导师风采
仉建国
个人信息
Personal Information
- 性别：男
- 导师类型：博导
- 职称：主任医师
- 该职称任职时间：2007
联系方式
Contact Information
- 所属院系：北京协和医院
- 所属专业：
- 邮箱 : jgzhang_pumch@yahoo.com
- 工作电话 : 69152700
个人简介
Personal Profile
仉建国，男，北京协和医院骨科主任，主任医师，教授，博士研究生导师，主要从事脊柱畸形和脊柱退变性疾病的研究，尤其是早发严重脊柱畸形的临床治疗及研究。目前已完成4000余例脊柱矫形手术，其治疗的患者构成了世界上最大的单中心半椎体切除病例数据库，在全世界首次提出截骨联合生长棒技术治疗重度早发性脊柱侧凸。在《Journal of Bone and Joint Surgery》、《Spine》、《European Spine Journal》和《Spine Journal》等杂志共发表论文60余篇。参与创立特发性脊柱侧凸协和分型(PUMC分型)，2005年获得国家科技进步二等奖。在后路半椎体切除及先天性脊柱侧凸的治疗方面，获得2023年北京市科学技术进步奖二等奖，并多次在IMAST、SRS和ICEOS等国际会议上做大会发言。
团队简介
Team Profile
仉建国教授团队要从事脊柱畸形和脊柱退变性疾病的研究，尤其是早发严重脊柱畸形的临床治疗及研究。目前已完成4000余例脊柱矫形手术，其治疗的患者构成了世界上最大的单中心半椎体切除病例数据库，在全世界首次提出截骨联合生长棒技术治疗重度早发性脊柱侧凸。在《Journal of Bone and Joint Surgery》、《Spine》、《European Spine Journal》和《Spine Journal》等杂志共发表论文60余篇。参与创立特发性脊柱侧凸协和分型(PUMC分型)，2005年获得国家科技进步二等奖。在后路半椎体切除及先天性脊柱侧凸的治疗方面，获得2023年北京市科学技术进步奖二等奖，并多次在IMAST、SRS和ICEOS等国际会议上做大会发言。
- 研究方向Research Directions
脊柱外科及脊柱畸形
- 在校研究生Current Graduate Students
硕士研究生 0 名，博士研究生 5 名
- 科研项目Research Projects
| # | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
|---|---|---|---|---|---|
| 1 | 重大高致残、致畸性骨骼疾病的早期识别及精准干预研究 | 2021-10-01 —— 2025-12-31 | 640万元/年 | 主持在研的国家或省部级科研项目 | 项目负责人 |
| 2 | TBX6相关先天性脊柱侧凸基因检测试剂盒的研发及推广应用 | 2023-11-01 —— 2026-10-31 | 100万元 | 主持的企业/行业委托重大项目 | 项目负责人 |
| 3 | 脊柱畸形筛诊治关键技术研究 | 2022-11-01 —— 2025-10-01 | 3000万元 | 主持的企业/行业委托重大项目 | 项目负责人 |
| 4 | 脊柱畸形术后智能化评估及一体化康复体系的建立与推广 | 2023-11-01 —— 2026-12-01 | 100万元 | 主持在研的国家或省部级科研项目 | 项目负责人 |
| 5 | 脊柱畸形精准诊疗体系构建及关键技术研究 | 2023-11-01 —— 2026-10-01 | 1700万元 | 主持在研的国家或省部级科研项目 | 项目负责人 |
| 6 | 先天性脊柱侧凸合并泌尿系统畸形的基因组学分析及机制研究 | 2022-01-01 —— 2025-12-31 | 55万元 | 主持在研的国家或省部级科研项目 | 项目负责人 |
- 发表论文Papers
| # | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
|---|---|---|---|---|
| 1 | 10) Outcomes of Posterior Lumbar Hemivertebra Resection and Short Fusion in Patients With Severe Sacral Tilt | Neurospine | 2022-06-11 | 仉建国 |
| 2 | Posterior hemivertebra resection with bisegmental fusion for congenital scoliosis: more than 3 year outcomes and analysis of unanticipated surgeries. | Eur Spine J | 2022-06-11 | 仉建国 |
| 3 | Outcomes of 360° osteotomy in the cervicothoracic spine (C7-T1) for congenital cervicothoracic kyphoscoliosis in children | J Bone Joint Surg Am | 2022-06-11 | 仉建国 |
| 4 | One-stage posterior osteotomy with short segmental fusion and dual growing rod technique for severe rigid congenital scoliosis: the preliminary clinical outcomes of a hybrid technique. | Spine | 2022-06-11 | 仉建国 |
| 5 | The efficacy and complications of posterior hemivertebra resection. | Eur Spine J | 2022-06-11 | 仉建国 |
| 6 | Dual growing rods technique for congenital scoliosis: more than 2 years outcomes: preliminary results of a single center. | Spine | 2022-06-11 | 仉建国 |
| 7 | How to select the lowest instrumented vertebra in Lenke type 5 adolescent idiopathic scoliosis patients? | Spine J | 2022-06-11 | 仉建国 |
