导师风采
曾小峰
个人信息
Personal Information
- 性别：男
- 导师类型：博导
- 职称：主任医师
- 该职称任职时间：1984-07-27
联系方式
Contact Information
- 所属院系：北京协和医院
- 所属专业：内科学
- 邮箱 : xiaofeng.zeng@cstar.org.cn
- 工作电话 : 13501069845
个人简介
Personal Profile
曾小峰教授 1979年考入上海第一医学院医学系，1984年7月毕业后一直在北京协和医院工作。现任北京协和医院风湿免疫科科主任、博士生/博士后导师、国家皮肤及免疫疾病临床医学研究中心主任，为第七届全国优秀科技工作者、第13届北京市政协委员和国务院特殊津贴获得者。担任中华医学会风湿病学分会委员会前任主任委员（第9、10届主委）、中国医师协会风湿免疫科医师分会委员会会长、中国康复医学会风湿免疫康复专业委员会主任委员、中国研究型医院学会风湿免疫专业委员会主任委员、国家心血管病专家委员会右心与肺血管病专业委员会副主任委员、中国免疫学会临床免疫学分会副主任委员。担任EUSTAR（欧洲抗风湿病联盟硬皮病试验研究组的简称）中国中心负责人，中国系统性红斑狼疮研究协作组（Chinese SLE Treatment And Research Group，CSTAR）和国家风湿病数据中心（Chinese Rheumatism Data Center，CRDC）负责人。在国际上担任亚太风湿病学会联盟（APLAR）副主席（2019-2022）、第18届APLAR大会主席，第10届欧洲狼疮大会科学委员会委员和第10及11届国际自身免疫病大会顾问委员会委员。是《中华临床免疫与变态反应学杂志》、《中华风湿病学杂志》，《中华内科学杂志》和《中国实用内科杂志》等杂志的副主编、我国首个英文杂志“Rheumatology and Immunology Research”的主编。目前已在国内外发表文章近200余篇并参与了《内科学》八年制全国统编教材、《内科学（英文版）》全国统编教材、《中华内科学》、《现代急诊医学》、《临床风湿病学》、《风湿病学》等专著的编写。主译《哈里森风湿病学》。完成多项国家级及部级以上科研课题，为“十一五”国家科技支撑课题“系统性红斑狼疮的临床诊断、综合治疗的研究”负责人，“十二五”国家863计划课题“系统性红斑狼疮分子分型和个体化诊疗技术”负责人，国家自然科学基金课题“白藜芦醇对系统性红斑狼疮的作用及其机制研究”， “CD146在系统性硬化症发展中的作用机制研究” 负责人。2017年获“十三五”国家重点研发计划项目“常见风湿免疫性疾病队列及预后研究”课题首席科学家。课题“类风湿关节炎早期诊断的血清学研究和临床应用”获2005年中华医学科技奖三等奖。“系统性红斑狼疮发病机制及诊断方法学研究”获2009年中华医学科技奖二等奖和北京市科学技术奖三等奖及教育部科学技术进步奖二等奖。入选 2020 年全球顶尖 10 万名科学家、风湿科 2020 年发表的 SCI 论文大数据分析“最有影响力的学者”中国际排名位居第 6 名（中国大陆排名第一），全国风湿免疫病领域学者论文学术影响力排名第 4 位，在 2012-2021 年间发表论文数排名第一。
团队简介
Team Profile
曾小峰教授 1979年考入上海第一医学院医学系，1984年7月毕业后一直在北京协和医院工作。现任北京协和医院风湿免疫科科主任、博士生/博士后导师、国家皮肤及免疫疾病临床医学研究中心主任，为第七届全国优秀科技工作者、第13届北京市政协委员和国务院特殊津贴获得者。担任中华医学会风湿病学分会委员会前任主任委员（第9、10届主委）、中国医师协会风湿免疫科医师分会委员会会长、中国康复医学会风湿免疫康复专业委员会主任委员、中国研究型医院学会风湿免疫专业委员会主任委员、国家心血管病专家委员会右心与肺血管病专业委员会副主任委员、中国免疫学会临床免疫学分会副主任委员。担任EUSTAR（欧洲抗风湿病联盟硬皮病试验研究组的简称）中国中心负责人，中国系统性红斑狼疮研究协作组（Chinese SLE Treatment And Research Group，CSTAR）和国家风湿病数据中心（Chinese Rheumatism Data Center，CRDC）负责人。在国际上担任亚太风湿病学会联盟（APLAR）副主席（2019-2022）、第18届APLAR大会主席，第10届欧洲狼疮大会科学委员会委员和第10及11届国际自身免疫病大会顾问委员会委员。是《中华临床免疫与变态反应学杂志》、《中华风湿病学杂志》，《中华内科学杂志》和《中国实用内科杂志》等杂志的副主编、我国首个英文杂志“Rheumatology and Immunology Research”的主编。目前已在国内外发表文章近200余篇并参与了《内科学》八年制全国统编教材、《内科学（英文版）》全国统编教材、《中华内科学》、《现代急诊医学》、《临床风湿病学》、《风湿病学》等专著的编写。主译《哈里森风湿病学》。完成多项国家级及部级以上科研课题，为“十一五”国家科技支撑课题“系统性红斑狼疮的临床诊断、综合治疗的研究”负责人，“十二五”国家863计划课题“系统性红斑狼疮分子分型和个体化诊疗技术”负责人，国家自然科学基金课题“白藜芦醇对系统性红斑狼疮的作用及其机制研究”， “CD146在系统性硬化症发展中的作用机制研究” 负责人。2017年获“十三五”国家重点研发计划项目“常见风湿免疫性疾病队列及预后研究”课题首席科学家。课题“类风湿关节炎早期诊断的血清学研究和临床应用”获2005年中华医学科技奖三等奖。“系统性红斑狼疮发病机制及诊断方法学研究”获2009年中华医学科技奖二等奖和北京市科学技术奖三等奖及教育部科学技术进步奖二等奖。入选 2020 年全球顶尖 10 万名科学家、风湿科 2020 年发表的 SCI 论文大数据分析“最有影响力的学者”中国际排名位居第 6 名（中国大陆排名第一），全国风湿免疫病领域学者论文学术影响力排名第 4 位，在 2012-2021 年间发表论文数排名第一。
- 研究方向Research Directions
风湿免疫病的精准诊治策略研究
- 在校研究生Current Graduate Students
硕士研究生 0 名，博士研究生 8 名
- 科研项目Research Projects
| # | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
|---|---|---|---|---|---|
| 1 | 系统性红斑狼疮患者肺动脉高压3年发病风险预测模型构建研究 | 2020-03-01 —— 2024-03-29 | 115.0 | 主持在研的国家或省部级科研项目 | 主持者 |
| 2 | CD146在系统性硬化症发展中的作用机制研究 | 2016-01-01 —— 2019-12-12 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 3 | 中国常见风湿免疫病临床队列及预后研究 | 2017-07-01 —— 2020-12-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 4 | 国家风湿病临床信息和生物样本共享平台的优化及数据挖掘 | 2017-07-01 —— 2020-12-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 5 | 系统性红斑狼疮患者肺动脉高压3年发病风险预测模型构建研究 | 2020-03-01 —— 2024-03-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
