导师风采
刘子文

个人信息

Personal Information

  • 性别:男
  • 导师类型:博导
  • 职称:主任医师
  • 该职称任职时间:2003-08-18

联系方式

Contact Information

  • 所属院系:北京协和医院
  • 所属专业:
  • 邮箱 : lzwpumch@sina.com
  • 工作电话 : 13691105638

个人简介

Personal Profile

刘子文,男,教授,博士生导师,主任医师。1992年毕业于哈尔滨医科大学,于协和医院工作至今,历任住院医师、总住院医师、主治医师、副主任医师、主任医师。2006-2008年美国知名大学访问学者。近年主要从事普通外科常见病诊治,尤其擅长胰腺良恶性疾病、甲状腺癌、疝和腹壁外科治疗,在胰腺癌早期诊断及综合治疗、甲状腺癌精准诊疗标志物的开发等方面均取得重要的研究成果。先后参与北京协和医院胰腺外科中心国家自然科学基金、九五攻关项目、科技部国家十一五科技支撑项目、卫生部属医疗机构临床学科重点项目、北京市自然科学基金等多项国家级及省部级临床和基础科研项目。目前主持国自然等国家省部级课题3项,累计发表科学论文50余篇,其中以第1作者或并列第1作者在Cancer research、Biochem J、Gene、Biochemical and Biophysical Research Communications等国际权威期刊发表SCI论文5篇,协助赵玉沛教授编写胰腺病学等多部专业书籍。作为课题组主要成员,2015年先后获得中华医学科技二等奖、北京市科技一等奖、高等学校科学研究优秀成果二等奖和国家科学技术进步二等奖等奖项。2010年获得协和医院优秀带教,2012年获得医科院、医院优秀党员等荣誉称号。

团队简介

Team Profile

刘子文,男,教授,博士生导师,主任医师。1992年毕业于哈尔滨医科大学,于协和医院工作至今,历任住院医师、总住院医师、主治医师、副主任医师、主任医师。2006-2008年美国知名大学访问学者。近年主要从事普通外科常见病诊治,尤其擅长胰腺良恶性疾病、甲状腺癌、疝和腹壁外科治疗,在胰腺癌早期诊断及综合治疗、甲状腺癌精准诊疗标志物的开发等方面均取得重要的研究成果。先后参与北京协和医院胰腺外科中心国家自然科学基金、九五攻关项目、科技部国家十一五科技支撑项目、卫生部属医疗机构临床学科重点项目、北京市自然科学基金等多项国家级及省部级临床和基础科研项目。目前主持国自然等国家省部级课题3项,累计发表科学论文50余篇,其中以第1作者或并列第1作者在Cancer research、Biochem J、Gene、Biochemical and Biophysical Research Communications等国际权威期刊发表SCI论文5篇,协助赵玉沛教授编写胰腺病学等多部专业书籍。作为课题组主要成员,2015年先后获得中华医学科技二等奖、北京市科技一等奖、高等学校科学研究优秀成果二等奖和国家科学技术进步二等奖等奖项。2010年获得协和医院优秀带教,2012年获得医科院、医院优秀党员等荣誉称号。

