导师风采
朱以诚
个人信息
Personal Information
- 性别：女
- 导师类型：博导
- 职称：主任医师
- 该职称任职时间：1995-08-18
联系方式
Contact Information
- 所属院系：北京协和医院
- 所属专业：神经病学
- 邮箱 : zhuych910@163.com
- 工作电话 : 13011093563
个人简介
Personal Profile
北京协和医院神经内科主任医师、教授、博士生导师，神经科主任，主要研究方向为脑小血管病，系统开展脑小血管病的临床和影像研究，重点关注脑小血管病的影像学特征及脑小血管病认知和步态障碍的发生机制。首创应用高分辨核磁和三维重建影像分析技术对血管周围间隙进行诊断，系统进行了血管周围间隙扩大的危险因素、临床表现和预后的相关性研究，在国际上首次报道血管周围间隙扩大和痴呆发病风险的相关性。2011年开始与中科院合作开发非干扰、定量化神经功能分析工具，相关研究成果已申请发明专利6项,获得国家科学技术二等奖1项，北京市科学技术一等奖1项，入选“2019年国家卫健委医疗健康人工智能应用落地30最佳案例”。设计并建立了北京顺义地区社区队列研究，应用定量化神经功能评价工具及影像评价方法对社区人群的神经功能进行长程随访研究，关注衰老相关神经功能改变的影响因素和相关机制。主持“863”、国家自然科学基金等国家级省部级科研项目5项，发表SCI研究论文40余篇。入选国家“百千万人才工程”，被授予“有突出贡献中青年专家”荣誉称号
团队简介
Team Profile
北京协和医院神经内科主任医师、教授、博士生导师，神经科主任，主要研究方向为脑小血管病，系统开展脑小血管病的临床和影像研究，重点关注脑小血管病的影像学特征及脑小血管病认知和步态障碍的发生机制。首创应用高分辨核磁和三维重建影像分析技术对血管周围间隙进行诊断，系统进行了血管周围间隙扩大的危险因素、临床表现和预后的相关性研究，在国际上首次报道血管周围间隙扩大和痴呆发病风险的相关性。2011年开始与中科院合作开发非干扰、定量化神经功能分析工具，相关研究成果已申请发明专利6项,获得国家科学技术二等奖1项，北京市科学技术一等奖1项，入选“2019年国家卫健委医疗健康人工智能应用落地30最佳案例”。设计并建立了北京顺义地区社区队列研究，应用定量化神经功能评价工具及影像评价方法对社区人群的神经功能进行长程随访研究，关注衰老相关神经功能改变的影响因素和相关机制。主持“863”、国家自然科学基金等国家级省部级科研项目5项，发表SCI研究论文40余篇。入选国家“百千万人才工程”，被授予“有突出贡献中青年专家”荣誉称号
- 研究方向Research Directions
神经病学，脑血管病
- 在校研究生Current Graduate Students
硕士研究生 0 名，博士研究生 7 名
- 科研项目Research Projects
| # | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
|---|---|---|---|---|---|
| 1 | 脑小血管病运动症状特征及其发生的脑结构基础研究 | 2017-01-05 —— 2020-12-03 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 2 | 淀粉样物质沉积在脑小静脉病相关脑萎缩发生中的作用 | 2024-01-01 —— 2027-12-31 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 3 | 炎症机制在衰老相关脑小静脉病发生中的作用 | 2020-01-01 —— 2023-12-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 4 | 衰老相关神经系统疾病诊疗关键技术研究 | 2022-11-01 —— 2025-10-01 | 主持的企业/行业委托重大项目 | 主持人 | |
| 5 | 神经系统证候学数字教材的设计和制作 | 2021-07-01 —— 2023-12-31 | 主持的企业/行业委托重大项目 | 主持人 |
- 发表论文Papers
| # | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
|---|---|---|---|---|
| 1 | Brain deep medullary veins on 3-T MRI in a population-based cohort | JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2020-04-01 | 通讯作者 |
| 2 | Carotid atherosclerosis, dilation, and stiffness relate to cerebral small vessel disease | NEUROLOGY | 2020-04-28 | 通讯作者 |
| 3 | Arterial Stiffness is Associated with Intracranial Arterial Stenosis other than Dolichoectasia in the General Population. | Journal of Atherosclerosis and Thrombosis | 2020-06-14 | 通讯作者 |
| 4 | Cerebral Microbleeds Are Associated with Loss of White Matter Integrity | AmERICAN JOURNAL OF NEURORADIOLOGY | 2020-08-01 | 通讯作者 |
| 5 | Carotid intima-media thickness relative to cognitive impairment in dialysis patients, and their relationship with brain volume and cerebral small vessel disease | THERAPEUTIC ADVANCES IN CHRONIC DISEASE | 2020-08-01 | 通讯作者 |
| 6 | Lacune and Large Perivascular Space: Two Kinds of Cavities Are of Different Risk Factors and Stroke Risk | CEREBROVASCULAR DISEASES | 2020-10-22 | 通讯作者 |
| 7 | Association between large artery stenosis, cerebral small vessel disease and risk of ischemic stroke | Science China-Life Sciences | 2021-06-08 | 通讯作者 |
| 8 | Disrupted white matter integrity and network connectivity are related to poor motor performance | Scientific Reports | 2020-10-27 | 通讯作者 |
| 9 | Metabolic syndrome, intracranial arterial stenosis and cerebral small vessel disease in community-dwelling populations | Stroke and Vascular Neurology | 2021-04-26 | 通讯作者 |
| 10 | Deep medullary veins are associated with widespread brain structural abnormalities | JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM | 2022-06-01 | 通讯作者 |
| 11 | Inflammatory biomarkers and cerebral small vessel disease: a community-based cohort study | STROKE AND VASCULAR NEUROLOGY | 2022-03-08 | 通讯作者 |
