导师风采
张抒扬
个人信息
Personal Information
- 性别：女
- 导师类型：博导
- 职称：主任医师
- 该职称任职时间：1991-07-31
联系方式
Contact Information
- 所属院系：北京协和医院
- 所属专业：内科学
- 邮箱 : shuyangzhang103@163.com
- 工作电话 : 13911667211
个人简介
Personal Profile
张抒扬，北京协和医院院长，内科学主任医师，教授，博士生导师，兼任中国医学科学院北京协和医学院副院校长。长江学者特聘教授，中国医学科学院北京协和医学院长聘教授。现任中华医学会罕见病分会首届主任委员，国家卫生健康委罕见病诊疗与保障专家委员会主任委员、药事管理与药物治疗学委员会主任委员，中国医师协会心血管内科医师分会候任会长，中华医学会心血管病分会常委兼秘书长。第十四届全国人大代表。2022年4月，荣获全国五一劳动奖章。张抒扬教授在我国率先建立了罕见病学科，从疾病定义、防诊治标准、研究体系、人才培养和政策研究等多方面建立了防诊治研管体系的中国方案。截至2023年6月，以第一或通信作者在NEJM、Lancet、Science、Nature等杂志发表SCI论文271篇，他引7550次，牵头罕见病多中心临床试验7项；主编《罕见病学》规划教材和专著11部；主持制定国家卫生健康委发布的《罕见病诊疗指南（2019版）》和专病指南8部。
团队简介
Team Profile
张抒扬，北京协和医院院长，内科学主任医师，教授，博士生导师，兼任中国医学科学院北京协和医学院副院校长。长江学者特聘教授，中国医学科学院北京协和医学院长聘教授。现任中华医学会罕见病分会首届主任委员，国家卫生健康委罕见病诊疗与保障专家委员会主任委员、药事管理与药物治疗学委员会主任委员，中国医师协会心血管内科医师分会候任会长，中华医学会心血管病分会常委兼秘书长。第十四届全国人大代表。2022年4月，荣获全国五一劳动奖章。张抒扬教授在我国率先建立了罕见病学科，从疾病定义、防诊治标准、研究体系、人才培养和政策研究等多方面建立了防诊治研管体系的中国方案。截至2023年6月，以第一或通信作者在NEJM、Lancet、Science、Nature等杂志发表SCI论文271篇，他引7550次，牵头罕见病多中心临床试验7项；主编《罕见病学》规划教材和专著11部；主持制定国家卫生健康委发布的《罕见病诊疗指南（2019版）》和专病指南8部。
- 研究方向Research Directions
罕见心血管疾病临床和基础研究
- 在校研究生Current Graduate Students
硕士研究生 0 名，博士研究生 12 名
- 科研项目Research Projects
| # | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
|---|---|---|---|---|---|
| 1 | 国家罕见病注册登记研究平台建设 | 2016-06-01 —— 2020-07-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 2 | 罕见病临床队列研究 | 2016-06-01 —— 2020-12-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 3 | 肠道菌群结构特征与冠心病亚型关联研究 | 2017-01-27 —— 2020-12-27 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 4 | 重型及危重型新型冠状病毒肺炎标准化临床数据库建立及治疗方案真实世界研究 | 2020-07-01 —— 2021-06-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 5 | 罕见病多模态分布式数据协作平台构建与应用 | 2022-12-01 —— 2025-11-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 6 | 罕见病多模态辅助诊疗平台建立及临床转化应用 | 2022-12-01 —— 2025-11-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 7 | 家族性高胆固醇血症患者肠道微生物组与血清脂质组研究 | 2022-01-01 —— 2025-12-31 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 8 | 基于SARS-CoV-2 RdRp复合物结构药物筛选与优化 | 2021-01-01 —— 2023-12-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 9 | 家族性高胆固醇血症新药研发：以PCSK9为靶点的PROTAC设计 | 2020-12-01 —— 2023-12-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 10 | 综合性医用设备研发测试创新示范中心建设 | 2022-11-01 —— 2025-10-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 11 | 疑难罕见心血管疾病诊治体系建立 | 2022-10-01 —— 2025-09-01 | 主持的企业/行业委托重大项目 | 主持人 | |
| 12 | 罕见病诊疗新技术研发及转化研究 | 2022-11-01 —— 2025-10-01 | 主持的企业/行业委托重大项目 | 主持人 | |
| 13 | 新型冠状病毒感染患者出院后长期随访队列研究 | 2023-03-01 —— 2025-12-04 | 主持的企业/行业委托重大项目 | 主持人 | |
| 14 | 基于尸体解剖的COVID-19 重要脏器损伤机制的研究 | 2020-01-01 —— 2020-12-01 | 主持的企业/行业委托重大项目 | 主持人 | |
| 15 | 临床医学（八年制）课程改革大纲编写（临床阶段） | 2020-07-01 —— 2022-12-31 | 主持的企业/行业委托重大项目 | 主持人 | |
| 16 | 罕见病的精准诊疗研究 | 2021-10-01 —— 2025-12-01 | 主持的企业/行业委托重大项目 | 主持人 |
- 发表论文Papers
| # | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
|---|---|---|---|---|
| 1 | Current Status of Familial Hypercholesterolemia in China: A Need for Patient FH Registry Systems | FRONT PHYSIOL | 2019-03-01 | 通讯作者 |