| 8 | Posterior-only hemivertebra resection with anterior structural reconstruction with titanium mesh cage and short segmental fusion for the treatment of congenital scoliokyphosis: the indications and preliminary results. | Spine | 2022-06-11 | 仉建国 |
| 9 | Diagnostic yield and clinical impact of exome sequencing in early-onset scoliosis (EOS) | J Med Genet | 2022-06-11 | 仉建国 |
| 10 | Estrogen Receptors (ESRs) Mutations in Adolescent Idiopathic Scoliosis: A Cross-Sectional Study | MEDICAL SCIENCE MONITOR | 2020-03-01 | 通讯作者 |
| 11 | Diagnostic yield and clinical impact of exome sequencing in early-onset scoliosis (EOS) | J MED GENET. | 2021-05-07 | 通讯作者 |
| 12 | Long noncoding RNA lncAIS downregulation in mesenchymal stem cells is implicated in the pathogenesis of adolescent idiopathic scoliosis | CELL DEATH AND DIFFERENTIATION | 2019-09-01 | 通讯作者 |
| 13 | Differential miRNAs profile and bioinformatics analyses in bone marrow mesenchymal stem cells from adolescent idiopathic scoliosis patients | SPINE JOURNAL | 2019-09-01 | 通讯作者 |
| 14 | Genetic and molecular mechanism for distinct clinical phenotypes conveyed by allelic truncating mutations implicated in FBN1 | MOLECULAR GENETICS & GENOMIC MEDICINE | 2020-01-01 | 通讯作者 |
| 15 | How to select the lowest instrumented vertebra in Lenke type 5 adolescent idiopathic scoliosis patients? | spine journal | 2021-01-01 | 通讯作者 |
| 16 | Variants Affecting the C-Terminal of CSF1R Cause Congenital Vertebral Malformation Through a Gain-of-Function Mechanism | frontiers in cell and developmental biology | 2021-03-19 | 通讯作者 |
| 17 | Posterior Vertebral Column Resection (pVCR) for Severe Thoracolumbar Kyphosis in Patients With Achondroplasia. | Global Spine Journal | 2021-02-22 | 通讯作者 |
| 18 | Posterior only instrumented fusion provides incomplete curve control for early-onset scoliosis in type 1 neurofibromatosis | BMC PEDIATRICS | 2020-02-01 | 通讯作者 |
| 19 | Survivals of the Intraoperative Motor-evoked Potentials Response in Pediatric Patients Undergoing Spinal Deformity Correction Surgery What Are the Neurologic Outcomes of Surgery? | SPINE | 2019-08-01 | 通讯作者 |
| 20 | Outcomes of 360 degrees Osteotomy in the Cervicothoracic Spine (C7-T1) for Congenital Cervicothoracic Kyphoscoliosis in Children | JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME | 2019-08-01 | 通讯作者 |
| 21 | Mutational burden and potential oligogenic model of TBX6-mediated genes in congenital scoliosis | MOLECULAR GENETICS & GENOMIC MEDICINE | 2020-08-01 | 通讯作者 |
| 22 | Factors and predictive model associated with perioperative complications after long fusion in the treatment of adult nondegenerative scoliosis | BMC MUSCULOSKELETAL DISORDERS | 2021-05-21 | 通讯作者 |
| 23 | Tranexamic acid given into wound reduces postoperative drainage, blood loss, and hospital stay in spinal surgeries: a meta-analysis | JOURNAL OF ORTHOPAEDIC RESEARCH | 2021-06-22 | 通讯作者 |
| 24 | Risk factors of postoperative pulmonary complications after primary posterior fusion and hemivertebra resection in congenital scoliosis patients younger than 10 years old: a retrospective study | BMC MUSCULOSKELETAL DISORDERS | 2022-01-26 | 通讯作者 |
