导师风采
李单青
个人信息
Personal Information
- 性别：男
- 导师类型：博导
- 职称：主任医师
- 该职称任职时间：17
联系方式
Contact Information
- 所属院系：北京协和医院
- 所属专业：
- 邮箱 : lishanqing@pumch.cn
- 工作电话 : 18612622232
个人简介
Personal Profile
李单青，主任医师，博士生研究生导师，现任北京协和医院胸外科主任，胸心外科党支部书记。1989年起于北京协和医院外科工作，2007年起担任胸外科主任，医风端正，技术精湛，以德施教、以德立身，培养了三十余名胸外科研究生。目前任中国医疗保健国际交流促进会常务理事兼胸外科分会副主任委员、中国医学基金会理事兼胸外科专业委员会副主任委员、中华医学会胸心血管外科学会常委、中国医师协会胸外科分会常委、北京医学会胸外科分会候任主任委员、北京医师协会胸外科分会副会长等多项学术职务。人民日报“国之名医”，科技部国家重点研发计划“智能机器人”重点专项首席科学家，另牵头负责多项教育部、医科院项目及课题，发表百余篇SCI、核心期刊论文。
团队简介
Team Profile
李单青教授领导的胸外科团队以亚专科建设为基础，以人才培养和科学研究为核心，致力于推动胸外科领域的发展。团队拥有丰富的教学经验、优秀的科研实力、完善的人才培养体系、显著的科研成果和优秀的教学成果。团队成员积极参与教学工作，承担课堂教学、临床教学、研究生培养等任务，并取得优异成绩。团队承担多项国家级、省部级科研项目，发表大量高水平论文，并获得多项国家级、省部级科技奖励。团队以亚专科建设为基础，全方位培养青年教师，提供良好的科研平台和学术交流机会，实行科学化、规范化的管理模式，强调团队合作和集体智慧，充分发挥团队成员的专长和优势。
- 研究方向Research Directions
胸部疾病外科综合治疗
- 在校研究生Current Graduate Students
硕士研究生 0 名，博士研究生 6 名
- 科研项目Research Projects
| # | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
|---|---|---|---|---|---|
| 1 | 炎性肺损伤和修复的系统生物医学研究 | 2017-12-01 —— 2020-12-01 | 主持的企业/行业委托重大项目 | 主持人 | |
| 2 | 超声成像技术在胸腔镜手术领域新技术适用性研究及临床实践体系建立 | 2023-12-01 —— 2025-11-30 | 主持的企业/行业委托重大项目 | 主持人 | |
| 3 | 胸部重大肿瘤疾病诊治策略完善与提高 | 2022-10-01 —— 2025-09-01 | 主持的企业/行业委托重大项目 | 主持人 | |
| 4 | 系统集成与实验研究 | 2020-12-01 —— 2023-11-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 5 | 面向肺部微小结节的支气管介入诊断机器人技术与系统研制 | 2020-12-01 —— 2023-11-01 | 主持在研的国家或省部级科研项目 | 主持人 |
- 发表论文Papers
| # | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
|---|---|---|---|---|
| 1 | KLF8 overexpression promotes the growth of human lung cancer cells by promoting the expression of JMJD2A | CANCER CELL INTERNATIONAL | 2019-10-01 | 通讯作者 |
| 2 | The analysis of prognosis factor in patients with non-small cell lung cancer receiving pneumonectomy | JOURNAL OF THORACIC DISEASE | 2020-04-01 | 通讯作者 |
| 3 | LncRNA HCG11 Suppresses Cell Proliferation and Promotes Apoptosis via Sponging miR-224-3p in Non-Small-Cell Lung Cancer Cells | OncoTargets and Therapy | 2020-06-14 | 通讯作者 |
| 4 | Potential treatment strategy for the rare osimertinib resistant mutation EGFR L718Q | JOURNAL OF THORACIC DISEASE | 2020-05-01 | 通讯作者 |
| 5 | Extended thymectomy with blood vessel resection and reconstruction improves therapeutic outcome for clinical stage III thymic carcinoma patients: a real-world research | JOURNAL OF CARDIOTHORACIC SURGERY | 2020-09-01 | 通讯作者 |
| 6 | Efficient isolation and quantification of circulating tumor cells in non-small cell lung cancer patients using peptide-functionalized magnetic nanoparticles | J Thoracic Disease | 2020-06-01 | 通讯作者 |
| 7 | Identification of a novel gene expression signature associated with overall survival in patients with lung adenocarcinoma: a comprehensive analysis based on TCGA and GEO databases | Lung Cancer | 2020-09-01 | 通讯作者 |
| 8 | Metastatic Patterns of Mediastinal Lymph Nodes in Small-Size Non-small Cell Lung Cancer (T1b) | FRONTIERS IN SURGERY | 2020-09-01 | 通讯作者 |