  • 研究方向Research Directions
胰腺癌侵袭和转移的分子机制
  • 在校研究生Current Graduate Students

硕士研究生 0 名,博士研究生 4 名

  • 科研项目Research Projects
# 项目名称 起止日期 金额 项目类型 本人角色
1NOP14与TP53 mRNA复合物在胰 腺癌发生及进展中的功能与分子机制研究2020-01-01 —— 2022-12-31主持在研的国家或省部级科研项目主持者
2RNF138介导胰腺癌II型干扰素抵抗与免疫检查点抑制治疗不反应的分子 机制2022-01-01 —— 2025-12-31主持在研的国家或省部级科研项目主持者
3内分泌代谢类疾病的精准分型和诊疗体系研究2021-10-01 —— 2025-12-31参与者
4NOP14与TP53 mRNA复合物在胰腺癌发生及进展中的功能与分子机制研究2020-01-01 —— 2022-12-01主持在研的国家或省部级科研项目主持人
5消化道肿瘤发生发展的分子特征和临床应用的研究2016-09-01 —— 2020-12-31主持的企业/行业委托重大项目主持人
6NOP14介导的miRNA加工在胰腺癌转移中的作用机制研究2016-01-01 —— 2019-12-22主持在研的国家或省部级科研项目主持人
7RNF138介导胰腺癌II型干扰素抵抗与免疫检查点抑制治疗不反应的分子机制2022-01-01 —— 2025-12-31主持在研的国家或省部级科研项目主持人
  • 发表论文Papers
# 论文题目 期刊名称 发表年份 论文署名
1Consistency analysis of microRNA-arm expression reveals microRNA-369-5p/3p as tumor suppressors in gastric cancerMol Oncol2022-06-02刘子文
2A novel prognostic model for papillary thyroid cancer based on epithelial-mesenchymal transition-related genescancer medicine2022-06-02刘子文
3Identification of a Nine-Gene Signature and Establishment of a Prognostic Nomogram Predicting Overall Survival of Pancreatic CancerFront Oncol.2022-06-01刘子文
4Risk factors for new-onset diabetes mellitus after distal pancreatectomy BMJ Open Diabetes Res Care.2022-06-01刘子文
5Diagnosis methods and treatment strategy for primary thyroid lymphoma: a retrospective analysis of 41 cases in ChinaEur J Cancer Prev2022-06-02刘子文
6Ultrasonography for the Prediction of High-Volume Lymph Node Metastases in Papillary Thyroid Carcinoma: Should Surgeons Believe Ultrasound Results?World J Surg2022-06-02刘子文
7Pancreatic Cancer Progression Relies upon Mutant p53-Induced Oncogenic Signaling Mediated by NOP14cancer research2022-06-02刘子文
8Use of Vaginal Reconstructive Surgery in Cervical Cancer Patients to Prevent Vaginal Stump ContractureJ Invest Surg 2022-06-01刘子文
9Correction: Long non-coding RNA DLEU1 predicts poor prognosis of gastric cancer and contributes to cell proliferation by epigenetically suppressing KLF2Cancer Gene Ther2022-06-02刘子文
10Development and validation of a metastasis-related Gene Signature for predicting the Overall Survival in patients with Pancreatic Ductal AdenocarcinomaJ Cancer .2022-06-02刘子文
11Identification of a Five-Gene Signature and Establishment of a Prognostic Nomogram to Predict Progression-Free Interval of Papillary Thyroid CarcinomaFront Endocrinol (Lausanne) .2022-06-02刘子文
12Predictors of metastasis to lymph nodes posterior to the right recurrent laryngeal nerve in differentiated thyroid carcinoma: A prospective studyAsian J Surg .2022-06-02刘子文
13Risk factors for thyroid hormone replacement therapy after hemithyroidectomy and development of a predictive nomogramendocrine2022-06-02刘子文
145-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancerscancer research2022-06-01刘子文
15Analysis of primary and secondary squamous cell carcinoma of the thyroid gland: a retrospective studygland surgery2022-06-01刘子文
16Emergency laparoscopic pancreatoduodenectomy as treatment for pancreatic head cancer-induced acute gastrointestinal hemorrhage, safe or not?Hepatobiliary Surg Nutr2022-06-01刘子文
17Gastric adenocarcinoma at stage IV with complete remission after neoadjuvant therapy concurrent with adenosquamous carcinoma of the ampulla of Vater: a case report and literature reviewBMC surgery2022-06-01刘子文
18Retrospective analysis of seven cases of pancreatic mixed adenoneuroendocrine carcinoma from a high-volume center and review of the literatureBMC Surg .2022-06-01刘子文
19Serum Linkage-Specific Sialylation Changes Are Potential Biomarkers for Monitoring and Predicting the Recurrence of Papillary Thyroid Cancer Following ThyroidectomyFront Endocrinol (Lausanne)2022-06-02刘子文