| 6 | 常见重大风湿免疫病诊疗协和策略研究 | 2022-10-01 —— 2025-09-01 | 主持的企业/行业委托重大项目 | 主持人 | |
| 7 | 系统性红斑狼疮精准干预策略与智能管理体系研究 | 2022-11-01 —— 2024-03-01 | 主持的企业/行业委托重大项目 | 主持人 | |
| 8 | 国家免疫性疾病临床医学研究中心“四级协作网络”平台建设 | 2018-12-01 —— 2019-12-01 | 主持的企业/行业委托重大项目 | 主持人 | |
| 9 | 系统性红斑狼疮相关肺动脉高压精准分子分型研究 | 2018-12-02 —— 2021-10-01 | 主持的企业/行业委托重大项目 | 主持人 | |
| 10 | 类风湿关节炎相关间质性肺病的全基因组学研究 | 2018-12-03 —— 2022-08-31 | 主持的企业/行业委托重大项目 | 主持人 | |
| 11 | 风湿免疫病的精准诊治策略研究 | 2018-12-04 —— 2025-12-01 | 主持的企业/行业委托重大项目 | 主持人 |
- 发表论文Papers
| # | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
|---|---|---|---|---|
| 1 | High TLR7 Expression Drives the Expansion of CD19(+)CD24(hi)CD38(hi) Transitional B Cells and Autoantibody Production in SLE Patients | FRONTIERS IN IMMUNOLOGY | 2022-06-16 | 曾小峰 |
| 2 | Predictive Value of Pulmonary Arterial Compliance in Systemic Lupus Erythematosus Patients With Pulmonary Arterial Hypertension | HYPERTENSION | 2022-06-16 | 曾小峰 |
| 3 | Anti-Endothelin Receptor Type A Autoantibodies in Systemic Lupus Erythematosus-Associated Pulmonary Arterial Hypertension | ARTHRITIS & RHEUMATOLOGY | 2022-06-16 | 曾小峰 |
| 4 | Predicting the Risk of Pulmonary Arterial Hypertension in Systemic Lupus Erythematosus: A Chinese Systemic Lupus Erythematosus Treatment and Research Group Cohort Study | ARTHRITIS & RHEUMATOLOGY | 2022-06-16 | 曾小峰 |
| 5 | Chinese Registry of rheumatoid arthritis (CREDIT): II. prevalence and risk factors of major comorbidities in Chinese patients with rheumatoid arthritis | ARTHRITIS RESEARCH & THERAPY | 2022-06-16 | 曾小峰 |
| 6 | Sirolimus for patients with connective tissue disease-related refractory thrombocytopenia: a single-arm, open-label clinical trial | RHEUMATOLOGY | 2022-06-16 | 曾小峰 |
| 7 | Pulmonary arterial hypertension associated with primary Sjogren's syndrome: a multicentre cohort study from China | EUROPEAN RESPIRATORY JOURNAL | 2022-06-16 | 曾小峰 |
| 8 | Comparison of Different Test Systems for the Detection of Antiphospholipid Antibodies in a Chinese Cohort | FRONTIERS IN IMMUNOLOGY | 2022-06-16 | 曾小峰 |
| 9 | Long-term prognosis of patients with systemic lupus erythematosus-associated pulmonary arterial hypertension: CSTAR-PAH cohort study | EUROPEAN RESPIRATORY JOURNAL | 2022-06-16 | 曾小峰 |
| 10 | The renal artery is involved in Chinese Takayasu's arteritis patients | KIDNEY INTERNATIONAL | 2022-06-16 | 曾小峰 |
| 11 | Serum levels of Krebs von den Lungen-6 as a promising marker for predicting occurrence and deterioration of systemic sclerosis-associated interstitial lung disease from a Chinese cohort | International Journal of Rheumatic Diseases | 2019-01-01 | 通讯作者 |
| 12 | Characteristics of Chinese patients with primary Sjogren's syndrome: preliminary report of a multi-centre registration study | LUPUS | 2020-01-01 | 通讯作者 |
| 13 | Pulmonary arterial hypertension in systemic lupus erythematosus based on a CSTAR-PAH study: Baseline characteristics and risk factors | Int J Rheum Dis | 2019-05-01 | 通讯作者 |
| 14 | Chinese Systemic Lupus Erythematosus Treatment and Research Group (CSTAR) Registry XI: gender impact on long-term outcomes | Lupus | 2019-05-01 | 通讯作者 |
| 15 | Clinical characteristics and risk factors of microvascular involvement in primary antiphospholipid syndrome: a longitudinal single-center study in China | LUPUS | 2019-11-01 | 通讯作者 |
