导师风采
陈兴明
个人信息
Personal Information
- 性别：男
- 导师类型：博导
- 职称：主任医师
- 该职称任职时间：20150901
联系方式
Contact Information
- 所属院系：北京协和医院
- 所属专业：
- 邮箱 : xingming.chen@vip.163.com
- 工作电话 : 01069152720
个人简介
Personal Profile
陈兴明，中国医学科学院北京协和医院耳鼻咽喉头颈外科副主任，主任医师，教授，博士研究生导师。1996年毕业于白求恩医科大学临床医学系，毕业后分配至北京协和医院工作至今。2002年获得中国协和医科大学博士研究生学历和医学博士学位。主要从事喉癌、下咽癌、口咽癌、甲状腺癌等头颈肿瘤的临床及基础研究，尤其擅长头颈肿瘤的功能保留性手术及晚期头颈肿瘤的综合治疗，其中巨大气管缺损的修复技术处于国际领先水平。任中华医学会耳鼻咽喉头颈外科学分会头颈外科学组委员，中国中西医结合学会头颈肿瘤专家委员会委员，北京医学会肿瘤学分会委员，泛亚洲太平洋地区面部整形美容外科学会委员，国际头颈肿瘤流行病学协作组成员。于2007－2008年在美国Memorial Sloan-Kettering Cancer Center 头颈外科和M.D. Anderson Cancer Center 头颈外科及流行病学系做高级访问学者，学习掌握头颈肿瘤的流行病学研究方法。负责承担国家自然科学基金、科技部基础资源调查专项、中国医学科学院医学与健康科技创新工程、中国医学科学院基础与临床联合攻关项目、卫生部重点实验室面上项目、北京协和医院临床研究专项专科提升项目等课题多项，目前拥有科研总经费1000余万元。已建立国内最大规模的头颈肿瘤组织样本库和数据库，正在建设近10万人的自然人群队列及其口腔微生物数据平台，在《Annals of Oncology》(IF 50.5)、《Cancer Research》、《Cancer》、《Oncoimmunology》、《Carcinogenesis》、《Head and Neck》、《Journal of Translational Medicine》、《Journal of Surgical Oncology》、《Clinical Translational Oncology》等专业杂志上发表SCI论著30余篇，影响因子总计超过150分。
团队简介
Team Profile
团队目前有副主任医师3名，主治医师2名，临床博士后1名，博士生2名，研究生2名。团队长期从事喉癌、下咽癌、口咽癌等头颈肿瘤的临床和基础研究，熟练掌握流行病学分析方法等，研究团队成员有扎实的科研基础，曾以第一作者发表SCI及核心期刊论著多篇。
- 研究方向Research Directions
头颈肿瘤的临床和基础研究、HPV相关头颈肿瘤的流行病学系列研究、口腔微生物与疾病的关联研究
- 在校研究生Current Graduate Students
硕士研究生 2 名，博士研究生 2 名
- 科研项目Research Projects
| # | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
|---|---|---|---|---|---|
| 1 | 国民重要生理指标参考值范围研究，子任务：国民主要临床表型参数本底调查 | 2021-10-01 —— 2025-12 | 920.0 | 主持在研的国家或省部级科研项目 | 主持者 |
| 2 | 我国不同人群基本生理参数检测和应用研究 | 2022-10-01 —— 2027-09-01 | 169 | 主持在研的国家或省部级科研项目 | 主持人 |
| 3 | 基于口腔微生物构建头颈鳞癌疾病风险和复发预测模型的研究 | 2023-12 —— 2025-11 | 50 | 主持在研的国家或省部级科研项目 | 主持人 |
- 发表论文Papers
| # | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
|---|---|---|---|---|
| 1 | 头颈部髓外浆细胞瘤17例临床分析 | 中国实验诊断学 | 2022-06-14 | 陈兴明 |
| 2 | 成人头颈部朗格汉斯细胞组织细胞增生症的临床特征 | 中国实验诊断学 | 2022-06-14 | 陈兴明 |
| 3 | Papillary thyroglossal duct carcinoma: report of nine cases and review of literature | INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY | 2022-06-14 | 陈兴明 |
| 4 | Matched-pair analysis of survival in the patients with T3 laryngeal squamous cell carcinoma treated with supracricoid partial laryngectomy or total laryngectomy | ONCOTARGETS AND THERAPY | 2022-06-14 | 陈兴明 |
| 5 | 晚期扁桃体鳞状细胞癌手术治疗与非手术治疗的疗效比较 | 中华耳鼻咽喉头颈外科杂志 | 2022-06-14 | 陈兴明 |
| 6 | Circular RNA Expression Profile in Laryngeal Squamous Cell Carcinoma Revealed by Microarray | CELLULAR PHYSIOLOGY AND BIOCHEMISTRY | 2022-06-14 | 陈兴明 |
| 7 | Human Papillomavirus Seropositivity Synergizes with MDM2 Variants to Increase the Risk of Oral Squamous Cell Carcinoma | Cancer Research | 2022-06-14 | 陈兴明 |
| 8 | Prognostic Role of Epidermal Growth Factor Receptor in Head and Neck Cancer: A Meta-Analysis | Journal of Surgical Oncology | 2022-06-14 | 陈兴明 |
| 9 | 头颈部黏膜相关淋巴组织淋巴瘤的临床特征 | 临床耳鼻咽喉头颈外科杂志 | 2022-06-14 | 陈兴明 |
| 10 | Laryngeal Neuroendocrine Carcinomas: A Retrospective Study of 14 Cases | BioMed research international | 2022-06-14 | 陈兴明 |