| 25 | outcomes of posterior lumbar hemivetertebra resection and short fusion in patients with severe sacral tilt | Neurospine | 2021-09-12 | 通讯作者 |
| 26 | Novel FGFR1 V ariants Are Associated with Congenital Scoliosis | GENES | 2021-07-24 | 通讯作者 |
| 27 | Identification of Novel FBN2 Variants in a Cohort of Congenital Contractural Arachnodactyly | Frontiers in Genetics | 2022-03-10 | 通讯作者 |
| 28 | Delineation of dual molecular diagnosis in patients with skeletal deformity | Orphanet Journal of Rare Diseases | 2022-03-28 | 通讯作者 |
| 29 | Aberrant interaction between mutated ADAMTSL2 and LTBP4 is associated with adolescent idiopathic scoliosis | GENE | 2022-03-10 | 通讯作者 |
| 30 | Expanding the mutation and phenotype spectrum of MYH3-associated skeletal disorders | npj Genomic Medicine | 2022-02-15 | 通讯作者 |
| 31 | Revision Surgery After Spinal Fusion in Adolescent Idiopathic Scoliosis | GLOBAL SPINE JOURNAL | 2022-07-21 | 通讯作者 |
| 32 | Dissection of mendelian predisposition and complex genetic architecture of craniovertebral junction malformation | HUMAN GENETICS | 2022-09-13 | 通讯作者 |
| 33 | Retrospective Analysis of Associated Anomalies in 636 Patients with Operatively Treated Congenital Scoliosis. | JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME | 2023-04-05 | 通讯作者 |
| 34 | Clinical outcomes of the traditional dual growing rod technique combined with apical pedicle screws in the treatment of early-onset scoliosis: preliminary results from a single center | Journal of Neurosurgery-Pediatrics | 2023-02-03 | 通讯作者 |
| 35 | Hybrid technique versus traditional dual growing rod technique to treat congenital early-onset scoliosis: a comparative study with more than 3 years of follow-up | JOURNAL OF NEUROSURGERY-SPINE | 2022-10-07 | 通讯作者 |
| 36 | Transcriptome-wide Sequencing Reveals Molecules and Pathways Involved in Neurofibromatosis Type I Combined With Spinal Deformities | Spine Journal | 2020-05-01 | 通讯作者 |
| 37 | Cross‐sectional analysis of associated anomalies and vertebral anomaly location in 1289 surgical congenital scoliosis | EUROPEAN SPINE JOURNAL | 2021-12-01 | 通讯作者 |
| 38 | Older fusion-surgery age in congenital scoliosis patients is a risk factor for extended length of stay, more estimated blood loss, longer fused segments and higher medical costs: a retrospective study | BMC MUSCULOSKELETAL DISORDERS | 2021-09-12 | 通讯作者 |
| 39 | Comparison between surgical fusion and the growing-rod technique for early-onset neurofibromatosis type-1 dystrophic scoliosis. | BMC MUSCULOSKELETAL DISORDERS | 2020-07-11 | 通讯作者 |
| 40 | Neurofibromatosis Type 1 with Severe Dystrophic Kyphosis: Surgical Treatment and Prognostic Analysis of 27 Patients | Orthopaedic Surgery | 2020-12-01 | 通讯作者 |
| 41 | A pilot study of influence of pedicle screw instrumentation on immature vertebra: a minimal 5-year follow-up in children younger than 5 years | Journal of Neurosurgery-Pediatrics | 2019-03-15 | 通讯作者 |
