导师风采
邱玲
个人信息
Personal Information
- 性别：女
- 导师类型：博导
- 职称：研究员
- 该职称任职时间：2001-08-23
联系方式
Contact Information
- 所属院系：北京协和医院
- 所属专业：
- 邮箱 : lingqiubj@aliyun.com
- 工作电话 : 13901338944
个人简介
Personal Profile
邱玲，研究员,博士生导师。 北京协和医学院临床检验诊断学系副主任，北京协和医院检验科主任。 研究方向：生物标志物筛选、应用及检测标准化；质谱技术临床应用；大数据及人工智能在检验医学中的应用等。 主持国家自然科学基金、首发基金重点项目、科技部重点支撑子项目等共17项。作为中国区PI承担IFCC全球参考区间研究项目一项。以第一作者、通讯作者发表一百二十余篇SCI（IF>430分）及百余篇中文核心期刊论著。分别获北京市科技进步奖二等奖、四川省科技进步奖三等奖、河南省科技进步奖二等奖、河南省医学科学技术进步奖一等奖各一项，已获批发明专利16项，牵头体外诊断产品注册试验70余项。获全国民族团结进步先进个人，全国三八红旗手、2021中国最美医生等荣誉。 现担任中国老年医学学会检验医学分会副会长、北京医学会检验分会副主委、CNAS 医学实验室认可主任评审员、国家卫生标准委员临床检验标准专业委员会委员等社会职务。
团队简介
Team Profile
邱玲，研究员,博士生导师。 北京协和医学院临床检验诊断学系副主任，北京协和医院检验科主任。 研究方向：生物标志物筛选、应用及检测标准化；质谱技术临床应用；大数据及人工智能在检验医学中的应用等。 主持国家自然科学基金、首发基金重点项目、科技部重点支撑子项目等共17项。作为中国区PI承担IFCC全球参考区间研究项目一项。以第一作者、通讯作者发表一百二十余篇SCI（IF>430分）及百余篇中文核心期刊论著。分别获北京市科技进步奖二等奖、四川省科技进步奖三等奖、河南省科技进步奖二等奖、河南省医学科学技术进步奖一等奖各一项，已获批发明专利16项，牵头体外诊断产品注册试验70余项。获全国民族团结进步先进个人，全国三八红旗手、2021中国最美医生等荣誉。 现担任中国老年医学学会检验医学分会副会长、北京医学会检验分会副主委、CNAS 医学实验室认可主任评审员、国家卫生标准委员临床检验标准专业委员会委员等社会职务。
- 研究方向Research Directions
质谱临床应用及标准化、大数据及人工智能
- 在校研究生Current Graduate Students
硕士研究生 1 名，博士研究生 5 名
- 科研项目Research Projects
| # | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
|---|---|---|---|---|---|
| 1 | 2022年课程思政项目 | 2022-09-01 —— 2023-09-01 | 主持的企业/行业委托重大项目 | 主持人 | |
| 2 | 基于质谱技术的精准诊断方法研发及标准化应用研究 | 2022-10-01 —— 2025-09-01 | 主持的企业/行业委托重大项目 | 主持人 | |
| 3 | 基于能力胜任的临床检验诊断学学术型研究生模块化培训及清单式考核体系建立及电子化管理初探 | 2019-07-01 —— 2021-12-31 | 主持的企业/行业委托重大项目 | 主持人 | |
| 4 | 羟苯磺酸钙干扰酶法肌酐检测的临床研究及抗干扰试剂盒研发 | 2016-01-01 —— 2018-12-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 5 | 基于临床实验室真实世界数据建立质量控制、参考区间、自动审核及疾病诊断的智能模型 | 2020-07-01 —— 2023-06-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 6 | 基于真实世界数据建立生物参考区间的规范路径及关键步骤差异化算法研究 | 2023-01-01 —— 2026-12-31 | 主持在研的国家或省部级科研项目 | 主持人 |
- 发表论文Papers
| # | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
|---|---|---|---|---|
| 1 | Plasma or serum, which is the better choice for the measurement of metanephrines? | SCAND J CLIN LAB INVEST. | 2021-05-01 | 通讯作者 |
| 2 | Reference intervals for thyroid-stimulating hormone, free thyroxine, and free triiodothyronine in elderly Chinese persons. | CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2019-06-01 | 通讯作者 |
| 3 | identification of microRNA-mRNA networks involved in cisplatin-induced renal tubular epithelial cells injury | Eur J Pharmacol. | 2019-05-01 | 通讯作者 |
| 4 | Rapid liquid chromatography-tandem mass spectrometry method for determination of 24,25(OH)2D and 25OHD with efficient separation of 3-epi analogs. | J Steroid Biochem Mol Biol. | 2019-03-01 | 通讯作者 |
| 5 | Iodine status of euthyroid adults: A cross-sectional, multicenter study. | JOURNAL OF CLINICAL LABORATORY ANALYSIS | 2019-05-01 | 通讯作者 |
| 6 | Development and validation of a simple isotope dilution-liquid chromatography-tandem mass spectrometry method for detecting vitamins A and E in serum and amniotic fluid | INT J MASS SPECTROM | 2019-01-01 | 通讯作者 |
