导师风采
向阳
个人信息
Personal Information
- 性别：男
- 导师类型：博导
- 职称：主任医师
- 该职称任职时间：22
联系方式
Contact Information
- 所属院系：北京协和医院
- 所属专业：
- 邮箱 : XiangY@pumch.cn
- 工作电话 : 13511050222
个人简介
Personal Profile
中国医学科学院中国协和医科大学北京协和医院妇科肿瘤中心主任、教授、博士研究生导师、首批协和学者特聘教授，享受政府特殊津贴，第九届国家卫生健康突出贡献中青年专家。 主要学术兼职：国际滋养细胞肿瘤学会执行委员及第18届执行主席，亚洲妇科肿瘤学会常务理事，中华医学会妇科肿瘤分会候任主委国家卫健委“一带一路”医学人才培养联盟内镜（妇科）专业委员会-主任委员，中国医师协会微无创医学分会会长，中国医师协会妇产科分会妇科肿瘤学组组长，中国抗癌协会子宫肿瘤专业委员副主任委员，中国优生科学协会阴道镜和宫颈病理学分会（CSCCP）常委，中国初级卫生保健基金会妇科肿瘤专委会主任委员，北京医学会妇产科分会主任委员，北京医学会妇科肿瘤分会前任主任委员，北京医师协会妇产科分会副会长。主要致力于妇科肿瘤的临床及基础研究。
团队简介
Team Profile
作为妇科肿瘤中心主任，建立了一个结构完整、人才梯队合理的科研团队，在基础研究、应用基础研究、临床转化和临床试验中进行了全面而深入的探索。
- 研究方向Research Directions
妇科肿瘤
- 在校研究生Current Graduate Students
硕士研究生 2 名，博士研究生 6 名
- 科研项目Research Projects
| # | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
|---|---|---|---|---|---|
| 1 | 免疫检查点VISTA在妊娠滋养细胞肿瘤中的作用及其作为免疫治疗靶点的研究 | 2020-01-01 —— | 55.0 | 主持在研的国家或省部级科研项目 | 主持者 |
| 2 | 耗竭型CD8 肿瘤浸润淋巴细胞在子宫内膜癌中的作用及其作为免疫治疗新靶点的研究 | 2022-01-01 —— | 20.0 | 主持在研的国家或省部级科研项目 | 主持者 |
| 3 | 视黄醇代谢相关基因LRAT/RDH12在宫颈鳞癌进展中的作用及机制研究 | 2015-01-24 —— 2018-12-23 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 4 | UBD通过AKT信号通路促进宫颈癌发生发展的机制研究 | 2018-01-01 —— 2021-12-31 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 5 | 免疫检查点VISTA在妊娠滋养细胞肿瘤中的作用及其作为免疫治疗靶点的研究 | 2020-01-01 —— 2023-12-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 6 | 妊娠滋养细胞疾病精准诊治体系的建立与应用 | 2023-12-01 —— 2026-11-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 7 | 免疫检查点CD112/CD112R调控T细胞铁死亡促进宫颈癌免疫逃逸的机制研究 | 2024-01-01 —— 2027-12-31 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 8 | 耗竭型CD8 肿瘤浸润淋巴细胞在子宫内膜癌中的作用及其作为免疫治疗新靶点的研究 | 2022-01-01 —— 2024-12-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 9 | 妇科肿瘤基于临床病理、分子和免疫特征的综合治疗与预后评价体系的建立和优化 | 2022-10-01 —— 2025-09-01 | 主持的企业/行业委托重大项目 | 主持人 | |
| 10 | 妇产科学-妇科肿瘤导论 | 2020-07-01 —— 2022-12-31 | 主持的企业/行业委托重大项目 | 主持人 | |
| 11 | 基于MSLN-CAR-mRNA在体T细胞工程化技术的纳米核酸药物治疗宫颈癌的转化应用研究 | 2023-12-01 —— 2025-11-30 | 主持的企业/行业委托重大项目 | 主持人 |
- 发表论文Papers
| # | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
|---|---|---|---|---|
| 1 | Carcinoma of the lower female genital tract in patients | Journal of Cancer | 2019-06-02 | 通讯作者 |
| 2 | PD-L1, B7-H3 and VISTA are highly expressed in gestational trophoblastic neoplasia | Histopathology | 2019-04-23 | 通讯作者 |
| 3 | Epithelioid Trophoblastic Tumors: Treatments, Outcomes, and Potential Therapeutic Targets | J CANCER | 2019-01-01 | 通讯作者 |
| 4 | Cervical cancer in women aged 25 years or younger: a retrospective study | Cancer Management and Research | 2019-03-01 | 通讯作者 |
| 5 | Three-Dimensional Turbo-Spin-Echo Amide Proton Transfer-Weighted MRI for Cervical Cancer: A Preliminary Study | Journal of Magnetic Resonance Imaging | 2019-03-12 | 通讯作者 |
| 6 | Concurrence of ovarian cancer and dermatomyositis: a propensity score analysis | JOURNAL OF GYNECOLOGIC ONCOLOGY | 2019-11-01 | 通讯作者 |
| 7 | Expression of the immune checkpoint VISTA in breast cancer | CANCER IMMUNOLOGY IMMUNOTHERAPY | 2020-08-01 | 通讯作者 |
| 8 | Gestational Trophoblastic Neoplasia With Urinary System Metastasis: A Single Center Experience | FRONTIERS IN ONCOLOGY | 2020-07-01 | 通讯作者 |
