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个人简介
Personal Profile
赵玉沛,北京协和医院名誉院长,中国科学院院士,外科学教授、主任医师。现任中华医学会会长、外科学分会主任委员、全国胰腺外科学组组长,转化医学国家重大科技基础设施(北京协和)主任,疑难重症及罕见病全国重点实验室主任。2011年当选为中国科学院院士。中国共产党第十八、十九届中央候补委员。 历任北京协和医院副院长、院长,中央保健委员会副主任(副部长级),第九届中国科学技术协会副主席,中华医学会副会长、常务副会长,第十六届亚洲外科学会主席等。《中华外科杂志》总编辑、《Journal of Pancreatology》主编及十余种外科杂志的总编和名誉总编;国际外科学院、美洲外科学院、英格兰皇家外科学院及香港外科学院“Honorary Fellowship”、爱丁堡皇家外科学院“Fellowship Ad Hominem”。 倡导胰腺疾病多学科诊疗模式,牵头制定了中国胰腺癌诊治指南和中国胰岛素瘤诊治指南,带领团队在普外科尤其是胰腺疾病领域作出了系统性和开创性贡献。先后荣获国家科技进步二等奖两项、北京市科技进步一等奖、中华医学科技进步一等奖及何梁何利基金科学与技术进步奖、卫生部有突出贡献中青年专家、全国五一劳动奖章等荣誉。
团队简介
Team Profile
赵玉沛教授作为临床外科专家,带领团队通过艰苦的努力,做出了突出贡献。提出“胰腺癌高危人群”概念,有效促进高危人群尽早就诊和医务人员减少误诊。提出并建立“胰腺癌诊治绿色通道”,规范了胰腺癌诊治流程。率先在国内建立胰腺疾病会诊中心,通过多学科诊疗(MDT)模式使病人尽早得到最佳的治疗方案。对于合理利用医疗资源、提高手术成功率具有重要意义。通过完善手术适应证、规范手术切除范围和强化围手术期处理,使胰腺癌切除手术死亡率及并发症发生率明显降低。创立了经空肠胃造瘘术,其创伤性小,操作简单,避免了留置胃管所带来的多种并发症,明显改善了患者术后生活质量。他领导的课题组对胰腺内分泌肿瘤的诊断和手术治疗进行了系列的临床研究,成功完成了我国首例经腹腔镜胰岛素瘤摘除术,率先在国内开展机器人胰岛素瘤手术,目前已成功实施100余例,明显减轻了剖腹手术给患者带来的创伤,缩短了手术和住院时间。 赵玉沛教授大力倡导建立胰腺疾病诊治中心和胰腺外科专业队伍。针对胰腺癌诊治中的难点问题进行了相关基础研究,引领全国胰腺外科同道,共同推动了全国胰腺外科的进步和发展。牵头制定了中华医学会胰腺癌诊治指南和卫生部胰腺癌诊治的国家行业标准。带领全国16家胰腺外科中心,承担了国家863、973、科技支撑计划和行业专项基金等重大科研课题,就胰腺癌诊治中存在的重大问题开展前瞻性临床研究,搭建了全国胰腺癌诊治技术平台。他先后承担国家和省部级科研课题20余项,发表论著300余篇,荣获国家科技进步二等奖、中华医学科技进步一等奖及何梁何利基金科学与技术进步奖。
硕士研究生 1 名,博士研究生 10 名
# | 项目名称 | 起止日期 | 金额 | 项目类型 | 本人角色 |
---|---|---|---|---|---|
1 | 化疗诱导胰腺星形细胞转录重编程介导胰腺癌耐药的旁分泌机制研究 | 2017-01-18 —— 2020-12-16 | 主持在研的国家或省部级科研项目 | 主持人 | |
2 | OLR1/c-Myc/HMGA2轴在胰腺癌化疗耐药中的作用及机制研究 | 2020-01-01 —— 2023-12-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
3 | HIF-1调控STC1与VEGFR1的结合介导胰腺癌化疗耐药的机制研究 | 2022-01-01 —— 2025-12-31 | 主持在研的国家或省部级科研项目 | 主持人 | |
4 | 胰腺囊性病变鉴别诊断新技术的应用研究 | 2018-01-01 —— 2020-12-01 | 主持在研的国家或省部级科研项目 | 主持人 | |
5 | 胰腺肿瘤“四早”防治体系的建立与关键技术和策略研究 | 2022-11-01 —— 2025-10-01 | 主持的企业/行业委托重大项目 | 主持人 | |
6 | 内分泌肿瘤基础与临床研究 | 2017-01-01 —— 2020-12-01 | 主持的企业/行业委托重大项目 | 主持人 | |
7 | 疑难重症及罕见病协同创新研究 | 2019-01-01 —— 2020-12-31 | 主持的企业/行业委托重大项目 | 主持人 | |
8 | 内分泌代谢类疾病的精准分型和诊疗体系研究 | 2021-10-01 —— 2025-12-01 | 主持的企业/行业委托重大项目 | 主持人 |
# | 论文题目 | 期刊名称 | 发表年份 | 论文署名 |
---|---|---|---|---|
1 | The role of histone methylation in the development of digestive cancers: a potential direction for cancer management | Signal Transduct Target Ther | 2020-08 | 通讯作者 |
2 | Targeting hypoxic tumor microenvironment in pancreatic cancer | J Hematol Oncol | 2021-01 | 通讯作者 |
3 | Preliminary exploration of potential molecular therapeutic targets in recurrent and metastatic parathyroid carcinomas | INTERNATIONAL JOURNAL OF CANCER | 2018-10 | 通讯作者 |
4 | Integrated analysis of gene expression and methylation profiles of novel pancreatic cancer cell lines with highly metastatic activity | Science China-Life Sciences | 2019-03-13 | 通讯作者 |
5 | When to Introduce Three-Dimensional Visualization Technology into Surgical Residency: A Randomized Controlled Trial | Journal of Medical Systems | 2019-03-01 | 通讯作者 |