| 16 | Predictive value of non-invasive right ventricle to pulmonary circulation coupling in systemic lupus erythematosus patients with pulmonary arterial hypertension | European Heart Journal-Cardiovascular Imaging | 2019-12-23 | 通讯作者 |
| 17 | CD74 auto-antibodies display little clinical value in Chinese Han population with axial spondyloarthritis | Medicine (Baltimore) | 2020-11-01 | 通讯作者 |
| 18 | Chinese SLE Treatment and Research group (CSTAR) registry: Clinical significance of thrombocytopenia in Chinese patients with systemic lupus erythematosus | Plos One | 2019-11-01 | 通讯作者 |
| 19 | Clinical features of transverse myelitis associated with systemic lupus erythematosus | LUPUS | 2020-04-01 | 通讯作者 |
| 20 | Systemic lupus erythematosus associated diffuse alveolar hemorrhage: a single-center, matched case-control study in China | Lupus | 2020-07-01 | 通讯作者 |
| 21 | Long-Term Prognosis of Patients with Systemic Lupus Erythematosus-Associated Pulmonary Arterial Hypertension: CSTAR-PAH Cohort Study | Eur Respir J | 2019-02-01 | 通讯作者 |
| 22 | Satisfaction of Patients and Physicians with Treatments for Rheumatoid Arthritis: A Nationwide Survey in China | Patient Prefer Adher. | 2020-06-01 | 通讯作者 |
| 23 | Efficacy and safety of ambrisentan in Chinese patients with connective tissue disease-pulmonary arterial hypertension: a post-hoc analysis | BMC CARDIOVASCULAR DISORDERS | 2020-07-01 | 通讯作者 |
| 24 | Prolonged-Release (PR) Oxycodone/Naloxone Improves Bowel Function Compared with Oxycodone PR and Provides Effective Analgesia in Chinese Patients with Non-malignant Pain: A Randomized, Double-Blind Trial | ADVANCES IN THERAPY | 2020-03-01 | 通讯作者 |
| 25 | Contrast-enhanced ultrasound for evaluating arteritis activity in Takayasu arteritis patients | CLINICAL RHEUMATOLOGY | 2020-04-01 | 通讯作者 |
| 26 | Red blood cell distribution width as a potential predictor of survival of pulmonary arterial hypertension associated with primary Sjogren's syndrome: a retrospective cohort study | CLINICAL RHEUMATOLOGY | 2019-02-01 | 通讯作者 |
| 27 | Cysteine-rich protein 61 as a novel biomarker in systemic lupus erythematosus-associated pulmonary arterial hypertension | CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | 2019-04-01 | 通讯作者 |
| 28 | Immunoglobulin A isotype of antiphospholipid antibodies does not provide added value for the diagnosis of antiphospholipid syndrome in a Chinese population | Front. Immunol. | 2020-10-01 | 通讯作者 |
| 29 | Comparison of the Efficacy and Safety of Adalimumab (Humira) and the Adalimumab Biosimilar Candidate (HS016) in Chinese Patients with Active Ankylosing Spondylitis: A Multicenter, Randomized, Double-Blind, Parallel, Phase III Clinical Trial | BIODRUGS | 2020-06-01 | 通讯作者 |
| 30 | Clinical features and long-term outcomes of Chinese patients with scleroderma renal crisis | Internatoional Journal of Rheumatic Diseases | 2020-09-01 | 通讯作者 |
| 31 | Interventricular systolic asynchrony predicts prognosis in patients with systemic sclerosis-associated pulmonary arterial hypertension | RHEUMATOLOGY | 2021-05-01 | 通讯作者 |
| 32 | Association between acute phase reactants, interleukin-6, tumor necrosis factor-α, and disease activity in Takayasu’s arteritis patients | ARTHRITIS RESEARCH & THERAPY | 2020-12-10 | 通讯作者 |
