRILLIANCE, a 12-Month, Randomized, Double-Masked Study | RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 2019-10-01 | 第一作者 |
| 2 | Treatment of primary full-thickness macular hole by intravitreal injection of expansile gas | EYE | 2019-01-01 | 通讯作者 |
| 3 | Optical coherence tomography angiography analysis of the choriocapillary layer in treatment-naive diabetic eyes | GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY | 2019-07-01 | 通讯作者 |
| 4 | The occurrence, characteristic, management, and prognosis of retinal pigment epithelium tears in patients with polypoidal choroidal vasculopathy: a retrospective study of 397 patients | Retina | 2020-03-01 | 通讯作者 |
| 5 | Choroidal thickening and pachychoroid in cushing syndrome: correlation with endogenous cortisol level | Retina | 2019-02-01 | 通讯作者 |
| 6 | Five-year real-world outcomes of anti-vascular endothelial growth factor monotherapy versus combination therapy for polypoidal choroidal vasculopathy in a Chinese population: a retrospective study | BMC Ophthalmology | 2019-11-21 | 通讯作者 |
| 7 | Three-dimensional choroidal vascularity index in acute central serous chorioretinopathy using swept-source optical coherence tomography | Graefes Archive for Clinical and Experimental Ophthalmology | 2020-02-01 | 通讯作者 |
| 8 | Noninvasive multimodal imaging in diagnosing polypoidal choroidal vasculoathy | BMC Ophthalmology | 2019-11-16 | 通讯作者 |
| 9 | Comparison of the Repeatability of Macular Vascular Density Measurements Using Four Optical Coherence Tomography Angiography Systems | JOURNAL OF OPHTHALMOLOGY | 2019-11-01 | 通讯作者 |
| 10 | six-year real-world outcomes of antivascular endothelial growth factor monotherapy and combination therapy for various subtypes of polypoidal choroidal vasculopathy | Journal of Ophthalmology | 2019-12-14 | 通讯作者 |
| 11 | Comparison of face-down posturing with nonsupine posturing after macular hole surgery: a meta-analysis | BMC Ophthalmology | 2019-01-28 | 通讯作者 |
| 12 | Utility of a public-available artificial intelligence in diagnosis of polypoidal choroidal vasculopathy | Graefes Archive for Clinical and Experimental Ophthalmology | 2020-01-01 | 通讯作者 |
| 13 | Comparison of OCT and OCTA manifestations among untreated PCV, neovascular AMD, and CSC in Chinese population | International journal of ophthalmology | 2020-01-01 | 通讯作者 |
| 14 | Evaluation of microvascular network with optical coherence tomography angiography (OCTA) in branch retinal vein occulsion (BRVO) | BMC Ophthalmology | 2020-04-19 | 通讯作者 |
| 15 | Prediction of OCT images of short-term response to anti-VEGF treatment for neovascular age-related macular degeneration using generative adversarial network | British Journal of Ophthalmology | 2020-03-26 | 通讯作者 |
| 16 | Comparison of choriocapillary flow density etween fellow eyes of polypoidal choroidal vasculopathy and neovascular age-related macular degeneration | BMC Ophthalmology | 2020-04-22 | 通讯作者 |
| 17 | The association of polypoidal choroidal vasculopathy clinical phenotypes with previously reported genetic markers | Graefes Archive for Clinical and Experimental Ophthalmology | 2020-06-01 | 通讯作者 |
| 18 | Analysis of choroidal morphology and comparison of imaging findings of subtypes of polypoidal choroidal vasculopathy: a new classification system. | International Journal of Ophthalmology | 2020-05-18 | 通讯作者 |
| 19 | Automated diagnoses of age-related macular degeneration and polypoidal choroidal vasculopathy using bi-modal deep convolutional neural networks | British Journal of Ophthalmology | 2020-06-04 | 通讯作者 |
| 20 | Visualization of deep choroidal vasculatures and measurement of choroidal vascular density: a swept-source optical coherence tomography angiography approach | BMC OPHTHALMOLOGY | 2020-08-01 | 通讯作者 |