| 42 | The Progress of CRISPR/Cas9-Mediated Gene Editing in Generating Mouse/Zebrafish Models of Human Skeletal Diseases | Computational and Structural Biotechnology Journal | 2019-06-13 | 通讯作者 |
| 43 | Dual Growing Rods Combined With the Apical Convex Control Pedicle Screw Technique Versus Traditional Dual Growing Rods for the Surgical Treatment of Early-Onset Scoliosis: A Case-Matched 2-Year Study | NEUROSURGERY | 2023-08-01 | 通讯作者 |
| 44 | A Novel growth guidance system for early onset scoliosis: a preliminary in vitro study | Journal of Orthopaedic Surgery and Research | 2024-04-24 | 通讯作者 |
| 45 | Ten-year trends in surgical management of 1207 congenital scoliosis | EUROPEAN SPINE JOURNAL | 2023-07-01 | 通讯作者 |
| 46 | Molecular Diagnostic Yield of Exome Sequencing and Chromosomal Microarray in Short Stature: A Systematic Review and Meta-Analysis | JAMA Pediatrics | 2023-11-01 | 通讯作者 |
| 47 | Risk factors for intensive care unit admission following correction surgery for adult spinal deformity. | Journal of Orthopaedic Surgery and Research | 2023-10-04 | 通讯作者 |
| 48 | Traditional Dual Growing Rods With 2 Different Apical Control Techniques in the Treatment of Early-Onset Scoliosis. | Neurospine | 2023-09-20 | 通讯作者 |
| 49 | Validity of evoked potential as biomarker for predicting early neural function changes after thoracic spinal decompression surgery in patients with neurological deficits | EUROPEAN SPINE JOURNAL | 2023-11-27 | 通讯作者 |
| 50 | Core planar cell polarity genes VANGL1 and VANGL2 in predisposition to congenital vertebral malformations | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2024-04-30 | 通讯作者 |
| 51 | Unraveling the genetic architecture of congenital vertebral malformation with reference to the developing spine | Nature Communications | 2024-02-06 | 通讯作者 |
| 52 | Emergence and clonal expansion of Aeromonas hydrophila ST1172 that simultaneously produces MOX-13 and OXA-724 | Antimicrobial Resistance and Infection Control | 2024-03-03 | 通讯作者 |
| 53 | SIGMA leverages protein structural information to predict the pathogenicity of missense variants | Cell Reports Methods | 2024-06-22 | 通讯作者 |
| 54 | Dual Growing Rods and the Apical Control Technique for Treating Congenital Early-Onset Scoliosis: Lessons Learned. | JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME | 2024-02-21 | 通讯作者 |
| 55 | Early mobilization can reduce the incidence of surgical site infections in patients undergoing spinal fusion surgery: A nested case-control study | AMERICAN JOURNAL OF INFECTION CONTROL | 2024-06-01 | 通讯作者 |
| 56 | Outcomes of Ponte osteotomy combined with posterior lumbar interbody fusion for reconstruction of coronal and sagittal balance in degenerative scoliosis | Journal of Orthopaedic Surgery and Research | 2023-11-28 | 通讯作者 |
| 57 | Defining Age-Adjusted PI–LL Targets for Surgical Realignment in Adult Degenerative Scoliosis: A Retrospective Cohort Study | Journal of Clinical Medicine | 2024-06-21 | 通讯作者 |
