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孙强,男,58岁,现任中国医学科学院北京协和医院外科学系教授、博士生及博士后导师、乳腺外科主任及乳腺疾病诊疗中心主任。于1988年起专业从事乳腺疾病的诊治研究,积累了丰富的临床经验;共主刀乳腺癌手术6000余例,近3年来每年主刀乳腺癌手术超过800例;改进并优化了传统的外科手术方法,可在15分钟内完成乳癌改良根治术,并取得了术后并发症 <2% 的满意疗效。近年来,孙强教授主持开展了多项在国内首创、世界领先的高难度乳腺癌根治手术,如环乳晕入路的保乳根治术、外上单切口保乳根治术、环乳晕单切口保乳根治术、保留皮肤的环乳晕入路改良根治(SSM)术、保留乳头乳晕的环乳晕入路改良根治(NSM)术、同期乳房再造术等。并注重在保证安全性的前提下,适当拓展乳腺癌保乳手术的适应证,获得了满意的疗效。孙强教授领衔的北京协和医院乳腺外科团队多年来一直致力于乳腺癌的早期诊断及个体化的最优综合治疗,并围绕该主攻方向开展了一系列的基础、临床及转化医学研究。在早期诊断方面,于90年代在国内率先开展了不可触及乳腺病变(NPBL)的B超、钼靶等影像学引导的立体定位切除活检术;将超声影像学的最新技术应用于乳腺癌的早期诊断、术前评估、术式选择、立体定位等多个方面,实现了科研成果向临床的转化,并发表了一系列的科研论著;率先在国内提出B超是适合我国女性乳腺癌筛查的影像学检查,做为专家组成员参与制订北京市基于B超的乳腺癌、宫颈癌两癌筛查流程。孙强教授主持和承担多项国家重点科技项目,如国家“十一五”支撑项目“基于社区的乳腺癌筛查方案的比较与评价”、北京市科委科技计划重大项目“乳腺癌筛查的技术方案和诊断规范化流程的建立”、“隐匿性乳腺癌的诊断和治疗”、“乳腺肿瘤影像学诊断”、“从基因水平研究中国妇女乳腺癌的易感性”、“人类重要功能基因编码蛋白质研究及重大疾病遗传资源的收集”中乳腺癌遗传资源的大规模收集和“家族性乳腺癌的遗传资源收集”、“十二五”支撑项目“建立适合中国国情的乳腺癌筛查模式”等多项有关乳腺癌研究的课题。
团队简介
Team Profile
北京协和医院乳腺专业组20 世纪 80 年代由我国外科奠基人之一曾宪九教授提议和支持帮助下成立,2006年2月将乳腺专业组扩大为北京协和医院乳腺外科,为外科学系重要组成科室,现任科主任为周易冬教授,全科共有在职医师28人,其中在站临床博士后5人,已出站临床博士后3人,另有副研究员1人,全科超过80%为博士研究生。乳腺外科共培养毕业专科硕士、博士10余人,目前硕士在读15人,博士在读1人。全科年均发表SCI论文超20篇,影响因子超过100分,另有年均数十篇中文核心论著、国家共识指南等等,科内人员主持多项国自然、北自然、国家科技支撑项目等。整体团队技术力量雄厚,在医疗、教学、科研等方面均有相当的水平,综合实力位于全国先进行列。 目前乳腺外科主要位于北京协和医院西院区,包括普通病房、国疗病房、日间病房、化疗日间病房等,下设乳腺良恶性疾病的手术治疗评估、乳癌化疗、非哺乳期乳腺炎、哺乳指导、乳癌术后淋巴水肿、乳癌术后脂代谢、乳腺癌遗传咨询等7个亚专业组,年诊治病人超过 9 万余人次,年均手术量超5000台次,其中乳腺癌超过3000台次。特色诊疗方向及技术主要包括:乳腺良恶性疾病的手术治疗与综合治疗;乳腺癌隐匿性切口保乳手术;乳腺癌保留皮肤及乳头乳晕的乳腺切除 同期乳房再造手术;钼靶或超声定位不可触及乳腺病变的活检手术;乳腺癌的筛查与早诊早治;乳腺癌患者的全程健康管理等。 乳腺外科自十余年前起就致力于乳腺癌筛查项目研究,对于乳腺癌早诊早治有着较为丰富的经验。曾承担十一五、十二五国家科技支撑项目、北京市科技计划课题等一系列关于乳腺癌筛查模式研究的课题任务,探索适合国人的乳腺癌筛查模式,并与北京市卫健委、北京妇幼保健院签署乳腺癌筛查基地合同,建立了北京市乳腺癌筛查基地。目前,乳腺外科重点发展方向为:中国女性乳腺癌筛查和早期诊断策略研究;乳腺癌保乳及腋窝淋巴结精准外科治疗新技术;老年乳腺癌治疗评价体系的建立及应用;乳腺癌全程管理方案探索;遗传性乳腺癌随访队列的建立及研究;乳腺罕见病队列的建立及随访研究。
硕士研究生 3 名,博士研究生 3 名
# | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
---|---|---|---|---|---|
1 | 适合中国国情的乳腺癌诊治体系的建立 | 2022-10-01 —— 2025-09-01 | 主持的企业/行业委托重大项目 | 主持人 | |
2 | 北京市适龄妇女乳腺癌筛查方案优化研究 | 2016-01-01 —— 2020-05-01 | 主持在研的国家或省部级科研项目 | 主持人 |
# | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
---|---|---|---|---|
1 | Predictors of nonsentinel lymph node metastasis in patients with breast cancer with metastasis in the sentinel node | MEDICINE | 2019-01-01 | 通讯作者 |
2 | Fractures due to Aromatase Inhibitor Therapy for Breast Cancer: A Real-World Analysis of FAERS Data in the Past 15 Years | ONCOLOGY RESEARCH AND TREATMENT | 2020-03-01 | 通讯作者 |
3 | MicroRNA-27b-3p Promotes Tumor Progression and Metastasis by Inhibiting Peroxisome Proliferator-Activated Receptor Gamma in Triple-Negative Breast Cancer | FRONTIERS IN ONCOLOGY | 2020-08-01 | 通讯作者 |
4 | Extracting comprehensive clinical information for breast cancer using deep learning methods | INTERNATIONAL JOURNAL OF MEDICAL INFORMATICS | 2019-12-02 | 通讯作者 |
