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刘子文,男,教授,博士生导师,主任医师。1992年毕业于哈尔滨医科大学,于协和医院工作至今,历任住院医师、总住院医师、主治医师、副主任医师、主任医师。2006-2008年美国知名大学访问学者。近年主要从事普通外科常见病诊治,尤其擅长胰腺良恶性疾病、甲状腺癌、疝和腹壁外科治疗,在胰腺癌早期诊断及综合治疗、甲状腺癌精准诊疗标志物的开发等方面均取得重要的研究成果。先后参与北京协和医院胰腺外科中心国家自然科学基金、九五攻关项目、科技部国家十一五科技支撑项目、卫生部属医疗机构临床学科重点项目、北京市自然科学基金等多项国家级及省部级临床和基础科研项目。目前主持国自然等国家省部级课题3项,累计发表科学论文50余篇,其中以第1作者或并列第1作者在Cancer research、Biochem J、Gene、Biochemical and Biophysical Research Communications等国际权威期刊发表SCI论文5篇,协助赵玉沛教授编写胰腺病学等多部专业书籍。作为课题组主要成员,2015年先后获得中华医学科技二等奖、北京市科技一等奖、高等学校科学研究优秀成果二等奖和国家科学技术进步二等奖等奖项。2010年获得协和医院优秀带教,2012年获得医科院、医院优秀党员等荣誉称号。
团队简介
Team Profile
刘子文,男,教授,博士生导师,主任医师。1992年毕业于哈尔滨医科大学,于协和医院工作至今,历任住院医师、总住院医师、主治医师、副主任医师、主任医师。2006-2008年美国知名大学访问学者。近年主要从事普通外科常见病诊治,尤其擅长胰腺良恶性疾病、甲状腺癌、疝和腹壁外科治疗,在胰腺癌早期诊断及综合治疗、甲状腺癌精准诊疗标志物的开发等方面均取得重要的研究成果。先后参与北京协和医院胰腺外科中心国家自然科学基金、九五攻关项目、科技部国家十一五科技支撑项目、卫生部属医疗机构临床学科重点项目、北京市自然科学基金等多项国家级及省部级临床和基础科研项目。目前主持国自然等国家省部级课题3项,累计发表科学论文50余篇,其中以第1作者或并列第1作者在Cancer research、Biochem J、Gene、Biochemical and Biophysical Research Communications等国际权威期刊发表SCI论文5篇,协助赵玉沛教授编写胰腺病学等多部专业书籍。作为课题组主要成员,2015年先后获得中华医学科技二等奖、北京市科技一等奖、高等学校科学研究优秀成果二等奖和国家科学技术进步二等奖等奖项。2010年获得协和医院优秀带教,2012年获得医科院、医院优秀党员等荣誉称号。
硕士研究生 0 名,博士研究生 4 名
# | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
---|---|---|---|---|---|
1 | NOP14与TP53 mRNA复合物在胰 腺癌发生及进展中的功能与分子机制研究 | 2020-01-01 —— 2022-12-31 | 主持在研的国家或省部级科研项目 | 主持者 | |
2 | RNF138介导胰腺癌II型干扰素抵抗与免疫检查点抑制治疗不反应的分子 机制 | 2022-01-01 —— 2025-12-31 | 主持在研的国家或省部级科研项目 | 主持者 | |
3 | 内分泌代谢类疾病的精准分型和诊疗体系研究 | 2021-10-01 —— 2025-12-31 | 参与者 | ||
4 | NOP14与TP53 mRNA复合物在胰腺癌发生及进展中的功能与分子机制研究 | 2020-01-01 —— 2022-12-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
5 | 消化道肿瘤发生发展的分子特征和临床应用的研究 | 2016-09-01 —— 2020-12-31 | 主持的企业/行业委托重大项目 | 主持人 | |
6 | NOP14介导的miRNA加工在胰腺癌转移中的作用机制研究 | 2016-01-01 —— 2019-12-22 | 主持在研的国家或省部级科研项目 | 主持人 | |
7 | RNF138介导胰腺癌II型干扰素抵抗与免疫检查点抑制治疗不反应的分子机制 | 2022-01-01 —— 2025-12-31 | 主持在研的国家或省部级科研项目 | 主持人 |
# | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
---|---|---|---|---|
1 | Consistency analysis of microRNA-arm expression reveals microRNA-369-5p/3p as tumor suppressors in gastric cancer | Mol Oncol | 2022-06-02 | 刘子文 |
2 | A novel prognostic model for papillary thyroid cancer based on epithelial-mesenchymal transition-related genes | cancer medicine | 2022-06-02 | 刘子文 |
3 | Identification of a Nine-Gene Signature and Establishment of a Prognostic Nomogram Predicting Overall Survival of Pancreatic Cancer | Front Oncol. | 2022-06-01 | 刘子文 |
4 | Risk factors for new-onset diabetes mellitus after distal pancreatectomy | BMJ Open Diabetes Res Care. | 2022-06-01 | 刘子文 |
5 | Diagnosis methods and treatment strategy for primary thyroid lymphoma: a retrospective analysis of 41 cases in China | Eur J Cancer Prev | 2022-06-02 | 刘子文 |
6 | Ultrasonography for the Prediction of High-Volume Lymph Node Metastases in Papillary Thyroid Carcinoma: Should Surgeons Believe Ultrasound Results? | World J Surg | 2022-06-02 | 刘子文 |
7 | Pancreatic Cancer Progression Relies upon Mutant p53-Induced Oncogenic Signaling Mediated by NOP14 | cancer research | 2022-06-02 | 刘子文 |