| 21 | Perioperative anti-vascular endothelial growth factor agents treatment in patients undergoing vitrectomy for complicated proliferative diabetic retinopathy：a network meta-analysis | Scientific Report | 2020-11-01 | 通讯作者 |
| 22 | Progress of artificial intelligence in diabetic retinopathy screening | DIABETES METAB RES REV | 2020-10-29 | 通讯作者 |
| 23 | Transient reduction in macular deep capillary density on optical coherence tomography angiography after phacoemulsification surgery in diabetic patients | BMC OPHTHALMOLOGY | 2020-08-01 | 通讯作者 |
| 24 | Comparison of cytokine levels in the aqueous humor of polypoidal choroidal vasculopathy and neovascular age-related macular degeneration patients | BMC ophthalmology | 2020-01-01 | 通讯作者 |
| 25 | RETINAL DETACHMENT AFTER ACUTE RETINAL NECROSIS AND THE EFFICACIES OF DIFFERENT INTERVENTIONS: A Systematic Review and Metaanalysis | RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 2021-05-01 | 通讯作者 |
| 26 | Early Detection of Microvascular Impairments With Optical Coherence Tomography Angiography in Diabetic Patients Without Clinical Retinopathy: A Meta-analysis | AMERICAN JOURNAL OF OPHTHALMOLOGY | 2021-02-01 | 通讯作者 |
| 27 | Optical Coherence Tomography Parameters Related to Vision Impairment in Patients with Diabetic Macular Edema: A Quantitative Correlation Analysis | Journal of Ophthalmology | 2020-09-27 | 通讯作者 |
| 28 | The polyp regression rate and treatment prognosis of different interventions for polypoidal choroidal vasculopathy: a systematic review and meta-analysis | GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY | 2021-04-01 | 通讯作者 |
| 29 | Choroidal thickening in retinal vein occlusion patients with serous retinal detachment | GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY | 2020-04-01 | 通讯作者 |
| 30 | The characteristics of optic disc pit maculopathy and the efficacy of vitrectomy: a systematic review and meta-analysis | ACTA OPHTHALMOLOGICA | 2021-01-09 | 通讯作者 |
| 31 | Sensitivity and Specificity of Multispectral Imaging For Polypoidal Choroidal Vasculopathy | RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 2021-01-27 | 通讯作者 |
| 32 | Development of a deep-learning system for detection of lattice degeneration, retinal breaks, and retinal detachment in tessellated eyes using ultra-wide-field fundus images: a pilot study | GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY | 2021-02-04 | 通讯作者 |
| 33 | Deep learning-based detection and stage grading for optimising diagnosis of diabetic retinopathy | DIABETES METAB RES REV | 2021-05-01 | 通讯作者 |
| 34 | Ultra-wide field swept-source optical coherence tomography angiography in patients with diabetes without clinically detectable retinopathy | BMC Ophthalmology | 2021-05-01 | 通讯作者 |
| 35 | FOVEA-SPARING VERSUS COMPLETE INTERNAL LIMITING MEMBRANE PEELING IN VITRECTOMY FOR VITREOMACULAR INTERFACE DISEASES: A Systematic Review and Meta-Analysis | RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 2021-06-01 | 通讯作者 |
| 36 | Relationships Between Retinal Vascular Characteristics and Renal Function in Patients With Type 2 Diabetes Mellitus | Translational Vision Science & Technology | 2021-02-05 | 通讯作者 |
| 37 | Optical coherence tomography-based short-term effect prediction of anti-vascular endothelial growth factor treatment in neovascular age-related macular degeneration using sensitive structure guided network | GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY | 2021-06-07 | 通讯作者 |
| 38 | The influence of delayed treatment due to COVID-19 on patients with neovascular age-related macular degeneration and polypoidal choroidal vasculopathy | THER ADV CHRONIC DIS | 2021-06-22 | 通讯作者 |
| 39 | Application of 5G Technology to Conduct Real-Time Teleretinal Laser Photocoagulation for the Treatment of Diabetic Retinopathy | JAMA Ophthalmology | 2021-07-08 | 通讯作者 |
| 40 | The Efficacy and Safety of Ocriplasmin for Patients with Vitreous Macular Traction | ACTA OPHTHALMOLOGICA | 2021-05-21 | 通讯作者 |