5 | Diagnostic value of an automated breast volume scanner compared with a hand-held ultrasound: a meta-analysis | GLAND SURGERY | 2019-12-01 | 通讯作者 |
6 | A systematic surgical approach for the treatment of idiopathic granulomatous mastitis: a case series | GLAND SURGERY | 2020-04-01 | 通讯作者 |
7 | lncRNA AFAP1-AS1 promotes triple negative breast cancer cell proliferation and invasion via targeting miR-145 to regulate MTH1 expression | SCIENTIFIC REPORTS | 2020-05-01 | 通讯作者 |
8 | Clinical factors associated with circulating tumor DNA (ctDNA) in primary breast cancer | Molecular Oncology | 2019-02-06 | 通讯作者 |
9 | The prognostic comparison among unilateral, bilateral, synchronous bilateral, and metachronous bilateral breast cancer: A meta-analysis of studies from recent decade (2008-2018) | Cancer Medicine | 2019-06-01 | 通讯作者 |
10 | Preliminary study of contrast-enhanced ultrasound in combination with blue dye vs. indocyanine green fluorescence, in combination with blue dye for sentinel lymph node biopsy in breast cancer | BMC CANCER | 2019-10-01 | 通讯作者 |
11 | Discordance of immunohistochemical markers between primary and recurrent or metastatic breast cancer A retrospective analysis of 107 cases | MEDICINE | 2020-05-01 | 通讯作者 |
12 | Adjuvant addition of capecitabine to early‐stage triple‐negative breast cancer patients receiving standard chemotherapy: a meta‐analysis | BREAST CANCER RESEARCH AND TREATMENT | 2019-12-16 | 通讯作者 |
13 | Web-Based Medical Information Searching by Chinese Patients With Breast Cancer and its Influence on Survival: Observational Study | JOURNAL OF MEDICAL INTERNET RESEARCH | 2020-04-17 | 通讯作者 |
14 | Validation of CTS5 model in large- scale breast cancer population and the impact of menopausal and HER2 status on its prognostic value | Scientific Reports | 2020-03-13 | 通讯作者 |
15 | Breast-conserving surgery without axillary lymph node surgery or radiotherapy is safe for HER2-positive and triple negative breast cancer patients over 70 years of age | BREAST CANCER RESEARCH AND TREATMENT | 2020-07-01 | 通讯作者 |
16 | Breast-conserving therapy is safe both within BRCA1/2 mutation carriers and noncarriers with breast cancer in the Chinese population | GLAND SURGERY | 2020-06-01 | 通讯作者 |
17 | Identification of Potential Key Genes Associated With the Pathogenesis, Metastasis, and Prognosis of Triple-Negative Breast Cancer on the Basis of Integrated Bioinformatics Analysis | FRONTIERS IN ONCOLOGY | 2020-06-01 | 通讯作者 |
18 | Reconsidering the therapeutic use for vacuum-assisted breast biopsy in breast cancer patients: a retrospective single-center study | TRANSLATIONAL CANCER RESEARCH | 2020-06-01 | 通讯作者 |
19 | Clinical characteristics and survival outcomes of patients with both primary breast cancer and primary ovarian cancer | MEDICINE | 2020-08-01 | 通讯作者 |