| 11 | HPV16 DNA and integration in normal and malignant epithelium: implications for the etiology of laryngealsquamous cell carcinoma | ANNALS OF ONCOLOGY | 2022-06-14 | 陈兴明 |
| 12 | 以急性化脓性甲状腺炎为首发症状的先天性梨状窝瘘的临床诊疗 | 临床耳鼻咽喉头颈外科杂志 | 2022-06-14 | 陈兴明 |
| 13 | A novel classification of tracheal defects and the reconstruction strategies: a retrospective study based on 106 cases. | WORLD J OTORHINOLARYNGOL HEAD NECK SURG | 2022-06-14 | 陈兴明 |
| 14 | p73 G4C14-to-A4T14 Polymorphism and Risk of Human Papillomavirus-associated Squamous Cell Carcinoma of the Oropharynx in Never Smokers and Never Drinkers | Cancer | 2022-06-14 | 陈兴明 |
| 15 | 倾向性评分匹配分析口咽癌PD-L1的表达与HPV感染及预后的相关性研究 | 中国实验诊断学 | 2022-06-14 | 陈兴明 |
| 16 | Combined effects of the p53 codon 72 and p73 G4C14-to-A4T14 polymorphisms on the risk of HPV16-associated oral cancer in never-smokers | Carcinogenesis | 2022-06-14 | 陈兴明 |
| 17 | Bamboo nodes of the vocal cords | CANADIAN MEDICAL ASSOCIATION JOURNAL | 2022-06-14 | 陈兴明 |
| 18 | Peripheral primitive neuroectodermal tumors: a retrospective analysis of 89 cases and literature review | Oncology Letters | 2019-08-22 | 通讯作者 |
| 19 | Prognostic implications of human papillomavirus status and p16 expression in laryngeal squamous cell carcinoma | HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2019-12-01 | 通讯作者 |
| 20 | Prognostic implications of human papillomavirus type 16 status in non-oropharyngeal head and neck cancer: a propensity score matching analysis | ANNALS OF TRANSLATIONAL MEDICINE | 2019-12-01 | 通讯作者 |
| 21 | The prognostic significance of tumor deposits in patients with head and neck squamous cell carcinomas | Annals of Translational Medicine | 2021-03-01 | 通讯作者 |
| 22 | Postoperative Concurrent Chemoradiotherapy versus Postoperative Radiotherapy Alone for Larynx Squamous Cell Carcinoma Patients with Lymphovascular Invasion: A Propensity Score Matching Study | CANCER MANAGEMENT AND RESEARCH | 2020-05-01 | 通讯作者 |
| 23 | Extramedullary Plasmacytoma: Long-Term Clinical Outcomes in a Single-Center in China and Literature Review | ENT-EAR NOSE & THROAT JOURNAL | 2021-04-01 | 通讯作者 |
| 24 | Tracheal window resection and reconstruction via sternocleidomastoid flap for invasive thyroid carcinoma | INTERACTIVE CARDIOVASCULAR AND THORACIC SURGERY. | 2021-07-13 | 通讯作者 |
| 25 | Perineural Invasion as a Prognostic Factor in Laryngeal Squamous Cell Cancer: A Matched-Pair Survival Analysis | Cancer Invest | 2021-10-21 | 通讯作者 |
| 26 | Use of Propensity Score Matching to Compare Short Outcomes from Transoral and External Surgical Approaches in Patients with Deep-Lobe Parotid Pleomorphic Adenomas | Current oncology | 2021-08-18 | 通讯作者 |
| 27 | Association between pathological differentiation and survival outcomes of patients with laryngeal squamous cell carcinoma | EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY | 2022-09-01 | 通讯作者 |