| 9 | Oncologic and Reproductive Outcomes of Uterine Smooth Muscle Tumor of Uncertain Malignant Potential: A Single Center Retrospective Study of 67 Cases | FRONTIERS IN ONCOLOGY | 2020-05-01 | 通讯作者 |
| 10 | CD105 overexpression mediates drug-resistance in choriocarcinoma cells through BMP9/Smad pathway | JOURNAL OF CANCER | 2020-01-01 | 通讯作者 |
| 11 | Expression and Significance of Immune Checkpoints in Clear Cell Carcinoma of the Uterine Cervix | JOURNAL OF IMMUNOLOGY RESEARCH | 2020-03-01 | 通讯作者 |
| 12 | Diagnosis and Management of Mixed Gestational Trophoblastic Neoplasia: A Study of 16 Cases and a Review of the Literature | FRONTIERS IN ONCOLOGY | 2019-11-01 | 通讯作者 |
| 13 | Diagnosis and management of growing teratoma syndrome after ovarian immature teratoma: A single center experience | GYNECOLOGIC ONCOLOGY | 2020-04-01 | 通讯作者 |
| 14 | Reproductive outcomes after floxuridine-based regimens for gestational trophoblastic neoplasia：A retrospective cohort study in a national referral center in China | Gynecologic Oncology | 2020-08-01 | 通讯作者 |
| 15 | Role of staging surgery and adjuvant chemotherapy in adult patients with apparent stage I pure immature ovarian teratoma after fertility-sparing surgery | INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER | 2020-05-01 | 通讯作者 |
| 16 | Clinical features of a Chinese female nongestational choriocarcinoma cohort: a retrospective study of 37 patients | ORPHANET J RARE DIS | 2020-11-18 | 通讯作者 |
| 17 | The tumor-stroma ratio is an independent predictor of survival in patients with 2018 FIGO stage IIIC squamous cell carcinoma of the cervix following primary radical surgery | GYNECOLOGIC ONCOLOGY | 2020-03-01 | 通讯作者 |
| 18 | VISTA expression is associated with a favorable prognosis in patients with high-grade serous ovarian cancer | CANCER IMMUNOLOGY IMMUNOTHERAPY | 2020-01-01 | 通讯作者 |
| 19 | Management and risk factors of recurrent gestational trophoblastic neoplasia: An update from 2004 to 2017. | Cancer Medicine | 2020-09-01 | 通讯作者 |
| 20 | Emerging Targets of Immunotherapy in Gynecology Cancer | OncoTargets and Therapy | 2020-11-01 | 通讯作者 |
| 21 | Three-dimensional turbo spin echo amide proton transfer-weighted MRI for cervical cancer: A preliminary study | J MAGN RESON IMAGING | 2019-10-01 | 通讯作者 |
| 22 | Clinical characteristics and survival outcomes of malignant struma ovarii confined to the ovary | BMC CANCER | 2021-04-09 | 通讯作者 |
| 23 | Oncological and Reproductive Outcomes of Cystectomy Compared with Unilateral Salpingo-Oophorectomy as Fertility-Sparing Surgery in Patients with Apparent Early Stage Pure Immature Ovarian Teratomas | ANN SURG ONCOL | 2021-05-26 | 通讯作者 |
| 24 | The impact of pulmonary metastases on therapeutic response and prognosis in malignant gestational trophoblastic neoplasia patients: a retrospective cohort study | EUROPEAN JOURNAL OF CANCER | 2022-01-01 | 通讯作者 |
| 25 | Genomic and TCR profiling data reveal the distinct molecular traits in epithelial ovarian cancer histotypes | ONCOGENE | 2022-04-25 | 通讯作者 |