| 2 | Alterations in the gut microbiome and metabolism with coronary artery disease severity | MICROBIOME | 2019-04-01 | 通讯作者 |
| 3 | Correlation between cytokines and coagulation-related parameters in patients with coronavirus disease 2019 admitted to ICU | Clinica chimica Acta | 2020-07-01 | 通讯作者 |
| 4 | TCOF1 pathogenic variants identified by Whole-exome sequencing in Chinese Treacher Collins syndrome families and hearing rehabilitation effect. | Orphanet Journal of Rare Diseases | 2019-07-16 | 通讯作者 |
| 5 | Identification and validation of four hub genes involved in the plaque deterioration of atherosclerosis. | Aging-US | 2019-08-26 | 通讯作者 |
| 6 | Effect of different ranges of systolic blood pressure on left ventricular structure and diastolic function in a Chinese population: a cross-sectional population-based Shunyi study | BMJ OPEN | 2019-08-01 | 通讯作者 |
| 7 | Takayasu Arteritis With Coronary Artery Involvement: Differences Between Pediatric and Adult Patients | CANADIAN JOURNAL OF CARDIOLOGY | 2020-04-20 | 通讯作者 |
| 8 | Comparing the effects of different management strategies on long-term outcomes for significant coronary stenosis in patients with Takayasu arteritis | INTERNATIONAL JOURNAL OF CARDIOLOGY | 2020-05-01 | 通讯作者 |
| 9 | Brief Report: Anti-phospholipid antibodies in critically ill patients with Coronavirus Disease 2019 (COVID-19). | Arthritis & Rheumatology | 2020-07-30 | 通讯作者 |
| 10 | Clinical characteristics and prognosis of Chinese patients with hereditary transthyretin amyloid cardiomyopathy. | ORPHANET J RARE DIS | 2019-11-12 | 通讯作者 |
| 11 | Eltrombopag is a potential target for drug intervention in SARS-CoV-2 spike protein | INFECTION GENETICS AND EVOLUTION | 2020-06-12 | 通讯作者 |
| 12 | Establishment of an induced pluripotent stem cell line from a patient with hereditary transthyretin amyloidosis carrying transthyretin (TTR) mutation p.Phe53Val | Stem Cell Research | 2020-08-03 | 通讯作者 |
| 13 | Gut microbiota from coronary artery disease patients contributes to vascular dysfunction in mice by regulating bile acid metabolism and immune activation | JOURNAL OF TRANSLATIONAL MEDICINE | 2020-10-01 | 通讯作者 |
| 14 | Platelet Inhibition with Ticagrelor versus Clopidogrel in Diabetic Patients after Percutaneous Coronary Intervention for Chronic Coronary Syndromes | THROMBOSIS AND HAEMOSTASIS | 2020-08-01 | 通讯作者 |
| 15 | Structural Basis for Inhibition of the RNA-dependent RNA Polymerase From SARS-CoV-2 by Remdesivir | SCIENCE | 2020-06-01 | 通讯作者 |
| 16 | Impact of coronary involvement on long-term outcomes in patients with Takayasu‘s arteries | Clinical and experimental rheumatology | 2020-12-01 | 通讯作者 |
| 17 | Ventricular arrhythmia predicts poor outcome in polymyositis/dermatomyositis with myocardial involvement | RHEUMATOLOGY | 2020-12-28 | 通讯作者 |
| 18 | Neutrophil activation and neutrophil derived neutrophil extracellular trap formation in patients with coronary artery ectasia | BMC CARDIOVASCULAR DISORDERS | 2020-03-01 | 通讯作者 |
| 19 | Risk factors for progression of carotid intima-media thickness in patients with systemic lupus erythematosus: protocol for an observational cohort study in China | BMJ OPEN | 2019-09-01 | 通讯作者 |