| 28 | Oncological outcomes from surgical vs. non-surgical treatments for advanced hypopharyngeal squamous cell carcinoma: a surveillance, epidemiology,Oncological outcomes from surgical vs. non-surgical treatments for advanced hypopharyngeal squamous cell carcinoma: a surveillance, epidemiology, and end results-based study | Clinical & Translational Oncology | 2022-12-01 | 通讯作者 |
| 29 | Clinical characteristics of paraneoplastic syndromes in patients with head and neck cancer | Laryngoscope Investigative Otolaryngology | 2022-07-06 | 通讯作者 |
| 30 | A preliminary biomechanical study on trachea reconstruction surgery using the clavicular periosteum | Frontiers in Bioengineering and Biotechnology | 2023-01-17 | 通讯作者 |
| 31 | Correlation of immune makers with HPV 16 infections and the prognosis in oropharyngeal squamous cell carcinoma | Clinical Oral Investigations | 2023-03-08 | 通讯作者 |
| 32 | Matched-pair analysis of survival in patients with poorly differentiated versus well and moderately differentiated hypopharyngeal squamous cell carcinoma | MEDICINE | 2022-07-08 | 通讯作者 |
| 33 | Expression of OLR1 gene on tumor-associated macrophages of head and neck squamous cell carcinoma, and its correlation with clinical outcome | OncoImmunology | 2023-04-18 | 通讯作者 |
| 34 | Oral-microbiome-derived signitures enable non-invasive diagnosis of laryngeal cancers | Journal of Translational Medicine | 2023-07-05 | 通讯作者 |
| 35 | Prevalence and risk factors of oral human papillomavirus infection among 4212 healthy adults in Hebei, China | BMC INFECTIOUS DISEASES | 2023-11-08 | 通讯作者 |
| 36 | Effect of COVID-19 on the charactersitics and outcome of patients who have otitis media with effusion: a case-control study | Head & Face Medicine | 2024-05-10 | 通讯作者 |
| 37 | Sleeve resection with end-to-end anastomosis in the reconstruction of tracheal defects exceeding six rings: a clinical feasibility study and safety assessment | Frontiers in Surgery | 2024-04-12 | 通讯作者 |
| 38 | Epidemiology of Oral Human Papillomavirus Infection among Diverse Chinese Adults in Typical Areas of China: Findings from the DLCC Study | CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION | 2023-11-01 | 通讯作者 |
| 39 | Presence of SARS-CoV-2 in middle ear fluid and characterization of otitis media with effusion in patients with COVID-19 | INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES | 2023-11-01 | 通讯作者 |
| 40 | Prevalence and risk factors of oral human papillomavirus infection among 4212 healthy adults in Hebei, China | BMC Infectious Diseases | 2023-11 | 通讯作者 |
- 科研获奖Research Awards
| # | 获奖证书编号 | 奖项名称 | 获奖级别 | 获奖类别 | 获奖等级 | 获奖日期 | 颁奖单位 | 本单位是否为第一完成单位 | 完成单位排名 | 本人排序 | 备注 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2012医-3-013-06 | 嗅觉障碍机制、评估和治疗体系的建立和应用 | 省部级 | 其他省部级奖励 | 三等奖 | 2012-12-01 | 北京市人民政府 | 1 | 6 | ||
| 2 | 北京协和医院医疗科研成果奖 | 省部级以下 | 特等奖 | 2020-01-01 | 北京协和医院 | 是 | 1 |
- 研究成果Research Findings
| # | 成果类型 | 项目/专利/新品种名称 |
|---|---|---|
| 1 | 出版高水平专著 | 国民健康调查及自然人群队列研究现场调查标准化操作规程 |