| 33 | Clinical manifestations of Behcet's disease in large cohort of Chinese patients:gender- and age-related differences | clinical rheumatology | 2020-05-01 | 通讯作者 |
| 34 | Hierarchical cluster analysis of cytokine profiles reveals a cutaneous vasculitis-associated subgroup in dermatomyositis | CLIN RHEUMATOL | 2021-03-01 | 通讯作者 |
| 35 | Risk factors for progression of carotid intima-media thickness in patients with systemic lupus erythematosus: protocol for an observational cohort study in China | BMJ OPEN | 2019-09-01 | 通讯作者 |
| 36 | The Chinese herb Tripterygium wilfordii Hook F for the treatment of systemic sclerosis-associated interstitial lung disease: data from a Chinese EUSTAR Center | CLINICAL RHEUMATOLOGY | 2020-03-01 | 通讯作者 |
| 37 | Platelet distribution width is highly associated with thrombotic events in primary antiphospholipid syndrome | CLINICAL RHEUMATOLOGY | 2021-07-02 | 通讯作者 |
| 38 | Predictive Value of Pulmonary Arterial Compliance in Systemic Lupus Erythematosus Patients With Pulmonary Arterial Hypertension | HYPERTENSION | 2020-10-01 | 通讯作者 |
| 39 | Clinical efficacy and safety of sirolimus in systemic lupus erythematosus: a real-world study and meta-analysis | THERAPEUTIC ADVANCES IN MUSCULOSKELETAL DISEASE | 2020-09-01 | 通讯作者 |
| 40 | Prevalence and Associated Factors of Lupus in the United States: Third National Health and Nutritional Examination Survey (NHANES III) | FRONTIERS IN MEDICINE | 2020-05-01 | 通讯作者 |
| 41 | Clinical manifestation of behceet disease in a large cohort of Chinese patients:gender- and age- related differences | Clinical Rheumatology | 2020-05-01 | 通讯作者 |
| 42 | Predicting risk of pulmonary arterial hypertension in systemic lupus erythematosus: CSTAR cohort study | Arthritis & Rheumatology | 2021-06-09 | 通讯作者 |
| 43 | Validation of the REVEAL Prognostic Models in Systemic Lupus Erythematosus-associated Pulmonary Arterial Hypertension | frontiers in medicine | 2021-03-15 | 通讯作者 |
| 44 | Risk Osteonecrosis of systemic lupus erythematosus: an 11-year chinese single center cohort study | LUPUS | 2021-05-05 | 通讯作者 |
| 45 | Pulmonary arterial hypertension associated with primary Sjogren's syndrome: a multicentre cohort study from China | EUROPEAN RESPIRATORY JOURNAL | 2020-11-19 | 通讯作者 |
| 46 | Chinese SLE Treatment and Research Group (CSTAR) Registry XIII: prevalence and risk factors for chronic scarring alopecia in patients with systemic lupus erythematosus. | ARTHRITIS RESEARCH & THERAPY | 2021-01-15 | 通讯作者 |
| 47 | Changes in efficacy indicators for adalimumab biosimilar candidate (HS016) for the treatment of active ankylosing spondylitis at various time points. | Frontiers in Pharmacology | 2020-11-15 | 通讯作者 |
| 48 | Chinese registry of rheumatoid arthritis (CREDIT): III. The transition of disease activity during follow-ups and predictors of achieving treatment target | INT J RHEUM DIS | 2020-12-01 | 通讯作者 |
| 49 | Sirolimus for patients with connective tissue disease-related refractory thrombocytopenia: a single-arm, open-label clinical trial | RHEUMATOLOGY | 2020-11-17 | 通讯作者 |
| 50 | Comparison of Different Test Systems for the Detection of Antiphospholipid Antibodies in a Chinese Cohort | Frontiers in Immunology | 2021-07-02 | 通讯作者 |
| 51 | Evaluation of the Diagnostic Value of Non-criteria Antibodies for Antiphospholipid Syndrome Patients in a Chinese Cohort | Frontiers in Immunology | 2021-09-01 | 通讯作者 |