| 7 | Establishment of a rapid and simple liquid chromatography tandem mass spectrometry method for measuring aldosterone in urine | J CHROMATOGR B | 2019-05-01 | 通讯作者 |
| 8 | Effect of sampling time on estimates of thyroid-stimulating hormone, free thyroxine, and free triiodothyronine levels | SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION | 2019-11-01 | 通讯作者 |
| 9 | Nationwide chinese study for establishing reference intervals for thyroid hormones and related tests | CLINICA CHIMICA ACTA | 2019-06-11 | 通讯作者 |
| 10 | Data mining: Biological and temporal factors associated with blood cardiac troponin I concentration in a Chinese population | CLINICA CHIMICA ACTA | 2019-08-01 | 通讯作者 |
| 11 | rapid liquid chromatography-tandem mass spectrometry to determine very-long-chain fatty acids in human and to establish reference intervals for the chineses population | CLINICA CHIMICA ACTA | 2019-04-08 | 通讯作者 |
| 12 | Comparative analysis of the serum proteome profiles of thyroid cancer: An initial focus on the lipid profile | ONCOLOGY LETTERS | 2019-09-01 | 通讯作者 |
| 13 | Establishing thresholds and effects of gender, age, and season for thyroglobulin and thyroid peroxidase antibodies by mining real-world big data | CLINICAL BIOCHEMISTRY | 2019-12-01 | 通讯作者 |
| 14 | Distribution of free 25OHD in elderly population based on LC-MS/MS | JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2020-06-01 | 通讯作者 |
| 15 | Clinical diagnostic performance of a fully automated TSIimmunoassay vs. that of an automated anti-TSHR immunoassay for Graves’ disease: a Chinese multicenter study | ENDOCRINE | 2020-06-01 | 通讯作者 |
| 16 | Reference Intervals for Thyroid-Associated Hormones and the Prevalence of Thyroid Diseases in the Chinese Population | ANN LAB MED. | 2020-08-06 | 通讯作者 |
| 17 | Comparison of three different chemiluminescence assays and a rapid liquid chromatography tandem mass spectrometry method for measuring serum aldosterone | CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2020-01-01 | 通讯作者 |
| 18 | Establishment of variation source and age-related reference interval models for 22 common biochemical analytes in older people using real-world big data mining | Age and ageing | 2020-11-01 | 通讯作者 |
| 19 | Validation of an approach using only patient big data from clinical laboratories to establish reference intervals for thyroid hormones based on data mining | CLINICAL BIOCHEMISTRY | 2020-06-01 | 通讯作者 |
| 20 | Rapid inductively coupled plasma mass spectrometry method to determine iodine in amniotic fluid, breast milk and cerebrospinal fluid | CLINICAL BIOCHEMISTRY | 2020-08-01 | 通讯作者 |
| 21 | Data mining seasonal fluctuations and associations between thyroid stimulating hormone and lipid profiles | CLINICA CHIMICA ACTA | 2020-03-06 | 通讯作者 |
| 22 | Sources of variation evaluation of 24,25(OH)2D levels and the ratio of 250HD to 24,25(OH)2D in apparently healthy Chinese adults: a multicenter cross-sectional study | JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY | 2019-09-01 | 通讯作者 |