| 9 | Preoperative Prediction of Lymph Node Metastasis in Patients With Early-T-Stage Non-small Cell Lung Cancer by Machine Learning Algorithms | FRONTIERS IN ONCOLOGY | 2020-05-01 | 通讯作者 |
| 10 | An Externally-Validated Dynamic Nomogram Based on Clinicopathological Characteristics for Evaluating the Risk of Lymph Node Metastasis in Small-Size Non-small Cell Lung Cancer | FRONTIERS IN ONCOLOGY | 2020-07-01 | 通讯作者 |
| 11 | First-line treatment selection with organoids of an EGFRm+TP53m stage IA1 patient with early metastatic recurrence after radical surgery and follow-up | JOURNAL OF THORACIC DISEASE | 2020-07-01 | 通讯作者 |
| 12 | Role of chemotherapy for survival in patients with second primary non-small cell lung cancer | Thorac Cancer | 2020-12-01 | 通讯作者 |
| 13 | Ultrasensitive detection of circulating tumour DNA via deep methylation sequencing aided by machine learning | Nature Biomedical Engineering | 2021-06-15 | 通讯作者 |
| 14 | Postoperative short-term outcomes between sublobar resection and lobectomy in patients with lung adenocarcinoma. | Cancer Management and Research | 2020-10-01 | 通讯作者 |
| 15 | DNA methylation patterns at and beyond the histological margin of early-stage invasive lung adenocarcinoma radiologically manifested as pure ground-glass opacity | Clinical Epigenetics | 2021-08-19 | 通讯作者 |
| 16 | Clinicopathological Features and Prognosis of Primary Mediastinal Malignant Germ Cell Tumors: A Retrospective Single-Institution Analysis | Cancer Management and Research | 2021-11-13 | 通讯作者 |
| 17 | Prognostic factors of T2aN0M0 (T3-4cmN0M0, stage IB) non-small-cell lung cancer after surgery: Single-center real-world research | Thoracic Cancer | 2021-12-01 | 通讯作者 |
| 18 | Surgical treatment is effective in treating thymoma accompanied with non-myathenia gravis autoimmune dieases: a single-center clinical experience | Scandinavian Journal of Surgery | 2021-09-01 | 通讯作者 |
| 19 | Clinicopathological models for predicting lymph node metastasis in patients with early-stage lung adenocarcinoma: the application of machine learning algorithms. | J Thorac Dis | 2021-09-01 | 通讯作者 |
| 20 | Transcriptomic and Mutational Analysis Discovering Distinct Molecular Characteristics Among Chinese Thymic Epithelial Tumor Patients | Front Oncol | 2021-09-08 | 通讯作者 |
| 21 | Identification and validation of an individualized prognostic signature of lung squamous cell carcinoma based on ferroptosis-related genes | Thoracic Cancer | 2021-10-20 | 通讯作者 |
| 22 | Delayed Discharge after Thoracic Surgery under the Guidance of ERAS Protocols | THORACIC AND CARDIOVASCULAR SURGEON | 2022-08-01 | 通讯作者 |
| 23 | Comprehensive analysis of T cell receptor repertoire in patients with KRAS mutant non-small cell lung cancer | Translational Lung Cancer Research | 2022-09-14 | 通讯作者 |
| 24 | Prognosis of segmentectomy in the treatment of stage IA non-small cell lung cancer | Oncology Letters | 2021-01-01 | 通讯作者 |
| 25 | Compare the prognosis of Da Vinci robot-assisted thoracic surgery (RATS) with video-assisted thoracic surgery (VATS) for non-small cell lung cancer A Meta-analysis | MEDICINE | 2019-09-01 | 通讯作者 |