| 41 | Automated detection of severe diabetic retinopathy using deep learning method | GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY | 2022-03-01 | 通讯作者 |
| 42 | Three-Dimensional Analysis of Choroidal Vessels in the Eyes of Patients With Unilateral BRVO | Frontiers in Medicine | 2022-04-05 | 通讯作者 |
| 43 | The Validation of Deep Learning-Based Grading Model for Diabetic Retinopathy | Frontiers in Medicine | 2022-05-16 | 通讯作者 |
| 44 | Clinical Features, Diagnosis, Management and Prognosis of Primary Intraocular Lymphoma | FRONTIERS IN ONCOLOGY | 2022-02-03 | 通讯作者 |
| 45 | Macular Bruch's membrane defects and other myopic lesions in high myopia | INTERNATIONAL JOURNAL OF OPHTHALMOLOGY | 2022-03-18 | 通讯作者 |
| 46 | Deep-Learning-Based Hemoglobin Concentration Prediction and Anemia Screening Using Ultra-Wide Field Fundus Images | Frontiers in Cell and Developmental Biology | 2022-05-19 | 通讯作者 |
| 47 | Using artificial intelligence reading label system in diabetic retinopathy grading training of junior ophthalmology residents and medical students | BMC MEDICAL EDUCATION | 2022-04-09 | 通讯作者 |
| 48 | Development and quantitative assessment of deep learning-based image enhancement for optical coherence tomography | BMC OPHTHALMOLOGY | 2022-03-26 | 通讯作者 |
| 49 | Clinical and imaging features of sympathetic ophthalmia and efficacy of the current therapy | ACTA OPHTHALMOLOGICA | 2022-01-27 | 通讯作者 |
| 50 | Application of a 3D-printed eye model for teaching direct ophthalmoscopy to undergraduates | GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY | 2022-01-17 | 通讯作者 |
| 51 | Angiotensin II is a crucial factor in retinal aneurysm formation | Exp Eye Res | 2021-10-29 | 通讯作者 |
| 52 | PUMCH experience and strategy for the management of idiopathic macular hole: a retrospective cohort study | Int Ophthalmol | 2021-11-07 | 通讯作者 |
| 53 | THE INCIDENCE, CHARACTERISTICS, MANAGEMENT, PROGNOSIS, AND CLASSIFICATION OF BREAKTHROUGH VITREOUS HEMORRHAGE SECONDARY TO POLYPOIDAL CHOROIDAL VASCULOPATHY | Retina | 2021-08-01 | 通讯作者 |
| 54 | A Review of Intraocular Biomolecules in Retinal Vein Occlusion: Toward Potential Biomarkers for Companion Diagnostics | Frontiers in Pharmacology | 2022-04-26 | 通讯作者 |
| 55 | Validating automated eye disease screening AI algorithm in community and in-hospital scenarios | Frontiers in Public Health | 2022-07-22 | 通讯作者 |
| 56 | Surgery-related characteristics, efficacy, safety and surgical team satisfaction of three-dimensional heads-up system versus traditional microscopic equipment for various vitreoretinal diseases | GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY | 2022-10-16 | 通讯作者 |
| 57 | Complement 3a Mediates CCN2/CTGF in Human Retinal Pigment Epithelial Cells | Journal of Ophthalmology | 2022-07-30 | 通讯作者 |
| 58 | Publication trends of artificial intelligence in retina in 10 years: Where do we stand? | Frontiers in Medicine | 2022-11-02 | 通讯作者 |
| 59 | Endophthalmitis at a tertiary referral center: Clinical Characteristics and Treatment Outcomes Over Three Decades | Frontiers in Cell and Developmental Biology | 2022-08-08 | 通讯作者 |
| 60 | Different Morphology of Branching Neovascular Network in Polypoidal Choroidal Vasculopathy: A Swept?Source Optical Coherence Tomography Angiography Study | Journal of Clinical Medicine | 2023-01-17 | 通讯作者 |
| 61 | Three-dimensional heads-up system assisted pars plana vitrectomy and subretinal recombinant tissue plasminogen activator injection for submacular hemorrhage | Eye and Vision | 2023-03-01 | 通讯作者 |
| 62 | THREE-DIMENSIONAL HEAD-UP DISPLAY VERSUS STANDARD OPERATING MICROSCOPE FOR VITRECTOMY SURGERY A Systematic Review and Meta-analysis | RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES | 2022-06-01 | 通讯作者 |