| 20 | Reduction in SLEDAI is associated with improved arterial stiffness in systemic lupus erythematosus | SCI REP-UK | 2020-03-01 | 通讯作者 |
| 21 | Patient Characteristics, Diagnostic Delays, Treatment Patterns, Treatment Outcomes, Comorbidities, and Treatment Costs of Acromegaly in China: A Nationwide Study | Frontiers in Endocrinology | 2020-12-01 | 通讯作者 |
| 22 | Swollen heart in COVID-19 patients who progress to critical illness: a perspective from echo-cardiologists | ESC Heart Failure | 2020-09-01 | 通讯作者 |
| 23 | Safety and efficacy of tracheotomy for critically ill patients with coronavirus disease 2019（COVID-19）in Wuhan：a case series of 14 patients | European Journal of Cardio-Thoracic Surgery | 2020-09-01 | 通讯作者 |
| 24 | ECCO2R in 12 COVID-19 ARDS Patients With Extremely Low Compliance and Refractory Hypercapnia | frontiers in medicine | 2021-07-01 | 通讯作者 |
| 25 | Clinical characteristics and survival analysis in critical and non-critical patients with COVID-19 in Wuhan，China：a single-center restrospective case control study | SCIENTIFIC REPORTS | 2020-10-01 | 通讯作者 |
| 26 | Intracellular calcium current disorder and disease phenotype in OBSCN mutant iPSC-based cardiomyocytes in arrhythmogenic right ventricular cardiomyopathy | THERANOSTICS | 2020-09-01 | 通讯作者 |
| 27 | Plasma concentration of receptor-interacting protein kinase-3 as a potential biomarker for diagnosis and prognosis in heart failure | CLINICA CHIMICA ACTA | 2020-10-01 | 通讯作者 |
| 28 | Antiphospholipid Antibodies in Critically Ill Patients With COVID-19 | Arthritis & rheumatolog | 2020-12-01 | 通讯作者 |
| 29 | IP-10 and MCP-1 as biomarkers associated with disease severity of COVID-19 | Molecular medicine (Cambridge, Mass.) | 2020-10-01 | 通讯作者 |
| 30 | Long noncoding RNA ASB16-AS1 inhibits adrenocortical carcinoma cell growth by promoting ubiquitination of RNA-binding protein HuR | Cell death & disease | 2020-11-01 | 通讯作者 |
| 31 | Risk factors for mortality due to COVID-19 in intensive care units: a single-center study | Annals of Translational Medicine | 2021-04-01 | 通讯作者 |
| 32 | Gut microbiota dysbiosis in stable coronary artery disease combined with type 2 diabetes mellitus influences cardiovascular prognosis | NUTRITION METABOLISM AND CARDIOVASCULAR DISEASES | 2021-01-21 | 通讯作者 |
| 33 | Establishment of an induced pluripotent stem cell line PUMCHi004-A from a hereditary transthyretin amyloid cardiomyopathy patient with transthyretin (TTR) p.Asp38Asn mutation. | Stem Cell Research | 2020-12-15 | 通讯作者 |
| 34 | The Effects of Cumulative Dose and Polymorphisms in CYP2B6 on the Mitotane Plasma Trough Concentrations in Chinese Patients With Advanced Adrenocortical Carcinoma | Frontiers in Oncology | 2022-06-30 | 通讯作者 |
| 35 | Fighting COVID-19：a qualitative study into the lives of intensive care unit survivors in Wuhan, China | BMJ Open | 2022-02-25 | 通讯作者 |
| 36 | Shock in China 2018(SIC-Study): a cross-sectional survey | Annals of Translational Medicine | 2021-08-01 | 通讯作者 |