| 26 | Physical activity and cancer risk: a dose-response analysis for the Global Burden of Disease Study 2019 | Cancer Communications | 2023-09-24 | 通讯作者 |
| 27 | SUMOylation-triggered ALIX activation modulates extracellular vesicles circTLCD4-RWDD3 to promote lymphatic metastasis of non-small cell lung cancer | Signal Transduction and Targeted Therapy | 2023-11-04 | 通讯作者 |
| 28 | Re-exploration of prognosis in type B thymomas: establishment of a predictive nomogram model | World Journal of Surgical Oncology | 2024-01-23 | 通讯作者 |
| 29 | Real-world efficacy of adjuvant therapy for totally resected stage I lung adenocarcinoma patients with pathological high-risk factors: propensity score analysis | BMC Surgery | 2024-05-08 | 通讯作者 |
| 30 | Clonal expansion of shared T cell receptors reveals the existence of immune commonality among different lesions of synchronous multiple primary lung cancer | CANCER IMMUNOLOGY IMMUNOTHERAPY | 2024-04-01 | 通讯作者 |
| 31 | Identification of predictors of long-term survival and prognostic outcomes in thymic squamous cell carcinoma: A real-world study | Cancer Medicine | 2023-07-01 | 通讯作者 |
| 32 | SABR for operable stage I non-small-cell lung cancer: comparison to surgery | LANCET ONCOLOGY | 2021-11-30 | 通讯作者 |
| 33 | Skip N2 Metastasis Shows Similar Prognosis to N1 Disease in Lung Cancer: Mechanism Discussion | Clinical Lung Cancer | 2021-03-01 | 通讯作者 |
| 34 | The impact of radiological features of part-solid nodules on the choice of surgical mode choice and prognosis | Asian Journal of Surgery | 2020-05-29 | 通讯作者 |
| 35 | Clinical implications of EGFR-associated MAPK/ERK pathway in multiple primary lung cancer | CLINICAL AND TRANSLATIONAL MEDICINE | 2022-05-11 | 通讯作者 |
| 36 | Primary desmoplastic fibroblastoma of diaphragm | Thoracic Cancer | 2021-09-27 | 通讯作者 |
| 37 | Lymphadenectomy during pulmonary metastasectomy: Necessity and feasibility | J Surg Oncol | 2021-07-01 | 通讯作者 |
| 38 | PD-1/PD-L1 co-location: A novel biomarker for immunotherapy response in non-small cell lung cancer | Thoracic Cancer | 2022-04-28 | 通讯作者 |
| 39 | Abscopal effect induced by modulated radiation therapy and pembrolizumab in a patient with pancreatic metastatic lung squamous cell carcinoma | Thoracic Cancer | 2020-11-01 | 通讯作者 |
| 40 | Influence of treatment-related lymphopenia on the efficacy of immune checkpoint inhibitors in lung cancer: a meta-analysis | Frontiers in Oncology | 2023-12-01 | 通讯作者 |
- 科研获奖Research Awards
| # | 获奖证书编号 | 奖项名称 | 获奖级别 | 获奖类别 | 获奖等级 | 获奖日期 | 颁奖单位 | 本单位是否为第一完成单位 | 完成单位排名 | 本人排序 | 备注 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 北京协和医院医疗科研成果攻坚克难(疑难病例专项)三等奖 | 省部级以下 | 特等奖 | 北京协和医院 | 是 | ||||||
| 2 | 北京协和医院医疗科研成果未来之星三等奖 | 省部级以下 | 特等奖 | 北京协和医院 | 是 | ||||||
| 3 | 京协和医院2017年度医疗成果奖二等奖 | 省部级以下 | 特等奖 | 北京协和医院 | 是 |
- 研究成果Research Findings
| # | 成果类型 | 项目/专利/新品种名称 |
|---|---|---|
| 1 | 出版高水平专著 | SABISTON & SPENCER心胸外科学 |
| 2 | 出版高水平专著 | 临床路径释义-胸外科分册 |
| 3 | 出版高水平专著 | 协和胸外科学 |