6 | Profiling analysis of long non-coding RNA and mRNA in parathyroid carcinoma | Endocrine-Related Cancer | 2019-02-01 | 通讯作者 |
7 | WT1 associated protein promotes metastasis and chemo-resistance to gemcitabine by stabilizing Fak mRNA in pancreatic cancer | CANCER LETTERS | 2019-04-01 | 通讯作者 |
8 | Clinicopathologic and prognostic significance of MKK4 and MKK7 in resectable pancreatic ductal adenocarcinoma. | HUMAN PATHOLOGY | 2019-04-01 | 通讯作者 |
9 | Long noncoding RNA GSTM3TV2 upregulates LAT2 and OLR1 by competitively sponging let-7 to promote gemcitabine resistance in pancreatic cancer. | Journal of Hematology & Oncology | 2019-08-16 | 通讯作者 |
10 | Circular RNA profile of parathyroid neoplasms: analysis of co-expression networks of circular RNAs and mRNAs | RNA Biology | 2019-06-18 | 通讯作者 |
11 | Early detection of cognitive impairment in patients with insulinoma | ENDOCRINE | 2019-09-01 | 通讯作者 |
12 | Single-cell RNA-seq highlights intra-tumoral heterogeneity and malignant progression in pancreatic ductal adenocarcinoma | CELL RESEARCH | 2019-09-01 | 通讯作者 |
13 | Identification of a Nine-Gene Signature and Establishment of a Prognostic Nomogram Predicting Overall Survival of Pancreatic Cancer | FRONTIERS IN ONCOLOGY | 2019-09-01 | 通讯作者 |
14 | Pancreatic cancer-educated macrophages protect cancer cells from complement-dependent cytotoxicity by up-regulation of CD59 | Cell Death & Disease | 2019-11-01 | 通讯作者 |
15 | Whole-genome sequencing reveals distinct genetic bases for insulinomas and non-functional pancreatic neuroendocrine tumours: leading to a new classification system | GUT | 2020-05-01 | 通讯作者 |
16 | Fibroblast activation protein alpha-positive pancreatic stellate cells promote the migration and invasion of pancreatic cancer by CXCL1-mediated Akt phosphorylation | ANNALS OF TRANSLATIONAL MEDICINE | 2019-10-01 | 通讯作者 |
17 | CXCL5 overexpression predicts a poor prognosis in pancreatic ductal adenocarcinoma and is correlated with immune cell infiltration | JOURNAL OF CANCER | 2020-02-01 | 通讯作者 |
18 | The influence of surgical extent and parafibromin staining on the outcome of parathyroid carcinoma: 20-year experience from a single institute. | Endocrine Practice | 2019-07-15 | 通讯作者 |
19 | Immunocyte density in parathyroid carcinoma is correlated with disease relapse | JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION | 2020-03-01 | 通讯作者 |
20 | High expression of Cancer-Derived glycosylated immunoglobulin g predicts poor prognosis in pancreatic ductal adenocarcinoma. | Journal of Cancer | 2020-02-03 | 通讯作者 |
21 | Cancer-derived immunoglobulin g: A novel marker for differential diagnosis and relapse prediction in parathyroid carcinoma. | CLINICAL ENDOCRINOLOGY | 2020-05-01 | 通讯作者 |
22 | High Expression of MUC15 Is Correlated with Poor Prognosis of Pancreatic Cancer and Promotes Migration, Invasion, and Chemo-Resistance In Vitro | MEDICAL SCIENCE MONITOR | 2020-10-01 | 通讯作者 |