| 23 | Establishing reference intervals for urine and serum iodine levels: A nationwide multicenter study of a euthyroid Chinese population | CLINICA CHIMICA ACTA | 2020-03-01 | 通讯作者 |
| 24 | Comparison of Six Automated Immunoassays With Isotope-Diluted Liquid Chromatography-Tandem Mass Spectrometry for Total Thyroxine Measurement | ANNALS OF LABORATORY MEDICINE | 2019-07-01 | 通讯作者 |
| 25 | Association between lipoprotein(a) concentration and the risk of stroke in the Chinese Han population: a retrospective case-control study | ANNALS OF TRANSLATIONAL MEDICINE | 2020-03-01 | 通讯作者 |
| 26 | Effects of calcium dobesilate (CaD) interference on serum creatinine measurements: a national External Quality Assessment (EQA)-based educational survey of drug-laboratory test interactions | CLINICAL CHEMISTRY AND LABORATORY MEDICINE | 2020-08-01 | 通讯作者 |
| 27 | Effect of sample size and the traditional parametric, nonparametric, and robust methods on the establishment of reference intervals: Evidence from real world data | CLINICAL BIOCHEMISTRY | 2021-03-01 | 通讯作者 |
| 28 | Novel circulating protein biomarkers for thyroid cancer determined through data-independent acquisition mass spectrometry | PeerJ | 2020-07-01 | 通讯作者 |
| 29 | Validation of an improved liquid chromatography tandem mass spectrometry method for rapid and simultaneous analysis of plasma catecholamine and their metabolites | JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2019-10-01 | 通讯作者 |
| 30 | The effect of ALDH2 rs671 gene mutation on clustering of cardiovascular risk factors in a big data study of Chinese population:association differ between the sexes | BMC CARDIOVASCULAR DISORDERS | 2020-12-01 | 通讯作者 |
| 31 | Analysis of gender-specific associations between aldehyde dehydrogenase 2 (ALDH2) rs671 genetic polymorphisms and serum uric acid levels in Han Chinese | Annals of Translational Medicine | 2021-05-01 | 通讯作者 |
| 32 | An evaluation of urine and serum iodine status in the population of Tibet, China No longer an iodine-deficient region | NUTRITION | 2021-02-01 | 通讯作者 |
| 33 | Establishment of Early Pregnancy Related Thyroid Hormone Models and Reference Intervals for Pregnant Women in China Based on Real World Dat | HORMONE AND METABOLIC RESEARCH | 2021-04-14 | 通讯作者 |
| 34 | Establishment of Reference Interval and Aging Model of Homocysteine Using Real-World Data | FRONTIERS IN CARDIOVASCULAR MEDICINE | 2022-06-30 | 通讯作者 |
| 35 | A robust method for simultaneous measurement of serum 25(OH)D, 1,25(OH)(2)D, and 24,25(OH)(2)D by liquid chromatography-tandem mass spectrometry with efficient separation of 3-epi analogs, 23R,25(OH)(2)D-3, and 4 beta,25(OH)(2)D-3 | JOURNAL OF MASS SPECTROMETRY | 2022-01-01 | 通讯作者 |
| 36 | An automated magnetic bead extraction method for measuring plasma metanephrines and 3-methoxytyramine using liquid chromatography tandem mass spectrometry | ANALYTICAL AND BIOANALYTICAL CHEMISTRY | 2022-03-02 | 通讯作者 |
| 37 | Long-term ambient PM(2.5) exposure associated with cardiovascular risk factors in Chinese less educated population | BMC PUBLIC HEALTH | 2021-12-10 | 通讯作者 |
