导师风采
马文斌

个人信息

Personal Information

  • 性别:男
  • 导师类型:博导
  • 职称:主任医师
  • 该职称任职时间:19961212

联系方式

Contact Information

  • 所属院系:北京协和医院
  • 所属专业:
  • 邮箱 : mawb2001@hotmail.com
  • 工作电话 : 13701364566

个人简介

Personal Profile

北京协和医院神经外科主任医师,教授,博士研究生导师。主要致力于恶性脑肿瘤的综合治疗和全病程管理,对恶性胶质瘤/转移瘤的手术、化疗、分子靶向治疗、免疫治疗、及耐药复发的治疗等有较深入的研究;在微创神经外科领域,开展多模式影像学融合(如PET/CT,fMRI, MRI, CT)的神经导航引导下的脑肿瘤切除,以及影像引导下-术中电生理检测下-唤醒麻醉下重要皮层及白质纤维束功能区病变切除。目前担任中国抗癌协会脑胶质瘤专业委员会主任委员,中国药促会脑神经药物专业委员会副主任委员,北京医学奖励基金会脑转移瘤专委会主任委员,中国脑转移瘤协作组副组长,曾任中国脑胶质瘤协作组第三任组长。现任中国现代神经疾病杂志编委,中华外科杂志,中华神经外科杂志,中华神经科杂志及中国神经精神疾病杂志审稿专家。 研究经历:在国外研修期间,对垂体瘤的克隆分析研究颇深,在著名杂志《CANCER》上首先报道多激素分泌性垂体泌乳素腺瘤大多数起源于单克隆,并在《Hormone Research》杂志上发表有关垂体TSH腺瘤合并增生的临床及基础研究结果,上述研究对垂体腺瘤的发生研究具有一定的指导意义,为此获日本东北医学会特别奖,获中华医学会联合主办中青年奖学金优秀论文二等奖。2014年卫计委卫生行业专项基金“脑肿瘤分子分类指导个体化诊疗体系的建立和应用推广”项目分课题负责人,后主持国家自然科学基金课题“自杀基因疗法治疗脑胶质瘤的实验研究”,部分成果在第三届中-日-法国际神经外科会议上宣读。目前主要致力于脑胶质瘤和脑转移瘤的临床和基础研究,主持多项国家级、省级、院校及医院课题,并且作为主要研究者指导并开展20余项针对脑胶质瘤的药物临床试验。主持及参与编写《脑胶质瘤技术与进展2011》、《脑肿瘤的化学治疗》、《颅脑肿瘤外科学》、《神经外科诊疗常规》、《中国脑胶质瘤临床管理指南2020》等专著,以及国内多项针对脑胶质瘤的临床诊治指南,主持及参与翻译《脑肿瘤免疫治疗及转化研究》、《中枢神经系统转移性肿瘤》等国外专著,已以第一作者或通讯作者发表SCI论文100余篇,中文核心期刊10余篇。

团队简介

Team Profile

北京协和医院神经外科脑恶性肿瘤团队由马文斌教授和王裕教授共同领导,成员包括6名博士后(2名出站留院,4名在站)、多名硕博士研究生和协和八年制、4加4试点班学生。团队主要致力于脑胶质瘤、脑转移瘤的临床和基础研究,与清华大学、北京航天航空大学、北京交通大学、协和基础医学研究所等院校及机构合作,开展脑胶质瘤多模态影像组学研究、脑胶质瘤发生与耐药研究、植入式肿瘤治疗电场设备研发等研究。