23 | Glutathione S-Transferase Mu-3 Predicts a Better Prognosis and Inhibits Malignant Behavior and Glycolysis in Pancreatic Cancer | FRONTIERS IN ONCOLOGY | 2020-08-01 | 通讯作者 |
24 | The genomic profile of parathyroid carcinoma based on whole-genome sequencing | INTERNATIONAL JOURNAL OF CANCER | 2020-11-01 | 通讯作者 |
25 | Transducin-Like Enhancer of Split-1 Inhibits Malignant Behaviors in vitro and Predicts a Better Prognosis in Pancreatic Ductal Adenocarcinoma1 | Frontiers in Oncology | 2020-05-05 | 通讯作者 |
26 | Identification of prognosis-related genes and construction of multi-regulatory networks in pancreatic cancer microenvironment by bioinformatics analysis | CANCER CELL INTERNATIONAL | 2020-07-01 | 通讯作者 |
27 | CREPT serves as a biomarker of poor survival in pancreatic ductal adenocarcinoma | Cellular Oncology | 2020-10-01 | 通讯作者 |
28 | Three-Dimensional Visualization Technology Used in Pancreatic Surgery: a Valuable Tool for Surgical Trainees | JOURNAL OF GASTROINTESTINAL SURGERY | 2020-04-01 | 通讯作者 |
29 | Impact of ischemia on sample quality of human pancreatic tissues | PANCREATOLOGY | 2020-03-01 | 通讯作者 |
30 | Matrix Metalloproteinase 11 as a Novel Tumor Promoter and Diagnostic and Prognostic Biomarker for Pancreatic Ductal Adenocarcinoma | PANCREAS | 2020-07-01 | 通讯作者 |
31 | Combined blockade of TGf-beta 1 and GM-CSF improves chemotherapeutic effects for pancreatic cancer by modulating tumor microenvironment | CANCER IMMUNOLOGY IMMUNOTHERAPY | 2020-08-01 | 通讯作者 |
32 | Metformin inhibits pancreatic cancer metastasis caused by SMAD4 deficiency and consequent HNF4G upregulation | Protein & Cell | 2020-07-31 | 通讯作者 |
33 | Integrative Genomic Analysis of Gemcitabine Resistance in Pancreatic Cancer by Patient-derived Xenograft Models | CLINICAL CANCER RESEARCH | 2021-06-13 | 通讯作者 |
34 | Risk factors and prevention of postoperative pancreatic fistula after insulinoma enucleation:a retrospective study from a high-volume center | PANCREATOLOGY | 2021-06-05 | 通讯作者 |
35 | Interleukin-17 activates and synergizes with the notch signaling pathway in the progression of pancreatic ductal adenocarcinoma | CANCER LETTERS | 2021-06-28 | 通讯作者 |
36 | Quantitative assessment of the diagnostic role of mucin family members in pancreatic cancer: a meta-analysis | Annals of Translational Medicine | 2021-02-01 | 通讯作者 |
37 | HIF-1α-regulated stanniocalcin-1 mediates gemcitabine resistance in pancreatic ductal adenocarcinoma via PI3K/AKT signaling pathway | MOLECULAR CARCINOGENESIS | 2022-07-04 | 通讯作者 |
38 | High-resolution Hi-C maps highlight multiscale 3D epigenome reprogramming during pancreatic cancer metastasis | Journal of Hematology & Oncology | 2021-08-04 | 通讯作者 |
39 | Construction of a prognostic model with histone modification‑related genes and identification of potential drugs in pancreatic cancer | Cancer Cell International | 2021-06-05 | 通讯作者 |