| 52 | Sirolimus versus tacrolimus for systemic lupus erythematosus treatment: results from a real-world CSTAR cohort study | LUPUS SCIENCE & MEDICINE | 2022-01-01 | 通讯作者 |
| 53 | Characteristics and risk factors of retinal vasculopathy in antiphospholipid syndrome | LUPUS | 2022-04-11 | 通讯作者 |
| 54 | Right Ventricle to Pulmonary Artery Coupling Predicts the Risk Stratification in Patients With Systemic Sclerosis-Associated Pulmonary Arterial Hypertension | Frontiers in Cardiovascular Medicine | 2022-05-11 | 通讯作者 |
| 55 | Thrombocytopenia in primary antiphospholipid syndrome: Association with prognosis and clinical implications | RHEUMATOLOGY | 2022-05-10 | 通讯作者 |
| 56 | The Prevalence and Clinical Relevance of the DFS Immunofluorescence Staining Pattern in a Large ANA-Positive Cohort | frontiers in medicine | 2022-05-10 | 通讯作者 |
| 57 | Clinical characteristics and prognosis of patients with antiphospholipid antibodies based on cluster analysis: an 8-year cohort study | ARTHRITIS RESEARCH & THERAPY | 2022-05-04 | 通讯作者 |
| 58 | Myocardial involvement in idiopathic inflammatory myopathies: a multi-center cross-sectional study in the CRDC-MYO Registry | CLINICAL RHEUMATOLOGY | 2021-11-20 | 通讯作者 |
| 59 | Prevalence and risk factors for left ventricular diastolic dysfunction in systemic sclerosis: a multi-center study of CRDC cohort in China | CLIN RHEUMATOL | 2021-11-01 | 通讯作者 |
| 60 | Comparison of Clinical Features in HLA-B27 Positive and Negative Patients With Axial Spondyloarthritis: Results From a Cohort of 4,131 Patients | FRONT MED | 2020-12-23 | 通讯作者 |
| 61 | Ideal physical activity in association with incident ankylosing spondylitis: a community-based, prospective cohort study. | CLIN EXP RHEUMATOL | 2020-04-09 | 通讯作者 |
| 62 | Baseline high-sensitivity C-reactive protein predicts the risk of incident ankylosing spondylitis: Results of a community-based prospective study. | PLoS One | 2019-02-15 | 通讯作者 |
| 63 | Evaluation of adalimumab biosimilar candidate (HS016) in Chinese patients with active ankylosing spondylitis based on a health survey: sub-analysis of a phase 3 study. | CLIN RHEUMATOL | 2022-03-01 | 通讯作者 |
| 64 | Clinical characteristics of axial spondyloarthritis patients in China: results from ChinaSpA, the Chinese Spondyloarthritis Registry. | CLIN EXP RHEUMATOL | 2022-03-01 | 通讯作者 |
| 65 | Clinical characteristics and outcomes of lupus myocarditis: a retrospective case control study in Chinese patients | CLINICAL AND EXPERIMENTAL RHEUMATOLOGY | 2022-04-20 | 通讯作者 |
| 66 | Pregnancy outcomesi in Takayasu's arteritis patients | SEMINARS IN ARTHRITIS AND RHEUMATISM | 2022-04-12 | 通讯作者 |
| 67 | Whole Exome Sequencing Revealed Variants That Predict Pulmonary Artery Involvement in Patients with Takayasu Arteritis | Journal of Inflammation Research | 2022-08-24 | 通讯作者 |
| 68 | Risk assessment in systemic lupus erythematosus-associated pulmonary arterial hypertension: CSTAR-PAH cohort study | Therapeutic Advances in Chronic Disease | 2022-07-21 | 通讯作者 |
| 69 | The clinical value of indirect immunofluorescence for screening anti-rods and rings antibodies: A retrospective study of two centers in China | Frontiers in Immunology | 2022-09-27 | 通讯作者 |