| 63 | Lipid accumulation and protein modifications of Bruch's membrane in age-related macular degeneration | International Journal of Ophthalmology | 2021-05-18 | 通讯作者 |
| 64 | Detection rate and diagnostic value of optical coherence tomography angiography in the diagnosis of polypoidal choroidal vasculpothy: a systematic review and meta-analysis | Journal of Ophthalmology | 2019-12-14 | 通讯作者 |
| 65 | Purtscher-like retinopathy in systemic lupus erythematosus: clinical features, risk factors and prognosis | QJM-AN INTERNATIONAL JOURNAL OF MEDICINE | 2023-11-24 | 通讯作者 |
| 66 | Scleral changes in systemic lupus erythematosus patients using swept source optical coherence tomography | Frontiers in Immunology | 2023-11-02 | 通讯作者 |
| 67 | The incidence, risk factors, management and prognosis of postoperative systemic complications after ophthalmic surgery: a retrospective study at a tertiary, academic referral hospital over a decade | ANNALS OF MEDICINE | 2023-10-05 | 通讯作者 |
| 68 | Air tamponade in vitrectomies for primary rhegmatogenous retinal detachment caused by superior breaks | MEDICINE | 2023-10-27 | 通讯作者 |
| 69 | Efficacy and Safety of Biosimilar QL1207 vs. the Reference Aflibercept for Patients with Neovascular Age-Related Macular Degeneration: A Randomized Phase 3 Trial | Ophthalmology and Therapy | 2024-01-01 | 通讯作者 |
| 70 | Comparison of three-dimensional heads-up system versus traditional microscopic system in medical education for vitreoretinal surgeries: a prospective study | BMC Medical Education | 2024-03-01 | 通讯作者 |
| 71 | Differences between young and elderly polypoidal choroidal vasculopathy patients with and without pachychoroid phenotypes. | GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY | 2024-01-17 | 通讯作者 |
| 72 | Evaluation of the First-dose Anti-VEGF Anatomical Response in Polypoidal Choroidal Vasculopathy Patients: Correlation with the Third-dose Response and Risk Factors Analysis | OPHTHALMIC RESEARCH | 2023-12-18 | 通讯作者 |
| 73 | A bioengineered anti-VEGF protein with high affinity and high concentration for intravitreal treatment of wet age-related macular degeneration | Bioengineering & Translational Medicine | 2024-01-01 | 通讯作者 |
| 74 | Advances in multi-modal non-invasive imaging techniques in the diagnosis and treatment of polypoidal choroidal vasculopathy | Frontiers in Medicine | 2023-07-27 | 通讯作者 |
| 75 | Granular cell tumor presenting as an intraocular mass: a case report | BMC OPTHALMOLOGY | 2019-04-25 | 通讯作者 |
| 76 | Purtscher-like retinopathy presented a honeycomb-like pattern in optical coherence topography angiography | BMC Ophthalmology | 2019-11-21 | 通讯作者 |
| 77 | Scattered Multilayered Retinal Hemorrhage Secondary to Anterior Chamber Paracentesis, Mimicking a Hematological Disorder | JAMA Ophthalmology | 2020-12-01 | 通讯作者 |
| 78 | A case of paracentral acute middle maculopathy after small incision lenticule extraction surgery | INTERNATIONAL JOURNAL OF OPHTHALMOLOGY | 2022-01-18 | 通讯作者 |
| 79 | Retinopathy in an Older Adult Man With Waldenstrom Macroglobulinemia | JAMA Ophthalmology | 2022-03-30 | 通讯作者 |
| 80 | Recent Advances in Imaging Polypoidal Choroidal Vasculopathy with Swept-Source Optical Coherence Tomography Angiography | Diagnostics | 2023-08-03 | 通讯作者 |
- 科研获奖Research Awards
| # | 获奖证书编号 | 奖项名称 | 获奖级别 | 获奖类别 | 获奖等级 | 获奖日期 | 颁奖单位 | 本单位是否为第一完成单位 | 完成单位排名 | 本人排序 | 备注 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2022-J106-R1 | 息肉状脉络膜血管病变诊疗体系的建立及理论创新 | 国际级 | 华夏医学科技奖 | 二等奖 | 2022-12-15 | 中国医疗保健国际交流促进会 | 是 |
- 研究成果Research Findings
| # | 成果类型 | 项目/专利/新品种名称 |
|---|---|---|
| 1 | 出版高水平专著 | 眼底疾病病例精解-问题导向学习手册 |
| 2 | 出版高水平专著 | 视网膜黄斑病变陈有信2020观点 |
| 3 | 出版高水平专著 | 视网膜血管性疾病多模影像图谱 |
| 4 | 出版高水平专著 | 扫频源光相干断层扫描及血流成像图谱 |
| 5 | 出版高水平专著 | 眼科诊疗常规 |
| 6 | 获得省部级及以上科研奖励 | 息肉状脉络膜血管病变诊疗体系的建立及理论创新 |
| 7 | 作为主创人员获得授权的发明专利和新品种 | 一种眼科使用的注射特定剂量至特定深度的注射器 |
| 8 | 作为主创人员获得授权的发明专利和新品种 | 裂隙光源 |
| 9 | ||
| 10 | ||
| 11 |