  • 研究方向Research Directions
神经外科-中枢神经系统恶性肿瘤方向
  • 在校研究生Current Graduate Students

硕士研究生 0 名,博士研究生 10 名

  • 科研项目Research Projects
# 项目名称 起止日期 金额 项目类型 本人角色
1中频电场治疗胶质瘤的植入式设备研发2019-09-01 —— 2022-08-3190万元主持的企业/行业委托重大项目主持人
2脑恶性肿瘤精准诊疗关键技术平台的建立和应用2022-10-01 —— 2025-09-01170万主持的企业/行业委托重大项目主持人
3针对间质性胶纸母细胞瘤表型特征的双靶点精准治疗研究2019-10-01 —— 2022-09-0120万主持在研的国家或省部级科研项目主持人
4颅骨植入式肿瘤电场治疗设备治疗胶质母细胞瘤的体内体外研究2022-01-01 —— 2024-12-31100万主持在研的国家或省部级科研项目主持人
  • 发表论文Papers
# 论文题目 期刊名称 发表年份 论文署名
1Fusion Radiomics Features from Conventional MRI Predict MGMT Promoter Methylation Status in Lower Grade GliomasEUROPEAN JOURNAL OF RADIOLOGY2019-12-01通讯作者
2Efficacy and safety of therapies for EGFR-mutant non-small cell lung cancer with brain metastasis: an evidence-based Bayesian network pooled study of multivariable survival analysesAGING-US2020-07-01通讯作者
3Development of a nomogram for prognostic prediction of lower-grade glioma based on alternative splicing signaturesCancer Med-US2020-12-01通讯作者
4F-18-FDG-PET-based Radiomics signature predicts MGMT promoter methylation status in primary diffuse gliomaCANCER IMAGING2019-08-01通讯作者
5Thin-Slice Magnetic Resonance Imaging-Based Radiomics Signature Predicts Chromosomal 1P/19q Co-deletion Status in Grade II and III GliomasFrontiers in Neurology2020-10-01通讯作者
6Radiomics signature based on FDG-PET predicts proliferative activity in primary gliomaCLINICAL RADIOLOGY2019-10-01通讯作者
7Prognostic Prediction Model for Glioblastoma: A Metabolic Gene Signature and Independent External ValidationJournal of Cancer2021-05-01通讯作者
8Machine learning revealed stemness features and a novel stemness-based classification with appealing implications in discriminating the prognosis, immunotherapy and temozolomide responses of 906 glioblastoma patientsBRIEFINGS IN BIOINFORMATICS2021-04-01通讯作者
9Role of Traditional CHO PET Parameters in Distinguishing IDH, TERT and MGMT Alterations in Primary Diffuse GliomasANNALS OF NUCLEAR MEDICINE2021-04-01通讯作者
10investigation of genetic determinants of glioma immune phenotype by integrative immunogenomic scale analysisFrontiers in Immunology2021-06-01通讯作者
11Classification of pediatric gliomas based on immunological profiling: implications for immunotherapy strategiesMolecular Therapy-Oncolytics2021-02-01通讯作者
12Comprehensive ability evaluation and trend analysis of patients with malignant intracranial tumors in the perisurgery periodBrain and Behavior2021-05-31通讯作者
13Systematic identification, development, and validation of prognostic biomarkers involving the tumor-immune microenvironment for glioblastoma.JOURNAL OF CELLULAR PHYSIOLOGY2022-01-01通讯作者
14Clinical updates on gliomas and implications of the 5th edition of the WHO classification of central nervous system tumorsFrontiers in Oncology2023-03-14通讯作者
15An online survival predictor in glioma patients using machine learning based on WHO CNS5 dataFrontiers in Neurology2023-05-19通讯作者
16Grade scoring system reveals distinct molecular subtypes and identifies KIF20A as a novel biomarker for predicting temozolomide treatment efficiency in gliomasJOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY2023-05-29通讯作者
17Spotlights on adult patients with pediatric-type diffuse gliomas in accordance with the 2021 WHO classification of CNS tumorsFrontiers in Neuroscience2023-05-05通讯作者
18Prognostic Prediction Model for Glioblastoma: A Ferroptosis-Related Gene Prediction Model and Independent External ValidationJournal of Clinical Medicine2023-02-08通讯作者
19Single-cell transcriptomic analyses provide insights into the cellular origins and drivers of brain metastasis from lung adenocarcinomaNEURO-ONCOLOGY2023-01-19通讯作者
20Feasibility of evaluating the histologic and genetic subtypes of WHO grade II-IV gliomas by diffusion-weighted imagingBMC NEUROSCIENCE2022-12-05通讯作者
21Prognostic Value of Choline and Other Metabolites Measured Using 1H-Magnetic Resonance Spectroscopy in Gliomas: A Meta-Analysis and Systemic ReviewMetabolites2022-12-05通讯作者