20 | Prognostic significance of branched-chain amino acid transferase 1 and CD133 in triple-negative breast cancer | BMC CANCER | 2020-06-01 | 通讯作者 |
21 | Sentinel 1ymph node biopsy should be considered for clinically node-negative breast cancer regardless of BRCA1/2 mutation status | Annals of Translational Medicine | 2020-08-01 | 通讯作者 |
22 | Genomic Profiling Comparison of Germline BRCA and Non-BRCA Carriers Reveals CCNE1 Amplification as a Risk Factor for Non-BRCA Carriers in Patients With Triple-Negative Breast Cancer | Frontiers in Oncology | 2020-10-01 | 通讯作者 |
23 | miR-452 Reverses Abnormal Glycosylation Modification of ER alpha and Estrogen Resistance in TNBC (Triple-Negative Breast Cancer) Through Targeting UGT1A1 | FRONTIERS IN ONCOLOGY | 2020-08-01 | 通讯作者 |
24 | Pyrotinib with trastuzumab and aromatase inhibitors as first-line treatment for HER2 positive and hormone receptor positive metastatic or locally advanced breast cancer: study protocol of a randomized controlled trial | BMC CANCER | 2020-07-01 | 通讯作者 |
25 | GnRHa for Ovarian Protection and the Association between AMH and Ovarian Function during Adjuvant Chemotherapy for Breast Cancer | JOURNAL OF CANCER | 2019-07-01 | 通讯作者 |
26 | Ki-67 index, progesterone receptor expression, histologic grade and tumor size in predicting breast cancer recurrence risk: A consecutive cohort study | CANCER COMMUNICATIONS | 2020-03-01 | 通讯作者 |
27 | Mismatch Repair Deficiency and Microsatellite Instability in Triple-Negative Breast Cancer: A Retrospective Study of 440 Patients | Frontiers in Oncology | 2021-03-04 | 通讯作者 |
28 | Phosphatidylinositol-3,4,5-Trisphosphate Dependent Rac Exchange Factor 1 (PREX1) is a Novel Predictor of Prognosis for Breast Cancer Patients: A Retrospective Case Series | MEDICAL SCIENCE MONITOR | 2019-09-01 | 通讯作者 |
29 | Mammographic casting-type calcification is an independent prognostic factor in invasive breast cancer | SCIENTIFIC REPORTS | 2019-07-01 | 通讯作者 |
30 | The influence on survival of delay in the treatment initiation of screening detected non-symptomatic breast cancer | SCIENTIFIC REPORTS | 2019-07-01 | 通讯作者 |
31 | The impact of pre-existed and SERM-induced non-alcoholic fatty liver disease on breast cancer survival: a meta-analysis | JOURNAL OF CANCER | 2020-05-01 | 通讯作者 |
32 | Genetic factors associated with cancer racial disparity - an integrative study across twenty-one cancer types. | MOL ONCOL | 2020-09-24 | 通讯作者 |
33 | Neoadjuvant chemotherapy:practice and thinking for Chinese patients with early breast cancer | Chinese medical journal | 2020-10-01 | 通讯作者 |
34 | Cancer-derived exosomal miR-7641 promotes breast cancer progression and metastasis. Cell Commun Signal | CELL COMMUN SIGNAL | 2021-02-22 | 通讯作者 |