| 70 | Risk factors for avascular necrosis in patients with systemic lupus erythematosus: a multi-center cohort study of Chinese SLE Treatment and Research Group (CSTAR) Registry XXII | ARTHRITIS RESEARCH & THERAPY | 2023-05-12 | 通讯作者 |
| 71 | Immune Thrombocytopenia Could be an Independent Clinical Phenotype of Antiphospholipid Syndrome: A Prospective Cohort Study | Rheumatology and Therapy | 2023-01-30 | 通讯作者 |
| 72 | Safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of WBP216, a novel IL-6 monoclonal antibody, in patients with rheumatoid arthritis: A phase Ia randomized placebo-controlled study | Frontiers in Immunology | 2023-02-28 | 通讯作者 |
| 73 | Age, sex and angiographic type related phenotypic differences in inpatients with Takayasu arteritis: A 13-year retrospective study at a national referral center in China | Frontiers in Cardiovascular Medicine | 2023-03-16 | 通讯作者 |
| 74 | The influence of intrathecal injection of methotrexate and dexamethasone on neuropsychiatric systemic lupus erythematosus (NPSLE): a retrospective cohort study of 386 patients with NPSLE | ARTHRITIS RESEARCH & THERAPY | 2023-03-28 | 通讯作者 |
| 75 | Efficacy and safety of tofacitinib in Chinese patients with active psoriatic arthritis: a phase 3, randomised, double-blind, placebo-controlled study | RMD Open | 2023-01-09 | 通讯作者 |
| 76 | Efficacy and safety of Janus kinase inhibitors in patients with psoriasis and psoriatic arthritis: a systematic review and meta-analysis | CLINICAL RHEUMATOLOGY | 2023-01-28 | 通讯作者 |
| 77 | The diagnostic and prognostic value of growth differentiation factor‐15 in systemic lupus erythematosus‐associated pulmonary arterial hypertension | Pulmonary Circulation | 2023-01-23 | 通讯作者 |
| 78 | A multi-center, open-label, randomized study to explore efficacy and safety of baricitinib in active primary Sjogren's syndrome patients | Trials | 2023-02-15 | 通讯作者 |
| 79 | Changes of serum IgG glycosylation patterns in rheumatoid arthritis | Clinical Proteomics | 2023-02-21 | 通讯作者 |
| 80 | Changes of Serum IgG Glycosylation Patterns in Primary Biliary Cholangitis Patients | Frontiers in Immunology | 2021-06-25 | 通讯作者 |
| 81 | Predictors of relapse in Takayasu arteritis | European Journal of Internal Medicine | 2023-03-12 | 通讯作者 |
| 82 | Prevalence and Clinical characteristics of the Dense Fine Speckled Pattern:Antinuclear Antibody Screening in the Chinese population | SCANDINAVIAN JOURNAL OF IMMUNOLOGY | 2023-01-01 | 通讯作者 |
| 83 | Identification of the Association Between Toll-Like Receptors and T-Cell Activation in Takayasu's Arteritis. | Frontiers in Immunology | 2022-01-20 | 通讯作者 |
| 84 | The modulatory roles of T cell glycosylation in systemic lupus erythematosus | CLIN EXP RHEUMATOL | 2021-07-08 | 通讯作者 |
| 85 | Spectrum of Spondyloarthritis Among Chinese Populations | CURRENT RHEUMATOLOGY REPORTS | 2022-07-13 | 通讯作者 |
| 86 | The treatment strategy of connective tissue disease associated pulmonary arterial hypertension: Evolving into the future. | Pharmacology & therapeutics | 2022-11-01 | 通讯作者 |
| 87 | Anti-inflammatory and immune therapy in severe coronavirus disease 2019 (COVID-19) patients: An update. | Clinical immunology (Orlando, Fla.) | 2022-04-25 | 通讯作者 |