| 37 | Physicians' knowledge on specific rare diseases and its associated factors: a national cross-sectional study from China | Orphanet Journal of Rare Diseases | 2022-05-05 | 通讯作者 |
| 38 | Burnout and Well-Being Among Medical Professionals in China: A National Cross-Sectional Study | FRONTIERS IN PUBLIC HEALTH | 2022-01-17 | 通讯作者 |
| 39 | National Rare Diseases Registry System (NRDRS): China's first nation-wide rare diseases demographic analyses | ORPHANET JOURNAL OF RARE DISEASES | 2021-12-18 | 通讯作者 |
| 40 | Lipopolysacchride Alters the m6A Epitransscriptomic Tagging of RNAs in the Cardiac Tissure | Frontiers in Molecular Biosciences | 2021-07-28 | 通讯作者 |
| 41 | Validation of diagnostic and predictive biomarkers for hereditary angioedema via plasma N-glycomics | CLINICAL AND TRANSLATIONAL ALLERGY | 2021-12-27 | 通讯作者 |
| 42 | Retrospective Study of Critically Ill COVID-19 Patients With and Without Extracorporeal Membrane Oxygenation Support in Wuhan, China | Frontiers in medicine | 2021-10-12 | 通讯作者 |
| 43 | The risk factors for weaning failure of mechanically ventilated patients with COVID-19： a retrospective study in national medical team work | Frontiers in Medicine | 2021-08-31 | 通讯作者 |
| 44 | The effects of moderate alcohol consumption on circulating metabolities and gut microbiota in patients with coronary artery disease | frontiers in cardiovascular medicine | 2021-11-02 | 通讯作者 |
| 45 | impacts of cigarette smoking status on metabolomic and gut microbiota profile in male patients with coronary artery disease：a multi-omics study | frontiers in cardiovascular medicine | 2021-10-28 | 通讯作者 |
| 46 | Dynamic landscape mapping of humoral immunity to SARS-CoV-2 identifies non-structural protein antibodies associated with the survival of critical COVID-19 patients. | Signal Transduct Target Ther | 2021-08-17 | 通讯作者 |
| 47 | Design of the Shunyi study on cardiovascular disease and age-related brain changes: a community-based, prospective, cohort study. | Annals of Translational Medicine | 2020-12-08 | 通讯作者 |
| 48 | Risk Factors for Cardiac Complications in Patients With Pheochromocytoma and Paraganglioma: A Retrospective Single-Center Study. | Frontiers in Endocrinology | 2022-06-01 | 通讯作者 |
| 49 | CCL17 acts as a novel therapeutic target in pathological cardiac hypertrophy and heart failure | JOURNAL OF EXPERIMENTAL MEDICINE | 2022-08-01 | 通讯作者 |
| 50 | Plasma levels of receptor interacting protein kinase-3 correlated with coronary artery disease | CHINESE MEDICAL JOURNAL | 2019-07-20 | 通讯作者 |
| 51 | Identification of sequence variants associated with severe microtia-astresia by targeted sequencing | BMC Medical Genomics | 2019-01-28 | 通讯作者 |
| 52 | Application of an iPSC-derived organoid model for located scleroderma therapy | Advanced Science | 2022-05-01 | 通讯作者 |
| 53 | Establishment of human pluripotent stem cell-derived skin organoids enabled pathophysiological model of SARS-CoV-2 infections | Advanced Science | 2022-03-01 | 通讯作者 |