| 38 | Predicting Elevated TSH Levels in the Physical Examination Population With a Machine Learning Model. | Frontiers in Endocrinology | 2022-02-01 | 通讯作者 |
| 39 | Comparison of glycation degrees of HbG-Coushatta and HbG-Taipei with HbA using liquid chromatography with tandem mass spectrometry | Clinica Chimica Acta | 2021-07-02 | 通讯作者 |
| 40 | Evaluation of bone metabolism-associated biomarkers in Tibet, China | J Clin Lab Anal | 2021-09-30 | 通讯作者 |
| 41 | Analytical and Clinical Performance of a Liquid Chromatography-Tandem Mass Spectrometry Method for Measuring Gastrin Subtypes G34 and G17 in Serum | CLINICAL CHEMISTRY | 2021-09-01 | 通讯作者 |
| 42 | Oncogene or tumor suppressor gene: An integrated pan-cancer analysis of NBPF1 | Frontiers in Endocrinology | 2022-08-17 | 通讯作者 |
| 43 | High-throughput analysis of total homocysteine and methylmalonic acid with the efficiency to separate succinic acid in serum and urine via liquid chromatography tandem mass spectrometry. | JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2022-02-11 | 通讯作者 |
| 44 | Establishing reference intervals for vitamins A and E in Chinese elderly people using liquid chromatography-tandem mass spectrometry | JOURNAL OF CLINICAL LABORATORY ANALYSIS | 2021-04-01 | 通讯作者 |
| 45 | An innovative approach based on real-world big data mining for calculating the sample size of the reference interval established using transformed parametric and non-parametric methods | BMC Medical Research Methodology | 2022-10-29 | 通讯作者 |
| 46 | Validation and comparison of five data mining algorithms using big data from clinical laboratories to establish reference intervals of thyroid hormones for older adults | CLINICAL BIOCHEMISTRY | 2022-09-01 | 通讯作者 |
| 47 | Analysis of two intestinal bacterial metabolites (trimethylamine N-oxide and phenylacetylglutamine) in human serum samples of patients with T2DM and AMI using a liquid chromatography tandem mass spectrometry method | CLINICA CHIMICA ACTA | 2022-11-01 | 通讯作者 |
| 48 | A robust LC-MS/MS method to measure 8-oxoGuo, 8-oxodG, and NMN in human serum and urine | ANALYTICAL BIOCHEMISTRY | 2022-10-29 | 通讯作者 |
| 49 | Comparison of the profiles of patients defined by age-adapted and fixed threshold CKD criteria: a nationwide, cross-sectional study | Clinical Kidney Journal | 2022-11-27 | 通讯作者 |
| 50 | Utilization of five data mining algorithms combined with simplified preprocessing to establish reference intervals of thyroid-related hormones for non-elderly adults | BMC Medical Research Methodology | 2023-05-02 | 通讯作者 |
| 51 | Reference intervals for LC-MS /MS measurements of plasma renin activity, aldosterone, angiotensin II, and 24-hour urinary aldosterone in Northern Chinese Han population | CLINICA CHIMICA ACTA | 2023-03-27 | 通讯作者 |
| 52 | Novel Magnetic-Bead-Assisted Sequential Extraction Method for Liquid Chromatography-Mass Spectrometry (MS)/MS of Components with Diverse Properties: Gastrin Determination as a Case Study | ANALYTICAL CHEMISTRY | 2022-12-29 | 通讯作者 |