35 | Serial circulating tumor DNA identifcation associated with the efcacy and prognosis of neoadjuvant chemotherapy in breast cancer | BREAST CANCER RESEARCH AND TREATMENT | 2021-05-18 | 通讯作者 |
36 | Omitting radiotherapy is safe in breast cancer patients ≥ 70 years old after breast-conserving surgery without axillary lymph node operation | SCI REP-UK | 2020-11-10 | 通讯作者 |
37 | Platinum-Based Neoadjuvant Chemotherapy for Breast Cancer With BRCA Mutations: A Meta-Analysis | FRONT ONCOL | 2020-11-09 | 通讯作者 |
38 | VISTA Expression on Immune Cells Correlates With Favorable Prognosis in Patients With Triple-Negative Breast Cancer | FRONT ONCOL | 2021-01-11 | 通讯作者 |
39 | Combination of preoperative fibrinogen concentration and neutrophil-to-lymphocyte ratio for prediction of the prognosis of patients with resectable breast cancer | Oncology Letters | 2020-07-30 | 通讯作者 |
40 | Long noncoding RNA AFAP1-AS1 promotes tumor progression and invasion by regulating the miR-2110/Sp1 axis in triple-negative breast cancer | Cell Death & Disease | 2021-06-18 | 通讯作者 |
41 | Optimal duration of endocrine therapy with extended aromatase inhibitors for postmenopausal patients with hormone receptor‑positive breast cancer: a meta‑analysis | Breast Cancer | 2021-05-01 | 通讯作者 |
42 | Breast conserving therapy for breast cancer with BRCA mutations: a meta-analysis | Breast Cancer | 2021-11-11 | 通讯作者 |
43 | Identification and validation of an epigenetically regulated long noncoding RNA model for breast cancer metabolism and prognosis | BMC Medical Genomics | 2022-05-14 | 通讯作者 |
44 | Rationale and design of a phase II trial of pyrotinib in combination with nab-paclitaxel as adjuvant therapy for N0/N1mi, HER2+early breast cancer (PHAEDRA) | BMC CANCER | 2022-03-14 | 通讯作者 |
45 | Comparison of CTS5 risk model and 21-gene recurrence score assay in large-scale breast cancer population and combination of CTS5 and recurrence score to develop a novel nomogram for prognosis prediction | BREAST | 2022-03-16 | 通讯作者 |
46 | Changes in the detection of human epidermal growth factor receptor 2 gene (Her-2) status for Her-2 fluorescent in situ hybridization testing | CHINESE MEDICAL JOURNAL | 2022-04-05 | 通讯作者 |
47 | Identification and characterization of three Siglec15-related immune and prognostic subtypes of breast-invasive cancer. | International immunopharmacology | 2022-02-10 | 通讯作者 |
48 | Discordance in ER, PR, HER2, and Ki-67 Expression Between Primary and Recurrent/Metastatic Lesions in Patients with Primary Early Stage Breast Cancer and the Clinical Significance: Retrospective Analysis of 75 Cases | PATHOLOGY & ONCOLOGY RESEARCH | 2021-04-09 | 通讯作者 |
49 | Long-term survival of screen-detected synchronous and metachronous bilateral non-palpable breast cancer among Chinese women: a hospital-based study (2003–2017) | BREAST CANCER RESEARCH AND TREATMENT | 2022-11-01 | 通讯作者 |