8 | Use of Vaginal Reconstructive Surgery in Cervical Cancer Patients to Prevent Vaginal Stump Contracture | J Invest Surg | 2022-06-01 | 刘子文 |
9 | Correction: Long non-coding RNA DLEU1 predicts poor prognosis of gastric cancer and contributes to cell proliferation by epigenetically suppressing KLF2 | Cancer Gene Ther | 2022-06-02 | 刘子文 |
10 | Development and validation of a metastasis-related Gene Signature for predicting the Overall Survival in patients with Pancreatic Ductal Adenocarcinoma | J Cancer . | 2022-06-02 | 刘子文 |
11 | Identification of a Five-Gene Signature and Establishment of a Prognostic Nomogram to Predict Progression-Free Interval of Papillary Thyroid Carcinoma | Front Endocrinol (Lausanne) . | 2022-06-02 | 刘子文 |
12 | Predictors of metastasis to lymph nodes posterior to the right recurrent laryngeal nerve in differentiated thyroid carcinoma: A prospective study | Asian J Surg . | 2022-06-02 | 刘子文 |
13 | Risk factors for thyroid hormone replacement therapy after hemithyroidectomy and development of a predictive nomogram | endocrine | 2022-06-02 | 刘子文 |
14 | 5-Hydroxymethylcytosine signatures in circulating cell-free DNA as diagnostic biomarkers for human cancers | cancer research | 2022-06-01 | 刘子文 |
15 | Analysis of primary and secondary squamous cell carcinoma of the thyroid gland: a retrospective study | gland surgery | 2022-06-01 | 刘子文 |
16 | Emergency laparoscopic pancreatoduodenectomy as treatment for pancreatic head cancer-induced acute gastrointestinal hemorrhage, safe or not? | Hepatobiliary Surg Nutr | 2022-06-01 | 刘子文 |
17 | Gastric adenocarcinoma at stage IV with complete remission after neoadjuvant therapy concurrent with adenosquamous carcinoma of the ampulla of Vater: a case report and literature review | BMC surgery | 2022-06-01 | 刘子文 |
18 | Retrospective analysis of seven cases of pancreatic mixed adenoneuroendocrine carcinoma from a high-volume center and review of the literature | BMC Surg . | 2022-06-01 | 刘子文 |
19 | Serum Linkage-Specific Sialylation Changes Are Potential Biomarkers for Monitoring and Predicting the Recurrence of Papillary Thyroid Cancer Following Thyroidectomy | Front Endocrinol (Lausanne) | 2022-06-02 | 刘子文 |
20 | Machine Learning Algorithms for the Prediction of Central Lymph Node Metastasis in Patients With Papillary Thyroid Cancer | Front Endocrinol (Lausanne) | 2022-06-02 | 刘子文 |
21 | Long non-coding RNA DLEU1 predicts poor prognosis of gastric cancer and contributes to cell proliferation by epigenetically suppressing KLF2 | Cancer Gene Ther . | 2022-06-02 | 刘子文 |
22 | Risk factors for high-volume lymph node metastases in cN0 papillary thyroid microcarcinoma | Gland Surg | 2022-06-02 | 刘子文 |
23 | Molecular Subtyping of Pancreatic Cancer: Translating Genomics and Transcriptomics into the Clinic | J Cancer | 2022-06-01 | 刘子文 |
24 | Correction: Long non-coding RNA DLEU1 predicts poor prognosis of gastric cancer and contributes to cell proliferation by epigenetically suppressing KLF2 | Cancer Gene Ther | 2022-06-02 | 刘子文 |
25 | Advances in understanding the molecular mechanism of pancreatic cancer metastasis | Hepatobiliary Pancreat Dis Int. | 2022-06-01 | 刘子文 |