| 53 | Development and clinical evaluation of an online automated quality control system for improving laboratory quality management | CLINICA CHIMICA ACTA | 2023-02-15 | 通讯作者 |
| 54 | Establishing and Verifying a Robust Liquid Chromatography-Tandem Mass Spectrometry Method to Simultaneously Measure Seven Androgens Present in Plasma Samples | Separations | 2022-12-21 | 通讯作者 |
| 55 | Nightshift work can induce oxidative DNA damage: a pilot study | BMC PUBLIC HEALTH | 2023-06-15 | 通讯作者 |
| 56 | Research in the genetics of pheochromocytoma and paraganglioma: a bibliometric analysis from 2002 to 2022 | CLINICAL AND EXPERIMENTAL MEDICINE | 2023-04-27 | 通讯作者 |
| 57 | Molecular analysis of 12 Chinese patients with 11β-hydroxylase deficiency and in vitro functional study of 20 CYP11B1 missense variants | FASEB JOURNAL | 2023-04-01 | 通讯作者 |
| 58 | Data mining: traditional spring festival associated with hypercholesterolemia | BMC Cardiovascular Disorders | 2021-11-06 | 通讯作者 |
| 59 | Gender and age-specific reference intervals of common biochemical analytes in Chinese population: Derivation using real laboratory data | Journal of Medical Biochemistry | 2020-09-01 | 通讯作者 |
| 60 | Copeptin with high-sensitivity cardiac troponin to rule out non-ST-elevation myocardial infarction early on: A systematic review and meta-analysis | CLINICAL BIOCHEMISTRY | 2023-02-23 | 通讯作者 |
| 61 | Reasons and Resulotions for Variant Interpretation Inconsistency | HUMAN MUTATION | 2023-05-22 | 通讯作者 |
| 62 | How far is the goal of applying β-amyloid in cerebrospinal fluid for clinical diagnosis of Alzheimer's disease with standardization of measurements? | CLINICAL BIOCHEMISTRY | 2023-02-01 | 通讯作者 |
| 63 | High Thyrotropin Levels and Risk of Mortality in the Elderly With Subclinical Hypothyroidism: A Systematic Review and Meta-analysis | Endocrine Practice | 2023-05-16 | 通讯作者 |
| 64 | Review on the roles of specific cell-derived exosomes in Alzheimer's disease | Frontiers in Neuroscience | 2022-07-28 | 通讯作者 |
| 65 | Copeptin as a Diagnostic and Prognostic Biomarker in Cardiovascular Diseases | Frontiers in Cardiovascular Medicine | 2022-07-04 | 通讯作者 |
| 66 | Effect of Vitamin D Supplementation on Glycose Homeostasis and Islet Function in Vitamin D Deficient or Insufficient Diabetes and Prediabetes: A Systematic Review and Meta-Analysis | JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION | 2021-05-01 | 通讯作者 |
| 67 | Real-world big-data studies in laboratory medicine: Current status, application, and future considerations | CLINICAL BIOCHEMISTRY | 2020-10-01 | 通讯作者 |
| 68 | Association between FIB-4, all-cause mortality, cardiovascular mortality, and cardiovascular disease risk among diabetic individuals: NHANES 1999-2008 | Frontiers in Cardiovascular Medicine | 2023-09-25 | 通讯作者 |
| 69 | Automated magnetic-bead-assisted sequential extraction technology for simultaneous detection of Aβ1-42 and Aβ1-40 in cerebrospinal fluid: An advance toward fully automated liquid chromatography-tandem mass spectrometry method | JOURNAL OF CHROMATOGRAPHY A | 2024-01-04 | 通讯作者 |