50 | Insulin-like growth factor 2 receptor is a key immune-related gene that is correlated with a poor prognosis in patients with triple-negative breast cancer: A bioinformatics analysis | FRONTIERS IN ONCOLOGY | 2022-10-18 | 通讯作者 |
51 | Syndecan-1 as an immunogene in Triple-negative breast cancer: regulation tumor-infiltrating lymphocyte in the tumor microenviroment and EMT by TGFb1/Smad pathway | Cancer Cell International | 2023-04-17 | 通讯作者 |
52 | Comparison of ultrasound and mammography for early diagnosis of breast cancer among Chinese women with suspected breast lesions: A prospective trial | Thoracic Cancer | 2022-09-30 | 通讯作者 |
53 | Novel immune-related prognostic model and nomogram for breast cancer based on ssGSEA | Frontiers in Genetics | 2023-01-10 | 通讯作者 |
54 | High expression of cuproptosis-related SLC31A1 gene in relation to unfavorable outcome and deregulated immune cell infiltration in breast cancer: an analysis based on public databases | BMC BIOINFORMATICS | 2022-08-22 | 通讯作者 |
55 | Clinicopathologic features, treatment, and prognosis of pregnancy-associated breast cancer | Frontiers in Oncology | 2022-12-14 | 通讯作者 |
56 | G6PD activation in TNBC cells induces macrophage recruitment and M2 polarization to promote tumor progression | CELLULAR AND MOLECULAR LIFE SCIENCES | 2023-06-01 | 通讯作者 |
57 | Breast-conserving surgery without axillary surgery and radiation versus mastectomy plus axillary dissection in elderly breast cancer patients: A retrospective study | FRONTIERS IN ONCOLOGY | 2023-03-20 | 通讯作者 |
58 | Identification of tumor antigens and immunogenic cell death-related subtypes for the improvement of immunotherapy of breast cancer | Frontiers in Cell and Developmental Biology | 2022-10-25 | 通讯作者 |
59 | COVID-19 vaccination status, side effects, and perceptions among breast cancer survivors: a cross-sectional study in China | Frontiers in Public Health | 2023-04-17 | 通讯作者 |
60 | Geriatric assessment for older patients with breast cancer: A single-institution study | FRONTIERS IN ONCOLOGY | 2023-02-23 | 通讯作者 |
61 | Targeting glucose-6-phosphate dehydrogenase by 6-AN induces ROS-mediated autophagic cell death in breast cancer | FEBS Journal | 2023-02-01 | 通讯作者 |
62 | T1a triple negative breast cancer has the worst prognosis among all the small tumor (<1 cm) of TNBC and HER2-rich subtypes | Gland Surgery | 2021-01-21 | 通讯作者 |
63 | Efficacy and Safety Profile of Histone Deacetylase Inhibitors for Metastatic Breast Cancer: A Meta-Analysis | Frontiers in Oncology | 2022-05-31 | 通讯作者 |
64 | The Prognostic and Clinical Value of Tumor-Associated Macrophages in Patients With Breast Cancer: A Systematic Review and Meta-Analysis | Frontiers in Oncology | 2022-06-30 | 通讯作者 |