20Machine Learning Algorithms for the Prediction of Central Lymph Node Metastasis in Patients With Papillary Thyroid CancerFront Endocrinol (Lausanne)2022-06-02刘子文
21Long non-coding RNA DLEU1 predicts poor prognosis of gastric cancer and contributes to cell proliferation by epigenetically suppressing KLF2Cancer Gene Ther .2022-06-02刘子文
22Risk factors for high-volume lymph node metastases in cN0 papillary thyroid microcarcinomaGland Surg2022-06-02刘子文
23Molecular Subtyping of Pancreatic Cancer: Translating Genomics and Transcriptomics into the Clinic J Cancer2022-06-01刘子文
24Correction: Long non-coding RNA DLEU1 predicts poor prognosis of gastric cancer and contributes to cell proliferation by epigenetically suppressing KLF2Cancer Gene Ther2022-06-02刘子文
25Advances in understanding the molecular mechanism of pancreatic cancer metastasisHepatobiliary Pancreat Dis Int.2022-06-01刘子文
26Identification of a Nine-Gene Signature and Establishment of a Prognostic Nomogram Predicting Overall Survival of Pancreatic CancerFRONTIERS IN ONCOLOGY2019-09-01通讯作者
27Identification of a five-gene signature and establishment of a prognostic nomogram to predict progression-free interval of papillary thyroid carcinomasFrontiers in Endocrinology2019-11-15通讯作者
28MicroRNA-7 regulates the proliferation and metastasis of human papillary carcinoma cells by targeting Bcl-2American Journal of Translational Research2020-09-01通讯作者
29New-Onset Diabetes Mellitus After Distal Pancreatectomy:A Systematic Review and Meta-analysisJOURNAL OF LAPAROENDOSCOPIC &ADVANCED SURGICAL TECHNIQUES2020-06-01通讯作者
30Development and validation of a metastasis-related gene signature for predicting the overall survival in patients with pancreatic ductal adenocarcinomaJournal of Cancer2020-08-01通讯作者
31Progression Risk Assessment of Post-surgical Papillary Thyroid Carcinoma Based on Circular RNA-Associated Competing Endogenous RNA Mechanismsfrontiers in cell and developmental biology2021-01-12通讯作者
32Risk factors for thyroid hormone replacement therapy after hemithyroidectomy and development of a predictive nomogramENDOCRINE2022-04-01通讯作者
33Serum Linkage-Specific Sialylation Changes Are Potential Biomarkers for Monitoring and Predicting the Recurrence of Papillary Thyroid Cancer Following ThyroidectomyFrontiers in Endocrinology2022-04-29通讯作者
34A novel prognostic model for papillary thyroid cancer based on epithelial-mesenchymal transition-related genes.Cancer Medicine2022-05-24通讯作者
35Comprehensive analysis of tissue proteomics in patients with papillary thyroid microcarcinoma uncovers the underlying mechanism of lymph node metastasis and its significant sex disparitiesFrontiers in Oncology2022-08-29通讯作者
36Nomograms Based on Serum N-glycome for Diagnosis of Papillary Thyroid Microcarcinoma and Prediction of Lymph Node MetastasisCurrent Oncology2022-08-23通讯作者
37A bibliometric analysis based on Web of Science from 2012 to 2021: Current situation, hot spots, and global trends of medullary thyroid carcinomaFrontiers in Oncology2023-03-07通讯作者
38Golgi-apparatus genes related signature for predicting the progression-free interval of patients with papillary thyroid carcinomaBMC Medical Genomics2023-03-22通讯作者
39Suppression of Tafazzin promotes thyroid cancer apoptosis via activating the JNK signaling pathway and enhancing INF2-mediated mitochondrial fissionJ Cell Physiol2019-02-11通讯作者
  • 科研获奖Research Awards
# 获奖证书编号 奖项名称 获奖级别 获奖类别 获奖等级 获奖日期 颁奖单位 本单位是否为第一完成单位 完成单位排名 本人排序 备注
1R736.7胰岛素瘤诊治体系的建立及临床应用国家最高科学技术奖、自然科学奖、技术发明奖、科技进步奖二等奖2016-06-01中华人民共和国国务院19
2KEYAN666206230666胰腺癌综合诊治方案的基础研究与临床应用国家最高科学技术奖、自然科学奖、技术发明奖、科技进步奖二等奖2008-06-01中华人民共和国国务院17
  • 研究成果Research Findings
# 成果类型 项目/专利/新品种名称
1出版高水平专著腹外疝手术学
2作为主创人员获得授权的发明专利和新品种预测甲状腺癌术后复发的糖链标志物及其应用
3作为主创人员获得授权的发明专利和新品种生物标志物在制备甲状腺癌鉴别诊断和危险分层的产品中的应用