40 | A randomised, multicentre trial of somatostatin to prevent clinically relevant postoperative pancreatic fistula in intermediaterisk patients after pancreaticoduodenectomy | JOURNAL OF GASTROENTEROLOGY | 2021-08-28 | 通讯作者 |
41 | Identification and Validation of Constructing the Prognostic Model With Four DNA Methylation-Driven Genes in Pancreatic Cancer | frontiers in cell and developmental biology | 2021-09-07 | 通讯作者 |
42 | Comprehensive Analysis of Autophagy-Associated lncRNAs Reveal Potential Prognostic Prediction in Pancreatic Cance | Frontiers in Oncology | 2021-05-07 | 通讯作者 |
43 | S100A2 Is a Prognostic Biomarker Involved in Immune Infiltration and Predict Immunotherapy Response in Pancreatic Cancer | Frontiers in Immunology | 2021-11-23 | 通讯作者 |
44 | Early Drain Removal is Safe in Patients With Low or Intermediate Risk of Pancreatic Fistula After Pancreaticoduodenectomy A Multicenter, Randomized Controlled Trial | ANNALS OF SURGERY | 2022-02-01 | 通讯作者 |
45 | Convergence between germline and somatic mutations in pancreatic neuroendocrine tumors | EUROPEAN JOURNAL OF ENDOCRINOLOGY | 2022-05-01 | 通讯作者 |
46 | Association between Temporal Glycemic Change and Risk of Pancreatic Cancer in Men: A Prospective Cohort Study | CANCERS | 2022-07-13 | 通讯作者 |
47 | Construction of immune-related signature and identification of S100A14 determining immune-suppressive microenvironment in pancreatic cancer | BMC CANCER | 2022-08-11 | 通讯作者 |
48 | Construction of a novel model based on cell-in-cell-related genes and validation of KRT7 as a biomarker for predicting survival and immune microenvironment in pancreatic cancer | BMC CANCER | 2022-08-16 | 通讯作者 |
49 | Epigenetic reprogramming-induced guanidinoacetic acid synthesis promotes pancreatic cancer metastasis and transcription-activating histone modifications | JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH | 2023-06-28 | 通讯作者 |
50 | Surgical Treatment for Postprandial Hypoglycemia After Roux-en-Y Gastric Bypass: a Literature Review | OBESITY SURGERY | 2021-04-01 | 通讯作者 |
51 | Mechanisms of obesity- and diabetes mellitus-related pancreatic carcinogenesis: a comprehensive and systematic review | Signal Transduction and Targeted Therapy | 2023-03-24 | 通讯作者 |
52 | Mind the tributary of the canal: Are stents necessary for insulinoma enucleation in proximity to a prominent Duct of Santorini: A case report and literature review | MEDICINE | 2022-10-28 | 通讯作者 |
53 | Human microbiota colonization and pancreatic ductal carcinoma | CRITICAL REVIEWS IN MICROBIOLOGY | 2022-08-04 | 通讯作者 |
54 | Imaging Features for Predicting High-Grade Dysplasia or Malignancy in Branch Duct Type Intraductal Papillary Mucinous Neoplasm of the Pancreas: A Systematic Review and Meta-Analysis. | ANNALS OF SURGICAL ONCOLOGY | 2021-09-23 | 通讯作者 |
55 | Novel technologies in cfDNA analysis and potential utility in clinic | CHINESE JOURNAL OF CANCER RESEARCH | 2021-12-31 | 通讯作者 |