65 | Dermis-retained breast dermo-glandular flap: a newsurgical approach forgranulomatous lobular mastitis | Frontiers in Surgery | 2023-06-16 | 通讯作者 |
66 | Loco-regional therapy and the risk of breast cancer-related lymphedema:a systematic review and meta-analysis | Breast Cancer | 2022-06-09 | 通讯作者 |
67 | Efficacy and Safety of Anti-HER2 Agents in Comobination With Chemotherapy for Metastatic HER2-Positive Breast Cancer Patient: A Network Meta-Analysis | Frontiers in Oncology | 2021-08-09 | 通讯作者 |
68 | The Diagnostic Performance of Minimally Invasive Biopsy in Predicting Breast Pathological Complete Response After Neoadjuvant Systemic Therapy in Breast Cancer: A Meta-Analysis | FRONTIERS IN ONCOLOGY | 2020-06-01 | 通讯作者 |
69 | Nomogram prediction of the 70-gene signature (MammaPrint) binary and quartile categorized risk using medical history, imaging features and clinicopathological data among Chinese breast cancer patients | Journal of Translational Medicine | 2023-11-09 | 通讯作者 |
70 | C-X-C Motif Chemokine Ligand 9 Correlates with Favorable Prognosis in Triple-Negative Breast Cancer by Promoting Immune Cell Infiltration | MOLECULAR CANCER THERAPEUTICS | 2023-08-20 | 通讯作者 |
71 | plasma metabolic signatures of breast cancer | Frontiers in Medicine | 2023-07-31 | 通讯作者 |
72 | Considerable Long-Term Aesthetic Outcomes and Oncologic Safety of Breast-Conserving Surgery Via a Periareolar Incision: A Retrospective Study | Clinical Breast Cancer | 2023-09-09 | 通讯作者 |
73 | Assessment of geriatric and clinical domains for development and validation of a novel nomogram to predict the prognosis of older patients with breast cancer: A real-world retrospective cohort study | Frontiers in Oncology | 2023-11-28 | 通讯作者 |
74 | Ga-68-NEB PET/CT can be a new method for diagnosing chylous fistula Case reports of a rare complication after breast cancer surgery | MEDICINE | 2020-07-01 | 通讯作者 |
75 | Tall cell carcinoma of the breast with reverse polarity: case report with gene sequencing and literature review | Gland Surgery | 2020-12-05 | 通讯作者 |
76 | Novel Paradigm for Treating Idiopathic Granulomatous Mastitis | J Invest Surg . | 2021-07-01 | 通讯作者 |
77 | Development and validation of a model and nomogram for breast cancer diagnosis based on quantitative analysis of serum disease-specific haptoglobin N-glycosylation | Journal of Translational Medicine | 2024-04-04 | 通讯作者 |
# | 获奖证书编号 | 奖项名称 | 获奖级别 | 获奖类别 | 获奖等级 | 获奖日期 | 颁奖单位 | 本单位是否为第一完成单位 | 完成单位排名 | 本人排序 | 备注 |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | 北京市科学技术奖 | 省部级 | 北京市科学技术奖 | 特等奖 | 是 | 1 | 1 | ||||
2 | 国家科技进步二等奖 | 国际级 | 国家科技进步二等奖 | 二等奖 | 是 | 1 | 1 | ||||
3 | 中华医学科技奖 | 国际级 | 中华医学科技奖 | 其他 | 是 | 11 |
# | 成果类型 | 项目/专利/新品种名称 |
---|---|---|
1 | 出版高水平专著 | 乳腺疾病145个怎么办 |
2 | 获得省部级及以上科研奖励 | 2019年国家科学技术进步奖二等奖 |
3 | 作为主创人员获得授权的发明专利和新品种 | 一种乳腺红外检查文胸 |
4 | 作为主创人员获得授权的发明专利和新品种 | 一种麻尖头吸烟带灯电烧 |