| 70 | A comprehensive LC-MS/MS method for the simultaneous measurement of 24 adrenal steroids: From research to clinical practice | JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2024-01-19 | 通讯作者 |
| 71 | Integrated identification-quantification (ID-Quant) workflow utilizing UPLC-QTOF-MS for the therapeutic drug monitoring of multi-component antibiotics without pure standards: Validation using teicoplanin | JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2024-04-28 | 通讯作者 |
| 72 | Molecular characterization and functional roles of circulating cell-free extrachromosomal circular DNA | CLINICA CHIMICA ACTA | 2024-03-15 | 通讯作者 |
| 73 | Thyroid stimulating receptor autoantibodies | CLIN CHIM ACTA | 2024-04-30 | 通讯作者 |
| 74 | Steroid profiling in adrenal disease | CLINICA CHIMICA ACTA | 2024-01-15 | 通讯作者 |
| 75 | Liquid chromatography-tandem mass spectrometry in fat-soluble vitamin deficiency | CLINICA CHIMICA ACTA | 2023-08-01 | 通讯作者 |
| 76 | Evolution of LC-MS/MS in clinical laboratories | CLINICA CHIMICA ACTA | 2024-03-01 | 通讯作者 |
| 77 | Development of next-generation reference interval models to establish reference intervals based on medical data: current status, algorithms and future consideration | CRITICAL REVIEWS IN CLINICAL LABORATORY SCIENCES | 2024-05-18 | 通讯作者 |
| 78 | M-protein detection by mass spectrometry for minimal residual disease in multiple myeloma | CLINICA CHIMICA ACTA | 2024-01-01 | 通讯作者 |
| 79 | Variations in Blood Copper and Possible Mechanisms During Pregnancy | BIOLOGICAL TRACE ELEMENT RESEARCH | 2023-09-30 | 通讯作者 |
| 80 | Research trends and hotspots of glial fibrillary acidic protein in body fluid for Alzheimer’s disease: A bibliometric analysis | Frontiers in Aging Neuroscience | 2023-09-27 | 通讯作者 |
| 81 | In Reply to LC-MS/MS Peptide Assay Validation: A Plea for Robust Stability Studies | CLINICAL CHEMISTRY | 2022-05-18 | 通讯作者 |
| 82 | Prevalence of metabolic syndrome among ethnic groups in China. | BMC PUBLIC HEALTH | 2020-03-06 | 第一作者 |
- 科研获奖Research Awards
无
- 研究成果Research Findings
| # | 成果类型 | 项目/专利/新品种名称 |
|---|---|---|
| 1 | 出版高水平专著 | 老年常见疾病实验室诊断及检验路径 |
| 2 | 出版高水平专著 | 临床检验仪器（第3版） |
| 3 | 出版高水平专著 | Henry临床实验诊断学 |
| 4 | 出版高水平专著 | 女性生殖系统与乳腺疾病 |
| 5 | 出版高水平专著 | 维生素D与临床 |
| 6 | 出版高水平专著 | 医学实验室ISO 15189认可迎检思路与申请路径 |
| 7 | 出版高水平专著 | 全国高级卫生专业技术资格考试指导 |
| 8 | 出版高水平专著 | 临床医学检验习题集 |
| 9 | 出版高水平专著 | 检验医学科住院医师规范化培训课程 |
| 10 | 出版高水平专著 | 协和肾上腺外科学 |
| 11 | 作为主创人员获得授权的发明专利和新品种 | 基于质谱技术的内分泌代谢病精准检测平台构建与推广应用 |
| 12 | 作为主创人员获得授权的发明专利和新品种 | 用于测定尿酸的试剂盒和方法 |
| 13 | 作为主创人员获得授权的发明专利和新品种 | 一种用于测定肌酐的试剂盒和方法 |
| 14 | 作为主创人员获得授权的发明专利和新品种 | A Kit and Method for Detecting Creatinine（德国） |
| 15 | 作为主创人员获得授权的发明专利和新品种 | 用于测定总胆固醇的试剂盒和方法 |
| 16 | 作为主创人员获得授权的发明专利和新品种 | 液相色谱串联质谱测定样品中游离维生素D的方法 |
| 17 | 作为主创人员获得授权的发明专利和新品种 | 一种检测嗜铬细胞瘤和副神经节瘤致病基因的扩增引物组及其应用 |
| 18 | 作为主创人员获得授权的发明专利和新品种 | 同时检测硫酸化及未硫酸化胃泌素G17的方法及其检测试剂盒 |
| 19 | 作为主创人员获得授权的发明专利和新品种 | 一种医学检测数据误差识别模型构建方法与装置 |