56 | Advances in the epidemiology of pancreatic cancer: Trends, risk factors, screening, and prognosis | CANCER LETTERS | 2021-06-30 | 通讯作者 |
57 | Application of multiomics sequencing and advances in the molecular mechanisms of pancreatic neuroendocrine neoplasms | CANCER LETTERS | 2021-01-28 | 通讯作者 |
58 | GSTM3 Function and Polymorphism in Cancer:Emerging but Promising | Cancer Management and Research | 2020-10-01 | 通讯作者 |
59 | Pancreatic head cancer: Open or minimally invasive pancreaticoduodenectomy? | CHINESE JOURNAL OF CANCER RESEARCH | 2019-12-01 | 通讯作者 |
60 | Reprogramming of amino acid metabolism in pancreatic cancer:recent advances and therapeutic strategies | Frontiers in Oncology | 2020-09-01 | 通讯作者 |
61 | Mucins in pancreatic cancer: A well-established but promising family for diagnosis, prognosis and therapy | Journal of Cellular & Molecular Medicine | 2020-08-01 | 通讯作者 |
62 | Tumor microenvironment in chemoresistance, metastasis and immunotherapy of pancreatic cancer | American Journal of Cancer Research | 2020-07-01 | 通讯作者 |
63 | Novel discoveries targeting gemcitabine‐based chemoresistance and new therapies in pancreatic cancer: How far are we from the destination? | Cancer Medicine | 2019-10-01 | 通讯作者 |
64 | Pancreatic Cancer, Gut Microbiota, and Therapeutic Efficacy | Journal of Cancer | 2020-02-01 | 通讯作者 |
65 | Metabolism of pancreatic cancer: paving the way to better anticancer strategies | Molecular Cancer | 2020-03-01 | 通讯作者 |
66 | Role of the microbiome in occurrence, development and treatment of pancreatic cancer | Molecular Cancer | 2019-12-01 | 通讯作者 |
67 | Role of the complement system in the tumor microenvironment | Cancer Cell International | 2019-11-01 | 通讯作者 |
68 | MicroRNA-27a (miR-27a) in Solid Tumors: A Review Based on Mechanisms and Clinical Observations | FRONT ONCOL | 2019-09-01 | 通讯作者 |
69 | Research progress on CD-169-positive macrophages in tumors | Am J Transl Res | 2020-05-31 | 通讯作者 |
70 | The enhancement of glycolysis regulates pancreatic cancer metastasis | CELLULAR AND MOLECULAR LIFE SCIENCES | 2019-08-20 | 通讯作者 |
71 | Expression, function and clinical application of stanniocalcin-1 in cancer | JOURNAL OF CELLULAR AND MOLECULAR MEDICINE | 2020-05-01 | 通讯作者 |
72 | Cell-in-Cell-Mediated Entosis Reveals a Progressive Mechanism in Pancreatic Cancer | GASTROENTEROLOGY | 2023-12-01 | 通讯作者 |
73 | SQLE promotes pancreatic cancer growth by attenuating ER stress and activating lipid rafts-regulated Src/PI3K/Akt signaling pathway | Cell Death & Disease | 2023-08-04 | 通讯作者 |
74 | Application of metagenomic sequencing of drainage fluid in rapid and accurate diagnosis of postoperative intra-abdominal infection: a diagnostic study | International Journal of Surgery | 2023-09-01 | 通讯作者 |
75 | Cyst fluid glycoproteins accurately distinguishing malignancies of pancreatic cystic neoplasm | Signal Transduction and Targeted Therapy | 2023-10-18 | 通讯作者 |