22Recent advances and future challenges of tumor vaccination therapy for recurrent glioblastomaCell Communication and Signaling2023-04-12通讯作者
23Cytomegalovirus and Glioblastoma: A Review of the Biological Associations and Therapeutic StrategiesJournal of Clinical Medicine2022-09-04通讯作者
24Palliative care for patients with glioma: A recent scientometric analysis of the Web of Science in 2022Frontiers in Oncology2022-12-13通讯作者
25Comparative efficacy and safety of therapeutics for elderly glioblastoma patients: A Bayesian network analysisPHARMACOLOGICAL RESEARCH2022-08-11通讯作者
26Immune checkpoint of B7-H3 in cancer: from immunology to clinical immunotherapyJournal of Hematology & Oncology2022-10-25通讯作者
27Imposing Phase II and Phase III Clinical Trials of Targeted Drugs for Glioblastoma: Current Status and ProgressFrontiers in Oncology2021-08-24通讯作者
28NTRK fusions and TRK inhibitors: potential targeted therapies for adult glioblastoma.Frontiers in Oncology2020-11-01通讯作者
29Effects of oncolytic viruses and viral vectors on immunity in glioblastomaGENE THERAPY2020-10-01通讯作者
30Optimal Therapies for Recurrent Glioblastoma: A Bayesian Network Meta-AnalysisFrontiers in Oncology2021-03-01通讯作者
31PD-1/PD-L1 immune checkpoint inhibitors in glioblastoma clinical studies,challenges and potentialHuman Vaccines &Immunotherapeutics2020-07-01通讯作者
32The effect of operations in patients with recurrent diffusse lowgrade glioma :A qualitative systematic reviewClinical Neurology and Neurosurgery2020-05-01通讯作者
33Pretreatment Geriatric Assessments of Elderly Patients with Glioma: Development and ImplicationsAging and Disease2020-03-15通讯作者
34Validation of the prognostic value of 9-gene ATE score for IDH wild-type glioblastomaNEURO-ONCOLOGY2021-05-01通讯作者
35IFN-γ Triggered IFITM2 Expression to Induce Malignant Phenotype in Elderly GBMJOURNAL OF MOLECULAR NEUROSCIENCE2023-10-27通讯作者
36Histological and molecular glioblastoma, IDH-wildtype: a real-world landscape using the 2021 WHO classification of central nervous system tumorsFrontiers in Oncology2023-07-06通讯作者
37Novel insight into histological and molecular astrocytoma, IDH-mutant, Grade 4 by the updated WHO classification of central nervous system tumors.Cancer Medicine2023-09-01通讯作者
38Clinical roles of EGFR amplification in diffuse gliomas: a real-world study using the 2021 WHO classification of CNS tumorsFrontiers in Neuroscience2024-02-26通讯作者
39Artificial neural network identified a 20-gene panel in predicting immunotherapy response and survival benefits after anti-PD1/PD-L1 treatment in glioblastoma patientsCancer Medicine2024-05-18通讯作者
40Identification of TMZ resistance‐associated histone post‐translational modifications in glioblastoma using multi‐omics dataCNS Neuroscience & Therapeutics2024-02-04通讯作者
41Validation of the prognostic value of 9-gene ATE score for IDH wild-type glioblastomaNEURO-ONCOLOGY2021-05-01通讯作者
42Glioma hexokinase 3 positively correlates with malignancy and macrophage infiltrationMETABOLIC BRAIN DISEASE2024-04-30通讯作者
43贝伐珠单抗对复发性高级别胶质瘤患者的疗效的单中心研究中华神经医学杂志2021-02通讯作者
44老年高级别胶质瘤的临床特点和治疗中华神经外科2020-02通讯作者
45脑转移瘤患者单纯手术治疗与手术联合术后脑部放疗对比分析中国现代神经疾病杂志2021-02通讯作者
46基于美国SEER数据库的儿童胶质瘤临床特点和预后分析中国现代神经疾病杂志2021-03通讯作者
47Clinical features, MRI, molecular alternations, and prognosis of astrocytoma based on WHO 2021 classification of central nervous system tumors: A single-center retrospective studyCancer medicine2024-07通讯作者
48Programmed cell death disrupts inflammatory tumor microenvironment (TME) and promotes glioblastoma evolutionCell communication and signaling2024-06通讯作者
49The molecular signature and prognosis of glioma with preoperative intratumoral hemorrhage: a retrospective cohort analysisBMC neurology2024-06通讯作者
  • 科研获奖Research Awards
# 获奖证书编号 奖项名称 获奖级别 获奖类别 获奖等级 获奖日期 颁奖单位 本单位是否为第一完成单位 完成单位排名 本人排序 备注
1202202011P401脑胶质瘤全病程管理体系的建立及应用推广省部级北京医学科技奖二等奖2023-07-26北京医学会11
  • 研究成果Research Findings
# 成果类型 项目/专利/新品种名称
1出版高水平专著脑肿瘤免疫治疗及转化研究
2出版高水平专著中国脑胶质瘤临床管理指南2020
3出版高水平专著颅脑肿瘤外科学
4作为主创人员获得授权的发明专利和新品种植入式电极装置及其制备方法
5获得省部级及以上科研奖励2022年北京医学科技奖二等奖