| 26 | Construction and Validation of a Platinum Sensitivity Predictive Model With Multiple Genomic Variations for Epithelial Ovarian Cancer | Frontiers in Oncology | 2021-09-16 | 通讯作者 |
| 27 | Efficacies of FAEV and EMA/CO regimens as primary treatment for gestational trophoblastic neoplasia | BRITISH JOURNAL OF CANCER | 2022-04-22 | 通讯作者 |
| 28 | Management of stage I occult uterine leiomyosarcoma: effects of morcellation, second-look surgery, and adjuvant treatments on survival | Annals of Translational Medicine | 2022-01-10 | 通讯作者 |
| 29 | Analysis of Outcomes and Prognostic Factors after Fertility-Sparing Surgery in Patients with Early Stage Juvenile Granulosa Cell Tumor of the Ovary: Experience from a Tertiary Center | Journal of Pediatric and Adolescent Gynecology | 2022-07-01 | 通讯作者 |
| 30 | Identification and treatment of primary cervical gestational trophoblastic neoplasia: a retrospective study of 13 patients and literature review | ORPHANET J RARE DIS | 2021-11-18 | 通讯作者 |
| 31 | Camrelizumab plus apatinib in patients with high-risk chemorefractory or relapsed gestational trophoblastic neoplasia(CAP01):a single-arm, open-label, phase 2 trial. | Lancet oncology | 2021-11-01 | 通讯作者 |
| 32 | Analysis of the immune checkpoint V-domain Ig-containing suppressor of T-cell activation (VISTA) in endometrial cancer | Modern pathology | 2021-09-07 | 通讯作者 |
| 33 | MRI-derived radiomics analysis improves the noninvasive pretreatment identification of multimodality therapy candidates with early-stage cervical cancer | EUR RADIOL | 2022-06-13 | 通讯作者 |
| 34 | Expression of B7 family checkpoint proteins in cervical cancer. | Modern pathology | 2021-11-30 | 通讯作者 |
| 35 | PD-L1 expression in tumor cells is associated with a favorable prognosis in patients with high-risk endometrial cancer | Gynecology Oncology | 2021-07-13 | 通讯作者 |
| 36 | Results with Floxuridine, Actinomycin D, Etoposide, and Vincristine in Gestational Trophoblastic Neoplasias with International Federation of Gynecology and Obstetrics Scores≥5 | The Oncologist | 2021-08-10 | 通讯作者 |
| 37 | Single-Cell Profiling of the Immune Atlas of Tumor-Infiltrating Lymphocytes in Endometrial Carcinoma | Cancers | 2022-09-02 | 通讯作者 |
| 38 | Immunologic Signatures across Molecular Subtypes and Potential Biomarkers for Sub-Stratification in Endometrial Cancer | INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2023-01-16 | 通讯作者 |
| 39 | Comparison of oncological outcomes in elderly early-stage cervical cancer patients treated with radical surgery or radiotherapy: A real-world retrospective study with propensity score matching | Frontiers in Oncology | 2023-02-15 | 通讯作者 |
| 40 | Clinical characteristics and oncological outcomes of recurrent adult granulosa cell tumor of ovary: A retrospective study of seventy patients | ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA | 2023-04-03 | 通讯作者 |
| 41 | De novo myeloid sarcoma mimicking gynecological tumors: a retrospective case series of eight patients | BMC Womens Health | 2023-04-16 | 通讯作者 |
| 42 | ADCY7 mRNA Is a Novel Biomarker in HPV Infection and Cervical High-Grade Squamous Lesions or Higher | Biomedicines | 2023-03-13 | 通讯作者 |