| 54 | Evaluating the national system for rare diseases in China from the point of drug access: progress and challenges | Orphanet Journal of Rare Diseases | 2022-09-10 | 通讯作者 |
| 55 | Management guideline for the off-label use of medicine in China (2021) | Expert Review of Clinical Pharmacology | 2022-09-01 | 通讯作者 |
| 56 | A cohort autopsy study defines COVID-19 systemic pathogenesis | CELL RESEARCH | 2021-06-16 | 通讯作者 |
| 57 | Evaluating the psychometric properties of the EQ-5D-5L and SF-6D among patients with haemophilia | European Journal of Health Economics | 2021-03-24 | 通讯作者 |
| 58 | Cardiac Involvement in COVID-19: A Global Bibliometric and Visualized Analysis | Frontiers in Cardiovascular Medicine | 2022-07-27 | 通讯作者 |
| 59 | Higher Serum 25-Hydroxyvitamin D Is Associated with Lower All-Cause and Cardiovascular Mortality among US Adults with Nonalcoholic Fatty Liver Disease | Nutrients | 2022-09-27 | 通讯作者 |
| 60 | The Prediction Value of D-Dimer on Prognosis in Intensive Care Unit among Old Patients ( >= 65 Years): A 9-Year Single-Center Retrospective Study of 9261 Cases | Oxidative Medicine and Cellular Longevity | 2022-12-17 | 通讯作者 |
| 61 | Phenotypic Disease Network-Based Multimorbidity Analysis in Idiopathic Cardiomyopathy Patients with Hospital Discharge Records | Journal of Clinical Medicine | 2022-11-25 | 通讯作者 |
| 62 | Clinical Characteristics, Treatment and Outcomes in Patients with Idiopathic Inflammatory Myopathy Concomitant with Heart Failure: A Retrospective Single-Center Study | International Heart Journal | 2020-09-01 | 通讯作者 |
| 63 | Spatial-region-resolved proteome map reveals mechanism of COVID-19-associated heart injury | Cell Reports | 2022-06-14 | 通讯作者 |
| 64 | Data-independent acquisition mass spectrometry reveals comprehensive plasma protein profiles in the natural history of patients with hereditary transthyretin amyloidosis (ATTRv) | Expert Review of Proteomics | 2023-04-06 | 通讯作者 |
| 65 | Hormone- and antibody-mediated activation of the thyrotropin receptor | NATURE | 2022-08-08 | 通讯作者 |
| 66 | Effect of berberine on global modulation of lncRNAs and mRNAs expression profiles in patients with stable coronary heart disease | BMC GENOMICS | 2022-05-26 | 通讯作者 |
| 67 | Assessing validity of the EQ-5D-5L proxy in children and adolescents with Duchenne muscular dystrophy or spinal muscular atrophy | European Journal of Health Economics | 2023-02-21 | 通讯作者 |
| 68 | Mapping the Haem-A-QoL to the EQ-5D-5L in patients with hemophilia | QUALITY OF LIFE RESEARCH | 2022-05-31 | 通讯作者 |
| 69 | Gut microbiota metabolic characteristics in coronary artery disease patients with hyperhomocysteine | JOURNAL OF MICROBIOLOGY | 2022-03-04 | 通讯作者 |
| 70 | Developing the health state classification system for a condition-specific preference-based measure for patients with myasthenia gravis | DISABILITY AND REHABILITATION | 2022-09-14 | 通讯作者 |
| 71 | Suppressing the intestinal farnesoid X receptor/sphingomyelin phosphodiesterase 3 axis decreases atherosclerosis | JOURNAL OF CLINICAL INVESTIGATION | 2022-05-03 | 通讯作者 |