| 88 | The use of anti-inflammatory drugs in the treatment of people with severe coronavirus disease 2019 (COVID-19): The perspective of clinical immunologists from China. | CLINICAL IMMUNOLOGY | 2020-05-25 | 通讯作者 |
| 89 | Comparative efficacy of traditional non-selective NSAIDs and selective cyclo-oxygenase-2 inhibitors in patients with acute gout: a systematic review and meta-analysis | BMJ open | 2020-01-01 | 通讯作者 |
| 90 | Prevalence, predictors and prognostic benefits of remission achievement in patients with systemic lupus erythematosus: a systematic review | Arthritis Care Res (Hoboken) | 2020-09-01 | 通讯作者 |
| 91 | Relationship between disease activity, organ damage and health-related quality of life in patients with systemic lupus erythematosus: a systemic review and meta-analysis | Autoimmun Rev | 2020-06-01 | 通讯作者 |
| 92 | JAK inhibitors: prospects in connective tissue diseases | Clin Rev Allergy Immunol | 2020-03-01 | 通讯作者 |
| 93 | Remission rate and predictors of remission in patients with rheumatoid arthritis under treat-to-target strategy in real-world studies: a systematic review and meta-analysis | Clin Rheumatol | 2019-03-01 | 通讯作者 |
| 94 | Efficacy and safety of telitacicept in primary Sjögren's syndrome: a randomized, double-blind, placebo-controlled, phase 2 trial. | RHEUMATOLOGY | 2023-07-03 | 通讯作者 |
| 95 | Chinese Registry of Psoriatic Arthritis (CREPAR): I. Clinical characteristics of Chinese patients with psoriatic arthritis | International Journal of Rheumatic Diseases | 2023-07-09 | 通讯作者 |
| 96 | Comparative Efficacy of Secukinumab Versus Tumor Necrosis Factor Inhibitors for the Treatment of Takayasu Arteritis | Arthritis & Rheumatology | 2023-08-01 | 通讯作者 |
| 97 | Anti-β2GPI-domain I antibody is associated with extra-criteria manifestations in a large prospective antiphospholipid syndrome cohort in China | Lupus Science & Medicine | 2023-08-01 | 通讯作者 |
| 98 | Serum CHI3L1 as abiomarker of interstitial lung disease in rheumatoid arthritis | Frontiers in Immunology | 2023-08-17 | 通讯作者 |
| 99 | Association study identified HLA-DQA1 as a novel genetic risk of systemic lupus erythematosus-associated pulmonary arterial hypertension. | Arthritis & Rheumatology | 2023-10-24 | 通讯作者 |
| 100 | Systemic sclerosis patients with negative antinuclear antibodies have distinctive clinical manifestations: a multicenter CRDC cohort in China | ZEITSCHRIFT FUR RHEUMATOLOGIE | 2024-02-01 | 通讯作者 |
| 101 | Prediction of progressive fibrosing interstitial lung disease in patients with systemic sclerosis: insight from the CRDC cohort study | RMD Open | 2024-03-06 | 通讯作者 |
| 102 | baricitinib for refractory Takayasu arteritis: a prospective cohort study in a tertiary referral centre | RMD Open | 2024-02-22 | 通讯作者 |
| 103 | A prognostic model for systemic lupus erythematosus-associated pulmonary arterial hypertension: CSTAR-PAH cohort study | RESPIRATORY RESEARCH | 2023-10-16 | 通讯作者 |
| 104 | Incidence, risk factors for active tuberculosis infection and changes of IGRA in patients with Takayasu arteritis: a prospective cohort study | Emerging Microbes & Infections | 2024-01-22 | 通讯作者 |
| 105 | Sex‑specifc diferences in patients with psoriatic arthritis:a nationwide study from the Chinese Registry of Psoriatic Arthritis (CREPAR IV) | CLINICAL RHEUMATOLOGY | 2024-03-10 | 通讯作者 |
| 106 | Serum proteome analysis identifies a potential biomarker for axial psoriatic arthritis | EUROPEAN JOURNAL OF MEDICAL RESEARCH | 2024-03-01 | 通讯作者 |