| 43 | Expression of the immune targets in tumor-infiltrating immunocytes of gestational trophoblastic neoplasia | PATHOLOGY & ONCOLOGY RESEARCH | 2023-02-16 | 通讯作者 |
| 44 | Management and Predictors of Treatment Failure in Patients with Chemo-Resistant/Relapsed Gestational Trophoblastic Neoplasia with Lung Metastasis | Journal of Clinical Medicine | 2022-12-07 | 通讯作者 |
| 45 | Anti-PD-1 therapy plus chemotherapy versus anti-PD-1therapy alone in patients with high-risk chemorefractory orrelapsed gestational trophoblastic neoplasia: a multicenter,retrospective study | EClinicalMedicine | 2023-05-01 | 通讯作者 |
| 46 | Operative and Oncological Outcomes Comparing Sentinel Node Mapping and Systematic Lymphadenectomy in Endometrial Cancer Staging: Meta-Analysis With Trial Sequential Analysis | Frontiers in Oncology | 2021-01-13 | 通讯作者 |
| 47 | Poly (adenosine diphosphate [ADP]-ribose) polymerase (PARP) inhibitors as maintenance therapy in women with newly diagnosed ovarian cancer: a systematic review and meta-analysis | ARCH GYNECOL OBSTET | 2021-08-03 | 通讯作者 |
| 48 | Oncological Outcomes and Safety of Ovarian Preservation for Early Stage Adenocarcinoma of Cervix: A Systematic Review and Meta-Analysis | Frontiers in Oncology | 2019-08-14 | 通讯作者 |
| 49 | Comparing biweekly single-dose actinomycin D with multiday methotrexate therapy for low-risk gestational trophoblastic neoplasia (FIGO Score 0-4): study protocol for a prospective, multicentre, randomized trial. | BMC CANCER | 2023-08-23 | 通讯作者 |
| 50 | PD-1 and TIGIT coexpressing CD8 + CD103 + tissue-resident memory cells in endometrial cancer as potential targets for immunotherapy. | INTERNATIONAL IMMUNOPHARMACOLOGY | 2024-01-25 | 通讯作者 |
| 51 | ASO author reflections: ovarian cystecotmy for apparent early-stage pure immature ovarian teratomas | Ann Surg Oncol | 2021-10-10 | 通讯作者 |
| 52 | Fertility-sparing surgery in children and adolescents with borderline ovarian tumors: a retrospective study | Journal of Ovarian Research | 2024-05-08 | 通讯作者 |
| 53 | The anti-PD-1 era of cervical cancer: achievement, opportunity, and challenge | Frontiers in Immunology | 2023-07-25 | 通讯作者 |
- 科研获奖Research Awards
| # | 获奖证书编号 | 奖项名称 | 获奖级别 | 获奖类别 | 获奖等级 | 获奖日期 | 颁奖单位 | 本单位是否为第一完成单位 | 完成单位排名 | 本人排序 | 备注 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 2017-260 | 滋养细胞肿瘤综合诊治技术的进一步发展与推广 | 省部级 | 教育部高校科研成果奖（科学技术、人文社科） | 二等奖 | 2018-02-27 | 教育部 | 是 | 1 | 1 | |
| 2 | 201702001P1001 | 滋养细胞肿瘤综合诊治技术的进一步发展与推广 | 省部级 | 其他省部级奖励 | 二等奖 | 2017-11-18 | 中国医疗保健国际交流促进会 | 是 | 1 | 1 |
- 研究成果Research Findings
| # | 成果类型 | 项目/专利/新品种名称 |
|---|---|---|
| 1 | 作为主创人员获得授权的发明专利和新品种 | B7H4在制备子宫内膜癌分子分型试剂及系统中的应 |
| 2 | 作为主创人员获得授权的发明专利和新品种 | 一种宫颈癌预后评分系统及其应用 |
| 3 | 出版高水平专著 | 宋鸿钊滋养细胞肿瘤学 |
| 4 | 出版高水平专著 | 妊娠滋养细胞肿瘤/协和2017观点 |
| 5 | 出版高水平专著 | 少见妇科恶性肿瘤 |
| 6 | 出版高水平专著 | 宋鸿钊滋养细胞肿瘤学（第4版） |
| 7 | 出版高水平专著 | 协和妇产科临床备忘录（第3版） |
| 8 | 出版高水平专著 | 生殖系统 |
| 9 | 获得省部级及以上科研奖励 | 关爱妇女，保护母亲：协和女性健康系列科普作品与普及活动 |
| 10 | 获得省部级及以上科研奖励 | 《话说生命之宫》（上下卷） |
| 11 | 作为主创人员获得授权的发明专利和新品种 | B7H4在制备子宫内膜癌分子分型试剂及系统中的应用 |
| 12 | 作为主创人员获得授权的发明专利和新品种 | 一种基于无瘤原则的腹腔镜宫颈癌根治术的操作系统及其装置 |