| 72 | Multi-omics study reveals that statin therapy is associated with restoration of gut microbiota homeostasis and improvement in outcomes in patients with acute coronary syndrome | Theranostics | 2021-03-31 | 通讯作者 |
| 73 | SARS-CoV-2 not found in pressure injury exudates from COVID-19 patients | Journal of Cosmetic Dermatology | 2021-02-01 | 通讯作者 |
| 74 | Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin | NATURE STRUCTURAL & MOLECULAR BIOLOGY | 2021-03-01 | 通讯作者 |
| 75 | Antiviral drug design based on structural insights into the N-terminal domain and C-terminal domain of the SARS-CoV-2 nucleocapsid protein | Science Bulletin | 2022-10-27 | 通讯作者 |
| 76 | Gut microbiota combined with metabolites reveals unique features of acute myocardial infarction patients different from stable coronary artery disease | Journal of Advanced Research | 2023-04-21 | 通讯作者 |
| 77 | First-In-Human Study to Assess the Safety, Pharmacokinetics, and Pharmacodynamics of SHR2285, a Small-Molecule Factor XIa Inhibitor in Healthy Subjects | Frontiers in Pharmacology | 2022-02-10 | 通讯作者 |
| 78 | The impact of CYP2D6*41 on CYP2D6 enzyme activity using phenotyping methods in urine, plasma, and saliva | Frontiers in Pharmacology | 2022-08-30 | 通讯作者 |
| 79 | Neutrophil infiltration and myocarditis in patients with severe COVID-19: A post-mortem study | Frontiers in Cardiovascular Medicine | 2022-10-14 | 通讯作者 |
| 80 | Alterations of Gut Microbiome and Serum Metabolome in Coronary Artery Disease Patients Complicated With Non-alcoholic Fatty Liver Disease Are Associated With Adverse Cardiovascular Outcomes | Frontiers in Cardiovascular Medicine | 2022-01-03 | 通讯作者 |
| 81 | Developing a Hybrid Risk Assessment Tool for Familial Hypercholesterolemia: A Machine Learning Study of Chinese Arteriosclerotic Cardiovascular Disease Patients | Frontiers in Cardiovascular Medicine | 2022-08-03 | 通讯作者 |
| 82 | EQ-5D and SF-6D health utility scores in patients with spinal and bulbar muscular atrophy | European Journal of Health Economics | 2022-11-23 | 通讯作者 |
| 83 | Myocardial Injury on Admission as a Risk in Critically Ill COVID-19 Patients: A Retrospective in-ICU Study | JOURNAL OF CARDIOTHORACIC AND VASCULAR ANESTHESIA | 2020-10-16 | 通讯作者 |
| 84 | Ultrasound-guided nusinersen administration for spinal muscular atrophy patients with severe scoliosis: an observational study | Orphanet Journal of Rare Diseases | 2021-06-13 | 通讯作者 |
| 85 | Effects of long-term right ventricular apex pacing on left ventricular dyssynchrony, morphology and systolic function | INTERNATIONAL JOURNAL OF CARDIOLOGY | 2021-05-15 | 通讯作者 |
| 86 | Quality of Life and its Determinants in Patients With Treated Acromegaly: A Cross-Sectional Nationwide Study in China | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM | 2021-01-01 | 通讯作者 |
| 87 | Mapping of the acromegaly quality of life questionnaire to ED-5D-5L index score among patients with acromegaly | European Journal of Health Economics | 2021-05-14 | 通讯作者 |
| 88 | A Comprehensive Analysis of Genomics and Metagenomics in a Heterozygote Familial Hypercholesterolemia Family | Frontiers in Cellular and Infection Microbiology | 2021-03-02 | 通讯作者 |