| 107 | Comparing tocilizumab biosimilar BAT1806/BIIB800 with reference tocilizumab in patients with moderate-to-severe rheumatoid arthritis with an inadequate response to methotrexate: a phase 3, randomised, multicentre, double-blind, active-controlled clinical trial | Lancet Rheumatology | 2024-01-03 | 通讯作者 |
| 108 | Efficacy and safety of mesenchymal stem cell-derived microvesicles in mouse inflammatory arthritis. Int Immunopharmacol | INTERNATIONAL IMMUNOPHARMACOLOGY | 2024-03-25 | 通讯作者 |
| 109 | Development and external validation of a prediction model for venous thromboembolism in systemic lupus erythematosus | RMD open | 2023-12-01 | 通讯作者 |
| 110 | Tacrolimus shows adequate efficacy in patients with antiphospholipid antibodies associated thrombocytopenia: a retrospective cohort study | CLINICAL AND EXPERIMENTAL MEDICINE | 2023-12-01 | 通讯作者 |
| 111 | Safety and Effectiveness of Baricitinib in Chinese Patients with Moderate-to-Severe Rheumatoid Arthritis: 24-Week Results from a Post-Marketing Safety Study | Rheumatology and Therapy | 2023-12-20 | 通讯作者 |
| 112 | Global trends in research of melanoma differentiation-associated gene 5: a bibliometric analysis from 2002 to 2022 | CLIN RHEUMATOL | 2024-01-06 | 通讯作者 |
| 113 | New investigational drugs to treat Sjogren's syndrome: lessons learnt from immunology. | EXPERT OPIN DRUG SAF | 2024-01-31 | 通讯作者 |
| 114 | Efficacy and safety of immunosuppressive agents for adults with lupus nephritis: a systematic review and network meta-analysis | Frontiers in Immunology | 2023-10-13 | 通讯作者 |
- 科研获奖Research Awards
| # | 获奖证书编号 | 奖项名称 | 获奖级别 | 获奖类别 | 获奖等级 | 获奖日期 | 颁奖单位 | 本单位是否为第一完成单位 | 完成单位排名 | 本人排序 | 备注 |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 200902020P004 | 系统性红斑狼疮发病机制及诊断方法学研究 | 国家级 | 其他省部级奖励 | 二等奖 | 2009-06-01 | 中国医学科学院协和医院 | 是 | 1 | 4 | |
| 2 | 200503024P0802 | 类风湿关节炎早期诊断的血清学研究和临床应用 | 省部级 | 其他省部级奖励 | 三等奖 | 2005-06-01 | 中国医学科学院协和医院 | 是 | 1 | 2 | |
| 3 | 2013-213 | 提高肺动脉高压诊断和治疗水平的关键技术研究 | 省部级 | 科技进步奖、哲学社科奖 | 一等奖 | 2014-06-02 | 中国医学科学院协和医院 | 是 | 1 | 6 | |
| 4 | 2009-257 | 系统性红斑狼疮发病机制及诊断方法学研 究 | 国家级 | 国家最高科学技术奖、自然科学奖、技术发明奖、科技进步奖 | 二等奖 | 2010-06-01 | 中国医学科学院协和医院 | 是 | 1 | 3 | |
| 5 | 2013 医-3-013-06 | 提高肺动脉高压诊断和治疗水平的关键技术研究 | 省部级 | 科技进步奖、哲学社科奖 | 三等奖 | 2013-06-01 | 中国医学科学院协和医院 | 是 | 1 | 6 | |
| 6 | 无 | 抗核抗体谱及其临床意义 | 国家级 | 国家最高科学技术奖、自然科学奖、技术发明奖、科技进步奖 | 三等奖 | 1988-06-01 | 中国医学科学院协和医院 | 是 | 1 | 8 | |
| 7 | 2009 医-3-022-03 | 系统性红斑狼疮发病机制及诊断方法学研究 | 省部级 | 科技进步奖、哲学社科奖 | 三等奖 | 2009-06-01 | 中国医学科学院协和医院 | 是 | 1 | 3 |
- 研究成果Research Findings
| # | 成果类型 | 项目/专利/新品种名称 |
|---|---|---|
| 1 | 作为主创人员获得授权的发明专利和新品种 | 白藜芦醇在制备用于预防和/或治疗系统性红斑狼疮的组合物中的用途 |
| 2 | 作为主创人员获得授权的发明专利和新品种 | CD146作为分子标记物在诊断、分期、预后神经精神狼疮中的用途 |
| 3 | 作为主创人员获得授权的发明专利和新品种 | 一种用于检测膜突蛋白抗体的试剂盒 |
| 4 | 出版高水平专著 | 哈里森 风湿病学 |
| 5 | 出版高水平专著 | 中国风湿病图谱-系统性红斑狼疮分册 |
| 6 | 出版高水平专著 | 类风湿关节炎诊断与治疗 |
| 7 | 出版高水平专著 | 哈里森 风湿病学 |
| 8 | 出版高水平专著 | 风湿免疫学高级教程 |
| 9 | 出版高水平专著 | 临床路径释义 风湿免疫疾病分册 |
| 10 | 出版高水平专著 | 风湿免疫性疾病综合征 |
| 11 | 出版高水平专著 | 临床医学综合能力考试（西医） |
| 12 | 出版高水平专著 | 北京协和医院 风湿免疫科疑难病诊断——协和医生临床思维例释 |
| 13 | 出版高水平专著 | 风湿免疫学习题集 |
| 14 | 出版高水平专著 | 中国类风湿关节炎发展报告2020 |
| 15 | 出版高水平专著 | 中国系统性红斑狼疮发展报告2020 |
| 16 | 出版高水平专著 | 类风湿关节炎患者教育手册 |
| 17 | 出版高水平专著 | 系统性红斑狼疮患者教育手册 |
| 18 | 出版高水平专著 | 内科学 风湿免疫科分册（第2版） |