| 12 | Different Types of Circulatory Inflammatory Biomarkers Associated with Cerebral Arterial Atherosclerosis and Dolichoectasia | CEREBROVASCULAR DISEASES | 2022-03-08 | 通讯作者 |
| 13 | Cerebral Microbleeds Correlated with White Matter and Hippocampal Volumes in Community-Dwelling Populations. | JOURNAL OF ALZHEIMERS DISEASE | 2019-09-17 | 通讯作者 |
| 14 | White matter but not gary matter volumes are associated with cognition in community-dwelling Chinese populations | Journal of Alzheimer's Disease | 2021-09-16 | 通讯作者 |
| 15 | Genetically predicted telomere length and multiple sclerosis. | Multiple Sclerosis and Related Disorders | 2022-05-07 | 通讯作者 |
| 16 | Rare NOTCH3 Variants in a Chinese Population-Based Cohort and Its Relationship with Cerebral Small Vessel Disease. | stroke | 2021-12-01 | 通讯作者 |
| 17 | Design of the Shunyi study on cardiovascular disease and age-related brain changes: a community-based, prospective, cohort study. | Annals of Translational Medicine | 2020-12-08 | 通讯作者 |
| 18 | Rates of intravenous thrombolysis and endovascular therapy for acute ischaemic stroke in China between 2019 and 2020. | Lancet Reg Health West Pac | 2022-02-22 | 通讯作者 |
| 19 | Arterial Stiffness Is Associated with White Matter Disruption and Cognitive Impairment: A Community-Based Cohort Study. | JOURNAL OF ALZHEIMERS DISEASE | 2021-02-06 | 通讯作者 |
| 20 | Investigating the Genetic Characteristics of Hippocampal Volume and Plasma β-Amyloid in a Chinese Community-Dwelling Population | NEUROLOGY | 2022-05-27 | 通讯作者 |
| 21 | Immunoreactivity and a new staining method of monocarboxylate transporter 1 located in endothelial cells of cerebral vessels of human brain in distinguishing cerebral venules from arterioles. | EUROPEAN JOURNAL OF HISTOCHEMISTRY | 2021-10-01 | 通讯作者 |
| 22 | Investigating the Genetic Characteristics of Hippocampal Volume and Plasma β-Amyloid in a Chinese Community-Dwelling Population | NEUROLOGY | 2022-07-19 | 通讯作者 |
| 23 | comparing characteristics and outcomes of in-hospital stroke and community-onset stroke | JOURNAL OF NEUROLOGY | 2022-10-08 | 通讯作者 |
| 24 | Association between Anatomical Variations of the Circle of Willis and Covert Vascular Brain Injury in the General Population | CEREBROVASCULAR DISEASES | 2022-11-29 | 通讯作者 |
| 25 | The prevalence and prognosis of asymptomatic intracranial atherosclerosis in a community-based population: Results based on high-resolution magnetic resonance imaging | EUROPEAN JOURNAL OF NEUROLOGY | 2023-09-21 | 通讯作者 |
| 26 | Extracellular Vesicles Play a Central Role in Cerebral Venous Disease-Associated Brain Atrophy | Advanced Science | 2023-09-01 | 通讯作者 |
| 27 | Basal ganglia and brainstem located cerebral microbleeds contributed to impaired gait in patients with symptomatic cerebral small vessel disease. | JOURNAL OF ALZHEIMERS DISEASE | 2023-08-01 | 通讯作者 |
| 28 | Pattern of Brain Parenchymal Damage Related to Cerebral Small Vessel Disease in Carriers of Rare NOTCH3 Variants. | NEUROLOGY | 2023-11-14 | 通讯作者 |
| 29 | Identifying underlying patterns in Alzheimer's disease trajectory: a deep learning approach and Mendelian randomization analysis. | EClinicalMedicine | 2023-10-01 | 通讯作者 |
| 30 | Association of Rare NOTCH3 Variants With Prevalent and Incident Stroke and Dementia in the General Population. | Journal of the American Heart Association | 2024-02-20 | 通讯作者 |
| 31 | Dynamic Mechanism of Cerebral Venous Disruption: Longitudinal Evidence From a Community-Based Cohort. | Journal of the American Heart Association | 2024-05-21 | 通讯作者 |
| 32 | Modifiable vascular risk factors for outcomes in patients with CADASIL: A literature review and meta-analysis of cross-sectional analyzes | Journal of Stroke and Cerebrovascular Diseases | 2023-12-01 | 通讯作者 |
- 科研获奖Research Awards
无
- 研究成果Research Findings
| # | 成果类型 | 项目/专利/新品种名称 |
|---|---|---|
| 1 | 出版高水平专著 | 罕见病学 |