| 58 | Association between Adverse Psychological Emotions and Postoperative Brace for Adolescent Idiopathic Scoliosis: A Prospective Cohort Study with Propensity Score Matching | Orthopaedic Surgery | 2024-06-10 | 通讯作者 |
| 59 | The effect of pedicle screw instrumentation at a young age on upper thoracic vertebra and canal development | THE SPINE JOURNAL | 2023-09-01 | 通讯作者 |
| 60 | A rare intraoperative spinal cord injury caused by thoracic 8 nerve root interruption during posterior vertebral column resection surgery for severe congenital kyphoscoliosis: a case report | BMC NEUROLOGY | 2020-05-01 | 通讯作者 |
| 61 | Transient tracheal stenosis due to trachea compression and stretching after spinal deformity correction surgery | J Clin Anesth | 2021-10-09 | 通讯作者 |
| 62 | Diagnosis and treatment of the Ehlers-Danlos syndromes in China: synopsis of the first guidelines | Orphanet Journal of Rare Diseases | 2024-05-13 | 通讯作者 |
| 63 | The role and mechanism of inflammatory response to growing rod implantation in early onset scoliosis. | Frontiers in Cell and Developmental Biology | 2023-10-26 | 通讯作者 |
- 科研获奖Research Awards
| # | 获奖证书编号 | 奖项名称 | 获奖级别 | 获奖类别 | 获奖等级 | 获奖日期 | 颁奖单位 | 本单位是否为第一完成单位 | 完成单位排名 | 本人排序 | 备注 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 202008146P0804 | 中华医学科技奖 青年科技奖 | 省部级 | 其他省部级奖励 | 其他 | 2021-03-10 | 中华医学会 | 是 | 1 | 4 | |
| 2 | 200402024P0907 | 中华医学科技奖 | 省部级 | 其他省部级奖励 | 二等奖 | 2005-01-13 | 中华医学会 | 是 | 1 | 7 | |
| 3 | 2004医-2-028-03 | 北京市科学技术进步奖 | 省部级 | 省（市、自治区）政府自然科学奖、技术发明奖 | 二等奖 | 2005-02-01 | 北京市人民政府 | 是 | 1 | 3 | |
| 4 | 卫生部归国留学人员优秀论文 | 省部级 | 其他省部级奖励 | 一等奖 | 2004-03-01 | 卫生部 | 是 | 1 | 1 | ||
| 5 | 2005-J-233-2-06-R03 | 国家科技进步奖 | 国家级 | 国家最高科学技术奖、自然科学奖、技术发明奖、科技进步奖 | 二等奖 | 2005-11-20 | 中华人民共和国国务院 | 是 | 1 | 3 | |
| 6 | KXS-2021-1-2-P1103 | 中国康复医学会科学技术奖 | 省部级 | 其他省部级奖励 | 一等奖 | 2021-10-25 | 中国康复医学会 | 是 | 1 | 3 | |
| 7 | 2023-K-E-27-01 | 妇幼健康科学技术奖 | 省部级 | 科学技术奖 | 二等奖 | 2023-09-26 | 中国妇幼健康研究会 | 是 | 1 | 1 | |
| 8 | 2022-J06-2-14-R01 | 北京市科学技术进步奖 | 省部级 | 科学技术进步奖 | 一等奖 | 2023-10-21 | 北京市人民政府 | 是 | 1 | 1 |
- 研究成果Research Findings
| # | 成果类型 | 项目/专利/新品种名称 |
|---|---|---|
| 1 | 作为主创人员获得授权的发明专利和新品种 | 钛棒连接器及脊柱后路内固定系统 |
| 2 | 作为主创人员获得授权的发明专利和新品种 | 一种自固定型腰椎融合器 |
| 3 | 作为主创人员获得授权的发明专利和新品种 | 脊柱侧弯用滑动式椎弓根螺钉 |
| 4 | 作为主创人员获得授权的发明专利和新品种 | 多米诺连接装置 |
| 5 | 作为主创人员获得授权的发明专利和新品种 | 可调节生长阀及脊柱后路内固定系统 |
| 6 | 作为主创人员获得授权的发明专利和新品种 | 定位针和婴幼儿脊柱用椎弓根螺钉定位器 |
| 7 | 作为主创人员获得授权的发明专利和新品种 | 一种用于脊柱微创手术的螺钉植入装置 |
| 8 | 作为主创人员获得授权的发明专利和新品种 | 一种用于脊柱微创手术的压棒装置 |
| 9 | 作为主创人员获得授权的发明专利和新品种 | 一种改良型锁死结构及其装配方法 |
| 10 | 出版高水平专著 | The Growing Spine |
| 11 | 出版高水平专著 | 当代骨科诊断与治疗 |
| 12 | 出版高水平专著 | 脊柱解剖新概念 |
| 13 | 出版高水平专著 | 早发性脊柱畸形 |
| 14 | 出版高水平专著 | Bridwell&DeWald脊柱外科学 |
| 15 | 出版高水平专著 | 现代脊柱畸形诊疗 |
| 16 | 出版高水平专著 | 脊柱外科学 |
| 17 | 获得省部级及以上科研奖励 | 脊柱畸形重要遗传学病因的发现及推广 |
| 18 | 获得省部级及以上科研奖励 | 先天性脊柱畸形诊疗体系的建立与推广-3 |
| 19 | 获得省部级及以上科研奖励 | 先天性脊柱畸形诊疗体系的建立与推广 |
| 20 | 获得省部级及以上科研奖励 | 先天性骨骼畸形全新遗传病因的发现及机制研究 |
| 21 | 作为主创人员获得授权的发明专利和新品种 | 断棒连接器及系统 |
| 22 | 作为主创人员获得授权的发明专利和新品种 | 一种用于脊柱微创手术的压棒系统及方法 |
| 23 | 作为主创人员获得授权的发明专利和新品种 | 一种改良型锁死结构及其装配方法 |