| 89 | Investigating the Added Value of the EQ-5D-5L With Two Bolt-On Items in Patients With Hemophilia | frontiers in medicine | 2021-08-05 | 通讯作者 |
| 90 | Establishing a Risk Prediction Model for Atherosclerosis in Systemic Lupus Erythematosus | Frontiers in Immunology | 2021-04-16 | 通讯作者 |
| 91 | Patient-Identified Problems and Influences Associated With Diagnostic Delay of Acromegaly: A Nationwide Cross-Sectional Study | Frontiers in Endocrinology | 2021-10-21 | 通讯作者 |
| 92 | Empirical anti-tuberculous therapy for the massive pericardial effusion of unknown etiology | CURRENT MEDICAL RESEARCH AND OPINION | 2021-07-10 | 通讯作者 |
| 93 | Neurological Manifestations in Critically Ill Patients With COVID-19:A Retrospective Study | Frontiers in Neurology | 2020-07-10 | 通讯作者 |
| 94 | Study design and rationale of EXPLORER-CN: a phase III, randomised, double-blind, placebo-controlled clinical study to evaluate the efficacy and safety of mavacamten in Chinese adults with symptomatic obstructive hypertrophic cardiomyopathy | BMJ Open | 2023-06-19 | 通讯作者 |
| 95 | Cardiovascular Impairment in COVID-19: Learning From Current Options for Cardiovascular Anti-Inflammatory Therapy | Frontiers in Cardiovascular Medicine | 2020-04-30 | 通讯作者 |
| 96 | Immunotherapy for the rheumatoid arthritis-associated coronary artery disease: promise and future. | CHINESE MEDICAL JOURNAL | 2019-12-20 | 通讯作者 |
| 97 | Innovation in Informatics to Improve Clinical Care and Drug Accessibility for Rare Diseases in China | Frontiers in Pharmacology | 2021-10-15 | 通讯作者 |
| 98 | Manifestations and Mechanism of SARS-CoV2 Mediated Cardiac Injury | International Journal of Biological Sciences | 2023-05-28 | 通讯作者 |
| 99 | Risk for newly diagnosed diabetes after COVID-19: a systematic review and meta-analysis | BMC Medicine | 2022-11-15 | 通讯作者 |
| 100 | Clinical phenotypes and genetic features of hereditary transthyretin amyloidosis patients in China | Orphanet Journal of Rare Diseases | 2022-09-02 | 通讯作者 |
| 101 | Relationship between gestational acrylamide exposure and offspring’s growth: a systematic review and meta-analysis of cohort studies | PUBLIC HEALTH NUTRITION | 2020-04-30 | 通讯作者 |
| 102 | Current understanding of gut microbiota alterations and related therapeutic intervention strategies in heart failure | CHINESE MEDICAL JOURNAL | 2019-08-05 | 通讯作者 |
| 103 | Anti-inflammatory and immune therapy in severe coronavirus disease 2019 (COVID-19) patients: An update. | Clinical immunology (Orlando, Fla.) | 2022-04-25 | 通讯作者 |
| 104 | The Structural Understanding of Transthyretin Misfolding and the Inspired Drug Approaches for the Treatment of Heart Failure Associated With Transthyretin Amyloidosis. | FRONT PHARMACOL | 2021-02-18 | 通讯作者 |
| 105 | The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The perspective of clinical immunologists from China. | CLINICAL IMMUNOLOGY | 2020-05-25 | 通讯作者 |
| 106 | Recommendations fromthe Peking Union Medical College Hospital for the management of acutemyocardial infarction during the COVID-19 outbreak | European Heart Journal | 2020-05-01 | 通讯作者 |