76 | Uncovering chromatin accessibility and cancer diagnostic potential via cell-free DNA utilization | Science Bulletin | 2024-04-08 | 通讯作者 |
77 | Local resection for solid pseudopapillary neoplasms of the pancreas shows improved postoperative gastrointestinal function and reduced mental stress: a multiquestionnaire survey from a large cohort | International Journal of Surgery | 2023-12-01 | 通讯作者 |
78 | Comprehensive Analysis of Bulk and Single-Cell Transcriptomic Data Reveals a Novel signature Associated with Endoplasmic Reticulum Stress, Lipid Metabolism, and Liver Metastasis in Pancreatic Cancer | Journal of Translational Medicine | 2024-04-29 | 通讯作者 |
79 | The impacts of exposure to risk factorsduring youth on the increasing global trend of early-onset pancreatic cancer | PUBLIC HEALTH | 2024-04-03 | 通讯作者 |
80 | Preoperative pancreatic stent placement before the enucleation of insulinoma located in the head and neck of the pancreas in proximity to the main pancreatic duct: study protocol for a multicentre randomised clinical trial in Chinese tertiary medical centres | BMJ Open | 2024-04-02 | 通讯作者 |
81 | ABCD1 as a Novel Diagnostic Marker for Solid Pseudopapillary Neoplasm of the Pancreas | AMERICAN JOURNAL OF SURGICAL PATHOLOGY | 2024-04-03 | 通讯作者 |
82 | Crosstalk between metabolic remodeling and epigenetic reprogramming: A new perspective on pancreatic cancer | CANCER LETTERS | 2024-04-10 | 通讯作者 |
83 | Mutant Kras co-opts a proto-oncogenic enhancer network in inflammation-induced metaplastic progenitor cells to initiate pancreatic cancer | Nature Cancer | 2021-01 | 通讯作者 |
# | 获奖证书编号 | 奖项名称 | 获奖级别 | 获奖类别 | 获奖等级 | 获奖日期 | 颁奖单位 | 本单位是否为第一完成单位 | 完成单位排名 | 本人排序 | 备注 |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | 1000000 | 胰腺癌综合诊治方案的基础研究和临床应用 | 国家级 | 国家最高科学技术奖、自然科学奖、技术发明奖、科技进步奖 | 二等奖 | 2008-06-01 | 中华人民共和国国务院 | 是 | 1 | 1 | |
2 | 1000000 | 胰腺癌综合诊治方案的基础与临床研究 | 省部级 | 教育部高校科研成果奖(科学技术、人文社科) | 二等奖 | 2007-06-01 | 教育部 | 是 | 1 | 1 | |
3 | 1000000 | 胰岛素瘤诊治体系的建立及临床应用 | 省部级 | 省(市、自治区)政府自然科学奖、技术发明奖 | 一等奖 | 2015-06-01 | 北京市人民政府 | 1 | 1 | ||
4 | 1000000 | 胰腺癌综合诊治方案的基础与临床研究 | 国家级 | 科技进步奖、哲学社科奖 | 一等奖 | 2007-06-01 | 中华医学会 | 是 | 1 | 1 | |
5 | 1000000 | 胰腺癌综合诊治方案的基础与临床研究 | 省部级 | 省(市、自治区)政府自然科学奖、技术发明奖 | 三等奖 | 2008-06-01 | 北京市人民政府 | 是 | 1 | 1 | |
6 | 1000000 | 胰岛素瘤诊治体系的建立及临床应用 | 省部级 | 教育部高校科研成果奖(科学技术、人文社科) | 二等奖 | 2016-06-01 | 教育部 | 是 | 1 | 1 | |
7 | 1000000 | 胰岛素瘤诊治体系的建立及临床应用 | 国家级 | 国家最高科学技术奖、自然科学奖、技术发明奖、科技进步奖 | 二等奖 | 2016-06-01 | 中华人民共和国国务院 | 是 | 1 | 1 | |
8 | 1000000 | 胰岛素瘤诊治体系的建立及临床应用 | 国家级 | 科技进步奖、哲学社科奖 | 二等奖 | 2015-06-01 | 中华医学会 | 是 | 1 | 1 |
# | 成果类型 | 项目/专利/新品种名称 |
---|---|---|
1 | 作为主创人员获得授权的发明专利和新品种 | 胰管空肠吻合器 |
2 | 作为主创人员获得授权的发明专利和新品种 | 成纤维激活蛋白α在制备胰腺癌预后试剂盒中的用途 |
3 | 作为主创人员获得授权的发明专利和新品种 | 手术设备、手术器械控制设备和医疗设备 |
4 | 出版高水平专著 | 曾宪九胰腺病学 |
5 | 出版高水平专著 | 《胰腺外科手术学》 |
6 | 出版高水平专著 | 《胰腺病学》 |
7 | 出版高水平专著 | 罕见病学 |
8 | 作为主创人员获得授权的发明专利和新品种 | CHIP蛋白在胰腺癌治疗中的用途 |