26 | Identification of a Nine-Gene Signature and Establishment of a Prognostic Nomogram Predicting Overall Survival of Pancreatic Cancer | FRONTIERS IN ONCOLOGY | 2019-09-01 | 通讯作者 |
27 | Identification of a five-gene signature and establishment of a prognostic nomogram to predict progression-free interval of papillary thyroid carcinomas | Frontiers in Endocrinology | 2019-11-15 | 通讯作者 |
28 | MicroRNA-7 regulates the proliferation and metastasis of human papillary carcinoma cells by targeting Bcl-2 | American Journal of Translational Research | 2020-09-01 | 通讯作者 |
29 | New-Onset Diabetes Mellitus After Distal Pancreatectomy:A Systematic Review and Meta-analysis | JOURNAL OF LAPAROENDOSCOPIC &ADVANCED SURGICAL TECHNIQUES | 2020-06-01 | 通讯作者 |
30 | Development and validation of a metastasis-related gene signature for predicting the overall survival in patients with pancreatic ductal adenocarcinoma | Journal of Cancer | 2020-08-01 | 通讯作者 |
31 | Progression Risk Assessment of Post-surgical Papillary Thyroid Carcinoma Based on Circular RNA-Associated Competing Endogenous RNA Mechanisms | frontiers in cell and developmental biology | 2021-01-12 | 通讯作者 |
32 | Risk factors for thyroid hormone replacement therapy after hemithyroidectomy and development of a predictive nomogram | ENDOCRINE | 2022-04-01 | 通讯作者 |
33 | Serum Linkage-Specific Sialylation Changes Are Potential Biomarkers for Monitoring and Predicting the Recurrence of Papillary Thyroid Cancer Following Thyroidectomy | Frontiers in Endocrinology | 2022-04-29 | 通讯作者 |
34 | A novel prognostic model for papillary thyroid cancer based on epithelial-mesenchymal transition-related genes. | Cancer Medicine | 2022-05-24 | 通讯作者 |
35 | Comprehensive analysis of tissue proteomics in patients with papillary thyroid microcarcinoma uncovers the underlying mechanism of lymph node metastasis and its significant sex disparities | Frontiers in Oncology | 2022-08-29 | 通讯作者 |
36 | Nomograms Based on Serum N-glycome for Diagnosis of Papillary Thyroid Microcarcinoma and Prediction of Lymph Node Metastasis | Current Oncology | 2022-08-23 | 通讯作者 |
37 | A bibliometric analysis based on Web of Science from 2012 to 2021: Current situation, hot spots, and global trends of medullary thyroid carcinoma | Frontiers in Oncology | 2023-03-07 | 通讯作者 |
38 | Golgi-apparatus genes related signature for predicting the progression-free interval of patients with papillary thyroid carcinoma | BMC Medical Genomics | 2023-03-22 | 通讯作者 |
39 | Suppression of Tafazzin promotes thyroid cancer apoptosis via activating the JNK signaling pathway and enhancing INF2-mediated mitochondrial fission | J Cell Physiol | 2019-02-11 | 通讯作者 |
# | 获奖证书编号 | 奖项名称 | 获奖级别 | 获奖类别 | 获奖等级 | 获奖日期 | 颁奖单位 | 本单位是否为第一完成单位 | 完成单位排名 | 本人排序 | 备注 |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | R736.7 | 胰岛素瘤诊治体系的建立及临床应用 | 国家最高科学技术奖、自然科学奖、技术发明奖、科技进步奖 | 二等奖 | 2016-06-01 | 中华人民共和国国务院 | 是 | 1 | 9 | ||
2 | KEYAN666206230666 | 胰腺癌综合诊治方案的基础研究与临床应用 | 国家最高科学技术奖、自然科学奖、技术发明奖、科技进步奖 | 二等奖 | 2008-06-01 | 中华人民共和国国务院 | 是 | 1 | 7 |
# | 成果类型 | 项目/专利/新品种名称 |
---|---|---|
1 | 出版高水平专著 | 腹外疝手术学 |
2 | 作为主创人员获得授权的发明专利和新品种 | 预测甲状腺癌术后复发的糖链标志物及其应用 |
3 | 作为主创人员获得授权的发明专利和新品种 | 生物标志物在制备甲状腺癌鉴别诊断和危险分层的产品中的应用 |