| 107 | GOVID-19:the role of excessive cytokine telease and potential ACE2 down-regulation in promoting hypercoagulable state associated with severe illness | JOURNAL OF THROMBOSIS AND THROMBOLYSIS | 2020-07-01 | 通讯作者 |
| 108 | Pathological Mechanisms and Potential Therapeutic Targets of Pulmonary Arterial Hypertension：A Review | Aging and disease | 2020-01-01 | 通讯作者 |
| 109 | Health-related quality of life in children and adolescents with Duchenne muscular dystrophy and comorbid attention-deficit hyperactivity disorder using propensity-score matching | JOURNAL OF AFFECTIVE DISORDERS | 2023-07-15 | 通讯作者 |
| 110 | Epidemiological research on rare diseases using large-scale online search queries and reported case data | Orphanet Journal of Rare Diseases | 2023-08-09 | 通讯作者 |
| 111 | Physicians' use and perceptions of genetic testing for rare diseases in China: a nationwide cross-sectional study | Orphanet Journal of Rare Diseases | 2023-08-10 | 通讯作者 |
| 112 | Drug Repositioning for Amyloid Transthyretin Amyloidosis by Interactome Network Corrected by Graph Neural Networks and Transcriptome Analysis | HUMAN GENE THERAPY | 2023-11-15 | 通讯作者 |
| 113 | Identification of gut microbiota dysbiosis in bullous pemphigoid under different disease activity | EXPERIMENTAL DERMATOLOGY | 2023-09-01 | 通讯作者 |
| 114 | Long-Term Prognosis of Different Subtypes of Left Ventricular Noncompaction Cardiomyopathy Patients: A Retrospective Study in China | Journal of Cardiovascular Development and Disease | 2023-08-28 | 通讯作者 |
| 115 | The Presence, Location, and Degree of Late Gadolinium Enhancement in Relation to Myocardial Dysfunction and Poor Prognosis in Patients with Systemic Lupus Erythematosus | Journal of Cardiovascular Development and Disease | 2023-10-31 | 通讯作者 |
| 116 | Effect of Mavacamten on Chinese Patients With Symptomatic Obstructive Hypertrophic Cardiomyopathy The EXPLORER-CN Randomized Clinical Trial | JAMA Cardiology | 2023-10-01 | 通讯作者 |
| 117 | Identifcation and validation of the association of Janus kinase 2 mutations with the response to immune checkpoint inhibitor therapy | INFLAMMATION RESEARCH | 2024-01-10 | 通讯作者 |
| 118 | Transcriptome and open chromatin analysis reveals the process of myocardial cell development and key pathogenic target proteins in Long QT syndrome type 7 | Journal of Translational Medicine | 2024-03-25 | 通讯作者 |
| 119 | Influence of plasma collection tubes on N-glycome in human blood sample | Practical Laboratory Medicine | 2024-03-02 | 通讯作者 |
| 120 | Chinese consensus on the diagnosis and treatment of immunoglobulin light-chain cardiac amyloidosis | CHINESE MEDICAL JOURNAL | 2023-12-22 | 通讯作者 |
- 科研获奖Research Awards
无
- 研究成果Research Findings
| # | 成果类型 | 项目/专利/新品种名称 |
|---|---|---|
| 1 | 出版高水平专著 | 罕见病诊疗指南（2019版） |
| 2 | 出版高水平专著 | 新冠肺炎疫情中各类人员心理防护实用手册 |
| 3 | 出版高水平专著 | 罕见病学 |
| 4 | 获得省部级及以上科研奖励 | 2019年全国住院医师规范化培训“优秀专业基地管理者” |
| 5 | 获得省部级及以上科研奖励 | 优秀教学论文 |
| 6 | 获得省部级及以上科研奖励 | 基于胜任力的“8+3”一贯式高层次复合型医学人才培养体系的探索与实践 |